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The map label for this gene is atoC [H]

Identifier: 220917934

GI number: 220917934

Start: 3133529

End: 3134956

Strand: Reverse

Name: atoC [H]

Synonym: A2cp1_2835

Alternate gene names: 220917934

Gene position: 3134956-3133529 (Counterclockwise)

Preceding gene: 220917937

Following gene: 220917932

Centisome position: 62.33

GC content: 73.46

Gene sequence:

>1428_bases
ATGGACAACGACTGCACCGTGCTCGTCATCGAGGACGACGACGAGGCCCGGGCACCCCTGTGCGAGTTCCTCGGCGCGGC
CGGCTACCGCGTGCGCGCCGCCCGCGGCGGCAACGAGGCGCTGGCCGACCTGGGCAGTGCGCCGGCGGGGGCGGTGCTGC
TGGATCTAGTGATGCCCGAGCCGGACGGCTTCGAGGTGCTGCGCCGGGTGCGCGAGCGGGATCCGGCGCTCCCGGTCATC
GTGCTCTCGGCGCTGTCGCAGACCGAGGACGTGGTGCGCGCCATGAAGCTCGGCGCGACCGACTACCTGCCGAAGCCGTT
CGATCCCGCGGAGCTGGAGCTGGTACTGCGCCGCGCGCTCGACGGGCGCGCGCGGACGCGCTCCGAGACCGCGCCGGATC
CCGGCACGCTGCCGCTGCTCTCCGGCGCGATGGACCGCGTCCGCGAGCTGGTCGAGCGGATCGCGGACACCGACGTGCCG
GTGCTGCTGGTGGGCGAGAGCGGCGTGGGCAAGGACGTCATCGCCCGGCGCATCCACGCGGAGAGCCGGCGCGCCGCGCG
GCCGTTCGTGAAGATCAACTGCGCCGCGCTGCCGGGCGAGCTGCTCGAGAGCGAGCTGTTCGGCCACGAGAAGGGCGCGT
TCACCGGCGCGCACGCGGAGAAGCCGGGCAAGTTCGAGCTGGCGCACCAGGGCACCATCTTCCTCGACGAGATCGGCGAG
ATGGACCCGCGCCTGCAGGCCAAGCTGCTCCAGGTCCTCCAGGACGAGGAGTTCTACCGGGTGGGCGGGAAGCGGCCGGT
GCGGGTGGACGCGCGCGTGGTGGTCGCGACCAACCGGAACCTCGAGCTGGCCATCCGGCAGGGCAGCTTCCGCGAGGACC
TGTTCTACCGGCTGAACGTGGTCACCGTCCGCGTGCCGCCGCTGCGCGAGCGCAAGGAGGAGATCGGGCCGCTGGTCCGG
CACTTCGTGCGCAAGTACCGCGAGCGCTACCAGGGTGGGCTGGAGGAGGTGCCGCCGGAGGTGATGGAGCGCTTCCACGC
GTACGACTGGCCCGGGAACGTCCGCGAGCTGGAGAACCTGGTGCGGCGGCTGGTGGTGCTGCGCGACCCGGCCATGGTGC
TCGGCGAGCTGGGCGCGCCCCGCGCCGCGGCCGGACCGGCGCCGGTGAACGTGGCCGCGAACCACGTGCGGCCGGGCGCC
CCCGCGCTCCACGCGGCGCTCCCGGAGGACGCGCCGCTGAAGGACGTGGCGCGCCGCGCGGCGCGGATCGCCGAGCGCGA
GGCCATCCTGCGCGCGCTCATGCGCACCGGCTGGAACAAGCGCAAGGCCGCGAAGCGGCTGCAGGTGAGCTACAAGGCGC
TGCTCTACAAGATCAAGGACTGCGGGATCGTGGATCCGCGCGACGCCGCGACCGTCGACGAGGCCTGA

Upstream 100 bases:

>100_bases
ACGCTCGCTCGCCCGCCGCCGCGATCGGGCCGGTGCCGGCCGTCGGAGGTGGCGCCAGCTTCTCCTCGGCGGCACTCCGC
CGCCCTGGAACGGAAACCGG

Downstream 100 bases:

>100_bases
CGCCGGCGCCGGGAGCGCGCGGCCTGCGCGGGCGCGGCGGTGCGTCCTCGCACGGTGACGCTATGCGGCCGCCTCCTTGG
TGGCGATGGTGCGGGCACGC

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MDNDCTVLVIEDDDEARAPLCEFLGAAGYRVRAARGGNEALADLGSAPAGAVLLDLVMPEPDGFEVLRRVRERDPALPVI
VLSALSQTEDVVRAMKLGATDYLPKPFDPAELELVLRRALDGRARTRSETAPDPGTLPLLSGAMDRVRELVERIADTDVP
VLLVGESGVGKDVIARRIHAESRRAARPFVKINCAALPGELLESELFGHEKGAFTGAHAEKPGKFELAHQGTIFLDEIGE
MDPRLQAKLLQVLQDEEFYRVGGKRPVRVDARVVVATNRNLELAIRQGSFREDLFYRLNVVTVRVPPLRERKEEIGPLVR
HFVRKYRERYQGGLEEVPPEVMERFHAYDWPGNVRELENLVRRLVVLRDPAMVLGELGAPRAAAGPAPVNVAANHVRPGA
PALHAALPEDAPLKDVARRAARIAEREAILRALMRTGWNKRKAAKRLQVSYKALLYKIKDCGIVDPRDAATVDEA

Sequences:

>Translated_475_residues
MDNDCTVLVIEDDDEARAPLCEFLGAAGYRVRAARGGNEALADLGSAPAGAVLLDLVMPEPDGFEVLRRVRERDPALPVI
VLSALSQTEDVVRAMKLGATDYLPKPFDPAELELVLRRALDGRARTRSETAPDPGTLPLLSGAMDRVRELVERIADTDVP
VLLVGESGVGKDVIARRIHAESRRAARPFVKINCAALPGELLESELFGHEKGAFTGAHAEKPGKFELAHQGTIFLDEIGE
MDPRLQAKLLQVLQDEEFYRVGGKRPVRVDARVVVATNRNLELAIRQGSFREDLFYRLNVVTVRVPPLRERKEEIGPLVR
HFVRKYRERYQGGLEEVPPEVMERFHAYDWPGNVRELENLVRRLVVLRDPAMVLGELGAPRAAAGPAPVNVAANHVRPGA
PALHAALPEDAPLKDVARRAARIAEREAILRALMRTGWNKRKAAKRLQVSYKALLYKIKDCGIVDPRDAATVDEA
>Mature_475_residues
MDNDCTVLVIEDDDEARAPLCEFLGAAGYRVRAARGGNEALADLGSAPAGAVLLDLVMPEPDGFEVLRRVRERDPALPVI
VLSALSQTEDVVRAMKLGATDYLPKPFDPAELELVLRRALDGRARTRSETAPDPGTLPLLSGAMDRVRELVERIADTDVP
VLLVGESGVGKDVIARRIHAESRRAARPFVKINCAALPGELLESELFGHEKGAFTGAHAEKPGKFELAHQGTIFLDEIGE
MDPRLQAKLLQVLQDEEFYRVGGKRPVRVDARVVVATNRNLELAIRQGSFREDLFYRLNVVTVRVPPLRERKEEIGPLVR
HFVRKYRERYQGGLEEVPPEVMERFHAYDWPGNVRELENLVRRLVVLRDPAMVLGELGAPRAAAGPAPVNVAANHVRPGA
PALHAALPEDAPLKDVARRAARIAEREAILRALMRTGWNKRKAAKRLQVSYKALLYKIKDCGIVDPRDAATVDEA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=472, Percent_Identity=39.6186440677966, Blast_Score=344, Evalue=7e-96,
Organism=Escherichia coli, GI1790437, Length=463, Percent_Identity=39.7408207343413, Blast_Score=315, Evalue=3e-87,
Organism=Escherichia coli, GI1790299, Length=470, Percent_Identity=39.1489361702128, Blast_Score=297, Evalue=8e-82,
Organism=Escherichia coli, GI1788905, Length=367, Percent_Identity=39.2370572207085, Blast_Score=258, Evalue=7e-70,
Organism=Escherichia coli, GI87082117, Length=332, Percent_Identity=41.8674698795181, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1789087, Length=227, Percent_Identity=49.3392070484581, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1789233, Length=334, Percent_Identity=41.3173652694611, Blast_Score=228, Evalue=9e-61,
Organism=Escherichia coli, GI87082152, Length=331, Percent_Identity=41.9939577039275, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1787583, Length=329, Percent_Identity=37.0820668693009, Blast_Score=198, Evalue=8e-52,
Organism=Escherichia coli, GI1786524, Length=244, Percent_Identity=44.672131147541, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI87081872, Length=319, Percent_Identity=37.3040752351097, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1789828, Length=234, Percent_Identity=36.3247863247863, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI87081858, Length=288, Percent_Identity=29.8611111111111, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1786911, Length=130, Percent_Identity=40, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1789809, Length=112, Percent_Identity=33.0357142857143, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1786784, Length=106, Percent_Identity=32.0754716981132, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1789402, Length=136, Percent_Identity=36.0294117647059, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082012, Length=147, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787375, Length=106, Percent_Identity=35.8490566037736, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1790552, Length=136, Percent_Identity=32.3529411764706, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1786599, Length=108, Percent_Identity=31.4814814814815, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788394, Length=122, Percent_Identity=29.5081967213115, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52477; Mature: 52477

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNDCTVLVIEDDDEARAPLCEFLGAAGYRVRAARGGNEALADLGSAPAGAVLLDLVMPE
CCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHCCCCCCCHHHHHHHCCC
PDGFEVLRRVRERDPALPVIVLSALSQTEDVVRAMKLGATDYLPKPFDPAELELVLRRAL
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
DGRARTRSETAPDPGTLPLLSGAMDRVRELVERIADTDVPVLLVGESGVGKDVIARRIHA
CCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHH
ESRRAARPFVKINCAALPGELLESELFGHEKGAFTGAHAEKPGKFELAHQGTIFLDEIGE
HHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCEEEHHHCC
MDPRLQAKLLQVLQDEEFYRVGGKRPVRVDARVVVATNRNLELAIRQGSFREDLFYRLNV
CCHHHHHHHHHHHCCCHHHHCCCCCCEEECCEEEEEECCCEEEEEECCCCHHHHHEEEEE
VTVRVPPLRERKEEIGPLVRHFVRKYRERYQGGLEEVPPEVMERFHAYDWPGNVRELENL
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHCCCCCCCHHHHHHH
VRRLVVLRDPAMVLGELGAPRAAAGPAPVNVAANHVRPGAPALHAALPEDAPLKDVARRA
HHHHHHHCCCHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHCCCCCCCHHHHHHHH
ARIAEREAILRALMRTGWNKRKAAKRLQVSYKALLYKIKDCGIVDPRDAATVDEA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDNDCTVLVIEDDDEARAPLCEFLGAAGYRVRAARGGNEALADLGSAPAGAVLLDLVMPE
CCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHCCCCCCCHHHHHHHCCC
PDGFEVLRRVRERDPALPVIVLSALSQTEDVVRAMKLGATDYLPKPFDPAELELVLRRAL
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
DGRARTRSETAPDPGTLPLLSGAMDRVRELVERIADTDVPVLLVGESGVGKDVIARRIHA
CCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHH
ESRRAARPFVKINCAALPGELLESELFGHEKGAFTGAHAEKPGKFELAHQGTIFLDEIGE
HHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCEEEHHHCC
MDPRLQAKLLQVLQDEEFYRVGGKRPVRVDARVVVATNRNLELAIRQGSFREDLFYRLNV
CCHHHHHHHHHHHCCCHHHHCCCCCCEEECCEEEEEECCCEEEEEECCCCHHHHHEEEEE
VTVRVPPLRERKEEIGPLVRHFVRKYRERYQGGLEEVPPEVMERFHAYDWPGNVRELENL
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHCCCCCCCHHHHHHH
VRRLVVLRDPAMVLGELGAPRAAAGPAPVNVAANHVRPGAPALHAALPEDAPLKDVARRA
HHHHHHHCCCHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHCCCCCCCHHHHHHHH
ARIAEREAILRALMRTGWNKRKAAKRLQVSYKALLYKIKDCGIVDPRDAATVDEA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]