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The map label for this gene is yoeA [H]

Identifier: 220931328

GI number: 220931328

Start: 519345

End: 520751

Strand: Reverse

Name: yoeA [H]

Synonym: Hore_04830

Alternate gene names: 220931328

Gene position: 520751-519345 (Counterclockwise)

Preceding gene: 220931343

Following gene: 220931323

Centisome position: 20.2

GC content: 41.01

Gene sequence:

>1407_bases
ATGGATACATATAAAGAAAAAAGAGACCTTATTATTAAAGGAAACATAGTTAAAGCCATCCTGGCCCTGGCAGGCCCGAT
CATGTTAAACAATCTTATCCAGACCATTTATAATCTAACTGATACTTACTGGGTTGGACAGCTCGGTGGAACTGAAGTGG
CTGCCATTACCCTTATCTGGCCAATAGTATTTTTTCTCCTGGCCCTGGGTTTCGGAATCAATATTGCCGGAACTTCCTTG
ATTTCTCAGTATACCGGAGCTGATGATAAAGAAAATGCCACCAGGGTAAGTGGACAGATTGTTTCTTTTTCCCTCTACTT
TTCAATCATAATTGGTATTATCGGTTTATTTGTGGCTGAACCTATTATAAAAATGATGGGTGGTGAAGGCAGGCTCCTGG
AGCTGGCCTCAAATTATTTAAAGATTATATTTGCCGGAATGCCGGCCATTTTTCTTTTTTTAGCCTTTACTTCCATCAAA
CAGGGACAGGGAGATACTGTTACCCCCATGAAATACAGTGCCATATCTGTAGCCCTGAATATGGTCCTTGACCCCATTTT
TATTTTTGGATTAGACCTGGGAGTAAGGGGAGCTGCCCTGGCCACAATATTTTCAAGAAGTGTTTTTGCCATCTACGCCA
TATATACCCTGTTTTACCGGAAAACAGGTATTCAACTCCATTTAAAACACCTGATTTTAAAACCCAATCTATTAAAAAAG
ATTATAAAAATAGGTTTGCCTTCTTCCCTGGGCCAGTCATCTGCAGCCCTGGGGTTCATCTTCCTGAATGCCTTTATTAT
TTCTTTTGGAAAATCAACCCTGGCTGCCTTCGGTATCGGAAACCGGATTAATTCAGTAATCCTTATGCCTGCCATGGGTA
TTGGAAATGCTCTGGCCACCATTGTCGGTCAAAACCTGGGGGCTGACCAGATTAAAAGGGCCAGACAGGCCGTAAAAACA
AGTGCTGTCCTTACCACTGTCTTATTAACATCGGGAGGGATTATTCTCTATCCTTTTGTCCCCACTATCATCAGGGCCTT
TAATACTGAACCTGCCATAGTATCCCAGGGGACATTTTATCTGAGGTTGATATCATTATCACTACCCCTAATGGGTTTTT
TCCAGATCTTTGTAGGTACCTTTCAGGGATCTGGCCATACCCTGATGGCTATGTTTATAATGACCGGACGTTTATGGGCT
TTAAGAATACCCCTGATTATTTTATTTAAAAAATATACTGACTGGGGCTCATCTTCAGTCTGGTATGCCATGGTATTAAG
TAATGCCATAATCTCACTGGTAGGTTTTATAATGTATCTAACTGGCAAATGGCAGAAAAAGGTAATAAAGAAAAAACCCC
CTTTGACAGGGAGTGAGGTAGACCAGAATCTGGATATTGATAATTAA

Upstream 100 bases:

>100_bases
ATATACAGTTTTTATACATACAGTACTGTCCAGTTATATACACACTATCTTCCTGTATAATGTTTTTTACAAAAAGCTTT
TTCCCTGAGGAAGCCCCTTA

Downstream 100 bases:

>100_bases
AGATAAATTCTCTCCATTTCGGGGGTAATCTCTTTTGTCTTGCATATTTTCCCATAAAAATAACCACTGATCCTGATGGA
TCGTTTCTGAGTTTTAAAAT

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MDTYKEKRDLIIKGNIVKAILALAGPIMLNNLIQTIYNLTDTYWVGQLGGTEVAAITLIWPIVFFLLALGFGINIAGTSL
ISQYTGADDKENATRVSGQIVSFSLYFSIIIGIIGLFVAEPIIKMMGGEGRLLELASNYLKIIFAGMPAIFLFLAFTSIK
QGQGDTVTPMKYSAISVALNMVLDPIFIFGLDLGVRGAALATIFSRSVFAIYAIYTLFYRKTGIQLHLKHLILKPNLLKK
IIKIGLPSSLGQSSAALGFIFLNAFIISFGKSTLAAFGIGNRINSVILMPAMGIGNALATIVGQNLGADQIKRARQAVKT
SAVLTTVLLTSGGIILYPFVPTIIRAFNTEPAIVSQGTFYLRLISLSLPLMGFFQIFVGTFQGSGHTLMAMFIMTGRLWA
LRIPLIILFKKYTDWGSSSVWYAMVLSNAIISLVGFIMYLTGKWQKKVIKKKPPLTGSEVDQNLDIDN

Sequences:

>Translated_468_residues
MDTYKEKRDLIIKGNIVKAILALAGPIMLNNLIQTIYNLTDTYWVGQLGGTEVAAITLIWPIVFFLLALGFGINIAGTSL
ISQYTGADDKENATRVSGQIVSFSLYFSIIIGIIGLFVAEPIIKMMGGEGRLLELASNYLKIIFAGMPAIFLFLAFTSIK
QGQGDTVTPMKYSAISVALNMVLDPIFIFGLDLGVRGAALATIFSRSVFAIYAIYTLFYRKTGIQLHLKHLILKPNLLKK
IIKIGLPSSLGQSSAALGFIFLNAFIISFGKSTLAAFGIGNRINSVILMPAMGIGNALATIVGQNLGADQIKRARQAVKT
SAVLTTVLLTSGGIILYPFVPTIIRAFNTEPAIVSQGTFYLRLISLSLPLMGFFQIFVGTFQGSGHTLMAMFIMTGRLWA
LRIPLIILFKKYTDWGSSSVWYAMVLSNAIISLVGFIMYLTGKWQKKVIKKKPPLTGSEVDQNLDIDN
>Mature_468_residues
MDTYKEKRDLIIKGNIVKAILALAGPIMLNNLIQTIYNLTDTYWVGQLGGTEVAAITLIWPIVFFLLALGFGINIAGTSL
ISQYTGADDKENATRVSGQIVSFSLYFSIIIGIIGLFVAEPIIKMMGGEGRLLELASNYLKIIFAGMPAIFLFLAFTSIK
QGQGDTVTPMKYSAISVALNMVLDPIFIFGLDLGVRGAALATIFSRSVFAIYAIYTLFYRKTGIQLHLKHLILKPNLLKK
IIKIGLPSSLGQSSAALGFIFLNAFIISFGKSTLAAFGIGNRINSVILMPAMGIGNALATIVGQNLGADQIKRARQAVKT
SAVLTTVLLTSGGIILYPFVPTIIRAFNTEPAIVSQGTFYLRLISLSLPLMGFFQIFVGTFQGSGHTLMAMFIMTGRLWA
LRIPLIILFKKYTDWGSSSVWYAMVLSNAIISLVGFIMYLTGKWQKKVIKKKPPLTGSEVDQNLDIDN

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=481, Percent_Identity=22.037422037422, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI226510954, Length=445, Percent_Identity=23.1460674157303, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI48994890, Length=349, Percent_Identity=24.3553008595989, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 51001; Mature: 51001

Theoretical pI: Translated: 10.38; Mature: 10.38

Prosite motif: PS00589 PTS_HPR_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTYKEKRDLIIKGNIVKAILALAGPIMLNNLIQTIYNLTDTYWVGQLGGTEVAAITLIW
CCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHH
PIVFFLLALGFGINIAGTSLISQYTGADDKENATRVSGQIVSFSLYFSIIIGIIGLFVAE
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PIIKMMGGEGRLLELASNYLKIIFAGMPAIFLFLAFTSIKQGQGDTVTPMKYSAISVALN
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
MVLDPIFIFGLDLGVRGAALATIFSRSVFAIYAIYTLFYRKTGIQLHLKHLILKPNLLKK
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHCCHHHHH
IIKIGLPSSLGQSSAALGFIFLNAFIISFGKSTLAAFGIGNRINSVILMPAMGIGNALAT
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHCCCHHHCCEEEECCCCCHHHHHH
IVGQNLGADQIKRARQAVKTSAVLTTVLLTSGGIILYPFVPTIIRAFNTEPAIVSQGTFY
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHCCCCCEEECCHHH
LRLISLSLPLMGFFQIFVGTFQGSGHTLMAMFIMTGRLWALRIPLIILFKKYTDWGSSSV
HHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHH
WYAMVLSNAIISLVGFIMYLTGKWQKKVIKKKPPLTGSEVDQNLDIDN
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDTYKEKRDLIIKGNIVKAILALAGPIMLNNLIQTIYNLTDTYWVGQLGGTEVAAITLIW
CCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHH
PIVFFLLALGFGINIAGTSLISQYTGADDKENATRVSGQIVSFSLYFSIIIGIIGLFVAE
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PIIKMMGGEGRLLELASNYLKIIFAGMPAIFLFLAFTSIKQGQGDTVTPMKYSAISVALN
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
MVLDPIFIFGLDLGVRGAALATIFSRSVFAIYAIYTLFYRKTGIQLHLKHLILKPNLLKK
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHCCHHHHH
IIKIGLPSSLGQSSAALGFIFLNAFIISFGKSTLAAFGIGNRINSVILMPAMGIGNALAT
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHCCCHHHCCEEEECCCCCHHHHHH
IVGQNLGADQIKRARQAVKTSAVLTTVLLTSGGIILYPFVPTIIRAFNTEPAIVSQGTFY
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHCCCCCEEECCHHH
LRLISLSLPLMGFFQIFVGTFQGSGHTLMAMFIMTGRLWALRIPLIILFKKYTDWGSSSV
HHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHH
WYAMVLSNAIISLVGFIMYLTGKWQKKVIKKKPPLTGSEVDQNLDIDN
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]