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The map label for this gene is 220932598

Identifier: 220932598

GI number: 220932598

Start: 1886380

End: 1888167

Strand: Direct

Name: 220932598

Synonym: Hore_17620

Alternate gene names: NA

Gene position: 1886380-1888167 (Clockwise)

Preceding gene: 220932576

Following gene: 220932621

Centisome position: 73.17

GC content: 43.46

Gene sequence:

>1788_bases
ATGTTTACTAGAGTTACATATGTTTTAAGGAAACCCGGAGTTGGACAGGTGACCTTAGCCCTGAAACTATTTATTCTATC
CATAATATTGATGTTTTCTCTATCAGCCTGTTCACCCATAACTCAGGATTATTCTGACACCGGATATGGAATAATCAAGG
GTAAGGTTACCCTTGGTGAACCCAATTCCTCAACTGTTAATAAAATTATTCATCCGGTAAATATCAATAAGAACTTAAAT
TCAATTCCACTGGCCACTTCTTCTATCTCTACCGCCCACACCCCCGGAGTCTATATACTTAAACTGGCTGAAACCTTAAG
TTACAGCTCTCTTAAAAAAAATATTTTGCAGGGTAAGGCCAGGCCCATAGAAAAAATTGCTAAAAACACATATAAAATTA
AAATTGAAGGGACCCGGTCCCCGGGACAGTTAATAACTAATATGGAAAAAAATCCAATGGTAGAATACATCGAGCCTGAC
TATCTGGTCCATATTCAGGCAATTCCTGATGATACCTATTACCCCCGCCAGTGGAATTATAAAATTCTCAATATGGAAAA
GGTATGGGAACATTACCACGGCAGTGAGGACATAACTGTAGCCGTTATCGACACCGGTATCCTTCCGGGACACCCTGACC
TTCAGGGAAGGATAACAGCAGGTTATGATTTTGTTGACAATGATACTGACCCGACCGATACCTCACCTGATTTTAGTCAT
GGAACCCATGTAGCCGGTATCATCGGGGCCGTAACCAATAATAGTGAAGGGGTATCCGGCTTCAACTGGAATATTAAAAT
AATGCCCATCAGGGTAATCGGCCCTGATGGAAGTGGGGGGTATAGCTCCCTTATATCAGGGATAAGGTGGGCTGTGGACC
ATGGTGCAGATGTCATCAACCTTAGCCTGGCAGGCCCCAGTAGTTCATATTCCCTTGAAGAAGCCGTTAATTATGCCGTG
GATAATGGGGTTACCGTTGTTGCCGCAGCCGGTAATAATGGTACAAGCCCGATTTTATACCCGGCCCGGTACTCCCGGGT
AATAAGCGTTGGAGCCGTAGGGCCAGAACTGGATAGGGCCTACTATTCAAATTATGGAGAGGACCTTGATGTTGTAGCTC
CGGGTGGAGACAGCAGTATTCCGGTCCCTGATAATAACATATTAAGTACAGCCGGTTATATGTCCGGTTCAAAACCGGTC
CACCAGTACACCTGGGCTCAGGGCACTTCCATGGCAGCACCGCATGTCACGGGACTGGTGGCCCTGCTATATAGTGCCGG
TTATAGTAACCCCTCATATATTGAAGACATTCTAAAAGAAACAGCCAGGGACCTGGGTCAACCGGGAGCTGATGGAGAGT
ATGGAGCTGGACTTATAAACCCTGTAAGAGCTCTGGGATTAGCACCAGATAGTAATACTGATAGTAATAATAATTTTAGC
AATGATAGCAGTACCGGCCTTAACAACAAAGATAGTAATAATAAAAGTAGTAATAATGGGGCCAGTACCTATTCTTTAAG
TGAAATAAAAATATACATCCTTGATAATAACTTTAATGGTAAAACCCTGGATTATGTTGAGGAGGCCAGGCCAATTACGA
CCCCTGATGTTTACGGCAACTACTCCATTAAAGTTAGAAAAGGAGTCTGGACAGTAATAGGATGGCTTGATACAAATAAC
AACCACGTTGTTGACCGGGGTGACTATTACGGTCAGGCAGAAGATATCGTTTCTTCTTCCGACTATTCCCCGGTTATCGT
AAATATTGACCTGAATATAAGGTCCTGA

Upstream 100 bases:

>100_bases
ACTTATTTAAAAAATCAATTAAAAGAACAAATTGGACTTGTTGTCTGTACCTGAACCTGAAAACAAATACGGGAATAACT
CATGAAATGGAGGCAGTAAC

Downstream 100 bases:

>100_bases
AAATTTTTGCAGGATATTAAAAAACCCCGGTTTAACCGGGGTTTTTATGTATAAACCTGATAATCTTCAGCCCTAAAAAC
TATATGATAATCCTGCCCTT

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: Ak.1 protease [H]

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MFTRVTYVLRKPGVGQVTLALKLFILSIILMFSLSACSPITQDYSDTGYGIIKGKVTLGEPNSSTVNKIIHPVNINKNLN
SIPLATSSISTAHTPGVYILKLAETLSYSSLKKNILQGKARPIEKIAKNTYKIKIEGTRSPGQLITNMEKNPMVEYIEPD
YLVHIQAIPDDTYYPRQWNYKILNMEKVWEHYHGSEDITVAVIDTGILPGHPDLQGRITAGYDFVDNDTDPTDTSPDFSH
GTHVAGIIGAVTNNSEGVSGFNWNIKIMPIRVIGPDGSGGYSSLISGIRWAVDHGADVINLSLAGPSSSYSLEEAVNYAV
DNGVTVVAAAGNNGTSPILYPARYSRVISVGAVGPELDRAYYSNYGEDLDVVAPGGDSSIPVPDNNILSTAGYMSGSKPV
HQYTWAQGTSMAAPHVTGLVALLYSAGYSNPSYIEDILKETARDLGQPGADGEYGAGLINPVRALGLAPDSNTDSNNNFS
NDSSTGLNNKDSNNKSSNNGASTYSLSEIKIYILDNNFNGKTLDYVEEARPITTPDVYGNYSIKVRKGVWTVIGWLDTNN
NHVVDRGDYYGQAEDIVSSSDYSPVIVNIDLNIRS

Sequences:

>Translated_595_residues
MFTRVTYVLRKPGVGQVTLALKLFILSIILMFSLSACSPITQDYSDTGYGIIKGKVTLGEPNSSTVNKIIHPVNINKNLN
SIPLATSSISTAHTPGVYILKLAETLSYSSLKKNILQGKARPIEKIAKNTYKIKIEGTRSPGQLITNMEKNPMVEYIEPD
YLVHIQAIPDDTYYPRQWNYKILNMEKVWEHYHGSEDITVAVIDTGILPGHPDLQGRITAGYDFVDNDTDPTDTSPDFSH
GTHVAGIIGAVTNNSEGVSGFNWNIKIMPIRVIGPDGSGGYSSLISGIRWAVDHGADVINLSLAGPSSSYSLEEAVNYAV
DNGVTVVAAAGNNGTSPILYPARYSRVISVGAVGPELDRAYYSNYGEDLDVVAPGGDSSIPVPDNNILSTAGYMSGSKPV
HQYTWAQGTSMAAPHVTGLVALLYSAGYSNPSYIEDILKETARDLGQPGADGEYGAGLINPVRALGLAPDSNTDSNNNFS
NDSSTGLNNKDSNNKSSNNGASTYSLSEIKIYILDNNFNGKTLDYVEEARPITTPDVYGNYSIKVRKGVWTVIGWLDTNN
NHVVDRGDYYGQAEDIVSSSDYSPVIVNIDLNIRS
>Mature_595_residues
MFTRVTYVLRKPGVGQVTLALKLFILSIILMFSLSACSPITQDYSDTGYGIIKGKVTLGEPNSSTVNKIIHPVNINKNLN
SIPLATSSISTAHTPGVYILKLAETLSYSSLKKNILQGKARPIEKIAKNTYKIKIEGTRSPGQLITNMEKNPMVEYIEPD
YLVHIQAIPDDTYYPRQWNYKILNMEKVWEHYHGSEDITVAVIDTGILPGHPDLQGRITAGYDFVDNDTDPTDTSPDFSH
GTHVAGIIGAVTNNSEGVSGFNWNIKIMPIRVIGPDGSGGYSSLISGIRWAVDHGADVINLSLAGPSSSYSLEEAVNYAV
DNGVTVVAAAGNNGTSPILYPARYSRVISVGAVGPELDRAYYSNYGEDLDVVAPGGDSSIPVPDNNILSTAGYMSGSKPV
HQYTWAQGTSMAAPHVTGLVALLYSAGYSNPSYIEDILKETARDLGQPGADGEYGAGLINPVRALGLAPDSNTDSNNNFS
NDSSTGLNNKDSNNKSSNNGASTYSLSEIKIYILDNNFNGKTLDYVEEARPITTPDVYGNYSIKVRKGVWTVIGWLDTNN
NHVVDRGDYYGQAEDIVSSSDYSPVIVNIDLNIRS

