Click here to switch to the map view.

The map label for this gene is cysK [H]

Identifier: 220916738

GI number: 220916738

Start: 1823862

End: 1824911

Strand: Direct

Name: cysK [H]

Synonym: A2cp1_1632

Alternate gene names: 220916738

Gene position: 1823862-1824911 (Clockwise)

Preceding gene: 220916736

Following gene: 220916739

Centisome position: 36.26

GC content: 70.1

Gene sequence:

>1050_bases
ATGGGCCGACGTTACGCGAGCATCCTGGAGACGATCGGAAACACTCCCGTAGTCCGGATCAACAGGCTCGCTCCACCGAA
CGTGAACCTGTTCGTGAAGGTGGAGGCCTTCAACCCGCTCGGCTCGGTGAAGGACCGTCTCGCCATCGCGGTGATCGAGG
CGGCGGAGCGCTCGGGAGCGCTGAAGCCGGGGCAGACGGTCATCGAGGCGACCAGCGGCAACACCGGCATCGGCCTGGCC
ATGGTCTGCGCGGCGAAGGGCTATCCGCTGGTGCTCGTGATGGCCGAGTCGTTCAGCGTCGAGCGGCGCCGGCTGATGCG
CTTCCTGGGTGCGAAGGTGGTGCTCACCCCGGCGGCGGAGCGCGCGGTGGGCATGATCAGGAAGACGGAGGCGCTGGCGG
CCGCGCACGGCTGGTTCATGACGCGTCAGTTCGAGAACGAGGCCAACCCCGACTACCACTCGCGCACGACGGCGCAGGAG
ATCCTGGCCGACTTCGCGGGCGACCGGCTCGACTACTGGGTGACCGGCTACGGGACCGGTGGGACGCTCAAGGGCGTGGC
CCGCGTGCTCCGCAAGGAACGGCCGGAGACGAAGATCGTGGTCTGCGAGCCGGCGGAGGCCCCGCTCCTGGGCAGCGGGG
CCGCGCAGTCACGCAATCCGGACGGCACCCCGGCCGCACCGCACCCGAGCTTCAAGCCGCATCCGATGCAGGGATGGACC
CCGGACTTCATCCCGAAGCTGACCGGCGACGCGGTGGACCTGAAGCTGGTGGACCGCATCCTGGCCGTCCCCGGCCCGGA
GGCGATCCGCTGCGCCAAGGAGCTGGCCGCACGGGAGGGCATCTTCGTGGGCATCACCTCCGGCGGCACGTTCGCCGGCG
CCCTCGAGATCGCCGCCAGCGCGGAGCCGGGGGCCAACATCCTCTGCATGCTGCCGGACACGGGGGAGCGTTACCTCAGC
ACGCCGCTCTTCGCGGACGTGCCGTCGGAGATGACCGAGGAGGAACAGTCGATCGCGCGTTCCGTGGCGGACGCGGGCCC
GAAGGCCTGA

Upstream 100 bases:

>100_bases
GTCGATGCGCCGACGCTCCCGTCCGGTTCCCGTCATGGCGACGCGTCTCCATTACAGATGTCGCCTCGAGCGGCTCCCCC
GCCGCTCCACGAGGTGCGCC

Downstream 100 bases:

>100_bases
GGGCGCACGGCCATGGCCATCGTGTCGCGCAGGGCGGCGGCGGCGGATCGGGCGTTCGAGGCGGTCAAGAGCTTCTACTT
CAGCTCGCGGTACGGCGAAC

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MGRRYASILETIGNTPVVRINRLAPPNVNLFVKVEAFNPLGSVKDRLAIAVIEAAERSGALKPGQTVIEATSGNTGIGLA
MVCAAKGYPLVLVMAESFSVERRRLMRFLGAKVVLTPAAERAVGMIRKTEALAAAHGWFMTRQFENEANPDYHSRTTAQE
ILADFAGDRLDYWVTGYGTGGTLKGVARVLRKERPETKIVVCEPAEAPLLGSGAAQSRNPDGTPAAPHPSFKPHPMQGWT
PDFIPKLTGDAVDLKLVDRILAVPGPEAIRCAKELAAREGIFVGITSGGTFAGALEIAASAEPGANILCMLPDTGERYLS
TPLFADVPSEMTEEEQSIARSVADAGPKA

Sequences:

>Translated_349_residues
MGRRYASILETIGNTPVVRINRLAPPNVNLFVKVEAFNPLGSVKDRLAIAVIEAAERSGALKPGQTVIEATSGNTGIGLA
MVCAAKGYPLVLVMAESFSVERRRLMRFLGAKVVLTPAAERAVGMIRKTEALAAAHGWFMTRQFENEANPDYHSRTTAQE
ILADFAGDRLDYWVTGYGTGGTLKGVARVLRKERPETKIVVCEPAEAPLLGSGAAQSRNPDGTPAAPHPSFKPHPMQGWT
PDFIPKLTGDAVDLKLVDRILAVPGPEAIRCAKELAAREGIFVGITSGGTFAGALEIAASAEPGANILCMLPDTGERYLS
TPLFADVPSEMTEEEQSIARSVADAGPKA
>Mature_348_residues
GRRYASILETIGNTPVVRINRLAPPNVNLFVKVEAFNPLGSVKDRLAIAVIEAAERSGALKPGQTVIEATSGNTGIGLAM
VCAAKGYPLVLVMAESFSVERRRLMRFLGAKVVLTPAAERAVGMIRKTEALAAAHGWFMTRQFENEANPDYHSRTTAQEI
LADFAGDRLDYWVTGYGTGGTLKGVARVLRKERPETKIVVCEPAEAPLLGSGAAQSRNPDGTPAAPHPSFKPHPMQGWTP
DFIPKLTGDAVDLKLVDRILAVPGPEAIRCAKELAAREGIFVGITSGGTFAGALEIAASAEPGANILCMLPDTGERYLST
PLFADVPSEMTEEEQSIARSVADAGPKA

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=327, Percent_Identity=37.0030581039755, Blast_Score=184, Evalue=7e-47,
Organism=Homo sapiens, GI295821200, Length=327, Percent_Identity=37.0030581039755, Blast_Score=184, Evalue=7e-47,
Organism=Homo sapiens, GI4557415, Length=327, Percent_Identity=37.0030581039755, Blast_Score=184, Evalue=7e-47,
Organism=Escherichia coli, GI1788754, Length=325, Percent_Identity=42.4615384615385, Blast_Score=214, Evalue=5e-57,
Organism=Escherichia coli, GI2367138, Length=322, Percent_Identity=36.9565217391304, Blast_Score=196, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17535051, Length=331, Percent_Identity=37.1601208459215, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17562970, Length=331, Percent_Identity=37.4622356495468, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI115535073, Length=322, Percent_Identity=40.6832298136646, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI32566674, Length=317, Percent_Identity=37.8548895899054, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17561720, Length=338, Percent_Identity=34.9112426035503, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17534315, Length=338, Percent_Identity=35.207100591716, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI25147552, Length=340, Percent_Identity=31.7647058823529, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI32566672, Length=245, Percent_Identity=34.6938775510204, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI71996324, Length=330, Percent_Identity=26.6666666666667, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17539800, Length=207, Percent_Identity=26.0869565217391, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17539640, Length=208, Percent_Identity=27.4038461538462, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=333, Percent_Identity=31.5315315315315, Blast_Score=155, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6321449, Length=337, Percent_Identity=33.8278931750742, Blast_Score=125, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24643623, Length=321, Percent_Identity=34.8909657320872, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI20129101, Length=321, Percent_Identity=34.8909657320872, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 37117; Mature: 36986

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRRYASILETIGNTPVVRINRLAPPNVNLFVKVEAFNPLGSVKDRLAIAVIEAAERSGA
CCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCC
LKPGQTVIEATSGNTGIGLAMVCAAKGYPLVLVMAESFSVERRRLMRFLGAKVVLTPAAE
CCCCCEEEEECCCCCCCHHHEEECCCCCCEEEEEECCCCHHHHHHHHHHCCEEEEECCHH
RAVGMIRKTEALAAAHGWFMTRQFENEANPDYHSRTTAQEILADFAGDRLDYWVTGYGTG
HHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCC
GTLKGVARVLRKERPETKIVVCEPAEAPLLGSGAAQSRNPDGTPAAPHPSFKPHPMQGWT
CHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PDFIPKLTGDAVDLKLVDRILAVPGPEAIRCAKELAAREGIFVGITSGGTFAGALEIAAS
CHHHHHCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEECCCCEEEEEEEEEC
AEPGANILCMLPDTGERYLSTPLFADVPSEMTEEEQSIARSVADAGPKA
CCCCCCEEEECCCCCHHHHCCCCHHCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GRRYASILETIGNTPVVRINRLAPPNVNLFVKVEAFNPLGSVKDRLAIAVIEAAERSGA
CHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCC
LKPGQTVIEATSGNTGIGLAMVCAAKGYPLVLVMAESFSVERRRLMRFLGAKVVLTPAAE
CCCCCEEEEECCCCCCCHHHEEECCCCCCEEEEEECCCCHHHHHHHHHHCCEEEEECCHH
RAVGMIRKTEALAAAHGWFMTRQFENEANPDYHSRTTAQEILADFAGDRLDYWVTGYGTG
HHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCC
GTLKGVARVLRKERPETKIVVCEPAEAPLLGSGAAQSRNPDGTPAAPHPSFKPHPMQGWT
CHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PDFIPKLTGDAVDLKLVDRILAVPGPEAIRCAKELAAREGIFVGITSGGTFAGALEIAAS
CHHHHHCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEECCCCEEEEEEEEEC
AEPGANILCMLPDTGERYLSTPLFADVPSEMTEEEQSIARSVADAGPKA
CCCCCCEEEECCCCCHHHHCCCCHHCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA