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The map label for this gene is rnhA

Identifier: 220916983

GI number: 220916983

Start: 2110924

End: 2111475

Strand: Direct

Name: rnhA

Synonym: A2cp1_1879

Alternate gene names: 220916983

Gene position: 2110924-2111475 (Clockwise)

Preceding gene: 220916981

Following gene: 220916984

Centisome position: 41.97

GC content: 76.45

Gene sequence:

>552_bases
ATGTCCCAGGCCCGCTTCATCGCCTTCTCCGACGGCTCGGCGCTCGTGAACCCCGGCGGCCCGGGCGGCACCGGCTTCGT
GGTGCTCGACCGCGCCCGCCCGGCCTACCGGTTCGGCGGCACGCGCTGGGTCGAGGACGGGCCGAACGCCGTCACCAACA
ACCGCATGGAGCTGCGGGCGGTGCTGGAGGCGCTGGAGGGGCTCCCGGGCGGCGAGCAGGTCGAGGTGATCTCCGACTCG
CGCTACGTGGTGGACGCGCTCTCCCGGTGGATCCACGGCTGGCGCAAGAAGGGCTGGCGCACCGCGAGCGGCGAGCCGGT
GCTGAACCGGGACCTCATCGAGGCGCTCGACGCGCGCGCCAGCGCGCTGACCGTCCGCTACACCTGGGTGCGCGGGCACG
ACGGGCACGCGGTGAACGAGGTGGTGGACCAGCTCGCGCAGGCGGCCGCGCGCGGCGTGGCCGGTCCGGGCGAGGCCGAG
GTCGTGGCGGCGCTGCGGGCGGAGGCGTTCCTGGCCGGCGGCTCGGCGGCGCCCCGCTCCTCGCGCGCCTGA

Upstream 100 bases:

>100_bases
CGAGCAGGCGGCGCACGGGAACAGGGTAGCGGGCCGGGCGCCCGCCGGCCACGCTGCGCCCCGAGGTGCTGTCAGGGCGG
CGGGGTAGGGTGCGCGCCCC

Downstream 100 bases:

>100_bases
CCGTGCACCGGACGCGGGCGGCGCGGCCGAGGCTCCCGCCGCGGCGCGGGCGGCCGCATCGTGTGGCGGAGATGCCGCCG
CTGACCCGCCGGGACTTCCT

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MSQARFIAFSDGSALVNPGGPGGTGFVVLDRARPAYRFGGTRWVEDGPNAVTNNRMELRAVLEALEGLPGGEQVEVISDS
RYVVDALSRWIHGWRKKGWRTASGEPVLNRDLIEALDARASALTVRYTWVRGHDGHAVNEVVDQLAQAAARGVAGPGEAE
VVAALRAEAFLAGGSAAPRSSRA

Sequences:

>Translated_183_residues
MSQARFIAFSDGSALVNPGGPGGTGFVVLDRARPAYRFGGTRWVEDGPNAVTNNRMELRAVLEALEGLPGGEQVEVISDS
RYVVDALSRWIHGWRKKGWRTASGEPVLNRDLIEALDARASALTVRYTWVRGHDGHAVNEVVDQLAQAAARGVAGPGEAE
VVAALRAEAFLAGGSAAPRSSRA
>Mature_182_residues
SQARFIAFSDGSALVNPGGPGGTGFVVLDRARPAYRFGGTRWVEDGPNAVTNNRMELRAVLEALEGLPGGEQVEVISDSR
YVVDALSRWIHGWRKKGWRTASGEPVLNRDLIEALDARASALTVRYTWVRGHDGHAVNEVVDQLAQAAARGVAGPGEAEV
VAALRAEAFLAGGSAAPRSSRA

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain

Homologues:

Organism=Homo sapiens, GI21359816, Length=106, Percent_Identity=30.188679245283, Blast_Score=71, Evalue=7e-13,
Organism=Escherichia coli, GI1786408, Length=143, Percent_Identity=45.4545454545455, Blast_Score=119, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI115532542, Length=107, Percent_Identity=42.0560747663551, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17505482, Length=138, Percent_Identity=34.0579710144928, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45552509, Length=151, Percent_Identity=29.8013245033113, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17137476, Length=151, Percent_Identity=29.8013245033113, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNH_ANAD2 (B8J731)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002492287.1
- ProteinModelPortal:   B8J731
- SMR:   B8J731
- GeneID:   7296405
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_1879
- HOGENOM:   HBG742437
- ProtClustDB:   CLSK946015
- GO:   GO:0005737
- HAMAP:   MF_00042
- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156

Pfam domain/function: PF00075 RnaseH; SSF53098 RNaseH_fold

EC number: =3.1.26.4

Molecular weight: Translated: 19433; Mature: 19302

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQARFIAFSDGSALVNPGGPGGTGFVVLDRARPAYRFGGTRWVEDGPNAVTNNRMELRA
CCCCEEEEEECCCEEECCCCCCCCEEEEECCCCCCHHCCCEEEECCCCCCCCCCHHHHHH
VLEALEGLPGGEQVEVISDSRYVVDALSRWIHGWRKKGWRTASGEPVLNRDLIEALDARA
HHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCC
SALTVRYTWVRGHDGHAVNEVVDQLAQAAARGVAGPGEAEVVAALRAEAFLAGGSAAPRS
CEEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
SRA
CCC
>Mature Secondary Structure 
SQARFIAFSDGSALVNPGGPGGTGFVVLDRARPAYRFGGTRWVEDGPNAVTNNRMELRA
CCCEEEEEECCCEEECCCCCCCCEEEEECCCCCCHHCCCEEEECCCCCCCCCCHHHHHH
VLEALEGLPGGEQVEVISDSRYVVDALSRWIHGWRKKGWRTASGEPVLNRDLIEALDARA
HHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCC
SALTVRYTWVRGHDGHAVNEVVDQLAQAAARGVAGPGEAEVVAALRAEAFLAGGSAAPRS
CEEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
SRA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA