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The map label for this gene is pleC [H]

Identifier: 220917574

GI number: 220917574

Start: 2731480

End: 2732733

Strand: Reverse

Name: pleC [H]

Synonym: A2cp1_2474

Alternate gene names: 220917574

Gene position: 2732733-2731480 (Counterclockwise)

Preceding gene: 220917575

Following gene: 220917573

Centisome position: 54.34

GC content: 76.63

Gene sequence:

>1254_bases
ATGCCGCGGGTGCTGCTCATCGAGGAGGACGGGCCGCGCCGCGACCGGGCGCGAGCCCTGCTCGAGGCCGAGGGGTTCGC
GGTGGACGCGACCGGCTCCGGCCTCGACGCCATCGCCCGCGCGCTCTCGCTCCCGCCCGACGTGATCGTCGCCGACCTGC
GCCTCCCGGATCTCGAGGGGCACGCGCTCGCGGCGCGGCTGAAGCGCGAGCGGTCGCTGCAGGCGGTGCCGTTCGTGGCG
CTGGGCGAGACGCAGGAGGATCACGACCTCGCGCTCGCGGCCGGGGCCGACGGCTTCGCGTCGCGCGAGCCGGACGCGCG
CCTGGGCGAGGAGGTGCGCGCGTTCCTCGGGGGGAAGCGCGAGCGGCTCAGCGAGGACGGCGAGCGCGCCGGGCTGCGGG
CGTTCTCGGGGACGCTGGCGGCGCAGCTCGAGTCGGCGGTCGCGGGCGAGCGCCGCGCCGCCGAGCGGCTGATCGAGGTG
GACCGGCTGAAGAGCGCGTTCATGCACAACCTGGCGCACGAGCTCTCCACGCCGCTCACCCCGCTCGCCGGGTACCTGCG
CATCCTCCAGTCCGACAAGCTGGGCCCGCTGCAGCCGCAGCAGCGCCGCATCGTGGAGGCGATGCTCGGCTCGGTGGCGC
GGCTGAGCCGCATCGTGGACAACCTGTCCGACTTCGCAAGCCTGCAGGCGGGGCGCGCGCCCATCGTCGAGCAACCGGTG
GTGCCGGACCAGTTCGCCGACGACGTGGTGGCCGAGCACCGGCCCGCGATCCGCGACGCGCGGCTGCACGTGGCGGTGTC
GCACGCGGGCGGCGGGGCGGTGCTCGCCGACGCGCGCAAGCTCCGGCAGGCGCTCTCCAACATCGTGTCGAACGCGGTGA
AGTTCTCGCCCCACGGCGGCGAGGTGCTGGTGGAGGTCGGGCGCGAGCCGGGGCGGCTGCGCTTCACCGTCTACGACCAG
GGCCCCGGCATCGGCGCGGCGGAGCTGGAGCAGGTGTTCGAGCCGCTGCACCACGCGGCGGCGCGGGCGGGGGAGGAGGC
CCGGCTGCCGGGCTCCGGCCTGGGGCTGCCGGTGGCGCGGCGCATCGCGGAGGCCCACGGCGGGCGGGTGTGGGTGGAGA
GCCCGCCGCGCACCCAGCCGGCGAGCGTGGCCCGCCACTTCACCGGCTGCAAGTTCGTGCTGGAGATTCCGGTCCGCCCG
GCCGACCAGCCCCCCGCGGATCCGGCGGCGCCGCCCAGCGCCTCGCTCGGTTGA

Upstream 100 bases:

>100_bases
GGAGGATCCTGCGCAGAACACGCGCGAGGCGCTCGCGGCCGAGCTGCGCCGATGGTGGGCCGGTCGGACCGGGGCCTTAT
AATTCAGGCGGGGTTTCGCG

Downstream 100 bases:

>100_bases
TCCGCGCCGCGGGCGGCGGTACACCCCCGCCTCCGGACCTGCCATGCGCATCCTGGTCGCCATGTCGGGCGGGGTCGACA
GCTCGACCGCCGCCGCCCTC

Product: response regulator receiver sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MPRVLLIEEDGPRRDRARALLEAEGFAVDATGSGLDAIARALSLPPDVIVADLRLPDLEGHALAARLKRERSLQAVPFVA
LGETQEDHDLALAAGADGFASREPDARLGEEVRAFLGGKRERLSEDGERAGLRAFSGTLAAQLESAVAGERRAAERLIEV
DRLKSAFMHNLAHELSTPLTPLAGYLRILQSDKLGPLQPQQRRIVEAMLGSVARLSRIVDNLSDFASLQAGRAPIVEQPV
VPDQFADDVVAEHRPAIRDARLHVAVSHAGGGAVLADARKLRQALSNIVSNAVKFSPHGGEVLVEVGREPGRLRFTVYDQ
GPGIGAAELEQVFEPLHHAAARAGEEARLPGSGLGLPVARRIAEAHGGRVWVESPPRTQPASVARHFTGCKFVLEIPVRP
ADQPPADPAAPPSASLG

Sequences:

>Translated_417_residues
MPRVLLIEEDGPRRDRARALLEAEGFAVDATGSGLDAIARALSLPPDVIVADLRLPDLEGHALAARLKRERSLQAVPFVA
LGETQEDHDLALAAGADGFASREPDARLGEEVRAFLGGKRERLSEDGERAGLRAFSGTLAAQLESAVAGERRAAERLIEV
DRLKSAFMHNLAHELSTPLTPLAGYLRILQSDKLGPLQPQQRRIVEAMLGSVARLSRIVDNLSDFASLQAGRAPIVEQPV
VPDQFADDVVAEHRPAIRDARLHVAVSHAGGGAVLADARKLRQALSNIVSNAVKFSPHGGEVLVEVGREPGRLRFTVYDQ
GPGIGAAELEQVFEPLHHAAARAGEEARLPGSGLGLPVARRIAEAHGGRVWVESPPRTQPASVARHFTGCKFVLEIPVRP
ADQPPADPAAPPSASLG
>Mature_416_residues
PRVLLIEEDGPRRDRARALLEAEGFAVDATGSGLDAIARALSLPPDVIVADLRLPDLEGHALAARLKRERSLQAVPFVAL
GETQEDHDLALAAGADGFASREPDARLGEEVRAFLGGKRERLSEDGERAGLRAFSGTLAAQLESAVAGERRAAERLIEVD
RLKSAFMHNLAHELSTPLTPLAGYLRILQSDKLGPLQPQQRRIVEAMLGSVARLSRIVDNLSDFASLQAGRAPIVEQPVV
PDQFADDVVAEHRPAIRDARLHVAVSHAGGGAVLADARKLRQALSNIVSNAVKFSPHGGEVLVEVGREPGRLRFTVYDQG
PGIGAAELEQVFEPLHHAAARAGEEARLPGSGLGLPVARRIAEAHGGRVWVESPPRTQPASVARHFTGCKFVLEIPVRPA
DQPPADPAAPPSASLG

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=267, Percent_Identity=27.7153558052434, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081816, Length=270, Percent_Identity=28.1481481481481, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI48994928, Length=254, Percent_Identity=29.9212598425197, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1789149, Length=293, Percent_Identity=25.2559726962457, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788393, Length=250, Percent_Identity=27.2, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786912, Length=233, Percent_Identity=27.8969957081545, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI87082128, Length=220, Percent_Identity=27.7272727272727, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786600, Length=251, Percent_Identity=27.4900398406374, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786783, Length=267, Percent_Identity=27.3408239700375, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790551, Length=245, Percent_Identity=25.3061224489796, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788549, Length=270, Percent_Identity=24.4444444444444, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788713, Length=252, Percent_Identity=25.7936507936508, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1789808, Length=258, Percent_Identity=25.968992248062, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 44442; Mature: 44311

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRVLLIEEDGPRRDRARALLEAEGFAVDATGSGLDAIARALSLPPDVIVADLRLPDLEG
CCCEEEEECCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHHCCCCCCEEEECCCCCCCC
HALAARLKRERSLQAVPFVALGETQEDHDLALAAGADGFASREPDARLGEEVRAFLGGKR
HHHHHHHHHHCCCCCCCEEEECCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCH
ERLSEDGERAGLRAFSGTLAAQLESAVAGERRAAERLIEVDRLKSAFMHNLAHELSTPLT
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
PLAGYLRILQSDKLGPLQPQQRRIVEAMLGSVARLSRIVDNLSDFASLQAGRAPIVEQPV
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
VPDQFADDVVAEHRPAIRDARLHVAVSHAGGGAVLADARKLRQALSNIVSNAVKFSPHGG
CCHHHHHHHHHHCCCCHHCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEECCCCC
EVLVEVGREPGRLRFTVYDQGPGIGAAELEQVFEPLHHAAARAGEEARLPGSGLGLPVAR
EEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
RIAEAHGGRVWVESPPRTQPASVARHFTGCKFVLEIPVRPADQPPADPAAPPSASLG
HHHHHCCCEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PRVLLIEEDGPRRDRARALLEAEGFAVDATGSGLDAIARALSLPPDVIVADLRLPDLEG
CCEEEEECCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHHCCCCCCEEEECCCCCCCC
HALAARLKRERSLQAVPFVALGETQEDHDLALAAGADGFASREPDARLGEEVRAFLGGKR
HHHHHHHHHHCCCCCCCEEEECCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCH
ERLSEDGERAGLRAFSGTLAAQLESAVAGERRAAERLIEVDRLKSAFMHNLAHELSTPLT
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
PLAGYLRILQSDKLGPLQPQQRRIVEAMLGSVARLSRIVDNLSDFASLQAGRAPIVEQPV
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
VPDQFADDVVAEHRPAIRDARLHVAVSHAGGGAVLADARKLRQALSNIVSNAVKFSPHGG
CCHHHHHHHHHHCCCCHHCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEECCCCC
EVLVEVGREPGRLRFTVYDQGPGIGAAELEQVFEPLHHAAARAGEEARLPGSGLGLPVAR
EEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
RIAEAHGGRVWVESPPRTQPASVARHFTGCKFVLEIPVRPADQPPADPAAPPSASLG
HHHHHCCCEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]