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The map label for this gene is zraS [H]

Identifier: 220917727

GI number: 220917727

Start: 2902648

End: 2903775

Strand: Direct

Name: zraS [H]

Synonym: A2cp1_2628

Alternate gene names: 220917727

Gene position: 2902648-2903775 (Clockwise)

Preceding gene: 220917726

Following gene: 220917736

Centisome position: 57.71

GC content: 74.29

Gene sequence:

>1128_bases
GTGAAGCACGGCGGCGGGCCGCGGCGGCCGCGCGTGCTGGTGGTGGACGACAACGCCAGCCTGGTGGACAACCTCTCCGA
GATCCTGGAGGGCGCCGGCTACGCGGTGGCCGGGGCCGGGAGCTGCGCCGCCGCGCTCGCGCTCGCCGAGCAGGGCTTCG
ACGTGGCGCTGGTGGACCTGAAGCTCCCCGACGGCGACGGCACCGCGCTCGCGCCGCGGCTGAAGGAGCTCTCGCCGAAC
GGCGAGGTGGTGCTGCTCACCGGGTTCGCCACGCTGGAGTCCGCGGTGGCCGCGGTGCGCGCCGGCGCCTGCGCCTACCT
GGTGAAGCCGTGCGCCACGCAGGAGCTGCTGCTGACGGTGGAGCAGGCCATGCGCCAGGTGCGCCTGCACCAGGAGAAGC
GCGACCTCGCCAGCCGCGCGCAGATGGCCGAGAAGCTGGCCGCGGTCGGCACCATGACCGCCGGGCTCTCGCACGAGATC
CGCAACCCGCTCAACGCCGCGGCGCTCCAGCTCTCGGTGCTGGAGCGGCGCATCCAGAAGCTCGAGGCGGAGCGGCAGGG
GCCGCTGCTCGAGCCGCTCACGCTGGTGAAGGACGAGATCCGCCGCCTCGACCACATCCTGGAGGACTTCCTCCAGTTCG
CCCGCCCCCGCGAGTTCGTCCGCAAGGCCATCGAGGTCGCGCCGGTGATCACGAAGGTGGTGGACCTGCTCGGCGGCGAG
GCCGAGCGCCGCGGCGTGCGCCTGGAGCGCGAGCTCGAGCCGGTGCCGCCGGTGGCGGGGGACGAGGAGCGGCTCCGGCA
GGTGCTGGTGAACCTGTGCCTGAACGCGCTCGAGGCGGTGGACGCGCGCGGGCTGGTCCGCGTCTCGTGCCGGCCCGCAC
CCGCCGACGTCGATCACCCCGAGGCGCCGGCGATGGTCGACCTCCTCATCGACGACGACGGCCCGGGCGTCGTGCCCGAC
CAGCGCGACCGCATCTTCGAGCCGTTCTTCACCACCAAGGCGCGCGGCTCCGGCCTGGGGCTCTCCATCGTGCACGCGAT
CGTGACGCAGCACGGGGGCACCATCCGGATCGAGGACAGCCCGGAGGGCGGCGCGCGCTTCGTGCTGCGGCTCCCGCGCG
CGCAGTGA

Upstream 100 bases:

>100_bases
CGCACCAGGGCTTCTTCCACAAGCCGTTCGACACCGCCTCGCTGCTCGCCGCGGTGGAGCGGCTCCACGGCGCCCGCGCC
CCCTCGCCGGTGCCCGCCCC

Downstream 100 bases:

>100_bases
GCGCGCGCGGCGCCGCGCCCTACTCCATCCCGCCGGCCTTCTCGGGCTCGTGCTCGCCGTCGTGGGAGTGGTCGTGCCCG
GCCCCGCCCTCCCGGCCGCC

Product: response regulator receiver sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MKHGGGPRRPRVLVVDDNASLVDNLSEILEGAGYAVAGAGSCAAALALAEQGFDVALVDLKLPDGDGTALAPRLKELSPN
GEVVLLTGFATLESAVAAVRAGACAYLVKPCATQELLLTVEQAMRQVRLHQEKRDLASRAQMAEKLAAVGTMTAGLSHEI
RNPLNAAALQLSVLERRIQKLEAERQGPLLEPLTLVKDEIRRLDHILEDFLQFARPREFVRKAIEVAPVITKVVDLLGGE
AERRGVRLERELEPVPPVAGDEERLRQVLVNLCLNALEAVDARGLVRVSCRPAPADVDHPEAPAMVDLLIDDDGPGVVPD
QRDRIFEPFFTTKARGSGLGLSIVHAIVTQHGGTIRIEDSPEGGARFVLRLPRAQ

Sequences:

>Translated_375_residues
MKHGGGPRRPRVLVVDDNASLVDNLSEILEGAGYAVAGAGSCAAALALAEQGFDVALVDLKLPDGDGTALAPRLKELSPN
GEVVLLTGFATLESAVAAVRAGACAYLVKPCATQELLLTVEQAMRQVRLHQEKRDLASRAQMAEKLAAVGTMTAGLSHEI
RNPLNAAALQLSVLERRIQKLEAERQGPLLEPLTLVKDEIRRLDHILEDFLQFARPREFVRKAIEVAPVITKVVDLLGGE
AERRGVRLERELEPVPPVAGDEERLRQVLVNLCLNALEAVDARGLVRVSCRPAPADVDHPEAPAMVDLLIDDDGPGVVPD
QRDRIFEPFFTTKARGSGLGLSIVHAIVTQHGGTIRIEDSPEGGARFVLRLPRAQ
>Mature_375_residues
MKHGGGPRRPRVLVVDDNASLVDNLSEILEGAGYAVAGAGSCAAALALAEQGFDVALVDLKLPDGDGTALAPRLKELSPN
GEVVLLTGFATLESAVAAVRAGACAYLVKPCATQELLLTVEQAMRQVRLHQEKRDLASRAQMAEKLAAVGTMTAGLSHEI
RNPLNAAALQLSVLERRIQKLEAERQGPLLEPLTLVKDEIRRLDHILEDFLQFARPREFVRKAIEVAPVITKVVDLLGGE
AERRGVRLERELEPVPPVAGDEERLRQVLVNLCLNALEAVDARGLVRVSCRPAPADVDHPEAPAMVDLLIDDDGPGVVPD
QRDRIFEPFFTTKARGSGLGLSIVHAIVTQHGGTIRIEDSPEGGARFVLRLPRAQ

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=261, Percent_Identity=33.3333333333333, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI1788549, Length=242, Percent_Identity=32.6446280991736, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1790346, Length=251, Percent_Identity=33.4661354581673, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1790300, Length=263, Percent_Identity=31.9391634980989, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786783, Length=251, Percent_Identity=31.4741035856574, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788393, Length=256, Percent_Identity=29.6875, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1790437, Length=140, Percent_Identity=36.4285714285714, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081816, Length=253, Percent_Identity=29.2490118577075, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786600, Length=244, Percent_Identity=25.8196721311475, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI145693157, Length=260, Percent_Identity=29.6153846153846, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789808, Length=231, Percent_Identity=26.4069264069264, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788550, Length=165, Percent_Identity=29.0909090909091, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI48994928, Length=257, Percent_Identity=25.2918287937743, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790299, Length=130, Percent_Identity=35.3846153846154, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787894, Length=247, Percent_Identity=28.7449392712551, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789149, Length=266, Percent_Identity=24.4360902255639, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786912, Length=341, Percent_Identity=26.3929618768328, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1787375, Length=117, Percent_Identity=35.042735042735, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787374, Length=266, Percent_Identity=24.0601503759398, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 40390; Mature: 40390

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHGGGPRRPRVLVVDDNASLVDNLSEILEGAGYAVAGAGSCAAALALAEQGFDVALVDL
CCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCEEEEEE
KLPDGDGTALAPRLKELSPNGEVVLLTGFATLESAVAAVRAGACAYLVKPCATQELLLTV
ECCCCCCCCCCCHHHHCCCCCCEEEEECHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHH
EQAMRQVRLHQEKRDLASRAQMAEKLAAVGTMTAGLSHEIRNPLNAAALQLSVLERRIQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LEAERQGPLLEPLTLVKDEIRRLDHILEDFLQFARPREFVRKAIEVAPVITKVVDLLGGE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCC
AERRGVRLERELEPVPPVAGDEERLRQVLVNLCLNALEAVDARGLVRVSCRPAPADVDHP
HHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCC
EAPAMVDLLIDDDGPGVVPDQRDRIFEPFFTTKARGSGLGLSIVHAIVTQHGGTIRIEDS
CCCCEEEEEEECCCCCCCCCCHHHHHCCHHHCCCCCCCCHHHHHHHHHHCCCCEEEEECC
PEGGARFVLRLPRAQ
CCCCCEEEEECCCCC
>Mature Secondary Structure
MKHGGGPRRPRVLVVDDNASLVDNLSEILEGAGYAVAGAGSCAAALALAEQGFDVALVDL
CCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCEEEEEE
KLPDGDGTALAPRLKELSPNGEVVLLTGFATLESAVAAVRAGACAYLVKPCATQELLLTV
ECCCCCCCCCCCHHHHCCCCCCEEEEECHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHH
EQAMRQVRLHQEKRDLASRAQMAEKLAAVGTMTAGLSHEIRNPLNAAALQLSVLERRIQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LEAERQGPLLEPLTLVKDEIRRLDHILEDFLQFARPREFVRKAIEVAPVITKVVDLLGGE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCC
AERRGVRLERELEPVPPVAGDEERLRQVLVNLCLNALEAVDARGLVRVSCRPAPADVDHP
HHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCC
EAPAMVDLLIDDDGPGVVPDQRDRIFEPFFTTKARGSGLGLSIVHAIVTQHGGTIRIEDS
CCCCEEEEEEECCCCCCCCCCHHHHHCCHHHCCCCCCCCHHHHHHHHHHCCCCEEEEECC
PEGGARFVLRLPRAQ
CCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]