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The map label for this gene is holB [H]

Identifier: 220917743

GI number: 220917743

Start: 2918214

End: 2919305

Strand: Reverse

Name: holB [H]

Synonym: A2cp1_2644

Alternate gene names: 220917743

Gene position: 2919305-2918214 (Counterclockwise)

Preceding gene: 220917745

Following gene: 220917742

Centisome position: 58.05

GC content: 78.21

Gene sequence:

>1092_bases
ATGCCGTTCTCCGAGCTCATCGCGCAGGAACGCGCCGTCGGCTCGCTCCGGTCCGCGCTCCGTCGCGGCTCGCTGCACCA
CGCCTACCTCTTCGGCGGCCCGGAGGGCGCCGGCAAGGCGCGGGCGGCCGTGCTCCTGGCGCAGGCCGCGAACTGCGAGG
GCGGGCAGGCCGGGCCGGGCGGCCTCCGCGAGGATCCCTGCGGCGCGTGCGGCCCCTGCCGGAAGATCGAGCGGGGCCTC
CACCCGGACGTCGTGGTGCTCGCCGCGGAGCGGACCATGGCGAAGGCCGGGCGATGGGAGCCGAAGGGCGGCCGCGCGCC
GTCGAAGGACATCGTGGTGGACCAGGTGCGCGACCTGGTGGACCACCGCCTGGCCATGAAGCGCTTCGAGGGGCGGCGGC
GCTTCGTGGTGATCGACCCGGCCGACGCCATGAACCCGCAGGCGCAGAACGCGCTCCTGAAGACGCTGGAGGAGCCGCCC
GAGGACACCACGCTCGTGCTGGTCGCCTCGAGCCCCGACGCGCTGCTCCCCACCATCCGCTCGCGCTGCCTGCGGGTGAG
CTTCCGGCCGCTGCCGGCCGCGGCGATCGCGGCGCGGCTGCAGGAGGAGGGGATCCCGGCGGAGGAGGCGCGCGTGGCCG
CGGCGCTCTCCGGCGGCTCGCTGGGCCGGGCGCGCGCGCACGCGGGCGACGCGGCCCGGCGGCCGCTGCGGGCCGTGGCC
CAGGCGGCGGCGCTCCGGCCGGACGACGCGGGCGCGTGGCTGGCCTGGGCGGCGGACCCGGGCGCCGACCCGGCCCAGGC
GCGCGCGAAGGACCGCGACCGCAAGGCCGAGGTGAAGGAGCTCGCGCCGGAGATCTGCGAGCTCATGCTGGTGTGGCTGC
GCGACGTGCTGGCGGTGCAGGCCGGCGCGGACCGGCTCGCGGTCGCCGACCTGGAGCCCGCCACGCGCCGGGCCGCCGCG
GCGCTCCCGCCCGGCGAGGTGGTGCGCCGGCGCGGCGAGGTGCTCCGGACGATGCGGGCGCTGCGGCAGAACGCGACCTC
GCAGCTCGCCCTCGAGCGGCTGATGATCGGGTGGTTCCATGGCCGGGCCTAG

Upstream 100 bases:

>100_bases
GCGGCCGGGTGTCCACCTCGCCCCCCGGCCGCCGGGGCGAGGGCCGCGACCCGGGAAGCGGCCGTGGGTTCCGGCGCTTA
TGCTATGTTCCGCGCCGCCC

Downstream 100 bases:

>100_bases
GGCCGGGGGAGGGCGCGCGCGCGCCGTCGCCGGGGCCACCCTGGAGACCTGCCTGGAGGAGGCACGCGCCGGGCGCGCGC
AGCCGGTCTACCTGTTCGAC

Product: DNA polymerase III subunit delta'

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MPFSELIAQERAVGSLRSALRRGSLHHAYLFGGPEGAGKARAAVLLAQAANCEGGQAGPGGLREDPCGACGPCRKIERGL
HPDVVVLAAERTMAKAGRWEPKGGRAPSKDIVVDQVRDLVDHRLAMKRFEGRRRFVVIDPADAMNPQAQNALLKTLEEPP
EDTTLVLVASSPDALLPTIRSRCLRVSFRPLPAAAIAARLQEEGIPAEEARVAAALSGGSLGRARAHAGDAARRPLRAVA
QAAALRPDDAGAWLAWAADPGADPAQARAKDRDRKAEVKELAPEICELMLVWLRDVLAVQAGADRLAVADLEPATRRAAA
ALPPGEVVRRRGEVLRTMRALRQNATSQLALERLMIGWFHGRA

Sequences:

>Translated_363_residues
MPFSELIAQERAVGSLRSALRRGSLHHAYLFGGPEGAGKARAAVLLAQAANCEGGQAGPGGLREDPCGACGPCRKIERGL
HPDVVVLAAERTMAKAGRWEPKGGRAPSKDIVVDQVRDLVDHRLAMKRFEGRRRFVVIDPADAMNPQAQNALLKTLEEPP
EDTTLVLVASSPDALLPTIRSRCLRVSFRPLPAAAIAARLQEEGIPAEEARVAAALSGGSLGRARAHAGDAARRPLRAVA
QAAALRPDDAGAWLAWAADPGADPAQARAKDRDRKAEVKELAPEICELMLVWLRDVLAVQAGADRLAVADLEPATRRAAA
ALPPGEVVRRRGEVLRTMRALRQNATSQLALERLMIGWFHGRA
>Mature_362_residues
PFSELIAQERAVGSLRSALRRGSLHHAYLFGGPEGAGKARAAVLLAQAANCEGGQAGPGGLREDPCGACGPCRKIERGLH
PDVVVLAAERTMAKAGRWEPKGGRAPSKDIVVDQVRDLVDHRLAMKRFEGRRRFVVIDPADAMNPQAQNALLKTLEEPPE
DTTLVLVASSPDALLPTIRSRCLRVSFRPLPAAAIAARLQEEGIPAEEARVAAALSGGSLGRARAHAGDAARRPLRAVAQ
AAALRPDDAGAWLAWAADPGADPAQARAKDRDRKAEVKELAPEICELMLVWLRDVLAVQAGADRLAVADLEPATRRAAAA
LPPGEVVRRRGEVLRTMRALRQNATSQLALERLMIGWFHGRA

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=208, Percent_Identity=36.5384615384615, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004622 [H]

Pfam domain/function: NA

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 38797; Mature: 38666

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFSELIAQERAVGSLRSALRRGSLHHAYLFGGPEGAGKARAAVLLAQAANCEGGQAGPG
CCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCC
GLREDPCGACGPCRKIERGLHPDVVVLAAERTMAKAGRWEPKGGRAPSKDIVVDQVRDLV
CCCCCCCCCCCHHHHHHCCCCCCEEEEECHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
DHRLAMKRFEGRRRFVVIDPADAMNPQAQNALLKTLEEPPEDTTLVLVASSPDALLPTIR
HHHHHHHHHCCCCEEEEECCHHHCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHH
SRCLRVSFRPLPAAAIAARLQEEGIPAEEARVAAALSGGSLGRARAHAGDAARRPLRAVA
HHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHH
QAAALRPDDAGAWLAWAADPGADPAQARAKDRDRKAEVKELAPEICELMLVWLRDVLAVQ
HHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGADRLAVADLEPATRRAAAALPPGEVVRRRGEVLRTMRALRQNATSQLALERLMIGWFH
CCCCCEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHC
GRA
CCC
>Mature Secondary Structure 
PFSELIAQERAVGSLRSALRRGSLHHAYLFGGPEGAGKARAAVLLAQAANCEGGQAGPG
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCC
GLREDPCGACGPCRKIERGLHPDVVVLAAERTMAKAGRWEPKGGRAPSKDIVVDQVRDLV
CCCCCCCCCCCHHHHHHCCCCCCEEEEECHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
DHRLAMKRFEGRRRFVVIDPADAMNPQAQNALLKTLEEPPEDTTLVLVASSPDALLPTIR
HHHHHHHHHCCCCEEEEECCHHHCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHH
SRCLRVSFRPLPAAAIAARLQEEGIPAEEARVAAALSGGSLGRARAHAGDAARRPLRAVA
HHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHH
QAAALRPDDAGAWLAWAADPGADPAQARAKDRDRKAEVKELAPEICELMLVWLRDVLAVQ
HHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGADRLAVADLEPATRRAAAALPPGEVVRRRGEVLRTMRALRQNATSQLALERLMIGWFH
CCCCCEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHC
GRA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]