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The map label for this gene is mtaD

Identifier: 220931909

GI number: 220931909

Start: 1156378

End: 1157673

Strand: Direct

Name: mtaD

Synonym: Hore_10670

Alternate gene names: 220931909

Gene position: 1156378-1157673 (Clockwise)

Preceding gene: 220931908

Following gene: 220931910

Centisome position: 44.85

GC content: 37.58

Gene sequence:

>1296_bases
GTGAAAATATTAATAAAAAATGTTGATGTTATATATACAGCTGATAGCAACAGAAGTATTATTAAAAATGGTTATATTAT
AATTCAGGATAATAAAATCAAAGAAATAAATGATATGGATAATTTAGTGTATCAGTCTAATGATTTTGATGATGTAATAA
GTGGAAAAGGGAAGATGGCTTTACCTGGACTGGTTAATGCCCATACCCATTCAGCCATGACCCTGTTGCGGGGGTTTGCT
GATGATATGCCTTTACATAAGTGGTTGCAGGAAAAAATATGGCCTTTTGAAAAAACGCTAATCCCTGAAGATATTTACTG
GGGTGCAAAACTGGCTATACTGGAAATGATCAAGACAGGTACTACTACTTTTGCCGATATGTATTTTGAAATGGGACAGG
TTGCAAAGGTGGTAGAAGAAGGAGGCCTTCGTGCTGTTTTAAGCCAGGGTCTAATTGAGGCCAATGATGGAGAAGAAGGA
TTAAACAGGGCTTTAAAATTCTGTCTTGAATGGAATAACCGGGCTGATGGGCGTATTTTAACAATGCTGGCTCCCCATGC
CCCTTACACCTGCTCACCTGATTTTTTCAGAAGAGTGGTTGATTTATCACAGGAATATAACCTCGGCATACATACCCATA
TCGCAGAGACAAAGGAAGAGTTTCAGCAGATTAGGGAAAAGTATGATTGTACCCCTTTACAATATTTAGAAAAAACAGGT
GCCCTTAAAAGGCCTGTTCTGGCTGCTCATTGTATTTATATTACAGAAGAAGATATGGATCTTATGGCTCAGAAACCGAT
CGGAGTGGCCTATAATCCCCAGAGTAATATGAAACTTGGAAGTGGTATTGCTCCGGTAACCAGGATGTTAAGTAAGGGTA
TTAAAGTAGGGATTGGAACAGACGGTACCTCCAGTAATAACAATCTGGATCTTATTGAAGAAGCAAGGAGTGGCTCCTTT
TTACAAAAGGTGAATGACCTTGATTCAACTGCTTTACCTGTTGATACTGTTTTAAAGATGTTGACTGTTAATGGGGCGAA
AATACTTGGTTTTGATAAACTCGGAGTGTTAAAGGAGGGTTATCTGGCCGATATTATTTTAATAGGATTAAATGAATCAA
CATTCTATTACCCCCACTATAACAATCTTTCAAATCTGTTTTATGCCGGTAGTGGTAATGATGTTACTACGGTAATTGTA
AATGGGCGGGTAATCATGAAGGATAGAGAAGTTTTAACTATAAATGAGGAAGAAGTATATTATAAGATTGAAGAAATCGC
CCGCAGAAAGCTATAA

Upstream 100 bases:

>100_bases
AATTTAGATAATATAATTATAAATTTAATCTAATAAAAAGGAATTTAATATTTAAATAGTGAATTTATTAGTAGAGAGTA
TAAAAAGGAGGTAAATACTG

Downstream 100 bases:

>100_bases
AGTTTCCCATGAATTACAACTTATTACAGGCAGGAATTACACCTTTTAGAAAGAATTATGTATTAAATTAAGCAGGGAGA
AATATAATGTAGTATATTAA

Product: guanine deaminase

Products: NA

Alternate protein names: MTA/SAH deaminase

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MKILIKNVDVIYTADSNRSIIKNGYIIIQDNKIKEINDMDNLVYQSNDFDDVISGKGKMALPGLVNAHTHSAMTLLRGFA
DDMPLHKWLQEKIWPFEKTLIPEDIYWGAKLAILEMIKTGTTTFADMYFEMGQVAKVVEEGGLRAVLSQGLIEANDGEEG
LNRALKFCLEWNNRADGRILTMLAPHAPYTCSPDFFRRVVDLSQEYNLGIHTHIAETKEEFQQIREKYDCTPLQYLEKTG
ALKRPVLAAHCIYITEEDMDLMAQKPIGVAYNPQSNMKLGSGIAPVTRMLSKGIKVGIGTDGTSSNNNLDLIEEARSGSF
LQKVNDLDSTALPVDTVLKMLTVNGAKILGFDKLGVLKEGYLADIILIGLNESTFYYPHYNNLSNLFYAGSGNDVTTVIV
NGRVIMKDREVLTINEEEVYYKIEEIARRKL

Sequences:

>Translated_431_residues
MKILIKNVDVIYTADSNRSIIKNGYIIIQDNKIKEINDMDNLVYQSNDFDDVISGKGKMALPGLVNAHTHSAMTLLRGFA
DDMPLHKWLQEKIWPFEKTLIPEDIYWGAKLAILEMIKTGTTTFADMYFEMGQVAKVVEEGGLRAVLSQGLIEANDGEEG
LNRALKFCLEWNNRADGRILTMLAPHAPYTCSPDFFRRVVDLSQEYNLGIHTHIAETKEEFQQIREKYDCTPLQYLEKTG
ALKRPVLAAHCIYITEEDMDLMAQKPIGVAYNPQSNMKLGSGIAPVTRMLSKGIKVGIGTDGTSSNNNLDLIEEARSGSF
LQKVNDLDSTALPVDTVLKMLTVNGAKILGFDKLGVLKEGYLADIILIGLNESTFYYPHYNNLSNLFYAGSGNDVTTVIV
NGRVIMKDREVLTINEEEVYYKIEEIARRKL
>Mature_431_residues
MKILIKNVDVIYTADSNRSIIKNGYIIIQDNKIKEINDMDNLVYQSNDFDDVISGKGKMALPGLVNAHTHSAMTLLRGFA
DDMPLHKWLQEKIWPFEKTLIPEDIYWGAKLAILEMIKTGTTTFADMYFEMGQVAKVVEEGGLRAVLSQGLIEANDGEEG
LNRALKFCLEWNNRADGRILTMLAPHAPYTCSPDFFRRVVDLSQEYNLGIHTHIAETKEEFQQIREKYDCTPLQYLEKTG
ALKRPVLAAHCIYITEEDMDLMAQKPIGVAYNPQSNMKLGSGIAPVTRMLSKGIKVGIGTDGTSSNNNLDLIEEARSGSF
LQKVNDLDSTALPVDTVLKMLTVNGAKILGFDKLGVLKEGYLADIILIGLNESTFYYPHYNNLSNLFYAGSGNDVTTVIV
NGRVIMKDREVLTINEEEVYYKIEEIARRKL

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family

Homologues:

Organism=Homo sapiens, GI4758426, Length=381, Percent_Identity=25.1968503937008, Blast_Score=125, Evalue=8e-29,
Organism=Escherichia coli, GI1789249, Length=431, Percent_Identity=24.5939675174014, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI87082177, Length=427, Percent_Identity=25.0585480093677, Blast_Score=101, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6319963, Length=337, Percent_Identity=25.5192878338279, Blast_Score=106, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24643849, Length=380, Percent_Identity=23.6842105263158, Blast_Score=118, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTAD_HALOH (B8CX03)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002508817.1
- ProteinModelPortal:   B8CX03
- GeneID:   7313057
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_10670
- HOGENOM:   HBG668170
- OMA:   MYLIEDA
- HAMAP:   MF_01281
- InterPro:   IPR006680
- InterPro:   IPR011059

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.4.28

Molecular weight: Translated: 48364; Mature: 48364

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: BINDING 97-97 BINDING 186-186 BINDING 216-216 BINDING 301-301

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILIKNVDVIYTADSNRSIIKNGYIIIQDNKIKEINDMDNLVYQSNDFDDVISGKGKMA
CEEEEECCEEEEECCCCCEEECCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHCCCCCEE
LPGLVNAHTHSAMTLLRGFADDMPLHKWLQEKIWPFEKTLIPEDIYWGAKLAILEMIKTG
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHCCCCHHHCCHHHHHHHHHHCC
TTTFADMYFEMGQVAKVVEEGGLRAVLSQGLIEANDGEEGLNRALKFCLEWNNRADGRIL
CHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEECCCCHHHHHHHHHHHHHCCCCCCCEEE
TMLAPHAPYTCSPDFFRRVVDLSQEYNLGIHTHIAETKEEFQQIREKYDCTPLQYLEKTG
EEECCCCCCCCCHHHHHHHHHCCHHCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
ALKRPVLAAHCIYITEEDMDLMAQKPIGVAYNPQSNMKLGSGIAPVTRMLSKGIKVGIGT
CCCCCCEEEEEEEEECCCHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHCCCEEEECC
DGTSSNNNLDLIEEARSGSFLQKVNDLDSTALPVDTVLKMLTVNGAKILGFDKLGVLKEG
CCCCCCCCCHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEECHHCHHCCC
YLADIILIGLNESTFYYPHYNNLSNLFYAGSGNDVTTVIVNGRVIMKDREVLTINEEEVY
CEEEEEEEECCCCEEECCCCCCCCCEEEECCCCCEEEEEECCEEEEECCEEEEECCHHHH
YKIEEIARRKL
HHHHHHHHHCC
>Mature Secondary Structure
MKILIKNVDVIYTADSNRSIIKNGYIIIQDNKIKEINDMDNLVYQSNDFDDVISGKGKMA
CEEEEECCEEEEECCCCCEEECCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHCCCCCEE
LPGLVNAHTHSAMTLLRGFADDMPLHKWLQEKIWPFEKTLIPEDIYWGAKLAILEMIKTG
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHCCCCHHHCCHHHHHHHHHHCC
TTTFADMYFEMGQVAKVVEEGGLRAVLSQGLIEANDGEEGLNRALKFCLEWNNRADGRIL
CHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEECCCCHHHHHHHHHHHHHCCCCCCCEEE
TMLAPHAPYTCSPDFFRRVVDLSQEYNLGIHTHIAETKEEFQQIREKYDCTPLQYLEKTG
EEECCCCCCCCCHHHHHHHHHCCHHCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
ALKRPVLAAHCIYITEEDMDLMAQKPIGVAYNPQSNMKLGSGIAPVTRMLSKGIKVGIGT
CCCCCCEEEEEEEEECCCHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHCCCEEEECC
DGTSSNNNLDLIEEARSGSFLQKVNDLDSTALPVDTVLKMLTVNGAKILGFDKLGVLKEG
CCCCCCCCCHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEECHHCHHCCC
YLADIILIGLNESTFYYPHYNNLSNLFYAGSGNDVTTVIVNGRVIMKDREVLTINEEEVY
CEEEEEEEECCCCEEECCCCCCCCCEEEECCCCCEEEEEECCEEEEECCEEEEECCHHHH
YKIEEIARRKL
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA