Click here to switch to the map view.

The map label for this gene is hup [H]

Identifier: 220931899

GI number: 220931899

Start: 1146703

End: 1147116

Strand: Direct

Name: hup [H]

Synonym: Hore_10570

Alternate gene names: 220931899

Gene position: 1146703-1147116 (Clockwise)

Preceding gene: 220931898

Following gene: 220931900

Centisome position: 44.48

GC content: 34.78

Gene sequence:

>414_bases
TTGAGCATTTTTTTTATAAAAAAATTTTTCAGAAAAAGCAGGAGAATTGGTGTTATACCACGAATAATAAGAAATGAAAA
TGCATTATCGATATACTTTAAGGAGGTGAATATCATGACAAAAACTGATTTAGTTGATGCTGTTGCTGCAAAAACTGGTT
TAACAAAAAAGGACAGCAATAAAGCAGTAAAAGCAGTTTTTGATTCAATTGTCGAACATTTAAGTGATGAGTCTAAAAAA
GCCGAAGGTGATCGTGATAGTGTACAGATAATTGGATTTGGTACTTTTGAAGTTAAAGATCGTAGTGCCCGTAAGGGACG
TAATCCCCAGACCGGTGAGGAGATTACTATTCCGGCCAGGACAGTACCTGTTTTCAGGCCTGGTAAATCATTTAAAGAAG
CTGTAGAAAAATAA

Upstream 100 bases:

>100_bases
ATAGAAAAAATAGTGAATGAGGGCAGTGGAGGCCTGTTATGTATAATCCTCTAGACAAACAAAACATGTATTTTTTTTTA
AAGCTTGAGGTAAAATAACC

Downstream 100 bases:

>100_bases
AGAAACATGTAAAATAAAAGTTCTATTAAAAGGACTTACATAAATATTATTTTTAAAGAAAGGGTTTTTAATCCCTTTCT
TTTTTTTATTTTTTAAAGTA

Product: histone family protein DNA-binding protein

Products: NA

Alternate protein names: DNA-binding protein II; HB [H]

Number of amino acids: Translated: 137; Mature: 136

Protein sequence:

>137_residues
MSIFFIKKFFRKSRRIGVIPRIIRNENALSIYFKEVNIMTKTDLVDAVAAKTGLTKKDSNKAVKAVFDSIVEHLSDESKK
AEGDRDSVQIIGFGTFEVKDRSARKGRNPQTGEEITIPARTVPVFRPGKSFKEAVEK

Sequences:

>Translated_137_residues
MSIFFIKKFFRKSRRIGVIPRIIRNENALSIYFKEVNIMTKTDLVDAVAAKTGLTKKDSNKAVKAVFDSIVEHLSDESKK
AEGDRDSVQIIGFGTFEVKDRSARKGRNPQTGEEITIPARTVPVFRPGKSFKEAVEK
>Mature_136_residues
SIFFIKKFFRKSRRIGVIPRIIRNENALSIYFKEVNIMTKTDLVDAVAAKTGLTKKDSNKAVKAVFDSIVEHLSDESKKA
EGDRDSVQIIGFGTFEVKDRSARKGRNPQTGEEITIPARTVPVFRPGKSFKEAVEK

Specific function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions [H]

COG id: COG0776

COG function: function code L; Bacterial nucleoid DNA-binding protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial histone-like protein family [H]

Homologues:

Organism=Escherichia coli, GI1786644, Length=97, Percent_Identity=48.4536082474227, Blast_Score=91, Evalue=3e-20,
Organism=Escherichia coli, GI1790433, Length=97, Percent_Identity=46.3917525773196, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI1788005, Length=98, Percent_Identity=37.7551020408163, Blast_Score=73, Evalue=6e-15,
Organism=Escherichia coli, GI1787141, Length=98, Percent_Identity=34.6938775510204, Blast_Score=63, Evalue=7e-12,

Paralogues:

None

Copy number: 860 Molecules/Cell In: Growth-Phase, Minimal Media (Based on E. coli). 2040 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000119
- InterPro:   IPR020816
- InterPro:   IPR010992 [H]

Pfam domain/function: PF00216 Bac_DNA_binding [H]

EC number: NA

Molecular weight: Translated: 15434; Mature: 15303

Theoretical pI: Translated: 10.75; Mature: 10.75

Prosite motif: PS00045 HISTONE_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIFFIKKFFRKSRRIGVIPRIIRNENALSIYFKEVNIMTKTDLVDAVAAKTGLTKKDSN
CCHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEEEEEEEEHHHHHHHHHHHHCCCCCCCCC
KAVKAVFDSIVEHLSDESKKAEGDRDSVQIIGFGTFEVKDRSARKGRNPQTGEEITIPAR
HHHHHHHHHHHHHHCCCHHCCCCCCCCEEEEEECEEEECCCHHHCCCCCCCCCEEEECCC
TVPVFRPGKSFKEAVEK
CCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
SIFFIKKFFRKSRRIGVIPRIIRNENALSIYFKEVNIMTKTDLVDAVAAKTGLTKKDSN
CHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEEEEEEEEHHHHHHHHHHHHCCCCCCCCC
KAVKAVFDSIVEHLSDESKKAEGDRDSVQIIGFGTFEVKDRSARKGRNPQTGEEITIPAR
HHHHHHHHHHHHHHCCCHHCCCCCCCCEEEEEECEEEECCCHHHCCCCCCCCCEEEECCC
TVPVFRPGKSFKEAVEK
CCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1644313 [H]