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The map label for this gene is srrA [H]

Identifier: 220932165

GI number: 220932165

Start: 1427403

End: 1428086

Strand: Direct

Name: srrA [H]

Synonym: Hore_13280

Alternate gene names: 220932165

Gene position: 1427403-1428086 (Clockwise)

Preceding gene: 220932153

Following gene: 220932166

Centisome position: 55.37

GC content: 39.18

Gene sequence:

>684_bases
TTGAACCCCAAAATACTGGTTGTAGATGATGAGAAAAAAATCAGGAAGGTCCTTAAGGCCTTCCTGGAAAAACATGATTT
TTCTATAGAAATGGCCAGTGATGGTAAGGAGGCCCTTTCTAAAGTAAATGAATTTAATCCAGATCTGATCATTCTTGATT
TAATGCTCCCTGAAATAAGTGGTGAAGAAGTCTGCCAGAAAATAAGGCAAGACAAACAGACTCCGATCCTGATGTTAACC
GCTAAAGGCACCGAGGAAGATAAAGTCAACGGTTTTGCTTATGGAGCCGATGATTACCTGGTCAAACCCTTCAGTCTTCG
GGAACTTTTAGCCCGAATTAAGGCAATTTTACGACGAAGTAACCAGAAGGCCGAAAAAGCAGAAATTTTTGTGTACCAGG
ATGGAAGGTTAAAAATTCATCCTAACAGAATGAAAGTATTAGTTAATGGTAGAGATGCTGACTTAACCAGAACCGAGTTC
AATATCTTAGTGACCCTGATCCGTAATCCCGGTCAGGTCTTTACCAGAGAACAGTTGGCCAAAAAAGTTATGGGCCTTGA
ATATAAAGGGTATGACCGGACAATCGATGCCCATATAAAAAATATCCGGAAAAAGCTTAATCTAGAAAAAAACCAACTTA
TTATAACTGTATATGGTGTCGGCTATAAATTTGAGGGGGATTAA

Upstream 100 bases:

>100_bases
CTTATATAAACTCTGACTTAATTGAAAACTTAAAATTTAATTGTTATAATTAAGAAAATTTAATAATAAATTTAAGACCA
CTAAAAAGGAGTGGTTAAGG

Downstream 100 bases:

>100_bases
AATGAGTAAACTGGGTATAAAAATTTTTTTAATAATGTTATCAGTAGCTATAATGGGTTTAGTATTTATAGGTTTATACC
TGAATTATAGCATTCCCGAA

Product: winged helix family two component transcriptional regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MNPKILVVDDEKKIRKVLKAFLEKHDFSIEMASDGKEALSKVNEFNPDLIILDLMLPEISGEEVCQKIRQDKQTPILMLT
AKGTEEDKVNGFAYGADDYLVKPFSLRELLARIKAILRRSNQKAEKAEIFVYQDGRLKIHPNRMKVLVNGRDADLTRTEF
NILVTLIRNPGQVFTREQLAKKVMGLEYKGYDRTIDAHIKNIRKKLNLEKNQLIITVYGVGYKFEGD

Sequences:

>Translated_227_residues
MNPKILVVDDEKKIRKVLKAFLEKHDFSIEMASDGKEALSKVNEFNPDLIILDLMLPEISGEEVCQKIRQDKQTPILMLT
AKGTEEDKVNGFAYGADDYLVKPFSLRELLARIKAILRRSNQKAEKAEIFVYQDGRLKIHPNRMKVLVNGRDADLTRTEF
NILVTLIRNPGQVFTREQLAKKVMGLEYKGYDRTIDAHIKNIRKKLNLEKNQLIITVYGVGYKFEGD
>Mature_227_residues
MNPKILVVDDEKKIRKVLKAFLEKHDFSIEMASDGKEALSKVNEFNPDLIILDLMLPEISGEEVCQKIRQDKQTPILMLT
AKGTEEDKVNGFAYGADDYLVKPFSLRELLARIKAILRRSNQKAEKAEIFVYQDGRLKIHPNRMKVLVNGRDADLTRTEF
NILVTLIRNPGQVFTREQLAKKVMGLEYKGYDRTIDAHIKNIRKKLNLEKNQLIITVYGVGYKFEGD

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=234, Percent_Identity=43.1623931623932, Blast_Score=172, Evalue=1e-44,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=39.9122807017544, Blast_Score=160, Evalue=5e-41,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=41.5929203539823, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=36.8888888888889, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=35.3448275862069, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI1790863, Length=233, Percent_Identity=33.0472103004292, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=37.5, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=34.2342342342342, Blast_Score=134, Evalue=3e-33,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=31.0810810810811, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=34.8214285714286, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=32.7354260089686, Blast_Score=120, Evalue=5e-29,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=35.4545454545455, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=28.1385281385281, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=30.7359307359307, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1788550, Length=123, Percent_Identity=31.7073170731707, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1790437, Length=148, Percent_Identity=30.4054054054054, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=32.6732673267327, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=32.5, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=29.7297297297297, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789149, Length=116, Percent_Identity=31.0344827586207, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87082052, Length=155, Percent_Identity=32.258064516129, Blast_Score=61, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=106, Percent_Identity=28.3018867924528, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26110; Mature: 26110

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPKILVVDDEKKIRKVLKAFLEKHDFSIEMASDGKEALSKVNEFNPDLIILDLMLPEIS
CCCCEEEECCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCC
GEEVCQKIRQDKQTPILMLTAKGTEEDKVNGFAYGADDYLVKPFSLRELLARIKAILRRS
HHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEECCCCCEECCHHHHHHHHHHHHHHHHC
NQKAEKAEIFVYQDGRLKIHPNRMKVLVNGRDADLTRTEFNILVTLIRNPGQVFTREQLA
CCCCCCEEEEEEECCEEEECCCEEEEEECCCCCCCCHHHEEEEEEEECCCCHHHHHHHHH
KKVMGLEYKGYDRTIDAHIKNIRKKLNLEKNQLIITVYGVGYKFEGD
HHHHCCEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCEEECCC
>Mature Secondary Structure
MNPKILVVDDEKKIRKVLKAFLEKHDFSIEMASDGKEALSKVNEFNPDLIILDLMLPEIS
CCCCEEEECCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCC
GEEVCQKIRQDKQTPILMLTAKGTEEDKVNGFAYGADDYLVKPFSLRELLARIKAILRRS
HHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEECCCCCEECCHHHHHHHHHHHHHHHHC
NQKAEKAEIFVYQDGRLKIHPNRMKVLVNGRDADLTRTEFNILVTLIRNPGQVFTREQLA
CCCCCCEEEEEEECCEEEECCCEEEEEECCCCCCCCHHHEEEEEEEECCCCHHHHHHHHH
KKVMGLEYKGYDRTIDAHIKNIRKKLNLEKNQLIITVYGVGYKFEGD
HHHHCCEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA