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The map label for this gene is tpiA [H]

Identifier: 220917523

GI number: 220917523

Start: 2681347

End: 2682108

Strand: Reverse

Name: tpiA [H]

Synonym: A2cp1_2423

Alternate gene names: 220917523

Gene position: 2682108-2681347 (Counterclockwise)

Preceding gene: 220917524

Following gene: 220917522

Centisome position: 53.33

GC content: 74.15

Gene sequence:

>762_bases
GTGGCCCGCACCAAGTTCGTCTGCGGCAACTGGAAGATGCACAAGACGGTCGCCGAGGCGGTCCAGCTCGTGAAGGAGCT
GGCCGCCGGGCTCGGCGACGCCGCCGGGAAGGTGCAGGTGGCGGTGGCGCCGCCGTTCACCGCCCTCCACGCCGCCGCGC
AGGCCGCGGCCGGCTCGGCCGTCGAGGTCGCGGGGCAGGACGTGCACTGGGAGGTCCAGGGCGCGTTCACCGGCGAGGTG
TCCGCCGCGATGCTGGCGGAGGCGGGCTGCCGCCACGGCATCGTGGGCCACAGCGAGCGGCGCCAGCTGTTCGGCGAGAC
CGACGAGGCCGTCCGCAGGAAGGCCGGGGCGCTGCTCGCCGCCGGGCTCGCGCCCATCGTCTGCGTCGGCGAGACGCTCG
CCGAGCGCGAGGCCGGCCGGACGCTCGAGGTGGTCGACCGGCAGGTGCGGCAGGGGCTCGCCGGGCTGGACGCCGGCGCG
CTGGGCCGGGTGACGGTCGCCTACGAGCCGGTGTGGGCCATCGGCACCGGGAAGACCGCCACCGCCGCCCAGGCGCAGGA
GGTCCACGCCGCCATCCGGAAGATCCTCCGCGACCTGGGGGGTTCCGTGTCGGACGCGATCCGGATTCAATACGGCGGCT
CGGTGAAGCCCGAGAACGCTCAGGAGCTCATGTCCCAGCCCGACGTCGACGGCGCGCTCGTCGGCGGGGCCAGCCTCAAG
GCGAAGGATTTCCTCGCCATCGTGAAAGGTGCACTCCGTTGA

Upstream 100 bases:

>100_bases
TCGTGGACGCGATGAAGCACGTCTCCACCGGCGGCGGCGCCAGCCTCGAGTTCATCGAGGGGCGAGAGCTGCCCGGCGTG
AAGGCTTGCGAGGAGTGACC

Downstream 100 bases:

>100_bases
TCACGCTCGTCACCGTCCTCCACGTCCTCGTCTGCATCTTCCTCATCCTCGTGATCCTGCTCCAGGCCGGTAAGGGCGGG
GGCATGGGCGCCGGCCTGGG

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MARTKFVCGNWKMHKTVAEAVQLVKELAAGLGDAAGKVQVAVAPPFTALHAAAQAAAGSAVEVAGQDVHWEVQGAFTGEV
SAAMLAEAGCRHGIVGHSERRQLFGETDEAVRRKAGALLAAGLAPIVCVGETLAEREAGRTLEVVDRQVRQGLAGLDAGA
LGRVTVAYEPVWAIGTGKTATAAQAQEVHAAIRKILRDLGGSVSDAIRIQYGGSVKPENAQELMSQPDVDGALVGGASLK
AKDFLAIVKGALR

Sequences:

>Translated_253_residues
MARTKFVCGNWKMHKTVAEAVQLVKELAAGLGDAAGKVQVAVAPPFTALHAAAQAAAGSAVEVAGQDVHWEVQGAFTGEV
SAAMLAEAGCRHGIVGHSERRQLFGETDEAVRRKAGALLAAGLAPIVCVGETLAEREAGRTLEVVDRQVRQGLAGLDAGA
LGRVTVAYEPVWAIGTGKTATAAQAQEVHAAIRKILRDLGGSVSDAIRIQYGGSVKPENAQELMSQPDVDGALVGGASLK
AKDFLAIVKGALR
>Mature_252_residues
ARTKFVCGNWKMHKTVAEAVQLVKELAAGLGDAAGKVQVAVAPPFTALHAAAQAAAGSAVEVAGQDVHWEVQGAFTGEVS
AAMLAEAGCRHGIVGHSERRQLFGETDEAVRRKAGALLAAGLAPIVCVGETLAEREAGRTLEVVDRQVRQGLAGLDAGAL
GRVTVAYEPVWAIGTGKTATAAQAQEVHAAIRKILRDLGGSVSDAIRIQYGGSVKPENAQELMSQPDVDGALVGGASLKA
KDFLAIVKGALR

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=249, Percent_Identity=44.578313253012, Blast_Score=184, Evalue=7e-47,
Organism=Homo sapiens, GI226529917, Length=249, Percent_Identity=44.578313253012, Blast_Score=184, Evalue=7e-47,
Organism=Escherichia coli, GI1790353, Length=249, Percent_Identity=48.1927710843374, Blast_Score=218, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17536593, Length=251, Percent_Identity=47.4103585657371, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6320255, Length=252, Percent_Identity=42.4603174603175, Blast_Score=181, Evalue=1e-46,
Organism=Drosophila melanogaster, GI28572004, Length=250, Percent_Identity=46.4, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI28572008, Length=250, Percent_Identity=46.4, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI28572006, Length=250, Percent_Identity=46.4, Blast_Score=192, Evalue=2e-49,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 26060; Mature: 25929

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00107 PROTEIN_KINASE_ATP ; PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTKFVCGNWKMHKTVAEAVQLVKELAAGLGDAAGKVQVAVAPPFTALHAAAQAAAGSA
CCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCE
VEVAGQDVHWEVQGAFTGEVSAAMLAEAGCRHGIVGHSERRQLFGETDEAVRRKAGALLA
EEECCCCEEEEEEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHH
AGLAPIVCVGETLAEREAGRTLEVVDRQVRQGLAGLDAGALGRVTVAYEPVWAIGTGKTA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCEEEECCCCCH
TAAQAQEVHAAIRKILRDLGGSVSDAIRIQYGGSVKPENAQELMSQPDVDGALVGGASLK
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCEEECCCCCC
AKDFLAIVKGALR
HHHHHHHHHHHCC
>Mature Secondary Structure 
ARTKFVCGNWKMHKTVAEAVQLVKELAAGLGDAAGKVQVAVAPPFTALHAAAQAAAGSA
CCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCE
VEVAGQDVHWEVQGAFTGEVSAAMLAEAGCRHGIVGHSERRQLFGETDEAVRRKAGALLA
EEECCCCEEEEEEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHH
AGLAPIVCVGETLAEREAGRTLEVVDRQVRQGLAGLDAGALGRVTVAYEPVWAIGTGKTA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCEEEECCCCCH
TAAQAQEVHAAIRKILRDLGGSVSDAIRIQYGGSVKPENAQELMSQPDVDGALVGGASLK
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCEEECCCCCC
AKDFLAIVKGALR
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA