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The map label for this gene is serA [H]

Identifier: 220931993

GI number: 220931993

Start: 1245575

End: 1247158

Strand: Direct

Name: serA [H]

Synonym: Hore_11540

Alternate gene names: 220931993

Gene position: 1245575-1247158 (Clockwise)

Preceding gene: 220931992

Following gene: 220932012

Centisome position: 48.31

GC content: 38.64

Gene sequence:

>1584_bases
ATGTATAAAGTACTGGTAAGTGATAATATATCTCCCAAGGGAATAGAAATTCTTGAACAGGAAGCAGATGTTACCTTTAA
TCCCGATCTTTCGCGGGAAGAATTCCTTGATATAATTGGTGAATATGATGGATTAATAGTTAGAAGTATGACTGAAGTTG
ATAAAGAGGCCCTGGATAAGGCCAGAAACTTAAAGGTAATCGGAAGAGCAGGTACGGGTTATGACAACATTGATATTGAA
GAAGCGAGCAAAAGAGGAATAATAGTTTTCAATACCCCAACCGGAAATACTATTTCTGCAGTGGAACACACTATCGGAAT
GATGCTGGCCTTATCAAGGAACATACCACAGGCAAATCAAGCCCTTCATGAGGGGATCTGGGACAGAAAAAAATACATGG
GGGTTGAAGTTAAAGGAAAAACCCTCGGAATTATTGGACTGGGAAGGATCGGTAGTCGGGTTGCTGTTCGAGCCCAGGCC
TTTGGTATGAAGGTTATTGCCAATGACCCTTATCTACCACCAGAGAAAGCAGCTAAAATAAATGTACCCCTGCTCGGATT
TAAGGAAGTATTAAAAAAATCTGATTATATAACACTCCATACCCCACTAACTGATGAAACATACCATATATTAAGCCATA
AAGAATTTGCCATTATGAAAGATAATGTAAGAATTATAAATTGTGCCCGGGGTAAAAACGTAGATACACAAGCCCTGGCA
AAGGCCCTTGCAGAACACAAGGTAGCCGGGGCTGCTATCGATGTTCATGAAGTAGAACCATTACCTGAAGATAATCCTTT
ACTGAAATATCAAGACAGGGTTATTATGACCTGCCACCTTGGTGGTACAACTACAGAAGCCATGGATAATGTCTCTATAG
CAGCTGCCGAACAGGTTCTTGATGTCCTGAATAATGGTCTACCTGAATCCCCGCTAAATATTCCTTCTATAAACATTCAG
GAATACAATAAAGCCAAACCCTATTTGAATCTTGTAAATAAACTGGGAAACTTTATAGCAAAATGGAAAGGACATGAACG
CATTGAGATGATTGAAGCTGAATATGGTGGAGAAGTTATTGGTCATGACCTGAAACCATTTACAACAAGTCTTATTAAAG
ATATCCTTGATCCTATCCTGGATAGCCGTGTTAACCTGGTAAATGCTCAGCTGGTTGCTAAAGAACGTGGTATAGAAATT
AAAGAAAGCCAGATTAGCAAACCGGACGGGGTTAATAACATAATAAGGGTCAGGGTAAAAACAAATAAGGGTAATTATAG
TGTGGCTGGAACTAATTTGCCCATTGGGTTAAGGATTATAGAAATTAATGATTTTCGGATTGACCTTAACCTTGAGGGTA
AATTCCTGGTTATCTCCTACCAGGATAAACCGGGGGTAATTGGTAAGGTAGGTAGCATTTTAGGTCAGGATAATGTGAAC
ATTGCCAGTATGCAGGTTGGAAGAAAATCATATGGTGGGCAGGCCATAATGATAATACAGACCGATAATAAACCTTCAAA
AGCAACTATGGAAAAAATAAATAAAAATATAGAGTTAACAGATTTAACATATCTGGAAATATAA

Upstream 100 bases:

>100_bases
ATTGAGATTTTCGGTAAAGGTTTAAAAGATTTTAATATTAATACTGATTTAGATGTCGCATTATCAGACTGTAAAGAAGT
TTTGAGAGGAGTTGAGGAGT

Downstream 100 bases:

>100_bases
CTACAATATTAAATTATGACAGTTATTTTTAAGTATTTAAATTTTTCTAAAAATAACATGTAAAAAGATTTTGTTACCTT
AAATTAGCTGATAATTATAA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MYKVLVSDNISPKGIEILEQEADVTFNPDLSREEFLDIIGEYDGLIVRSMTEVDKEALDKARNLKVIGRAGTGYDNIDIE
EASKRGIIVFNTPTGNTISAVEHTIGMMLALSRNIPQANQALHEGIWDRKKYMGVEVKGKTLGIIGLGRIGSRVAVRAQA
FGMKVIANDPYLPPEKAAKINVPLLGFKEVLKKSDYITLHTPLTDETYHILSHKEFAIMKDNVRIINCARGKNVDTQALA
KALAEHKVAGAAIDVHEVEPLPEDNPLLKYQDRVIMTCHLGGTTTEAMDNVSIAAAEQVLDVLNNGLPESPLNIPSINIQ
EYNKAKPYLNLVNKLGNFIAKWKGHERIEMIEAEYGGEVIGHDLKPFTTSLIKDILDPILDSRVNLVNAQLVAKERGIEI
KESQISKPDGVNNIIRVRVKTNKGNYSVAGTNLPIGLRIIEINDFRIDLNLEGKFLVISYQDKPGVIGKVGSILGQDNVN
IASMQVGRKSYGGQAIMIIQTDNKPSKATMEKINKNIELTDLTYLEI

Sequences:

>Translated_527_residues
MYKVLVSDNISPKGIEILEQEADVTFNPDLSREEFLDIIGEYDGLIVRSMTEVDKEALDKARNLKVIGRAGTGYDNIDIE
EASKRGIIVFNTPTGNTISAVEHTIGMMLALSRNIPQANQALHEGIWDRKKYMGVEVKGKTLGIIGLGRIGSRVAVRAQA
FGMKVIANDPYLPPEKAAKINVPLLGFKEVLKKSDYITLHTPLTDETYHILSHKEFAIMKDNVRIINCARGKNVDTQALA
KALAEHKVAGAAIDVHEVEPLPEDNPLLKYQDRVIMTCHLGGTTTEAMDNVSIAAAEQVLDVLNNGLPESPLNIPSINIQ
EYNKAKPYLNLVNKLGNFIAKWKGHERIEMIEAEYGGEVIGHDLKPFTTSLIKDILDPILDSRVNLVNAQLVAKERGIEI
KESQISKPDGVNNIIRVRVKTNKGNYSVAGTNLPIGLRIIEINDFRIDLNLEGKFLVISYQDKPGVIGKVGSILGQDNVN
IASMQVGRKSYGGQAIMIIQTDNKPSKATMEKINKNIELTDLTYLEI
>Mature_527_residues
MYKVLVSDNISPKGIEILEQEADVTFNPDLSREEFLDIIGEYDGLIVRSMTEVDKEALDKARNLKVIGRAGTGYDNIDIE
EASKRGIIVFNTPTGNTISAVEHTIGMMLALSRNIPQANQALHEGIWDRKKYMGVEVKGKTLGIIGLGRIGSRVAVRAQA
FGMKVIANDPYLPPEKAAKINVPLLGFKEVLKKSDYITLHTPLTDETYHILSHKEFAIMKDNVRIINCARGKNVDTQALA
KALAEHKVAGAAIDVHEVEPLPEDNPLLKYQDRVIMTCHLGGTTTEAMDNVSIAAAEQVLDVLNNGLPESPLNIPSINIQ
EYNKAKPYLNLVNKLGNFIAKWKGHERIEMIEAEYGGEVIGHDLKPFTTSLIKDILDPILDSRVNLVNAQLVAKERGIEI
KESQISKPDGVNNIIRVRVKTNKGNYSVAGTNLPIGLRIIEINDFRIDLNLEGKFLVISYQDKPGVIGKVGSILGQDNVN
IASMQVGRKSYGGQAIMIIQTDNKPSKATMEKINKNIELTDLTYLEI

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=408, Percent_Identity=40.4411764705882, Blast_Score=297, Evalue=2e-80,
Organism=Homo sapiens, GI145580578, Length=327, Percent_Identity=33.3333333333333, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI4557499, Length=327, Percent_Identity=33.3333333333333, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI61743967, Length=310, Percent_Identity=33.5483870967742, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI4557497, Length=306, Percent_Identity=33.9869281045752, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI145580575, Length=328, Percent_Identity=33.2317073170732, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI6912396, Length=311, Percent_Identity=33.1189710610932, Blast_Score=142, Evalue=7e-34,
Organism=Escherichia coli, GI1789279, Length=326, Percent_Identity=34.0490797546012, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI87082289, Length=280, Percent_Identity=31.7857142857143, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1787645, Length=245, Percent_Identity=33.469387755102, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1788660, Length=289, Percent_Identity=29.757785467128, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=300, Percent_Identity=43.3333333333333, Blast_Score=231, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI25147481, Length=315, Percent_Identity=29.5238095238095, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=331, Percent_Identity=34.7432024169184, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6322116, Length=330, Percent_Identity=34.5454545454545, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6324055, Length=310, Percent_Identity=31.2903225806452, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324964, Length=277, Percent_Identity=29.2418772563177, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324980, Length=198, Percent_Identity=28.2828282828283, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19921140, Length=311, Percent_Identity=40.8360128617363, Blast_Score=226, Evalue=4e-59,
Organism=Drosophila melanogaster, GI28571528, Length=312, Percent_Identity=35.5769230769231, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24646446, Length=326, Percent_Identity=30.6748466257669, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24646448, Length=326, Percent_Identity=30.6748466257669, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24646452, Length=326, Percent_Identity=30.6748466257669, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24646450, Length=326, Percent_Identity=30.6748466257669, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI62472511, Length=326, Percent_Identity=30.6748466257669, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI28574286, Length=325, Percent_Identity=28.9230769230769, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28574284, Length=324, Percent_Identity=28.3950617283951, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI45552429, Length=324, Percent_Identity=28.3950617283951, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI45551003, Length=324, Percent_Identity=28.3950617283951, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24585514, Length=324, Percent_Identity=28.3950617283951, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI28574282, Length=324, Percent_Identity=28.3950617283951, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24585516, Length=310, Percent_Identity=27.4193548387097, Blast_Score=120, Evalue=3e-27,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 58160; Mature: 58160

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKVLVSDNISPKGIEILEQEADVTFNPDLSREEFLDIIGEYDGLIVRSMTEVDKEALDK
CEEEEEECCCCCCCHHHHHCCCCEEECCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHH
ARNLKVIGRAGTGYDNIDIEEASKRGIIVFNTPTGNTISAVEHTIGMMLALSRNIPQANQ
HCCEEEEEECCCCCCCCCHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHH
ALHEGIWDRKKYMGVEVKGKTLGIIGLGRIGSRVAVRAQAFGMKVIANDPYLPPEKAAKI
HHHHHHHHHHHHCCEEECCCEEEEEEECCCCCCEEEEEHHCCEEEEECCCCCCCCCCCEE
NVPLLGFKEVLKKSDYITLHTPLTDETYHILSHKEFAIMKDNVRIINCARGKNVDTQALA
CCCEECHHHHHCCCCEEEEECCCCCCEEEECCCCEEEEEECCEEEEEECCCCCCCHHHHH
KALAEHKVAGAAIDVHEVEPLPEDNPLLKYQDRVIMTCHLGGTTTEAMDNVSIAAAEQVL
HHHHHHHHCCEEEEHHHCCCCCCCCCCEEECCCEEEEEECCCCCHHHHCCCHHHHHHHHH
DVLNNGLPESPLNIPSINIQEYNKAKPYLNLVNKLGNFIAKWKGHERIEMIEAEYGGEVI
HHHHCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCEE
GHDLKPFTTSLIKDILDPILDSRVNLVNAQLVAKERGIEIKESQISKPDGVNNIIRVRVK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCEEEHHHCCCCCCCCCEEEEEEE
TNKGNYSVAGTNLPIGLRIIEINDFRIDLNLEGKFLVISYQDKPGVIGKVGSILGQDNVN
ECCCCEEEECCCCCEEEEEEEEEEEEEEEEECCEEEEEEECCCCCCHHHHHHHHCCCCCE
IASMQVGRKSYGGQAIMIIQTDNKPSKATMEKINKNIELTDLTYLEI
EEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHCCCEEEEEEEEEEC
>Mature Secondary Structure
MYKVLVSDNISPKGIEILEQEADVTFNPDLSREEFLDIIGEYDGLIVRSMTEVDKEALDK
CEEEEEECCCCCCCHHHHHCCCCEEECCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHH
ARNLKVIGRAGTGYDNIDIEEASKRGIIVFNTPTGNTISAVEHTIGMMLALSRNIPQANQ
HCCEEEEEECCCCCCCCCHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHH
ALHEGIWDRKKYMGVEVKGKTLGIIGLGRIGSRVAVRAQAFGMKVIANDPYLPPEKAAKI
HHHHHHHHHHHHCCEEECCCEEEEEEECCCCCCEEEEEHHCCEEEEECCCCCCCCCCCEE
NVPLLGFKEVLKKSDYITLHTPLTDETYHILSHKEFAIMKDNVRIINCARGKNVDTQALA
CCCEECHHHHHCCCCEEEEECCCCCCEEEECCCCEEEEEECCEEEEEECCCCCCCHHHHH
KALAEHKVAGAAIDVHEVEPLPEDNPLLKYQDRVIMTCHLGGTTTEAMDNVSIAAAEQVL
HHHHHHHHCCEEEEHHHCCCCCCCCCCEEECCCEEEEEECCCCCHHHHCCCHHHHHHHHH
DVLNNGLPESPLNIPSINIQEYNKAKPYLNLVNKLGNFIAKWKGHERIEMIEAEYGGEVI
HHHHCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCEE
GHDLKPFTTSLIKDILDPILDSRVNLVNAQLVAKERGIEIKESQISKPDGVNNIIRVRVK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCEEEHHHCCCCCCCCCEEEEEEE
TNKGNYSVAGTNLPIGLRIIEINDFRIDLNLEGKFLVISYQDKPGVIGKVGSILGQDNVN
ECCCCEEEECCCCCEEEEEEEEEEEEEEEEECCEEEEEEECCCCCCHHHHHHHHCCCCCE
IASMQVGRKSYGGQAIMIIQTDNKPSKATMEKINKNIELTDLTYLEI
EEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHCCCEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]