Click here to switch to the map view.

The map label for this gene is melC2 [H]

Identifier: 220917018

GI number: 220917018

Start: 2151439

End: 2154063

Strand: Direct

Name: melC2 [H]

Synonym: A2cp1_1914

Alternate gene names: 220917018

Gene position: 2151439-2154063 (Clockwise)

Preceding gene: 220917017

Following gene: 220917020

Centisome position: 42.78

GC content: 70.13

Gene sequence:

>2625_bases
ATGAGGTGCCGCAAGAACTACCGCGACCTGGACGCCGCCGAGCGCGACCGCCTGGTCCAGGCGCTCCACCACGCGAAGGC
GGCAGGCGTCGTCGACCAGTTCGCCAGCGAGCACGAGGCCCACTTCAGCCACGGGATTCACACGAGCTCGCACTTCCTGC
CGTGGCATCGCGAGTTCATCCGGCGCTTCGAGGACGCGCTGCGCACGTATCACCCCCAGGTGACGCTCCCCTATTGGAAC
TCCGTCGTCGACCGCAGCCCGTCGGACTCGCTGTGGGACGGTCCGTTCCTCGGCCAGTTCGACTCGGCGTGGAACCTCGA
TCGGGCGCTGGGATCCGACACGCTGCCCACCGAGGGTCAGCTGAACACGGCGCTAGGCCGCGGGACGTACGACACGTTCT
GGCCCGACCTCGAGGTCAACCTCCACAATGCGCCGCACCGGTGGGTCGCGGGGAAGATGGCGCAGCGCGACTCACCCCAC
GACCCGGTGTTCTACCTCCACCACTGCTGGATCGACCTGCTCTGGGCGCAGTGGCAGCTAGGCCATCCCACCGCGCCGTT
CGTCTCGAGCGGAGCCGGGGCGGGGCTCACGGATCCGCTGATGGGGTACACCACCACGCCCGCGGACGTGCTGGACCATC
GGACGATCAACGTCTATCGCTACCCCCCGGGCTTCGTGCAGGACACGCCGCGCGTCACGCTCGACACGCCCGTCGTCAAC
TTCATCGAGGTGCCCGCCGGCGAGACGCGGATGGGCGCTGCCGTGTTCTCCCTCGACGCGTGCGAGACGCTGCACTTCAC
CGTCGTGAACGGACCCGTCGTGACGGCCGGGCCGCCGGGGACGTTCGGGCTTCCTGGGTCGCCCGGGCCGGCGGACCCGC
ACGTCGACGAGAAGGGACGGGTCTGGTTCACGTACACGGCGACCGCTGCCGGCGACGTCTCGGAGGGCGCCGCGACGATC
AGGTGCGACGAGACCGGCGATCAGTTCGCCGTCGCGCTGAGGGCCAACACGATCGCTCGACCGACGGCGGCGATGGTGAT
GGTGCTCGATCGATCGAACAGCATGACGTTCGACTCGGGGGTCGGCGCAGGCGTGACGCGGGCGGACGTCCTGAGGTTCT
CTGCGCCCACGGCGGTCGTCGTTCTCGAGGACACGAACGCAATGGCGGTGTGCAGCTTCGATCACGACGCGCATCCGGGC
ATCCCGATGACCGAGGCCGCCGGAGCCGGGAAGCTGACCATCAGCGCGGCCATCCAGAGCTACGCGCCGAATCCGAACGG
GTGGACCTCGATCGGAGAAGGGGTCGCGCTCGCGCACGGCATCGTCGCCCCCGTGACCGACCACGAGGTCAAGGCGCTGG
TCGTCCTGACCGACGGCGAGGAGAACCACGGTCCGCACGCTCGACGCTACATCCACGACGTGGAGGACCTGATCGCGTCG
CTCAACGGGCGCGTGTATGCGATCGGCCTCGGCCGCGCCGAGATCCTCAACCCCGTCGCGCTCCAGGCGCTGTGCAGCGG
AAACCGCGGCTACCTGCTCATGACGGGCGACCTCACGCCCGACGCGACCTACCGGGTGGCGAAGTACTACCAGCAGATCT
TCGCCGGCGTGACGAACCACGACATCGTGCTCGATCCTCAGGGATACGTCGGTCCCGGCCCCGAGGTGCGCATCCCCTTC
TGGCTGGCCGACACGGACATCTCGGCGAAGGCGTTCCTCCTGGCGCCCGCGCCCCACGCGATCCGGTTCCGGCTGGAGAC
GCCCGACGGCGACATCATCGATCCCGCGGTCGCGAGCGCCCACCCGACGCTCGCGTTCGAGGCGGGGCACCAGGTGGCGC
TGTATCGCCTCGGGCTCCCGGTGCCGCTCGGCGGGAAGAGCGCGCATGCGGGCCGGTGGTACGCACGGCTCGGCGTCGAG
AACGCGGGCTACAAGCGGTATCTCTCGTCGCTCGAGGATCGGTCGGCAGGGCGCGCGACCGCCGCGGCGCACGGCATCCT
GTACAACTTCAACGTGCACGCGTACTCCAACCTGAGGATGCGCGCCACGCTGTCCCAGACGAGCAACGTGCCCGGCGCGA
GCCTCGGCGTGCGCGCGGTCCTGACCGAGTACGGCCTGCCCGTGGCCGGGCGCGCCCACTGTCGCGCGGAGCTCACGCGC
CCAGACGGCGCGGCGTCGACGCTGCCGATGCCCGAGGTGCAGCCGGGCGCGTTCGAGACATCGTTCACGGCCCATGCTCA
CGGGATCTACCCGCTTCGGATCCTCGCCGAGGGGAGGACCCTGCGCGGGCTGCCCTTCACGCGCGAGCAGCTCCTGACGG
GCGCCGTGTGGCGCGGCGGAGACGACGCGCCGACCGTGAAGGACGATCCAGACCGCGACCGTGACCGGGTGTGCAGCCTC
GTCGCGTGCGTCCTCCGCAGCCGCGGCGTGCTCGGGGTGCTGAGCCAACAGGGGATCGATCCGGAGGAGCTCCGCCGCTG
CCTCGCCGAGTATTGCCGGAAGCCCTCGCCGGGCGAGCCGTCCCACCTCGCCTCGTCGGACGTGGAAGGCAGGCTCCGCG
TGATCCTGCGCGACGAGAACACGCTGCGCGCAGTGATGGAGATGATCAGGCCTGCGCTGGAGTGA

Upstream 100 bases:

>100_bases
GGACGGACGACCTGATGGAGCTCGCGCGGCGGTACGTCAGCCACCGGCGCCGGGCGCAGCAGATCCGGGCCAGGTCCTCC
GCGTCGAAGGAAGGTGCGTC

Downstream 100 bases:

>100_bases
GCCGGCGGCGCGACGCTACCTGGTGAGCGGGTGGAGGTGGTCCACCGGCCCGCGCCCCTTGCCGACGGTGTACGAGCGGC
GCAGCGCCTCGACCAGGTAG

Product: tyrosinase

Products: NA

Alternate protein names: Monophenol monooxygenase [H]

Number of amino acids: Translated: 874; Mature: 874

Protein sequence:

>874_residues
MRCRKNYRDLDAAERDRLVQALHHAKAAGVVDQFASEHEAHFSHGIHTSSHFLPWHREFIRRFEDALRTYHPQVTLPYWN
SVVDRSPSDSLWDGPFLGQFDSAWNLDRALGSDTLPTEGQLNTALGRGTYDTFWPDLEVNLHNAPHRWVAGKMAQRDSPH
DPVFYLHHCWIDLLWAQWQLGHPTAPFVSSGAGAGLTDPLMGYTTTPADVLDHRTINVYRYPPGFVQDTPRVTLDTPVVN
FIEVPAGETRMGAAVFSLDACETLHFTVVNGPVVTAGPPGTFGLPGSPGPADPHVDEKGRVWFTYTATAAGDVSEGAATI
RCDETGDQFAVALRANTIARPTAAMVMVLDRSNSMTFDSGVGAGVTRADVLRFSAPTAVVVLEDTNAMAVCSFDHDAHPG
IPMTEAAGAGKLTISAAIQSYAPNPNGWTSIGEGVALAHGIVAPVTDHEVKALVVLTDGEENHGPHARRYIHDVEDLIAS
LNGRVYAIGLGRAEILNPVALQALCSGNRGYLLMTGDLTPDATYRVAKYYQQIFAGVTNHDIVLDPQGYVGPGPEVRIPF
WLADTDISAKAFLLAPAPHAIRFRLETPDGDIIDPAVASAHPTLAFEAGHQVALYRLGLPVPLGGKSAHAGRWYARLGVE
NAGYKRYLSSLEDRSAGRATAAAHGILYNFNVHAYSNLRMRATLSQTSNVPGASLGVRAVLTEYGLPVAGRAHCRAELTR
PDGAASTLPMPEVQPGAFETSFTAHAHGIYPLRILAEGRTLRGLPFTREQLLTGAVWRGGDDAPTVKDDPDRDRDRVCSL
VACVLRSRGVLGVLSQQGIDPEELRRCLAEYCRKPSPGEPSHLASSDVEGRLRVILRDENTLRAVMEMIRPALE

Sequences:

>Translated_874_residues
MRCRKNYRDLDAAERDRLVQALHHAKAAGVVDQFASEHEAHFSHGIHTSSHFLPWHREFIRRFEDALRTYHPQVTLPYWN
SVVDRSPSDSLWDGPFLGQFDSAWNLDRALGSDTLPTEGQLNTALGRGTYDTFWPDLEVNLHNAPHRWVAGKMAQRDSPH
DPVFYLHHCWIDLLWAQWQLGHPTAPFVSSGAGAGLTDPLMGYTTTPADVLDHRTINVYRYPPGFVQDTPRVTLDTPVVN
FIEVPAGETRMGAAVFSLDACETLHFTVVNGPVVTAGPPGTFGLPGSPGPADPHVDEKGRVWFTYTATAAGDVSEGAATI
RCDETGDQFAVALRANTIARPTAAMVMVLDRSNSMTFDSGVGAGVTRADVLRFSAPTAVVVLEDTNAMAVCSFDHDAHPG
IPMTEAAGAGKLTISAAIQSYAPNPNGWTSIGEGVALAHGIVAPVTDHEVKALVVLTDGEENHGPHARRYIHDVEDLIAS
LNGRVYAIGLGRAEILNPVALQALCSGNRGYLLMTGDLTPDATYRVAKYYQQIFAGVTNHDIVLDPQGYVGPGPEVRIPF
WLADTDISAKAFLLAPAPHAIRFRLETPDGDIIDPAVASAHPTLAFEAGHQVALYRLGLPVPLGGKSAHAGRWYARLGVE
NAGYKRYLSSLEDRSAGRATAAAHGILYNFNVHAYSNLRMRATLSQTSNVPGASLGVRAVLTEYGLPVAGRAHCRAELTR
PDGAASTLPMPEVQPGAFETSFTAHAHGIYPLRILAEGRTLRGLPFTREQLLTGAVWRGGDDAPTVKDDPDRDRDRVCSL
VACVLRSRGVLGVLSQQGIDPEELRRCLAEYCRKPSPGEPSHLASSDVEGRLRVILRDENTLRAVMEMIRPALE
>Mature_874_residues
MRCRKNYRDLDAAERDRLVQALHHAKAAGVVDQFASEHEAHFSHGIHTSSHFLPWHREFIRRFEDALRTYHPQVTLPYWN
SVVDRSPSDSLWDGPFLGQFDSAWNLDRALGSDTLPTEGQLNTALGRGTYDTFWPDLEVNLHNAPHRWVAGKMAQRDSPH
DPVFYLHHCWIDLLWAQWQLGHPTAPFVSSGAGAGLTDPLMGYTTTPADVLDHRTINVYRYPPGFVQDTPRVTLDTPVVN
FIEVPAGETRMGAAVFSLDACETLHFTVVNGPVVTAGPPGTFGLPGSPGPADPHVDEKGRVWFTYTATAAGDVSEGAATI
RCDETGDQFAVALRANTIARPTAAMVMVLDRSNSMTFDSGVGAGVTRADVLRFSAPTAVVVLEDTNAMAVCSFDHDAHPG
IPMTEAAGAGKLTISAAIQSYAPNPNGWTSIGEGVALAHGIVAPVTDHEVKALVVLTDGEENHGPHARRYIHDVEDLIAS
LNGRVYAIGLGRAEILNPVALQALCSGNRGYLLMTGDLTPDATYRVAKYYQQIFAGVTNHDIVLDPQGYVGPGPEVRIPF
WLADTDISAKAFLLAPAPHAIRFRLETPDGDIIDPAVASAHPTLAFEAGHQVALYRLGLPVPLGGKSAHAGRWYARLGVE
NAGYKRYLSSLEDRSAGRATAAAHGILYNFNVHAYSNLRMRATLSQTSNVPGASLGVRAVLTEYGLPVAGRAHCRAELTR
PDGAASTLPMPEVQPGAFETSFTAHAHGIYPLRILAEGRTLRGLPFTREQLLTGAVWRGGDDAPTVKDDPDRDRDRVCSL
VACVLRSRGVLGVLSQQGIDPEELRRCLAEYCRKPSPGEPSHLASSDVEGRLRVILRDENTLRAVMEMIRPALE

Specific function: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tyrosinase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI193202602, Length=219, Percent_Identity=32.4200913242009, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17554098, Length=223, Percent_Identity=32.2869955156951, Blast_Score=98, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17551924, Length=218, Percent_Identity=29.3577981651376, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17505853, Length=217, Percent_Identity=32.7188940092166, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71999521, Length=173, Percent_Identity=36.9942196531792, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008922
- InterPro:   IPR002227 [H]

Pfam domain/function: PF00264 Tyrosinase [H]

EC number: =1.14.18.1 [H]

Molecular weight: Translated: 94782; Mature: 94782

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50194 FILAMIN_REPEAT ; PS50234 VWFA ; PS00498 TYROSINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCRKNYRDLDAAERDRLVQALHHAKAAGVVDQFASEHEAHFSHGIHTSSHFLPWHREFI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
RRFEDALRTYHPQVTLPYWNSVVDRSPSDSLWDGPFLGQFDSAWNLDRALGSDTLPTEGQ
HHHHHHHHHHCCCEEECHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCC
LNTALGRGTYDTFWPDLEVNLHNAPHRWVAGKMAQRDSPHDPVFYLHHCWIDLLWAQWQL
CHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHEEC
GHPTAPFVSSGAGAGLTDPLMGYTTTPADVLDHRTINVYRYPPGFVQDTPRVTLDTPVVN
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCEEEEEECCCCCCCCCCCEEECCCCEE
FIEVPAGETRMGAAVFSLDACETLHFTVVNGPVVTAGPPGTFGLPGSPGPADPHVDEKGR
EEECCCCCCHHCEEEEEECCCCEEEEEEECCCEEECCCCCCCCCCCCCCCCCCCCCCCCC
VWFTYTATAAGDVSEGAATIRCDETGDQFAVALRANTIARPTAAMVMVLDRSNSMTFDSG
EEEEEEECCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCEEEEEEEECCCCEEECCC
VGAGVTRADVLRFSAPTAVVVLEDTNAMAVCSFDHDAHPGIPMTEAAGAGKLTISAAIQS
CCCCCCHHHHEEECCCEEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEHHHH
YAPNPNGWTSIGEGVALAHGIVAPVTDHEVKALVVLTDGEENHGPHARRYIHDVEDLIAS
CCCCCCCCCHHCCCHHHHCCEECCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
LNGRVYAIGLGRAEILNPVALQALCSGNRGYLLMTGDLTPDATYRVAKYYQQIFAGVTNH
CCCCEEEEECCHHHHHCHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCC
DIVLDPQGYVGPGPEVRIPFWLADTDISAKAFLLAPAPHAIRFRLETPDGDIIDPAVASA
CEEECCCCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCEEEEEEECCCCCCCCCHHHCC
HPTLAFEAGHQVALYRLGLPVPLGGKSAHAGRWYARLGVENAGYKRYLSSLEDRSAGRAT
CCCEEEECCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCHH
AAAHGILYNFNVHAYSNLRMRATLSQTSNVPGASLGVRAVLTEYGLPVAGRAHCRAELTR
HHHCCEEEEEEEEEECCEEEEEEHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECC
PDGAASTLPMPEVQPGAFETSFTAHAHGIYPLRILAEGRTLRGLPFTREQLLTGAVWRGG
CCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEECCCEECCCCCCHHHHHHHHHCCCC
DDAPTVKDDPDRDRDRVCSLVACVLRSRGVLGVLSQQGIDPEELRRCLAEYCRKPSPGEP
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHCCCCHHHHHHHHHHHHCCCCCCCC
SHLASSDVEGRLRVILRDENTLRAVMEMIRPALE
CCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRCRKNYRDLDAAERDRLVQALHHAKAAGVVDQFASEHEAHFSHGIHTSSHFLPWHREFI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
RRFEDALRTYHPQVTLPYWNSVVDRSPSDSLWDGPFLGQFDSAWNLDRALGSDTLPTEGQ
HHHHHHHHHHCCCEEECHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCC
LNTALGRGTYDTFWPDLEVNLHNAPHRWVAGKMAQRDSPHDPVFYLHHCWIDLLWAQWQL
CHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHEEC
GHPTAPFVSSGAGAGLTDPLMGYTTTPADVLDHRTINVYRYPPGFVQDTPRVTLDTPVVN
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCEEEEEECCCCCCCCCCCEEECCCCEE
FIEVPAGETRMGAAVFSLDACETLHFTVVNGPVVTAGPPGTFGLPGSPGPADPHVDEKGR
EEECCCCCCHHCEEEEEECCCCEEEEEEECCCEEECCCCCCCCCCCCCCCCCCCCCCCCC
VWFTYTATAAGDVSEGAATIRCDETGDQFAVALRANTIARPTAAMVMVLDRSNSMTFDSG
EEEEEEECCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCEEEEEEEECCCCEEECCC
VGAGVTRADVLRFSAPTAVVVLEDTNAMAVCSFDHDAHPGIPMTEAAGAGKLTISAAIQS
CCCCCCHHHHEEECCCEEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEHHHH
YAPNPNGWTSIGEGVALAHGIVAPVTDHEVKALVVLTDGEENHGPHARRYIHDVEDLIAS
CCCCCCCCCHHCCCHHHHCCEECCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
LNGRVYAIGLGRAEILNPVALQALCSGNRGYLLMTGDLTPDATYRVAKYYQQIFAGVTNH
CCCCEEEEECCHHHHHCHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCC
DIVLDPQGYVGPGPEVRIPFWLADTDISAKAFLLAPAPHAIRFRLETPDGDIIDPAVASA
CEEECCCCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCEEEEEEECCCCCCCCCHHHCC
HPTLAFEAGHQVALYRLGLPVPLGGKSAHAGRWYARLGVENAGYKRYLSSLEDRSAGRAT
CCCEEEECCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCHH
AAAHGILYNFNVHAYSNLRMRATLSQTSNVPGASLGVRAVLTEYGLPVAGRAHCRAELTR
HHHCCEEEEEEEEEECCEEEEEEHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECC
PDGAASTLPMPEVQPGAFETSFTAHAHGIYPLRILAEGRTLRGLPFTREQLLTGAVWRGG
CCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEECCCEECCCCCCHHHHHHHHHCCCC
DDAPTVKDDPDRDRDRVCSLVACVLRSRGVLGVLSQQGIDPEELRRCLAEYCRKPSPGEP
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHCCCCHHHHHHHHHHHHCCCCCCCC
SHLASSDVEGRLRVILRDENTLRAVMEMIRPALE
CCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3932128 [H]