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The map label for this gene is sdhA [H]

Identifier: 220917917

GI number: 220917917

Start: 3115203

End: 3117113

Strand: Direct

Name: sdhA [H]

Synonym: A2cp1_2818

Alternate gene names: 220917917

Gene position: 3115203-3117113 (Clockwise)

Preceding gene: 220917916

Following gene: 220917918

Centisome position: 61.94

GC content: 73.26

Gene sequence:

>1911_bases
ATGCCGCTCGACGCGAAGATCCCGGCGGGGCCGATCGAGCAGAAGTGGGCGCAGCGCAAGTACGAGCTGAAGCTGGTGAA
CCCCGCCAACAAGCGCCGGCACCGGATCCTGGTGGTGGGCACCGGCCTGGCCGGCGCGTCCGCGGCGGCCTCGCTGGCCG
AGCTGGGCTACGAGGTCGAGACGTTCTGCTACCAGGACAGCCCGCGGCGCGCGCACTCGATCGCCGCGCAGGGCGGCATC
AACGCGGCGAAGAACTACCAGAACGACGGCGACTCGGTGGCGCGGCTCTTCTACGACACCGTGAAGGGCGGCGACTTCCG
CTCGCGCGAGGCCAACGTCCACCGGCTCGCCGAGCTGTCGGTGAACATCATCGACCAGTGCGCGGCGCAGGGCGTGCCGT
TCGCGCGCGAGTACGGCGGCCTGCTCGCGAACCGCTCCTTCGGCGGCGCGCTCGTCTCCCGGACGTTCTACGCCCGCGGC
CAGACCGGCCAGCAGCTCCTGCTCGGCGCCTACCAGGCGCTGCAACGCCAGGTGGCGGCGGGCAAGGTGGTGAGCCACCC
GCGCTGCGAGATGCTCGAGCTGGTGCTGGTGGACGGGCGGGCGCGCGGCGTGGTCACCCGCGACCTCGTCACCGGCGAGG
TGCGCTCGCATGCCGGCGACGCGGTGGTGCTCGCGACCGGCGGCTACGGCAACGTGTTCTACCTCTCCACGAACGCGCGC
GGCTGCAACGCCACCGCGGTCTGGCGCGCGCACCGCAAGGGCGCGCTGTTCGCGAACCCCTGCTACACGCAGATCCACCC
GACCTGCATCCCGCGCTCCGGCGAGTACCAGTCGAAGCTCACGCTCATGAGCGAGTCGCTCCGCAACGACGGGCGGGTCT
GGGTGCCCGCCCGCCGCGGCGACGGGCGCCCGCCCGCCGAGATCCCCGACCCGGAGCGCGACTACTACCTGGAGCGGATG
TACCCGACCTACGGCAACCTCGCGCCGCGCGACATCGCCTCGCGGGCGGCCAAGACCGTCTGCGACGAGGGGCGCGGCGT
CGGGCCCGGCGGGCTGGGCGTCTACCTCGACTTCCGCGACGCGTTCGCGCGGCTGGGCCGGCGCGTGCTCGACGAGCGGT
ACGGCAACCTGTTCGAGATGTACGAGCGCATCACCGGCGACGATCCGCACGACGTGCCGATGCGGATCTACCCCGCGGTG
CACTACACGATGGGCGGGCTGTGGGTGGACTACGACCTGCAGAGCACCCTCCCCGGCCTGTTCGTGCTCGGCGAGGCGAA
CTTCTCCGACCACGGGGCGAACCGGCTCGGCGCGAGCGCGCTCATGCAGGGGCTCGCCGACGGCTACTTCGTCGTCCCCT
ACACGGTGGGCGACCACGTGGCCCGCGCGCAGGCGAAGGTGGACACCTCGCACGCCGCCTTCCGGGACGCGGAGCGCGAG
GTGGCGTCGCGCACCGCGCGGCTGCTGTCCATCGGCGGCCGGCGCACCGCCGACGACCTGCACCGCGAGCTGGGCACGCT
CCTCTGGACCGACGCGGGGATGGCGCGCTCGCGGGCGTCGCTGGAGCACGCGCTCGCCGAGATCCCGCGCATCCGGGAGG
CGTTCTGGAGCGACCTGCGGGTACCGGGCACCGGCGAGGAGCTGAACCAGGAGCTGGAGCGCGCCGGCCGCGTGGCCGAC
TTCCTGGAGCTGGCGGAGCTCCTGTGCCGCGACGCGCTGCACCGCGAGGAGTCCTGCGGCGGGCACTTCCGGGTCGAGCA
CCAGACGCCCGACGGCGAGGCGCTTCGCGACGACGAGCGGTTCGCCTACGTGGCGGCGTGGGAGTGGACGGGGCCGGGCG
AGGCCCCGGCGCTGCACCGGGAGCCGCTCGCGTTCGAGTACGTCCCGCTCCAGCAGCGCAGCTACAAGTGA

Upstream 100 bases:

>100_bases
CCGGCCTGCAGCGCTTCGCGGTGACGGTGGCGTGGATCCTGGCGATCGGGTTCACCGCCATCCCGCTCGCGGTCGTCGTG
GGCGTGGTGAGGTAGCGCGC

Downstream 100 bases:

>100_bases
GGGGCGCGTGCGCATCGTCCTCGAGATCTGGCGGCAGCGGGACCCGCGGGCGGAGGGCCGGTTCGTCCGGTACGAGGTCA
CCGACGTCAGCGAGCACATG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 636; Mature: 635

Protein sequence:

>636_residues
MPLDAKIPAGPIEQKWAQRKYELKLVNPANKRRHRILVVGTGLAGASAAASLAELGYEVETFCYQDSPRRAHSIAAQGGI
NAAKNYQNDGDSVARLFYDTVKGGDFRSREANVHRLAELSVNIIDQCAAQGVPFAREYGGLLANRSFGGALVSRTFYARG
QTGQQLLLGAYQALQRQVAAGKVVSHPRCEMLELVLVDGRARGVVTRDLVTGEVRSHAGDAVVLATGGYGNVFYLSTNAR
GCNATAVWRAHRKGALFANPCYTQIHPTCIPRSGEYQSKLTLMSESLRNDGRVWVPARRGDGRPPAEIPDPERDYYLERM
YPTYGNLAPRDIASRAAKTVCDEGRGVGPGGLGVYLDFRDAFARLGRRVLDERYGNLFEMYERITGDDPHDVPMRIYPAV
HYTMGGLWVDYDLQSTLPGLFVLGEANFSDHGANRLGASALMQGLADGYFVVPYTVGDHVARAQAKVDTSHAAFRDAERE
VASRTARLLSIGGRRTADDLHRELGTLLWTDAGMARSRASLEHALAEIPRIREAFWSDLRVPGTGEELNQELERAGRVAD
FLELAELLCRDALHREESCGGHFRVEHQTPDGEALRDDERFAYVAAWEWTGPGEAPALHREPLAFEYVPLQQRSYK

Sequences:

>Translated_636_residues
MPLDAKIPAGPIEQKWAQRKYELKLVNPANKRRHRILVVGTGLAGASAAASLAELGYEVETFCYQDSPRRAHSIAAQGGI
NAAKNYQNDGDSVARLFYDTVKGGDFRSREANVHRLAELSVNIIDQCAAQGVPFAREYGGLLANRSFGGALVSRTFYARG
QTGQQLLLGAYQALQRQVAAGKVVSHPRCEMLELVLVDGRARGVVTRDLVTGEVRSHAGDAVVLATGGYGNVFYLSTNAR
GCNATAVWRAHRKGALFANPCYTQIHPTCIPRSGEYQSKLTLMSESLRNDGRVWVPARRGDGRPPAEIPDPERDYYLERM
YPTYGNLAPRDIASRAAKTVCDEGRGVGPGGLGVYLDFRDAFARLGRRVLDERYGNLFEMYERITGDDPHDVPMRIYPAV
HYTMGGLWVDYDLQSTLPGLFVLGEANFSDHGANRLGASALMQGLADGYFVVPYTVGDHVARAQAKVDTSHAAFRDAERE
VASRTARLLSIGGRRTADDLHRELGTLLWTDAGMARSRASLEHALAEIPRIREAFWSDLRVPGTGEELNQELERAGRVAD
FLELAELLCRDALHREESCGGHFRVEHQTPDGEALRDDERFAYVAAWEWTGPGEAPALHREPLAFEYVPLQQRSYK
>Mature_635_residues
PLDAKIPAGPIEQKWAQRKYELKLVNPANKRRHRILVVGTGLAGASAAASLAELGYEVETFCYQDSPRRAHSIAAQGGIN
AAKNYQNDGDSVARLFYDTVKGGDFRSREANVHRLAELSVNIIDQCAAQGVPFAREYGGLLANRSFGGALVSRTFYARGQ
TGQQLLLGAYQALQRQVAAGKVVSHPRCEMLELVLVDGRARGVVTRDLVTGEVRSHAGDAVVLATGGYGNVFYLSTNARG
CNATAVWRAHRKGALFANPCYTQIHPTCIPRSGEYQSKLTLMSESLRNDGRVWVPARRGDGRPPAEIPDPERDYYLERMY
PTYGNLAPRDIASRAAKTVCDEGRGVGPGGLGVYLDFRDAFARLGRRVLDERYGNLFEMYERITGDDPHDVPMRIYPAVH
YTMGGLWVDYDLQSTLPGLFVLGEANFSDHGANRLGASALMQGLADGYFVVPYTVGDHVARAQAKVDTSHAAFRDAEREV
ASRTARLLSIGGRRTADDLHRELGTLLWTDAGMARSRASLEHALAEIPRIREAFWSDLRVPGTGEELNQELERAGRVADF
LELAELLCRDALHREESCGGHFRVEHQTPDGEALRDDERFAYVAAWEWTGPGEAPALHREPLAFEYVPLQQRSYK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=410, Percent_Identity=30, Blast_Score=146, Evalue=5e-35,
Organism=Escherichia coli, GI1790597, Length=544, Percent_Identity=28.125, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1786942, Length=560, Percent_Identity=28.3928571428571, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1788928, Length=578, Percent_Identity=26.1245674740484, Blast_Score=116, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17505833, Length=540, Percent_Identity=27.7777777777778, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17550100, Length=394, Percent_Identity=31.4720812182741, Blast_Score=156, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6322701, Length=583, Percent_Identity=28.8164665523156, Blast_Score=181, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6322416, Length=603, Percent_Identity=28.0265339966833, Blast_Score=158, Evalue=2e-39,
Organism=Drosophila melanogaster, GI17137288, Length=557, Percent_Identity=28.9048473967684, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24655642, Length=557, Percent_Identity=28.9048473967684, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24655647, Length=557, Percent_Identity=28.9048473967684, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24663005, Length=573, Percent_Identity=25.130890052356, Blast_Score=135, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 70175; Mature: 70044

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLDAKIPAGPIEQKWAQRKYELKLVNPANKRRHRILVVGTGLAGASAAASLAELGYEVE
CCCCCCCCCCCHHHHHHCCEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHCCCHHE
TFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVARLFYDTVKGGDFRSREANVHRLAELS
EEEECCCCHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
VNIIDQCAAQGVPFAREYGGLLANRSFGGALVSRTFYARGQTGQQLLLGAYQALQRQVAA
HHHHHHHHHCCCCCHHHHCCHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
GKVVSHPRCEMLELVLVDGRARGVVTRDLVTGEVRSHAGDAVVLATGGYGNVFYLSTNAR
CHHCCCCCHHEEEEEEECCCCCCEEEHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCC
GCNATAVWRAHRKGALFANPCYTQIHPTCIPRSGEYQSKLTLMSESLRNDGRVWVPARRG
CCCCHHHHHHHCCCCEEECCCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCC
DGRPPAEIPDPERDYYLERMYPTYGNLAPRDIASRAAKTVCDEGRGVGPGGLGVYLDFRD
CCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHH
AFARLGRRVLDERYGNLFEMYERITGDDPHDVPMRIYPAVHYTMGGLWVDYDLQSTLPGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEECCEEEEECHHHCCCCE
FVLGEANFSDHGANRLGASALMQGLADGYFVVPYTVGDHVARAQAKVDTSHAAFRDAERE
EEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCHHHHHHHHHHH
VASRTARLLSIGGRRTADDLHRELGTLLWTDAGMARSRASLEHALAEIPRIREAFWSDLR
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
VPGTGEELNQELERAGRVADFLELAELLCRDALHREESCGGHFRVEHQTPDGEALRDDER
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
FAYVAAWEWTGPGEAPALHREPLAFEYVPLQQRSYK
EEEEEEEEECCCCCCCCCCCCCCEEEEECCHHCCCC
>Mature Secondary Structure 
PLDAKIPAGPIEQKWAQRKYELKLVNPANKRRHRILVVGTGLAGASAAASLAELGYEVE
CCCCCCCCCCHHHHHHCCEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHCCCHHE
TFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVARLFYDTVKGGDFRSREANVHRLAELS
EEEECCCCHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
VNIIDQCAAQGVPFAREYGGLLANRSFGGALVSRTFYARGQTGQQLLLGAYQALQRQVAA
HHHHHHHHHCCCCCHHHHCCHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
GKVVSHPRCEMLELVLVDGRARGVVTRDLVTGEVRSHAGDAVVLATGGYGNVFYLSTNAR
CHHCCCCCHHEEEEEEECCCCCCEEEHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCC
GCNATAVWRAHRKGALFANPCYTQIHPTCIPRSGEYQSKLTLMSESLRNDGRVWVPARRG
CCCCHHHHHHHCCCCEEECCCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCC
DGRPPAEIPDPERDYYLERMYPTYGNLAPRDIASRAAKTVCDEGRGVGPGGLGVYLDFRD
CCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHH
AFARLGRRVLDERYGNLFEMYERITGDDPHDVPMRIYPAVHYTMGGLWVDYDLQSTLPGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEECCEEEEECHHHCCCCE
FVLGEANFSDHGANRLGASALMQGLADGYFVVPYTVGDHVARAQAKVDTSHAAFRDAERE
EEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCHHHHHHHHHHH
VASRTARLLSIGGRRTADDLHRELGTLLWTDAGMARSRASLEHALAEIPRIREAFWSDLR
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
VPGTGEELNQELERAGRVADFLELAELLCRDALHREESCGGHFRVEHQTPDGEALRDDER
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
FAYVAAWEWTGPGEAPALHREPLAFEYVPLQQRSYK
EEEEEEEEECCCCCCCCCCCCCCEEEEECCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]