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The map label for this gene is phr [H]

Identifier: 220931344

GI number: 220931344

Start: 542198

End: 543598

Strand: Reverse

Name: phr [H]

Synonym: Hore_04990

Alternate gene names: 220931344

Gene position: 543598-542198 (Counterclockwise)

Preceding gene: 220931345

Following gene: 220931343

Centisome position: 21.08

GC content: 39.61

Gene sequence:

>1401_bases
ATGATACATAATAGTAGAATAAAACCCCTTAATAAAAAGAATATAAATCCACGCGGGGAATATATTCTATACTGGATGCA
GGCCTCCCAGAGAACAGAGTACAACCATGCCCTGGAGTATGCCATCATCGAGGCCAATAAATCCAATAAACCACTGCTTG
TCTATTTCGGGATTGATACCTCATTCCCGGAGGCTAATCGACGCCATTATCAATTTATGCTGGAAGGGTTACAGGAAGTA
AAGAAATCCCTCTATAACCGGGGAATAAAAATGATTATTGAATCCGTTCCCCCCGACAAGGATATTTTAAAGTTTGCAGA
GTATGCCTCTCTCCTGGTAGTAGACAGGGGTTATCTTAAAATCGAACGAACCTGGCGAAATAATGTGAGCCAACAGATTG
ACTGTCCACTGATCCAGGTTGAAAGCAATGTAATAGTTCCTGTTGAAGTGGCCTCTTCTAAAGAAGAATATGCTGCCTAT
ACCATCAGAAAAAAACTATACCGTAAGTTGCCTGAATTCCTCCATCCCTTACATACCAGGACCATCAGGGTAAGCTCCCT
TGACCTGAAGCTATCATTTATAAACTATAAGGATATTCCCCTTGATAATGTTACCCTGTGCCTTGATAGATTAAAAGTTG
ACAATACTGTACCGGAAGTTAACTTATACCGGGGTGGCACTACCCGTGCTCTGGCTTTATATAACGATTTTTTACATAAT
AAAATTAAAGACTACCATGAATACCGGAATGATCCTGTTAAAAACTGGATTTCCAACATGAGCCCCTACCTCCATTTTGG
ACAGGTCTCACCCCTGCACCTAATTATTAAGGGGAATAACTATTGTAAAAAACATGAAATAGATAAAGGCTTTAAAGAAT
TTTTTGAGGAGCTTGTAATCAGGAGGGAGCTATCTTTTAATTTTGTATATTATAACCCTGATTATGATTCTATTAAATCT
CTCCCGGACTGGGCTAAAAAAACTCTGAAAGAACATGAAAATGACACCCGGGAATTTAGCTATTCACTTCAGGAATTGGA
AGATGCTAAAACCCATGACCCTTACTGGAATGCTGCCCAGAAAGAACTTTTACTGACAGGTAAAATCCATGGGTATATGA
GAATGTACTGGGGCAAAAAAATACTGGAATGGACTTCCTCACCTGACCTTGCCTATAAATATGCCCTGTACTTAAATAAC
AAATATGCCCTTGATGGTCGTGACCCCAATGGGTTTGCCGGGGTAGCCTGGTGTTTTGGTAAGCATGACCGTCCCTGGCC
CGGGTGTAATATATTTGGAAAGGTAAGGTATATGAGTTCCGGTGGTCTTAAAAGAAAATTTAAAATAGACTTATATTTAA
AAAGAATACATAACCTTGAGGAGGCATCACATGTTGGATAA

Upstream 100 bases:

>100_bases
CTGCACAGTAACTTCCGTATCCCTGTCCTTCAGTTTATTATAAAAAAATAACTGGTTCTCTTTTTAAAAAATTCTCTTAC
ATAGTTCAAAGGTGAATAAT

Downstream 100 bases:

>100_bases
TCAATTTCCTAAACCAAATGTAGTTGTCAGTAAATGCCTCGGTTTTGAGGCCTGTAATTATAACGGTCACCAGTTTAATA
ATAAATTTATATCCATGCTT

Product: Deoxyribodipyrimidine photo-lyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MIHNSRIKPLNKKNINPRGEYILYWMQASQRTEYNHALEYAIIEANKSNKPLLVYFGIDTSFPEANRRHYQFMLEGLQEV
KKSLYNRGIKMIIESVPPDKDILKFAEYASLLVVDRGYLKIERTWRNNVSQQIDCPLIQVESNVIVPVEVASSKEEYAAY
TIRKKLYRKLPEFLHPLHTRTIRVSSLDLKLSFINYKDIPLDNVTLCLDRLKVDNTVPEVNLYRGGTTRALALYNDFLHN
KIKDYHEYRNDPVKNWISNMSPYLHFGQVSPLHLIIKGNNYCKKHEIDKGFKEFFEELVIRRELSFNFVYYNPDYDSIKS
LPDWAKKTLKEHENDTREFSYSLQELEDAKTHDPYWNAAQKELLLTGKIHGYMRMYWGKKILEWTSSPDLAYKYALYLNN
KYALDGRDPNGFAGVAWCFGKHDRPWPGCNIFGKVRYMSSGGLKRKFKIDLYLKRIHNLEEASHVG

Sequences:

>Translated_466_residues
MIHNSRIKPLNKKNINPRGEYILYWMQASQRTEYNHALEYAIIEANKSNKPLLVYFGIDTSFPEANRRHYQFMLEGLQEV
KKSLYNRGIKMIIESVPPDKDILKFAEYASLLVVDRGYLKIERTWRNNVSQQIDCPLIQVESNVIVPVEVASSKEEYAAY
TIRKKLYRKLPEFLHPLHTRTIRVSSLDLKLSFINYKDIPLDNVTLCLDRLKVDNTVPEVNLYRGGTTRALALYNDFLHN
KIKDYHEYRNDPVKNWISNMSPYLHFGQVSPLHLIIKGNNYCKKHEIDKGFKEFFEELVIRRELSFNFVYYNPDYDSIKS
LPDWAKKTLKEHENDTREFSYSLQELEDAKTHDPYWNAAQKELLLTGKIHGYMRMYWGKKILEWTSSPDLAYKYALYLNN
KYALDGRDPNGFAGVAWCFGKHDRPWPGCNIFGKVRYMSSGGLKRKFKIDLYLKRIHNLEEASHVG
>Mature_466_residues
MIHNSRIKPLNKKNINPRGEYILYWMQASQRTEYNHALEYAIIEANKSNKPLLVYFGIDTSFPEANRRHYQFMLEGLQEV
KKSLYNRGIKMIIESVPPDKDILKFAEYASLLVVDRGYLKIERTWRNNVSQQIDCPLIQVESNVIVPVEVASSKEEYAAY
TIRKKLYRKLPEFLHPLHTRTIRVSSLDLKLSFINYKDIPLDNVTLCLDRLKVDNTVPEVNLYRGGTTRALALYNDFLHN
KIKDYHEYRNDPVKNWISNMSPYLHFGQVSPLHLIIKGNNYCKKHEIDKGFKEFFEELVIRRELSFNFVYYNPDYDSIKS
LPDWAKKTLKEHENDTREFSYSLQELEDAKTHDPYWNAAQKELLLTGKIHGYMRMYWGKKILEWTSSPDLAYKYALYLNN
KYALDGRDPNGFAGVAWCFGKHDRPWPGCNIFGKVRYMSSGGLKRKFKIDLYLKRIHNLEEASHVG

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Drosophila melanogaster, GI24586398, Length=454, Percent_Identity=37.8854625550661, Blast_Score=303, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24586396, Length=454, Percent_Identity=37.8854625550661, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24586404, Length=150, Percent_Identity=52.6666666666667, Blast_Score=173, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008148
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 54866; Mature: 54866

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS01083 DNA_PHOTOLYASES_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHNSRIKPLNKKNINPRGEYILYWMQASQRTEYNHALEYAIIEANKSNKPLLVYFGIDT
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHEEEEEEEEECCCCCCEEEEECCCC
SFPEANRRHYQFMLEGLQEVKKSLYNRGIKMIIESVPPDKDILKFAEYASLLVVDRGYLK
CCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHEEEEECCCEE
IERTWRNNVSQQIDCPLIQVESNVIVPVEVASSKEEYAAYTIRKKLYRKLPEFLHPLHTR
EEEHHHCCCCHHCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
TIRVSSLDLKLSFINYKDIPLDNVTLCLDRLKVDNTVPEVNLYRGGTTRALALYNDFLHN
EEEEEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHH
KIKDYHEYRNDPVKNWISNMSPYLHFGQVSPLHLIIKGNNYCKKHEIDKGFKEFFEELVI
HHHHHHHHCCCHHHHHHHCCCCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
RRELSFNFVYYNPDYDSIKSLPDWAKKTLKEHENDTREFSYSLQELEDAKTHDPYWNAAQ
HHHCCEEEEEECCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHH
KELLLTGKIHGYMRMYWGKKILEWTSSPDLAYKYALYLNNKYALDGRDPNGFAGVAWCFG
HHEEEEEHHHHHHHHHHCHHHHHCCCCCCCEEEEEEEECCEEEECCCCCCCCEEEEEEEC
KHDRPWPGCNIFGKVRYMSSGGLKRKFKIDLYLKRIHNLEEASHVG
CCCCCCCCCCEEEEEEEECCCCCCEEEEHHHHHHHHHCHHHHHCCC
>Mature Secondary Structure
MIHNSRIKPLNKKNINPRGEYILYWMQASQRTEYNHALEYAIIEANKSNKPLLVYFGIDT
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHEEEEEEEEECCCCCCEEEEECCCC
SFPEANRRHYQFMLEGLQEVKKSLYNRGIKMIIESVPPDKDILKFAEYASLLVVDRGYLK
CCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHEEEEECCCEE
IERTWRNNVSQQIDCPLIQVESNVIVPVEVASSKEEYAAYTIRKKLYRKLPEFLHPLHTR
EEEHHHCCCCHHCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
TIRVSSLDLKLSFINYKDIPLDNVTLCLDRLKVDNTVPEVNLYRGGTTRALALYNDFLHN
EEEEEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHH
KIKDYHEYRNDPVKNWISNMSPYLHFGQVSPLHLIIKGNNYCKKHEIDKGFKEFFEELVI
HHHHHHHHCCCHHHHHHHCCCCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
RRELSFNFVYYNPDYDSIKSLPDWAKKTLKEHENDTREFSYSLQELEDAKTHDPYWNAAQ
HHHCCEEEEEECCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHH
KELLLTGKIHGYMRMYWGKKILEWTSSPDLAYKYALYLNNKYALDGRDPNGFAGVAWCFG
HHEEEEEHHHHHHHHHHCHHHHHCCCCCCCEEEEEEEECCEEEECCCCCCCCEEEEEEEC
KHDRPWPGCNIFGKVRYMSSGGLKRKFKIDLYLKRIHNLEEASHVG
CCCCCCCCCCEEEEEEEECCCCCCEEEEHHHHHHHHHCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2668276 [H]