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The map label for this gene is gyrA [H]

Identifier: 220932012

GI number: 220932012

Start: 1270197

End: 1272587

Strand: Direct

Name: gyrA [H]

Synonym: Hore_11750

Alternate gene names: 220932012

Gene position: 1270197-1272587 (Clockwise)

Preceding gene: 220931993

Following gene: 220932050

Centisome position: 49.27

GC content: 35.88

Gene sequence:

>2391_bases
ATGGCTGAAAAAATCAGATCAATAGCAATTGAAGATAAAATGAAAGATTCATATTTAAGTTACTCCTTAAGTGTTATTGC
CTCCCGGGCCCTTCCGGATGTCAGGGATGGTTTGAAACCTGTTCATCGCAGGATTCTTTATGCAGCCCGGGAATTAGGCT
TAACCCATGATAAACCACATAAAAAGTCTGCCAGGATAGTCGGGGAAGTATTAGGTAAATACCATCCCCATGGTGATGCC
TCAGTTTATGATGCTATGGTTCGTATGGCCCAGTATTTTAACCAGAGATATTGTCTTATTGATGGACATGGAAACTTTGG
CTCAATTGATGGGGACAGCCCCGCTGCTATGAGGTATACCGAGGCCAGGTTAACCGAACTGGCTGAGGATATTATGGCAG
ATATTACTCAGGATACAGTAGATTTTGTAGATAATTTTGATGGTTCTCTTCAAGAACCGGAGATACTTCCAACTAAAGTA
CCAAATTTACTCATTAATGGAGCCAGTGGTATTGCAGTCGGAATGAGTACCAGTATTCCGCCCCATAATCTTGGGGAAGT
AGTTGATGCCATGGTTCACCTTTTGAAACACCCCAATGCTAAACTTGAAACAATAATGAAATACATACCGGGGCCTGATT
TTCCTACCGGAGCCAAAATAGTTGGACTTTCAGGTATTAAAAAAGCCTATAAAACGGGAAATGGAAAAATAACCTTAAGG
GCCAGGACTCAAATTGAGAAAAAAGGCAGGAAAAAACAGATTATTATTAAAGAAATTCCTTATCATTTAAATAAAGTAAA
GTTACTGGAAGATATTGCAGAGCTAATTAATAAAGGAAAAATAGATAATGTATCCGATTTAAGGGATGAAAGTGACCAGG
AGGGTTTAAGGATTGTCGTTGAGTTGAAATCAGGAGCTGATCCGGATATCATTCTCAATCAATTATATAAATTTACTTCA
CTGCAGACAAATTATCGTATTAATATGCTTGCCCTGGATGGAAAACAACCCAGGGTTATGGATTTAATAACAATCTTAAA
AAATTTTATTAATTTCAGGCGTCAGGTTATTACCAGAAGGACAAAATATAAACTCAATAAGGCGAAAGAAAGATTCCACC
TTTTACAGGGCCTTATAACTGCAATTGATAAGCTTGACCTTGTTATTTCTATAATCAGACATTCCAAATCAACAAAAGAA
GCCAGGCAAAAACTTCAGGAGAAACTTGTTATTACTGAAAAGCAGGCAGAAGCCATCCTGAGAATGAGATTGCAAAAACT
TGTCGGTATGGAAGAGGAAAAGCTGCATCAGGAATCAGCAGGACTGGAAGAACAGATTAAGTATTATAAAAAAATCCTTA
ACAATAAAAATGAACTTGATAAAGTCTTGAAAAAAGAACTACTTGATATTAAAAATAAATATGCAGATAAACGTAAAACT
GAAATTATCGAAGATGAAGAAAAAGCCATAATTGAAAAAACAGATTTAATCAAAAAAGAAAAAGTCTTTTTGACCTTTTC
CTACCGCCAGAATATCAAACGCACCACTTCCTCAGAATATGCCCGGGCCGGCAAAAATGATTATATTATAGATACCATGA
CAGGGACAACCCTGGATACACTCCTTTTCTTTACCAATACCGGTGATGTTTATACATTACCAGTTCATAAAATACCAGAA
CATCATGGCTTATCAACAGGTGATAATATTAAAGATTTCCTTAAAATACCTCTCTCTAAAAAAATAGTTAAAGTTATTTG
CCTTAATGAAGAAACCAAAGAAAAATATATTACTATAGCTACCAAACAGGGTATGGTTAAGAAAACAATAGGTGGGGAAT
ATCAAACCACCTATTCCAGAATTAAAGCAATTAAATTAAATAAAGGTGATGAAGTGGTTGGTGTGGAAATAACAGATGGA
AACCAGGAAATACTACTGGGTACTAAAAAGGCAAAAACTATAAGGTTTGAAGAAGATTCAGTTAGTGATACCGGTCGGAA
CACCATTGGAAGTATTGGAATAAAACTTGCTAAAGGTGATGAGGTAGTTTCCTTCAATCTTGTTAATAATAATACCAGTG
TTGTCTCCATTTCAAAAACAGGCCGTGGTAAGAGAAGTCCTATCGAGGAATATAATCCCCAGAATAGAAATGGTAAGGGG
TTAAAAACCTGTGGTTCAAGTATCTATAAAATGGCCGGGGTTATTTGTGCTAACCCTGATGATTATATACTGATAACTAC
TGGTAATGAAAAACTTTATACAGTTAAGGTTAACGATTTAACCGAAACTTCCAGAACGGGTAATATGTATGAGGTGGTTT
CTTTGAAAAATGATGATAAAATTACAGGGGTTGAAAAACTACCTTTTGCCCCTGAGGAAGATAATAATTAA

Upstream 100 bases:

>100_bases
CAAAACGAACAGATTTTTACCAGCTGTTTCTTGAAATAGTTAATTATTTGTTATAATATCAAGTATGAAACAAGGAATTA
ATTGAGAAAGGGGAATATTA

Downstream 100 bases:

>100_bases
AGATTAGGGATAATAATATTCCGGGACTTTCTTTTATCTGGTCGCAAAACCAGGTGATGATAATATAAATTTAATTATTA
AGTCTAAATTTAGTAAAAAA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 796; Mature: 795

Protein sequence:

>796_residues
MAEKIRSIAIEDKMKDSYLSYSLSVIASRALPDVRDGLKPVHRRILYAARELGLTHDKPHKKSARIVGEVLGKYHPHGDA
SVYDAMVRMAQYFNQRYCLIDGHGNFGSIDGDSPAAMRYTEARLTELAEDIMADITQDTVDFVDNFDGSLQEPEILPTKV
PNLLINGASGIAVGMSTSIPPHNLGEVVDAMVHLLKHPNAKLETIMKYIPGPDFPTGAKIVGLSGIKKAYKTGNGKITLR
ARTQIEKKGRKKQIIIKEIPYHLNKVKLLEDIAELINKGKIDNVSDLRDESDQEGLRIVVELKSGADPDIILNQLYKFTS
LQTNYRINMLALDGKQPRVMDLITILKNFINFRRQVITRRTKYKLNKAKERFHLLQGLITAIDKLDLVISIIRHSKSTKE
ARQKLQEKLVITEKQAEAILRMRLQKLVGMEEEKLHQESAGLEEQIKYYKKILNNKNELDKVLKKELLDIKNKYADKRKT
EIIEDEEKAIIEKTDLIKKEKVFLTFSYRQNIKRTTSSEYARAGKNDYIIDTMTGTTLDTLLFFTNTGDVYTLPVHKIPE
HHGLSTGDNIKDFLKIPLSKKIVKVICLNEETKEKYITIATKQGMVKKTIGGEYQTTYSRIKAIKLNKGDEVVGVEITDG
NQEILLGTKKAKTIRFEEDSVSDTGRNTIGSIGIKLAKGDEVVSFNLVNNNTSVVSISKTGRGKRSPIEEYNPQNRNGKG
LKTCGSSIYKMAGVICANPDDYILITTGNEKLYTVKVNDLTETSRTGNMYEVVSLKNDDKITGVEKLPFAPEEDNN

Sequences:

>Translated_796_residues
MAEKIRSIAIEDKMKDSYLSYSLSVIASRALPDVRDGLKPVHRRILYAARELGLTHDKPHKKSARIVGEVLGKYHPHGDA
SVYDAMVRMAQYFNQRYCLIDGHGNFGSIDGDSPAAMRYTEARLTELAEDIMADITQDTVDFVDNFDGSLQEPEILPTKV
PNLLINGASGIAVGMSTSIPPHNLGEVVDAMVHLLKHPNAKLETIMKYIPGPDFPTGAKIVGLSGIKKAYKTGNGKITLR
ARTQIEKKGRKKQIIIKEIPYHLNKVKLLEDIAELINKGKIDNVSDLRDESDQEGLRIVVELKSGADPDIILNQLYKFTS
LQTNYRINMLALDGKQPRVMDLITILKNFINFRRQVITRRTKYKLNKAKERFHLLQGLITAIDKLDLVISIIRHSKSTKE
ARQKLQEKLVITEKQAEAILRMRLQKLVGMEEEKLHQESAGLEEQIKYYKKILNNKNELDKVLKKELLDIKNKYADKRKT
EIIEDEEKAIIEKTDLIKKEKVFLTFSYRQNIKRTTSSEYARAGKNDYIIDTMTGTTLDTLLFFTNTGDVYTLPVHKIPE
HHGLSTGDNIKDFLKIPLSKKIVKVICLNEETKEKYITIATKQGMVKKTIGGEYQTTYSRIKAIKLNKGDEVVGVEITDG
NQEILLGTKKAKTIRFEEDSVSDTGRNTIGSIGIKLAKGDEVVSFNLVNNNTSVVSISKTGRGKRSPIEEYNPQNRNGKG
LKTCGSSIYKMAGVICANPDDYILITTGNEKLYTVKVNDLTETSRTGNMYEVVSLKNDDKITGVEKLPFAPEEDNN
>Mature_795_residues
AEKIRSIAIEDKMKDSYLSYSLSVIASRALPDVRDGLKPVHRRILYAARELGLTHDKPHKKSARIVGEVLGKYHPHGDAS
VYDAMVRMAQYFNQRYCLIDGHGNFGSIDGDSPAAMRYTEARLTELAEDIMADITQDTVDFVDNFDGSLQEPEILPTKVP
NLLINGASGIAVGMSTSIPPHNLGEVVDAMVHLLKHPNAKLETIMKYIPGPDFPTGAKIVGLSGIKKAYKTGNGKITLRA
RTQIEKKGRKKQIIIKEIPYHLNKVKLLEDIAELINKGKIDNVSDLRDESDQEGLRIVVELKSGADPDIILNQLYKFTSL
QTNYRINMLALDGKQPRVMDLITILKNFINFRRQVITRRTKYKLNKAKERFHLLQGLITAIDKLDLVISIIRHSKSTKEA
RQKLQEKLVITEKQAEAILRMRLQKLVGMEEEKLHQESAGLEEQIKYYKKILNNKNELDKVLKKELLDIKNKYADKRKTE
IIEDEEKAIIEKTDLIKKEKVFLTFSYRQNIKRTTSSEYARAGKNDYIIDTMTGTTLDTLLFFTNTGDVYTLPVHKIPEH
HGLSTGDNIKDFLKIPLSKKIVKVICLNEETKEKYITIATKQGMVKKTIGGEYQTTYSRIKAIKLNKGDEVVGVEITDGN
QEILLGTKKAKTIRFEEDSVSDTGRNTIGSIGIKLAKGDEVVSFNLVNNNTSVVSISKTGRGKRSPIEEYNPQNRNGKGL
KTCGSSIYKMAGVICANPDDYILITTGNEKLYTVKVNDLTETSRTGNMYEVVSLKNDDKITGVEKLPFAPEEDNN

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=173, Percent_Identity=31.7919075144509, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI19913408, Length=417, Percent_Identity=24.9400479616307, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1788562, Length=847, Percent_Identity=40.7319952774498, Blast_Score=645, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=614, Percent_Identity=38.2736156351792, Blast_Score=420, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17535065, Length=190, Percent_Identity=29.4736842105263, Blast_Score=72, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI212645845, Length=173, Percent_Identity=30.635838150289, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI212645657, Length=189, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=212, Percent_Identity=30.6603773584906, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17136538, Length=407, Percent_Identity=26.044226044226, Blast_Score=83, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 89618; Mature: 89486

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKIRSIAIEDKMKDSYLSYSLSVIASRALPDVRDGLKPVHRRILYAARELGLTHDKPH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
KKSARIVGEVLGKYHPHGDASVYDAMVRMAQYFNQRYCLIDGHGNFGSIDGDSPAAMRYT
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHH
EARLTELAEDIMADITQDTVDFVDNFDGSLQEPEILPTKVPNLLINGASGIAVGMSTSIP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCC
PHNLGEVVDAMVHLLKHPNAKLETIMKYIPGPDFPTGAKIVGLSGIKKAYKTGNGKITLR
CCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHCCCCEEEEE
ARTQIEKKGRKKQIIIKEIPYHLNKVKLLEDIAELINKGKIDNVSDLRDESDQEGLRIVV
EHHHHHHCCCCCEEEHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCEEEEE
ELKSGADPDIILNQLYKFTSLQTNYRINMLALDGKQPRVMDLITILKNFINFRRQVITRR
EECCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
TKYKLNKAKERFHLLQGLITAIDKLDLVISIIRHSKSTKEARQKLQEKLVITEKQAEAIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
RMRLQKLVGMEEEKLHQESAGLEEQIKYYKKILNNKNELDKVLKKELLDIKNKYADKRKT
HHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
EIIEDEEKAIIEKTDLIKKEKVFLTFSYRQNIKRTTSSEYARAGKNDYIIDTMTGTTLDT
HHHCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCCCHHHHHCCCCCEEEEECCCCCEEE
LLFFTNTGDVYTLPVHKIPEHHGLSTGDNIKDFLKIPLSKKIVKVICLNEETKEKYITIA
EEEEECCCCEEEECHHHCCCCCCCCCCCCHHHHHHCCCHHHEEEEEECCCCCCCCEEEEE
TKQGMVKKTIGGEYQTTYSRIKAIKLNKGDEVVGVEITDGNQEILLGTKKAKTIRFEEDS
ECCCCHHHHCCCCHHHHHHHHEEEEECCCCEEEEEEEECCCCEEEEECCCCCEEEECCCC
VSDTGRNTIGSIGIKLAKGDEVVSFNLVNNNTSVVSISKTGRGKRSPIEEYNPQNRNGKG
CCCCCCCCHHHCEEEEECCCCEEEEEEECCCCEEEEEECCCCCCCCCHHHCCCCCCCCCC
LKTCGSSIYKMAGVICANPDDYILITTGNEKLYTVKVNDLTETSRTGNMYEVVSLKNDDK
HHHHHHHHHHHHCEEECCCCCEEEEEECCCEEEEEEECCCCCCCCCCCEEEEEEECCCCC
ITGVEKLPFAPEEDNN
CCCHHHCCCCCCCCCC
>Mature Secondary Structure 
AEKIRSIAIEDKMKDSYLSYSLSVIASRALPDVRDGLKPVHRRILYAARELGLTHDKPH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
KKSARIVGEVLGKYHPHGDASVYDAMVRMAQYFNQRYCLIDGHGNFGSIDGDSPAAMRYT
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHH
EARLTELAEDIMADITQDTVDFVDNFDGSLQEPEILPTKVPNLLINGASGIAVGMSTSIP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCC
PHNLGEVVDAMVHLLKHPNAKLETIMKYIPGPDFPTGAKIVGLSGIKKAYKTGNGKITLR
CCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHCCCCEEEEE
ARTQIEKKGRKKQIIIKEIPYHLNKVKLLEDIAELINKGKIDNVSDLRDESDQEGLRIVV
EHHHHHHCCCCCEEEHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCEEEEE
ELKSGADPDIILNQLYKFTSLQTNYRINMLALDGKQPRVMDLITILKNFINFRRQVITRR
EECCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
TKYKLNKAKERFHLLQGLITAIDKLDLVISIIRHSKSTKEARQKLQEKLVITEKQAEAIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
RMRLQKLVGMEEEKLHQESAGLEEQIKYYKKILNNKNELDKVLKKELLDIKNKYADKRKT
HHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
EIIEDEEKAIIEKTDLIKKEKVFLTFSYRQNIKRTTSSEYARAGKNDYIIDTMTGTTLDT
HHHCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCCCHHHHHCCCCCEEEEECCCCCEEE
LLFFTNTGDVYTLPVHKIPEHHGLSTGDNIKDFLKIPLSKKIVKVICLNEETKEKYITIA
EEEEECCCCEEEECHHHCCCCCCCCCCCCHHHHHHCCCHHHEEEEEECCCCCCCCEEEEE
TKQGMVKKTIGGEYQTTYSRIKAIKLNKGDEVVGVEITDGNQEILLGTKKAKTIRFEEDS
ECCCCHHHHCCCCHHHHHHHHEEEEECCCCEEEEEEEECCCCEEEEECCCCCEEEECCCC
VSDTGRNTIGSIGIKLAKGDEVVSFNLVNNNTSVVSISKTGRGKRSPIEEYNPQNRNGKG
CCCCCCCCHHHCEEEEECCCCEEEEEEECCCCEEEEEECCCCCCCCCHHHCCCCCCCCCC
LKTCGSSIYKMAGVICANPDDYILITTGNEKLYTVKVNDLTETSRTGNMYEVVSLKNDDK
HHHHHHHHHHHHCEEECCCCCEEEEEECCCEEEEEEECCCCCCCCCCCEEEEEEECCCCC
ITGVEKLPFAPEEDNN
CCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2987847; 7584024; 9384377 [H]