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The map label for this gene is ypdA [H]

Identifier: 220917951

GI number: 220917951

Start: 3152308

End: 3154554

Strand: Reverse

Name: ypdA [H]

Synonym: A2cp1_2852

Alternate gene names: 220917951

Gene position: 3154554-3152308 (Counterclockwise)

Preceding gene: 220917956

Following gene: 220917950

Centisome position: 62.72

GC content: 75.43

Gene sequence:

>2247_bases
ATGGACCTCGCCACCCTCTGGATCGTCTCCGGCTCCCTCGCCAGCGTCGGCCTGCTCGCGGGCGGCCACCTCGGCCGGCG
CTGGGCCCGCGAGCGCCGCGACGCGGCCGAGCTCGAGGCGAAGCGCGCCCGCGGCCAGCACCTGGCCCGCTCGCTCCACC
CGATCATCGATCCGAACGTCTGCATCGGCAGCCTCTCCTGCCTGCGCGCGTGCCCGGAGGGCGACATCCTCGGCATCGTG
GACGGCGCCGCGAAGCTGGTGCACGCCGACCACTGCATCGGCCACGGGCGCTGCGCCGCCGAGTGCCCGGTCGGCGCGAT
CCGGCTGGTGTTCGGCACCGCCGAGCGCGGCGTGGACCTGCCCGAGGTCGACGCGTTCTTCGAGTCCTCCCGGCCCGGCG
TGCACGTCGTCGGCGAGCTGGGCGGGATGGGGCTCATCAAGAACGCGATCCAGCAGGGGCTCCAGGTGGCGGAGCGGCTG
GCCGAGACCGCGTCGCGGCAGGCGCCGGTCGCGGTGGTGGGCGCCGGTCCGGCCGGCATCGCGACCGCGCTCGGCCTGAA
GGCGCGCGGCGTCCCGTTCCGCCTCCTCGAGCAGGGCACCATGGGCGGGTCGATCGCCCATTATCCGCGCAAGAAGGTGG
CGATGACCGAGCCGGTGGAGCTGCCGCTGGTGGGCCGGTTCGGGAAGCGCCTCATCAGCAAGGAGGAGCTGCTCGCGTCG
TGGCAGCGCGTGCTCGCGAAGGCCGGCATCCCGGTGGAGGAGGGCGTCAAGGTCACCGGCCTCGACGGCGAGGACGGCCG
CTTCGAGCTTCGCACCGAGCGCGGCACGGTGCAGGCGTCGAAGGTGGTGCTGGCGGTCGGGCGCCGCGGCACGCCGCGGC
GGCTGGGCGTGCCCGGGGAGGAGCAGGAGAAGGTCCTGTACGGCCTGCTCGACCCGGAGGCGTTCGACGGCAACCGCGTG
CTGGTGGTGGGTGGCGGAGACTCGGCGCTCGAGGCGGCCATCCAGCTCGCCACCGAGTCGAGCGCGGAGGTGACGCTCTC
GTACCGCGGCGCCGAGCTGGCGCGCTGCCGCGAGGCGAACCGCGCGCGGCTCCAGGAGCTCGCCGCGGCGCGCCGCGTGC
GCGTGCTGCTCGGCTCGCAGGTGACGGCCATCCGCCCGCGCCAGGTGGTCCTCGAAGTGGGCGGGCGCGCCGCCACGCTG
GAGAACGACTTCGTGGTGGTGAACGTCGGGGGCGAGCTGCCGGTGGAGCTGCTCTCGAAGGCGGGCGTGGCGCTGCGGCG
CTACCACGGCGAGGCGCCCGGACAGGTCCACCGGCCCGCGCGCCCGCGGCCCGCCGCACCCGGCGCCGCCGGCGCCCGGC
CCGCCGCCGGCGCGTCGCGCACCGCGGCCGGACGGCGCCGCCGCCGCGCCTTCCACGCCGCCTACGCGCTCGCCGGCCTG
GTGATCCTGGCGGTGCTGGCGTGGAAGGGGCGCGAGTACTACCCGCTGGCGCGGGTGGAGCGCCTCCGATCGCCGCTCCA
CCCCTCGATGAAGCCCGCCGGGCCATGGGGCCACGGCGTCGGCATCGCGGCGACGCTGTTCATGCTCTCGAACTTCCTCT
ACGCGGTCCGCAAGCGCTGGAAGCGCTTCGCGCCGCTGGGGAGCATCCGCGGCTGGCTCGACTTCCACGTGTTCGTGGGC
TTCATGAGCCCGCTCGTCATCGCGTTCCACGCCGCGTTCCAGTCGAACAACCTGCTCGCCACCGGCACGGCGGGCGCGCT
CTGCATCGTGGTGGGCACCGGGATCGTCGGCCGGTTCATCTACGGCGCGGTCCCGTCGGACGGGGGGAAGGCGGTGGAGC
TGGCCGACCTGCTGGCGCGCTTCGAGCGCTCCCGCGCCGCGCTCGGCCCGCTGCTGCAGGAGGCCGGTGCGCCGGCCCGC
GCGCTCCTCGACCGCGCCACCGCGCCGGTCCGCGCCGGCTCGCTGGCGCTGCTGTTCGTGCGCATGCCGGCGGAGTCGCT
CCTGCTCCGGCTGCGGCTGCTGCGGGTGCGCGGAAGCTTCCGCGGCACCGGCCACCACGCCGAGTTCCGGGCGACGCTGG
TCGCGCTGGCCCGGCTGCGCTGGCAGATCCGCTTCTACGCCTCGCTGAAGCGACTGCTCCGCGGCTGGCGCGTGTTCCAC
GCCTCCCTGGCCGGGTTCCTGGTCCTCGTCATCGCCGCGCACATCGGCGTCTCCCTCTACCTCGGCTACGGGCTCCTCCA
CCGGTGA

Upstream 100 bases:

>100_bases
ACGGTCAAACGCTCCCTGACGGGGACCCGCGTGGCCGGGCCTTGCTGATCGAGGTCAATCCCGCGAGCGTGCGACAGGGC
TGCCGCCGCGCCCGAACCTC

Downstream 100 bases:

>100_bases
AACCCTCGACCGCAGCGCTCCTCGCGTCGCTCGCGCTGGCCACCCCGGCGGCCGCCGACGTGTTCTCGCCCGGCCCGCTC
TCCCGCCCCCACCGCGACCT

Product: FAD-dependent pyridine nucleotide-disulfide oxidoreductase

Products: thioredoxin disulfide; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 748; Mature: 748

Protein sequence:

>748_residues
MDLATLWIVSGSLASVGLLAGGHLGRRWARERRDAAELEAKRARGQHLARSLHPIIDPNVCIGSLSCLRACPEGDILGIV
DGAAKLVHADHCIGHGRCAAECPVGAIRLVFGTAERGVDLPEVDAFFESSRPGVHVVGELGGMGLIKNAIQQGLQVAERL
AETASRQAPVAVVGAGPAGIATALGLKARGVPFRLLEQGTMGGSIAHYPRKKVAMTEPVELPLVGRFGKRLISKEELLAS
WQRVLAKAGIPVEEGVKVTGLDGEDGRFELRTERGTVQASKVVLAVGRRGTPRRLGVPGEEQEKVLYGLLDPEAFDGNRV
LVVGGGDSALEAAIQLATESSAEVTLSYRGAELARCREANRARLQELAAARRVRVLLGSQVTAIRPRQVVLEVGGRAATL
ENDFVVVNVGGELPVELLSKAGVALRRYHGEAPGQVHRPARPRPAAPGAAGARPAAGASRTAAGRRRRRAFHAAYALAGL
VILAVLAWKGREYYPLARVERLRSPLHPSMKPAGPWGHGVGIAATLFMLSNFLYAVRKRWKRFAPLGSIRGWLDFHVFVG
FMSPLVIAFHAAFQSNNLLATGTAGALCIVVGTGIVGRFIYGAVPSDGGKAVELADLLARFERSRAALGPLLQEAGAPAR
ALLDRATAPVRAGSLALLFVRMPAESLLLRLRLLRVRGSFRGTGHHAEFRATLVALARLRWQIRFYASLKRLLRGWRVFH
ASLAGFLVLVIAAHIGVSLYLGYGLLHR

Sequences:

>Translated_748_residues
MDLATLWIVSGSLASVGLLAGGHLGRRWARERRDAAELEAKRARGQHLARSLHPIIDPNVCIGSLSCLRACPEGDILGIV
DGAAKLVHADHCIGHGRCAAECPVGAIRLVFGTAERGVDLPEVDAFFESSRPGVHVVGELGGMGLIKNAIQQGLQVAERL
AETASRQAPVAVVGAGPAGIATALGLKARGVPFRLLEQGTMGGSIAHYPRKKVAMTEPVELPLVGRFGKRLISKEELLAS
WQRVLAKAGIPVEEGVKVTGLDGEDGRFELRTERGTVQASKVVLAVGRRGTPRRLGVPGEEQEKVLYGLLDPEAFDGNRV
LVVGGGDSALEAAIQLATESSAEVTLSYRGAELARCREANRARLQELAAARRVRVLLGSQVTAIRPRQVVLEVGGRAATL
ENDFVVVNVGGELPVELLSKAGVALRRYHGEAPGQVHRPARPRPAAPGAAGARPAAGASRTAAGRRRRRAFHAAYALAGL
VILAVLAWKGREYYPLARVERLRSPLHPSMKPAGPWGHGVGIAATLFMLSNFLYAVRKRWKRFAPLGSIRGWLDFHVFVG
FMSPLVIAFHAAFQSNNLLATGTAGALCIVVGTGIVGRFIYGAVPSDGGKAVELADLLARFERSRAALGPLLQEAGAPAR
ALLDRATAPVRAGSLALLFVRMPAESLLLRLRLLRVRGSFRGTGHHAEFRATLVALARLRWQIRFYASLKRLLRGWRVFH
ASLAGFLVLVIAAHIGVSLYLGYGLLHR
>Mature_748_residues
MDLATLWIVSGSLASVGLLAGGHLGRRWARERRDAAELEAKRARGQHLARSLHPIIDPNVCIGSLSCLRACPEGDILGIV
DGAAKLVHADHCIGHGRCAAECPVGAIRLVFGTAERGVDLPEVDAFFESSRPGVHVVGELGGMGLIKNAIQQGLQVAERL
AETASRQAPVAVVGAGPAGIATALGLKARGVPFRLLEQGTMGGSIAHYPRKKVAMTEPVELPLVGRFGKRLISKEELLAS
WQRVLAKAGIPVEEGVKVTGLDGEDGRFELRTERGTVQASKVVLAVGRRGTPRRLGVPGEEQEKVLYGLLDPEAFDGNRV
LVVGGGDSALEAAIQLATESSAEVTLSYRGAELARCREANRARLQELAAARRVRVLLGSQVTAIRPRQVVLEVGGRAATL
ENDFVVVNVGGELPVELLSKAGVALRRYHGEAPGQVHRPARPRPAAPGAAGARPAAGASRTAAGRRRRRAFHAAYALAGL
VILAVLAWKGREYYPLARVERLRSPLHPSMKPAGPWGHGVGIAATLFMLSNFLYAVRKRWKRFAPLGSIRGWLDFHVFVG
FMSPLVIAFHAAFQSNNLLATGTAGALCIVVGTGIVGRFIYGAVPSDGGKAVELADLLARFERSRAALGPLLQEAGAPAR
ALLDRATAPVRAGSLALLFVRMPAESLLLRLRLLRVRGSFRGTGHHAEFRATLVALARLRWQIRFYASLKRLLRGWRVFH
ASLAGFLVLVIAAHIGVSLYLGYGLLHR

Specific function: Serves To Protect The Cell Against DNA Damage By Alkyl Hydroperoxides. It Can Use Either NADH Or NADPH As Electron Donor For Direct Reduction Of Redox Dyes Or Of Alkyl Hydroperoxides When Combined With The Ahpc Protein. [C]

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.8.1.9

Molecular weight: Translated: 79917; Mature: 79917

Theoretical pI: Translated: 11.27; Mature: 11.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLATLWIVSGSLASVGLLAGGHLGRRWARERRDAAELEAKRARGQHLARSLHPIIDPNV
CCCEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
CIGSLSCLRACPEGDILGIVDGAAKLVHADHCIGHGRCAAECPVGAIRLVFGTAERGVDL
HHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECHHCCCCC
PEVDAFFESSRPGVHVVGELGGMGLIKNAIQQGLQVAERLAETASRQAPVAVVGAGPAGI
CHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHH
ATALGLKARGVPFRLLEQGTMGGSIAHYPRKKVAMTEPVELPLVGRFGKRLISKEELLAS
HHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
WQRVLAKAGIPVEEGVKVTGLDGEDGRFELRTERGTVQASKVVLAVGRRGTPRRLGVPGE
HHHHHHHCCCCHHHCEEEEECCCCCCCEEEEECCCCCHHHHEEEEECCCCCCCCCCCCCC
EQEKVLYGLLDPEAFDGNRVLVVGGGDSALEAAIQLATESSAEVTLSYRGAELARCREAN
CCCHHEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHH
RARLQELAAARRVRVLLGSQVTAIRPRQVVLEVGGRAATLENDFVVVNVGGELPVELLSK
HHHHHHHHHHHHHHHHHCCCCEEECCHHHHEECCCCEEEECCCEEEEEECCCCHHHHHHH
AGVALRRYHGEAPGQVHRPARPRPAAPGAAGARPAAGASRTAAGRRRRRAFHAAYALAGL
CCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VILAVLAWKGREYYPLARVERLRSPLHPSMKPAGPWGHGVGIAATLFMLSNFLYAVRKRW
HHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
KRFAPLGSIRGWLDFHVFVGFMSPLVIAFHAAFQSNNLLATGTAGALCIVVGTGIVGRFI
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEHHHHHHHHH
YGAVPSDGGKAVELADLLARFERSRAALGPLLQEAGAPARALLDRATAPVRAGSLALLFV
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEE
RMPAESLLLRLRLLRVRGSFRGTGHHAEFRATLVALARLRWQIRFYASLKRLLRGWRVFH
ECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASLAGFLVLVIAAHIGVSLYLGYGLLHR
HHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDLATLWIVSGSLASVGLLAGGHLGRRWARERRDAAELEAKRARGQHLARSLHPIIDPNV
CCCEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
CIGSLSCLRACPEGDILGIVDGAAKLVHADHCIGHGRCAAECPVGAIRLVFGTAERGVDL
HHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECHHCCCCC
PEVDAFFESSRPGVHVVGELGGMGLIKNAIQQGLQVAERLAETASRQAPVAVVGAGPAGI
CHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHH
ATALGLKARGVPFRLLEQGTMGGSIAHYPRKKVAMTEPVELPLVGRFGKRLISKEELLAS
HHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
WQRVLAKAGIPVEEGVKVTGLDGEDGRFELRTERGTVQASKVVLAVGRRGTPRRLGVPGE
HHHHHHHCCCCHHHCEEEEECCCCCCCEEEEECCCCCHHHHEEEEECCCCCCCCCCCCCC
EQEKVLYGLLDPEAFDGNRVLVVGGGDSALEAAIQLATESSAEVTLSYRGAELARCREAN
CCCHHEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHH
RARLQELAAARRVRVLLGSQVTAIRPRQVVLEVGGRAATLENDFVVVNVGGELPVELLSK
HHHHHHHHHHHHHHHHHCCCCEEECCHHHHEECCCCEEEECCCEEEEEECCCCHHHHHHH
AGVALRRYHGEAPGQVHRPARPRPAAPGAAGARPAAGASRTAAGRRRRRAFHAAYALAGL
CCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VILAVLAWKGREYYPLARVERLRSPLHPSMKPAGPWGHGVGIAATLFMLSNFLYAVRKRW
HHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
KRFAPLGSIRGWLDFHVFVGFMSPLVIAFHAAFQSNNLLATGTAGALCIVVGTGIVGRFI
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEHHHHHHHHH
YGAVPSDGGKAVELADLLARFERSRAALGPLLQEAGAPARALLDRATAPVRAGSLALLFV
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEE
RMPAESLLLRLRLLRVRGSFRGTGHHAEFRATLVALARLRWQIRFYASLKRLLRGWRVFH
ECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASLAGFLVLVIAAHIGVSLYLGYGLLHR
HHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: thioredoxin; NADP+

Specific reaction: thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377 [H]