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The map label for this gene is pepD [H]

Identifier: 220916981

GI number: 220916981

Start: 2108631

End: 2110085

Strand: Direct

Name: pepD [H]

Synonym: A2cp1_1877

Alternate gene names: 220916981

Gene position: 2108631-2110085 (Clockwise)

Preceding gene: 220916979

Following gene: 220916983

Centisome position: 41.93

GC content: 74.98

Gene sequence:

>1455_bases
ATGTCCGCCGATCTCGGAACCCTCGAGCCCAGGGCCCTCTGGAGCTACTTCCTCGACCTCTCGCGGATCCCGCGCAGCTC
GAAGAACGAGGCGGCGGCCGCCGCCTGGGTCGCCGGGGAGGCGACCCGGCTCGGCTGCGAGGTGGAGCGCGACGCCATCG
GGAACGTGCTGGTCCGCAAGCGCGCCTCGCCGGGTCGCGAGGGCCGGCCGGCCCTGGCGCTGCAGGGCCACCTCGACATG
GTGTGCGAGAAGAACGAGGGCACGCCGCACGACTTCGAGAAGGATCCGATCCAGGTGTGGCGCGACGGCGAGGTCCTGCG
CGCGCGGGGCACCACGCTCGGCGCCGACAACGGCGTGGGCGTGGCCGCGGCGCTGGCGGTGCTGGCCTCGCGCGACCTCG
CCCACCCCGCCATCGAGGCGCTGTTCACGGTGGACGAGGAGACCGGCCTCACCGGCGCGAACAACCTGAAGGCCGGCTGG
CTGCGCGCGCCGCGCCTGCTCAACCTCGACAGCGAGGAGGAGGGCGAGCTGACCATCGGCTGCGCCGGGGGCGTGGACAC
CGTCGCGTCGCGCGCGCTCGCCGTCGCGCCGGCGCCGGAAGGCCGGACCGCGCTGCGGCTGCGGGTGATGGGCCTGAAGG
GCGGCCACTCCGGCGTGGACATCGCGGCCGGCCGCGGGAACGCGGTCCGCCTGCTGGGGCAGGTGCTCGAGGCGCTGGTC
GCGAGGCACGGCCTCGAGGTCGCCGCGCTGAAGGGCGGCAACAAGCGGAACGCCATCCCGCGCGAGGCCTCGGCGGTGGT
GCGGGTCGAGCCGGCCCGCGAGGCGGCGCTCCGCGCGGACGTGGCGGCGCTGGCGCAGGACTGGAAGGCAGCGCTGGGCG
CGTTCGATCCCGGCCTCACGATCGTCCTCGAGCCCGGCGCGGCGACGCAGGTGATCGCGGCCGCCGACGCGCGCGCGGTG
ATCGGGCTGCTCGTGGCGGGGCCGCACGGCGTGGAGGCGATGAGCCCGGACATCCCGGGGCTGGTGCAGACCTCCACGAA
CCTCGCCATCGTGGACGCGGACGCGACGACGGGGCGGGCCGAGGTCTGCTTCCTCACGCGCAGCGCCATCGACGCCTCCA
AGCGCGCGCTGGCGGCCCGGATCGCCGCCATCGCGGCGCTGGCCGGGTTCGAGGCCCGGCACTCCGGCGGCTACCCCGGC
TGGAAGCCGGAGCCGGGGTCCGGGATGGTGAAGCTGGTGAACGGGGTCCACCAGGCGCTGTTCGGGAAGCCGATGCTGGT
GAAGGCCATCCACGCCGGCCTGGAGTGCGGCCTCATCGGCGAGAAGTACCCGGGCATGGAGATGGCCTCCATCGGCCCGA
GCATGTGGGACGCGCACACGCCGGACGAGCGGGTCTCGATCGCGTCGGTGGCGGCGTTCTGGCGCCTGCTCACCGCGATC
CTGGAGCAGGCGTAG

Upstream 100 bases:

>100_bases
GGCGTTCCGCCGCGCCGGCTTCCTGCTAGGCTTCGCGCGCACGGAGCCCGCCCGCACGGTGCGGGGACCGCATCCGCGAA
CCTTCGCAACGGGAGCACGC

Downstream 100 bases:

>100_bases
CCGGCGCGGCCCGCGGCGGCGCGGCGGGGGCCTCCAGCTCCGCCAGCGCCGCCGCGATCCGGCCGCGCACCTCCTCGCGG
AGCGCATCCACGTCGGCCGG

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSADLGTLEPRALWSYFLDLSRIPRSSKNEAAAAAWVAGEATRLGCEVERDAIGNVLVRKRASPGREGRPALALQGHLDM
VCEKNEGTPHDFEKDPIQVWRDGEVLRARGTTLGADNGVGVAAALAVLASRDLAHPAIEALFTVDEETGLTGANNLKAGW
LRAPRLLNLDSEEEGELTIGCAGGVDTVASRALAVAPAPEGRTALRLRVMGLKGGHSGVDIAAGRGNAVRLLGQVLEALV
ARHGLEVAALKGGNKRNAIPREASAVVRVEPAREAALRADVAALAQDWKAALGAFDPGLTIVLEPGAATQVIAAADARAV
IGLLVAGPHGVEAMSPDIPGLVQTSTNLAIVDADATTGRAEVCFLTRSAIDASKRALAARIAAIAALAGFEARHSGGYPG
WKPEPGSGMVKLVNGVHQALFGKPMLVKAIHAGLECGLIGEKYPGMEMASIGPSMWDAHTPDERVSIASVAAFWRLLTAI
LEQA

Sequences:

>Translated_484_residues
MSADLGTLEPRALWSYFLDLSRIPRSSKNEAAAAAWVAGEATRLGCEVERDAIGNVLVRKRASPGREGRPALALQGHLDM
VCEKNEGTPHDFEKDPIQVWRDGEVLRARGTTLGADNGVGVAAALAVLASRDLAHPAIEALFTVDEETGLTGANNLKAGW
LRAPRLLNLDSEEEGELTIGCAGGVDTVASRALAVAPAPEGRTALRLRVMGLKGGHSGVDIAAGRGNAVRLLGQVLEALV
ARHGLEVAALKGGNKRNAIPREASAVVRVEPAREAALRADVAALAQDWKAALGAFDPGLTIVLEPGAATQVIAAADARAV
IGLLVAGPHGVEAMSPDIPGLVQTSTNLAIVDADATTGRAEVCFLTRSAIDASKRALAARIAAIAALAGFEARHSGGYPG
WKPEPGSGMVKLVNGVHQALFGKPMLVKAIHAGLECGLIGEKYPGMEMASIGPSMWDAHTPDERVSIASVAAFWRLLTAI
LEQA
>Mature_483_residues
SADLGTLEPRALWSYFLDLSRIPRSSKNEAAAAAWVAGEATRLGCEVERDAIGNVLVRKRASPGREGRPALALQGHLDMV
CEKNEGTPHDFEKDPIQVWRDGEVLRARGTTLGADNGVGVAAALAVLASRDLAHPAIEALFTVDEETGLTGANNLKAGWL
RAPRLLNLDSEEEGELTIGCAGGVDTVASRALAVAPAPEGRTALRLRVMGLKGGHSGVDIAAGRGNAVRLLGQVLEALVA
RHGLEVAALKGGNKRNAIPREASAVVRVEPAREAALRADVAALAQDWKAALGAFDPGLTIVLEPGAATQVIAAADARAVI
GLLVAGPHGVEAMSPDIPGLVQTSTNLAIVDADATTGRAEVCFLTRSAIDASKRALAARIAAIAALAGFEARHSGGYPGW
KPEPGSGMVKLVNGVHQALFGKPMLVKAIHAGLECGLIGEKYPGMEMASIGPSMWDAHTPDERVSIASVAAFWRLLTAIL
EQA

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=482, Percent_Identity=42.5311203319502, Blast_Score=378, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 50294; Mature: 50163

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADLGTLEPRALWSYFLDLSRIPRSSKNEAAAAAWVAGEATRLGCEVERDAIGNVLVRK
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHEECCCHHHCCCEECHHHHHHHHHHC
RASPGREGRPALALQGHLDMVCEKNEGTPHDFEKDPIQVWRDGEVLRARGTTLGADNGVG
CCCCCCCCCCEEEEECCEEEEEECCCCCCCCCCCCCHHEECCCCEEEECCCCCCCCCCCH
VAAALAVLASRDLAHPAIEALFTVDEETGLTGANNLKAGWLRAPRLLNLDSEEEGELTIG
HHHHHHHHHHHHCCHHHHHHHEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCEEEE
CAGGVDTVASRALAVAPAPEGRTALRLRVMGLKGGHSGVDIAAGRGNAVRLLGQVLEALV
ECCCHHHHHHCEEEECCCCCCCCEEEEEEEEECCCCCCCEEECCCCHHHHHHHHHHHHHH
ARHGLEVAALKGGNKRNAIPREASAVVRVEPAREAALRADVAALAQDWKAALGAFDPGLT
HHCCCEEEEECCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
IVLEPGAATQVIAAADARAVIGLLVAGPHGVEAMSPDIPGLVQTSTNLAIVDADATTGRA
EEECCCCCCEEEEHHHHHHEEEEEEECCCCCCCCCCCCCCEEECCCCEEEEECCCCCCCE
EVCFLTRSAIDASKRALAARIAAIAALAGFEARHSGGYPGWKPEPGSGMVKLVNGVHQAL
EEEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
FGKPMLVKAIHAGLECGLIGEKYPGMEMASIGPSMWDAHTPDERVSIASVAAFWRLLTAI
HCCHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LEQA
HHCC
>Mature Secondary Structure 
SADLGTLEPRALWSYFLDLSRIPRSSKNEAAAAAWVAGEATRLGCEVERDAIGNVLVRK
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHEECCCHHHCCCEECHHHHHHHHHHC
RASPGREGRPALALQGHLDMVCEKNEGTPHDFEKDPIQVWRDGEVLRARGTTLGADNGVG
CCCCCCCCCCEEEEECCEEEEEECCCCCCCCCCCCCHHEECCCCEEEECCCCCCCCCCCH
VAAALAVLASRDLAHPAIEALFTVDEETGLTGANNLKAGWLRAPRLLNLDSEEEGELTIG
HHHHHHHHHHHHCCHHHHHHHEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCEEEE
CAGGVDTVASRALAVAPAPEGRTALRLRVMGLKGGHSGVDIAAGRGNAVRLLGQVLEALV
ECCCHHHHHHCEEEECCCCCCCCEEEEEEEEECCCCCCCEEECCCCHHHHHHHHHHHHHH
ARHGLEVAALKGGNKRNAIPREASAVVRVEPAREAALRADVAALAQDWKAALGAFDPGLT
HHCCCEEEEECCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
IVLEPGAATQVIAAADARAVIGLLVAGPHGVEAMSPDIPGLVQTSTNLAIVDADATTGRA
EEECCCCCCEEEEHHHHHHEEEEEEECCCCCCCCCCCCCCEEECCCCEEEEECCCCCCCE
EVCFLTRSAIDASKRALAARIAAIAALAGFEARHSGGYPGWKPEPGSGMVKLVNGVHQAL
EEEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
FGKPMLVKAIHAGLECGLIGEKYPGMEMASIGPSMWDAHTPDERVSIASVAAFWRLLTAI
HCCHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LEQA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]