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The map label for this gene is cysK [H]

Identifier: 220917776

GI number: 220917776

Start: 2953372

End: 2954301

Strand: Reverse

Name: cysK [H]

Synonym: A2cp1_2677

Alternate gene names: 220917776

Gene position: 2954301-2953372 (Counterclockwise)

Preceding gene: 220917777

Following gene: 220917775

Centisome position: 58.74

GC content: 72.47

Gene sequence:

>930_bases
ATGCGGATCGCGGACGACGTCACGAAGCTCATCGGCAACACGCCGCTGGTGCGGCTGAACCGCGTGATGGACGGGGCGGG
GGCGGTGGTCGCGGCCAAGCTGGAGATGCAGAACCCGGCGGGCAGCGTGAAGGACCGCATCGGCCTGTCGATGATCGAGG
CGGCGGAGCGCGAGGGGAAGATCGGGCCGGACACGATCCTGCTCGAGCCCACCAGCGGCAACACCGGCATCGGCCTGGCG
TGCGTGGCGGCGGCGAAGGGCTACAAGCTCGCGCTCACCATGCCCGAGACCATGAGCATCGAGCGGCGCAAGCTGCTGGC
GGCGCTCGGGGCCGAGCTCATCCTGACGCCCGGCGCCGAGGGGATGAAGGGCGCCATCCAGCGGGCCGAGCAGCTCGCGG
CGAAGGACCCGCGCTACCTCGTCCTCCAGCAGTTCGAGAACCCGGCCAACCCCGAGGTCCACCGGCGCACCACCGCCGAG
GAGATCTGGCGCGACACCGACGGCAAGGTGGACGTGCTGGTGTGCGCCACCGGGACCGGCGGCACGGTGACCGGCTGCGC
GCAGGTGCTGAAGCCGCGCAAGCCGTCCCTCCGCATCGTGGCCGCCGAGCCGGCGGACTCGCCCGTGCTCTCCGGCGGAA
AGCCCGGGCCGCACAAGATCCAGGGCTGGGGCGCCGGGTTCGTGCCGAAGGTGCTGGACCCGAAGCTGCTCGACGAGATC
GTCACCGTCCGTCACGAGGACGCCGGGGACATGGCCCGCCGGCTCTGCCGCGAGGAGGGGCTCCTGTCGGGCATCTCGGA
CGGCGGGGTCGCCTGGGCGGCGCGCGAGGTGGCGAGGCGGCCGGAGAACGCGGGCAAGCTGGTGGTGGCGGTCCTGCCGG
ACACGGGGGAGCGCTACCTCTCGACCTGGCTCTGGGAGGACGTCAAGTGA

Upstream 100 bases:

>100_bases
GACGCCGCGCTGGCCGACGAGGATGCGTCCCCGGAGCCCGCGGCTTAAGTCGGACGGCGGCCGGCCGGTTTGATAAGGTC
GGGGCTCCCGAGGAGACGAC

Downstream 100 bases:

>100_bases
GCGACGGCGTGAAGGCTCCGGCGGCCCCGGCGGTGGACCAGGTGGCGCTCGCGCCGGTGGTGGACGCGCTCTGCCGCGAC
GCGGCGGCGGCGTTCGGCGC

Product: cysteine synthase A

Products: NA

Alternate protein names: OAS sulfhydrylase; OASS; Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine-specific cysteine synthase; Sulfide-dependent cysteine synthase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MRIADDVTKLIGNTPLVRLNRVMDGAGAVVAAKLEMQNPAGSVKDRIGLSMIEAAEREGKIGPDTILLEPTSGNTGIGLA
CVAAAKGYKLALTMPETMSIERRKLLAALGAELILTPGAEGMKGAIQRAEQLAAKDPRYLVLQQFENPANPEVHRRTTAE
EIWRDTDGKVDVLVCATGTGGTVTGCAQVLKPRKPSLRIVAAEPADSPVLSGGKPGPHKIQGWGAGFVPKVLDPKLLDEI
VTVRHEDAGDMARRLCREEGLLSGISDGGVAWAAREVARRPENAGKLVVAVLPDTGERYLSTWLWEDVK

Sequences:

>Translated_309_residues
MRIADDVTKLIGNTPLVRLNRVMDGAGAVVAAKLEMQNPAGSVKDRIGLSMIEAAEREGKIGPDTILLEPTSGNTGIGLA
CVAAAKGYKLALTMPETMSIERRKLLAALGAELILTPGAEGMKGAIQRAEQLAAKDPRYLVLQQFENPANPEVHRRTTAE
EIWRDTDGKVDVLVCATGTGGTVTGCAQVLKPRKPSLRIVAAEPADSPVLSGGKPGPHKIQGWGAGFVPKVLDPKLLDEI
VTVRHEDAGDMARRLCREEGLLSGISDGGVAWAAREVARRPENAGKLVVAVLPDTGERYLSTWLWEDVK
>Mature_309_residues
MRIADDVTKLIGNTPLVRLNRVMDGAGAVVAAKLEMQNPAGSVKDRIGLSMIEAAEREGKIGPDTILLEPTSGNTGIGLA
CVAAAKGYKLALTMPETMSIERRKLLAALGAELILTPGAEGMKGAIQRAEQLAAKDPRYLVLQQFENPANPEVHRRTTAE
EIWRDTDGKVDVLVCATGTGGTVTGCAQVLKPRKPSLRIVAAEPADSPVLSGGKPGPHKIQGWGAGFVPKVLDPKLLDEI
VTVRHEDAGDMARRLCREEGLLSGISDGGVAWAAREVARRPENAGKLVVAVLPDTGERYLSTWLWEDVK

Specific function: Catalyzes the conversion of O-acetylserine (OAS) to cysteine through the elimination of acetate and addition of hydrogen sulfide [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=313, Percent_Identity=40.2555910543131, Blast_Score=215, Evalue=4e-56,
Organism=Homo sapiens, GI295821200, Length=313, Percent_Identity=40.2555910543131, Blast_Score=215, Evalue=4e-56,
Organism=Homo sapiens, GI4557415, Length=313, Percent_Identity=40.2555910543131, Blast_Score=215, Evalue=4e-56,
Organism=Escherichia coli, GI1788754, Length=316, Percent_Identity=55.6962025316456, Blast_Score=317, Evalue=5e-88,
Organism=Escherichia coli, GI2367138, Length=297, Percent_Identity=42.4242424242424, Blast_Score=226, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17535051, Length=302, Percent_Identity=51.3245033112583, Blast_Score=309, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI115535073, Length=308, Percent_Identity=52.9220779220779, Blast_Score=306, Evalue=8e-84,
Organism=Caenorhabditis elegans, GI17562970, Length=307, Percent_Identity=50.1628664495114, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI32566674, Length=299, Percent_Identity=50.5016722408027, Blast_Score=283, Evalue=8e-77,
Organism=Caenorhabditis elegans, GI17561720, Length=304, Percent_Identity=48.6842105263158, Blast_Score=264, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI32566672, Length=215, Percent_Identity=51.1627906976744, Blast_Score=217, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI17534315, Length=322, Percent_Identity=40.0621118012422, Blast_Score=181, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI25147552, Length=318, Percent_Identity=38.3647798742138, Blast_Score=167, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17561716, Length=118, Percent_Identity=46.6101694915254, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321594, Length=330, Percent_Identity=37.8787878787879, Blast_Score=197, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6321449, Length=334, Percent_Identity=33.8323353293413, Blast_Score=138, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24643623, Length=316, Percent_Identity=39.873417721519, Blast_Score=194, Evalue=4e-50,
Organism=Drosophila melanogaster, GI20129101, Length=316, Percent_Identity=39.873417721519, Blast_Score=194, Evalue=4e-50,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32916; Mature: 32916

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIADDVTKLIGNTPLVRLNRVMDGAGAVVAAKLEMQNPAGSVKDRIGLSMIEAAEREGK
CCCHHHHHHHHCCCCCEEHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCC
IGPDTILLEPTSGNTGIGLACVAAAKGYKLALTMPETMSIERRKLLAALGAELILTPGAE
CCCCEEEEECCCCCCCCHHHEEECCCCCEEEEECCHHHHHHHHHHHHHHCCCEEECCCCC
GMKGAIQRAEQLAAKDPRYLVLQQFENPANPEVHRRTTAEEIWRDTDGKVDVLVCATGTG
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCC
GTVTGCAQVLKPRKPSLRIVAAEPADSPVLSGGKPGPHKIQGWGAGFVPKVLDPKLLDEI
CHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHH
VTVRHEDAGDMARRLCREEGLLSGISDGGVAWAAREVARRPENAGKLVVAVLPDTGERYL
HHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHH
STWLWEDVK
HHHHHHCCC
>Mature Secondary Structure
MRIADDVTKLIGNTPLVRLNRVMDGAGAVVAAKLEMQNPAGSVKDRIGLSMIEAAEREGK
CCCHHHHHHHHCCCCCEEHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCC
IGPDTILLEPTSGNTGIGLACVAAAKGYKLALTMPETMSIERRKLLAALGAELILTPGAE
CCCCEEEEECCCCCCCCHHHEEECCCCCEEEEECCHHHHHHHHHHHHHHCCCEEECCCCC
GMKGAIQRAEQLAAKDPRYLVLQQFENPANPEVHRRTTAEEIWRDTDGKVDVLVCATGTG
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCC
GTVTGCAQVLKPRKPSLRIVAAEPADSPVLSGGKPGPHKIQGWGAGFVPKVLDPKLLDEI
CHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHH
VTVRHEDAGDMARRLCREEGLLSGISDGGVAWAAREVARRPENAGKLVVAVLPDTGERYL
HHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHH
STWLWEDVK
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]