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The map label for this gene is ribE [H]

Identifier: 220918024

GI number: 220918024

Start: 3238831

End: 3239478

Strand: Reverse

Name: ribE [H]

Synonym: A2cp1_2925

Alternate gene names: 220918024

Gene position: 3239478-3238831 (Counterclockwise)

Preceding gene: 220918025

Following gene: 220918023

Centisome position: 64.41

GC content: 76.08

Gene sequence:

>648_bases
ATGTTCACCGGACTCGTCGCCGACGTCGGCGTGGTGGAGCGGATCGTCCCCCGGCAGGGAGGCGCTCGCCTGACGCTCCG
CCCGGCGCGGCTGCCGGTGGACGAGCTGGTGCTGGGCGAGAGCATCGCCTGCTCCGGCGCGTGCCTCACGGTGGTCGAGC
GCGGCGGCGGCCTGGTGTCGTTCGACGCGGTCCCGGAGACGCTCGCGCGCACCACCGTCGGCGGCTGGAGGCCGGGCGCG
AAGGTGAACCTGGAGCGCGCCCTCGCCGTGGGCGAGCGGCTCGGGGGGCACCTGGTGCAGGGCCACGTGGACGCGGTGGG
CGAGGTGCTGCGCCGCGTGCCGGAGGGGCAGGGCGCGCGCCTCACGATCTCGCTGCCGCCCTCGATCGCGCCGCTCGTGG
CGGAGAAGGGCTCGATCGCGGTGGACGGGGTGTCGCTCACCGTGGCGACGGCCGGACGGGACCGGTTCGAGCTCGCGCTC
ATCCCGGAGACGCTGGCCCGCACCACGCTGGGCCAGGCCGCCGCGGGCACGAAGGTGAACCTCGAGGCCGACGTGCTGGC
GCGCCACGTGGCGCGCCTGCGGGCCTTCGAGGGGCTCGGGGCGGGCGATCTCGCCCGCTGGGGATACGCAGCAGAGGAGA
AGCCGTGA

Upstream 100 bases:

>100_bases
GGCGTTCGAGCGGGTGGGCGACGACCTGCTCGTCACGGGCGTCCCCGCGCGCCGCGCCGCGTTGGCCAAAAACCCCCAAC
GAGGCTAGGATTCGCGCGAA

Downstream 100 bases:

>100_bases
CGGAGCACGCGCAGCACGCCGTCGACTCGGTGGAGAAGGCCATCGCCTACCTCCGCGCCGGCAAGATGGTGATCCTGACC
GACGACGAGGACCGCGAGAA

Product: riboflavin synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MFTGLVADVGVVERIVPRQGGARLTLRPARLPVDELVLGESIACSGACLTVVERGGGLVSFDAVPETLARTTVGGWRPGA
KVNLERALAVGERLGGHLVQGHVDAVGEVLRRVPEGQGARLTISLPPSIAPLVAEKGSIAVDGVSLTVATAGRDRFELAL
IPETLARTTLGQAAAGTKVNLEADVLARHVARLRAFEGLGAGDLARWGYAAEEKP

Sequences:

>Translated_215_residues
MFTGLVADVGVVERIVPRQGGARLTLRPARLPVDELVLGESIACSGACLTVVERGGGLVSFDAVPETLARTTVGGWRPGA
KVNLERALAVGERLGGHLVQGHVDAVGEVLRRVPEGQGARLTISLPPSIAPLVAEKGSIAVDGVSLTVATAGRDRFELAL
IPETLARTTLGQAAAGTKVNLEADVLARHVARLRAFEGLGAGDLARWGYAAEEKP
>Mature_215_residues
MFTGLVADVGVVERIVPRQGGARLTLRPARLPVDELVLGESIACSGACLTVVERGGGLVSFDAVPETLARTTVGGWRPGA
KVNLERALAVGERLGGHLVQGHVDAVGEVLRRVPEGQGARLTISLPPSIAPLVAEKGSIAVDGVSLTVATAGRDRFELAL
IPETLARTTLGQAAAGTKVNLEADVLARHVARLRAFEGLGAGDLARWGYAAEEKP

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyze

COG id: COG0307

COG function: function code H; Riboflavin synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 lumazine-binding repeats [H]

Homologues:

Organism=Escherichia coli, GI1787952, Length=188, Percent_Identity=37.7659574468085, Blast_Score=116, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319733, Length=203, Percent_Identity=33.0049261083744, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001783
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00677 Lum_binding [H]

EC number: =2.5.1.9 [H]

Molecular weight: Translated: 22289; Mature: 22289

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS00693 LUM_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTGLVADVGVVERIVPRQGGARLTLRPARLPVDELVLGESIACSGACLTVVERGGGLVS
CCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHCCCCCCCCCCEEEEEECCCCEEE
FDAVPETLARTTVGGWRPGAKVNLERALAVGERLGGHLVQGHVDAVGEVLRRVPEGQGAR
ECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCCCCCCE
LTISLPPSIAPLVAEKGSIAVDGVSLTVATAGRDRFELALIPETLARTTLGQAAAGTKVN
EEEECCCCCHHHHHCCCCEEECCEEEEEEECCCCCEEEEECCHHHHHHHHCHHCCCCEEC
LEADVLARHVARLRAFEGLGAGDLARWGYAAEEKP
CHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCC
>Mature Secondary Structure
MFTGLVADVGVVERIVPRQGGARLTLRPARLPVDELVLGESIACSGACLTVVERGGGLVS
CCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHCCCCCCCCCCEEEEEECCCCEEE
FDAVPETLARTTVGGWRPGAKVNLERALAVGERLGGHLVQGHVDAVGEVLRRVPEGQGAR
ECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCCCCCCE
LTISLPPSIAPLVAEKGSIAVDGVSLTVATAGRDRFELALIPETLARTTLGQAAAGTKVN
EEEECCCCCHHHHHCCCCEEECCEEEEEEECCCCCEEEEECCHHHHHHHHCHHCCCCEEC
LEADVLARHVARLRAFEGLGAGDLARWGYAAEEKP
CHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]