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The map label for this gene is ribBA [H]

Identifier: 220918023

GI number: 220918023

Start: 3237506

End: 3238834

Strand: Reverse

Name: ribBA [H]

Synonym: A2cp1_2924

Alternate gene names: 220918023

Gene position: 3238834-3237506 (Counterclockwise)

Preceding gene: 220918024

Following gene: 220918022

Centisome position: 64.4

GC content: 71.86

Gene sequence:

>1329_bases
GTGACGGAGCACGCGCAGCACGCCGTCGACTCGGTGGAGAAGGCCATCGCCTACCTCCGCGCCGGCAAGATGGTGATCCT
GACCGACGACGAGGACCGCGAGAACGAGGGCGACCTGTGCCTCGCCGCGGAGAAGGTCACCCCGGCGGCGGTGAACTTCA
TGGCCCGCTACGGGCGCGGCCTGGTCTGCCTGTCGCTCACCGAGGAGAAGGTGCGGCAGCTGCGCCTCCCGCTCATGGTG
GACGAGACGGCGAACACGTCGGGCTTCGGCACCGCGTTCACCGTGTCGATCGAGGCGCGCCAGGGCGTGAGCACCGGCAT
CAGCGCCAAGGACCGCGCCCACACCATCCTCACCGCGGTCGCCGACGGCTGCCGCCCCGAGGACCTGGCGCGACCGGGCC
ACGTGTTCCCGCTGCGCGCCCGGAAGGGCGGCGTGCTGGTGCGCGCCGGCCAGACCGAGGGCTCGGTCGACCTGGCCCGC
CTCGCCGGCCTGAAGCCCGCCGGCGTGATCTGCGAGGTGATGAACGACGACGGCACCATGGCGCGCATGCCCGAGCTGGA
GAAGCTCTCCCGGGCGCACGACCTGCCCATCGTCTCCGTCGCCGACCTCATCTCCTACCGGATGATGAAGGACACGCTCG
TGCGCCGCGCGGCGGAGGCGCCGCTGCCCACCGAGCACGGCGAGTACCGCGCCGTCGCCTACGAGAACGACGTGGACCGG
CACCAGCACGTGGCGCTGGTGAAGGGCAAGTGGCGGCCGAACGAGGCGGTGCTGGTGCGGGTGCACTCGAAGTGCCTCAC
GGGCGACGTGTTCGGGAGCGAGCGCTGCGACTGCGGCCCGCAGCTCCACGCGGCGCTGGACCAGATCGACCGCGCCGGCA
AGGGCGTCCTGCTCTACCTCGACCAGGAGGGCAGGGGCATCGGCCTGGCGAACAAGCTGAAGGCGTACAACCTGCAGGAC
GAGGGCTACGACACCGCCGAGGCGAACGTGCGCCTCGGCTTCAAGCCGGACCTGCGGGACTACGGCATCGGTGCCCAGAT
CCTCCGCGATCTGGGCGTGCGCAAGATGCGGCTCCTCACCAACAACCCGAAGAAGATCATCGGGCTCGAGGGCTACGGCC
TCGAGGTGGTGGAGCGGGTGGCGATCGAGATGCCTGCGACGCGCCGCAACCGCGCGTACCTCATCACCAAGCGGGACAAG
ATGGGCCACCTGCTCACGCTGGCGCCGGTCGCGGCGGCGGCGGCGGCACGGGCGCCGGCGGCCCCGGCGCGGGCCGCCAA
GCGGCGGCGCCCGGCCCCCGCGTCCAGGAAGGGAAAGGGAAGGCGATGA

Upstream 100 bases:

>100_bases
AGGCCGACGTGCTGGCGCGCCACGTGGCGCGCCTGCGGGCCTTCGAGGGGCTCGGGGCGGGCGATCTCGCCCGCTGGGGA
TACGCAGCAGAGGAGAAGCC

Downstream 100 bases:

>100_bases
ACGTCTACGAAGGCTCGCTGGTCGGCACCGGCCTCAAGGCCGCGCTGGTGGTGGCGCGCTTCAACTCGCTCGTCACCGAG
CAGCTCCTGGTGGGCGCGGC

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MTEHAQHAVDSVEKAIAYLRAGKMVILTDDEDRENEGDLCLAAEKVTPAAVNFMARYGRGLVCLSLTEEKVRQLRLPLMV
DETANTSGFGTAFTVSIEARQGVSTGISAKDRAHTILTAVADGCRPEDLARPGHVFPLRARKGGVLVRAGQTEGSVDLAR
LAGLKPAGVICEVMNDDGTMARMPELEKLSRAHDLPIVSVADLISYRMMKDTLVRRAAEAPLPTEHGEYRAVAYENDVDR
HQHVALVKGKWRPNEAVLVRVHSKCLTGDVFGSERCDCGPQLHAALDQIDRAGKGVLLYLDQEGRGIGLANKLKAYNLQD
EGYDTAEANVRLGFKPDLRDYGIGAQILRDLGVRKMRLLTNNPKKIIGLEGYGLEVVERVAIEMPATRRNRAYLITKRDK
MGHLLTLAPVAAAAAARAPAAPARAAKRRRPAPASRKGKGRR

Sequences:

>Translated_442_residues
MTEHAQHAVDSVEKAIAYLRAGKMVILTDDEDRENEGDLCLAAEKVTPAAVNFMARYGRGLVCLSLTEEKVRQLRLPLMV
DETANTSGFGTAFTVSIEARQGVSTGISAKDRAHTILTAVADGCRPEDLARPGHVFPLRARKGGVLVRAGQTEGSVDLAR
LAGLKPAGVICEVMNDDGTMARMPELEKLSRAHDLPIVSVADLISYRMMKDTLVRRAAEAPLPTEHGEYRAVAYENDVDR
HQHVALVKGKWRPNEAVLVRVHSKCLTGDVFGSERCDCGPQLHAALDQIDRAGKGVLLYLDQEGRGIGLANKLKAYNLQD
EGYDTAEANVRLGFKPDLRDYGIGAQILRDLGVRKMRLLTNNPKKIIGLEGYGLEVVERVAIEMPATRRNRAYLITKRDK
MGHLLTLAPVAAAAAARAPAAPARAAKRRRPAPASRKGKGRR
>Mature_441_residues
TEHAQHAVDSVEKAIAYLRAGKMVILTDDEDRENEGDLCLAAEKVTPAAVNFMARYGRGLVCLSLTEEKVRQLRLPLMVD
ETANTSGFGTAFTVSIEARQGVSTGISAKDRAHTILTAVADGCRPEDLARPGHVFPLRARKGGVLVRAGQTEGSVDLARL
AGLKPAGVICEVMNDDGTMARMPELEKLSRAHDLPIVSVADLISYRMMKDTLVRRAAEAPLPTEHGEYRAVAYENDVDRH
QHVALVKGKWRPNEAVLVRVHSKCLTGDVFGSERCDCGPQLHAALDQIDRAGKGVLLYLDQEGRGIGLANKLKAYNLQDE
GYDTAEANVRLGFKPDLRDYGIGAQILRDLGVRKMRLLTNNPKKIIGLEGYGLEVVERVAIEMPATRRNRAYLITKRDKM
GHLLTLAPVAAAAAARAPAAPARAAKRRRPAPASRKGKGRR

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=196, Percent_Identity=55.1020408163265, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1787533, Length=193, Percent_Identity=53.3678756476684, Blast_Score=198, Evalue=7e-52,
Organism=Saccharomyces cerevisiae, GI6320695, Length=201, Percent_Identity=40.7960199004975, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6319438, Length=177, Percent_Identity=45.1977401129944, Blast_Score=132, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 48169; Mature: 48038

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHAQHAVDSVEKAIAYLRAGKMVILTDDEDRENEGDLCLAAEKVTPAAVNFMARYGRG
CCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHCCC
LVCLSLTEEKVRQLRLPLMVDETANTSGFGTAFTVSIEARQGVSTGISAKDRAHTILTAV
EEEEECCHHHHHHHCCCEEEECCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHH
ADGCRPEDLARPGHVFPLRARKGGVLVRAGQTEGSVDLARLAGLKPAGVICEVMNDDGTM
HCCCCHHHHCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHCCCCCCCEEEEEECCCCCC
ARMPELEKLSRAHDLPIVSVADLISYRMMKDTLVRRAAEAPLPTEHGEYRAVAYENDVDR
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCC
HQHVALVKGKWRPNEAVLVRVHSKCLTGDVFGSERCDCGPQLHAALDQIDRAGKGVLLYL
CCEEEEEECCCCCCCEEEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEE
DQEGRGIGLANKLKAYNLQDEGYDTAEANVRLGFKPDLRDYGIGAQILRDLGVRKMRLLT
CCCCCCCCCHHHHEEECCCCCCCCCCCCCEEECCCCCHHHCCCHHHHHHHHCHHEEEHHC
NNPKKIIGLEGYGLEVVERVAIEMPATRRNRAYLITKRDKMGHLLTLAPVAAAAAARAPA
CCCCEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHCCCC
APARAAKRRRPAPASRKGKGRR
CHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEHAQHAVDSVEKAIAYLRAGKMVILTDDEDRENEGDLCLAAEKVTPAAVNFMARYGRG
CCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHCCC
LVCLSLTEEKVRQLRLPLMVDETANTSGFGTAFTVSIEARQGVSTGISAKDRAHTILTAV
EEEEECCHHHHHHHCCCEEEECCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHH
ADGCRPEDLARPGHVFPLRARKGGVLVRAGQTEGSVDLARLAGLKPAGVICEVMNDDGTM
HCCCCHHHHCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHCCCCCCCEEEEEECCCCCC
ARMPELEKLSRAHDLPIVSVADLISYRMMKDTLVRRAAEAPLPTEHGEYRAVAYENDVDR
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCC
HQHVALVKGKWRPNEAVLVRVHSKCLTGDVFGSERCDCGPQLHAALDQIDRAGKGVLLYL
CCEEEEEECCCCCCCEEEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEE
DQEGRGIGLANKLKAYNLQDEGYDTAEANVRLGFKPDLRDYGIGAQILRDLGVRKMRLLT
CCCCCCCCCHHHHEEECCCCCCCCCCCCCEEECCCCCHHHCCCHHHHHHHHCHHEEEHHC
NNPKKIIGLEGYGLEVVERVAIEMPATRRNRAYLITKRDKMGHLLTLAPVAAAAAARAPA
CCCCEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHCCCC
APARAAKRRRPAPASRKGKGRR
CHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]