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4506775, Length=301, Percent_Identity=28.9036544850498, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI4505579, Length=144, Percent_Identity=29.1666666666667, Blast_Score=69, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6324576, Length=306, Percent_Identity=32.3529411764706, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319893, Length=254, Percent_Identity=32.6771653543307, Blast_Score=107, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6320775, Length=334, Percent_Identity=30.2395209580838, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45550681, Length=297, Percent_Identity=26.2626262626263, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 64259; Mature: 64259

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00018 EF_HAND_1 ; PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTRVTYVLRKPGVGQVTLALKLFILSIILMFSLSACSPITQDYSDTGYGIIKGKVTLGE
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECC
PNSSTVNKIIHPVNINKNLNSIPLATSSISTAHTPGVYILKLAETLSYSSLKKNILQGKA
CCCHHHHHEEEEEECCCCCCCCCEECCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCC
RPIEKIAKNTYKIKIEGTRSPGQLITNMEKNPMVEYIEPDYLVHIQAIPDDTYYPRQWNY
CHHHHHCCCEEEEEEEECCCCHHHHHCCCCCCCEEEECCCEEEEEEECCCCCCCCCCCCE
KILNMEKVWEHYHGSEDITVAVIDTGILPGHPDLQGRITAGYDFVDNDTDPTDTSPDFSH
EEECHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCEEEEECCEECCCCCCCCCCCCCCCC
GTHVAGIIGAVTNNSEGVSGFNWNIKIMPIRVIGPDGSGGYSSLISGIRWAVDHGADVIN
CCEEEEEEEEEECCCCCCCCEEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEE
LSLAGPSSSYSLEEAVNYAVDNGVTVVAAAGNNGTSPILYPARYSRVISVGAVGPELDRA
EEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCEEECCCCCEEEEECCCCCHHHHH
YYSNYGEDLDVVAPGGDSSIPVPDNNILSTAGYMSGSKPVHQYTWAQGTSMAAPHVTGLV
HHHCCCCCEEEEECCCCCCCCCCCCCEEECCCCCCCCCCCCEEECCCCCCCCCCHHHHHH
ALLYSAGYSNPSYIEDILKETARDLGQPGADGEYGAGLINPVRALGLAPDSNTDSNNNFS
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCC
NDSSTGLNNKDSNNKSSNNGASTYSLSEIKIYILDNNFNGKTLDYVEEARPITTPDVYGN
CCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCCCHHHHHHCCCCCCCCCCCC
YSIKVRKGVWTVIGWLDTNNNHVVDRGDYYGQAEDIVSSSDYSPVIVNIDLNIRS
EEEEEECCEEEEEEEEECCCCEEEECCCCCCCHHHHHCCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MFTRVTYVLRKPGVGQVTLALKLFILSIILMFSLSACSPITQDYSDTGYGIIKGKVTLGE
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECC
PNSSTVNKIIHPVNINKNLNSIPLATSSISTAHTPGVYILKLAETLSYSSLKKNILQGKA
CCCHHHHHEEEEEECCCCCCCCCEECCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCC
RPIEKIAKNTYKIKIEGTRSPGQLITNMEKNPMVEYIEPDYLVHIQAIPDDTYYPRQWNY
CHHHHHCCCEEEEEEEECCCCHHHHHCCCCCCCEEEECCCEEEEEEECCCCCCCCCCCCE
KILNMEKVWEHYHGSEDITVAVIDTGILPGHPDLQGRITAGYDFVDNDTDPTDTSPDFSH
EEECHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCEEEEECCEECCCCCCCCCCCCCCCC
GTHVAGIIGAVTNNSEGVSGFNWNIKIMPIRVIGPDGSGGYSSLISGIRWAVDHGADVIN
CCEEEEEEEEEECCCCCCCCEEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEE
LSLAGPSSSYSLEEAVNYAVDNGVTVVAAAGNNGTSPILYPARYSRVISVGAVGPELDRA
EEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCEEECCCCCEEEEECCCCCHHHHH
YYSNYGEDLDVVAPGGDSSIPVPDNNILSTAGYMSGSKPVHQYTWAQGTSMAAPHVTGLV
HHHCCCCCEEEEECCCCCCCCCCCCCEEECCCCCCCCCCCCEEECCCCCCCCCCHHHHHH
ALLYSAGYSNPSYIEDILKETARDLGQPGADGEYGAGLINPVRALGLAPDSNTDSNNNFS
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCC
NDSSTGLNNKDSNNKSSNNGASTYSLSEIKIYILDNNFNGKTLDYVEEARPITTPDVYGN
CCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCCCHHHHHHCCCCCCCCCCCC
YSIKVRKGVWTVIGWLDTNNNHVVDRGDYYGQAEDIVSSSDYSPVIVNIDLNIRS
EEEEEECCEEEEEEEEECCCCEEEECCCCCCCHHHHHCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7993087; 10588904 [H]