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The map label for this gene is fadD [C]

Identifier: 220916706

GI number: 220916706

Start: 1787080

End: 1788870

Strand: Direct

Name: fadD [C]

Synonym: A2cp1_1600

Alternate gene names: 220916706

Gene position: 1787080-1788870 (Clockwise)

Preceding gene: 220916705

Following gene: 220916707

Centisome position: 35.53

GC content: 77.11

Gene sequence:

>1791_bases
ATGCCCACGCGACTCCCCCTGCACCGATACGCCGCCCGCACGCTGCCGGCCATGCTCGAGCACACCGCGGCGCGGCTCCC
GGACAAGCCGTTCATCCGGTTCTTCGACCCCGCCACCCCCGGCGCGGCGCCGCGGGCGGTGACGTTCGCCGGGTTCCGCG
CCGGCGTGGGCCGCGCGGCCGCGTTCCTGCGCGCACACGGCGTCGGCCCCGGGACGCGCATCCTGCTGCTCGCCGACAAC
GCGCCGGAGTGGCAGATGGTGGCGCTCGGGGCGCAGCTCCTCCGCGCCGAGCCGGCCGCGATCTTCGCCAGCCTCTCGGC
CGAGGCGGCCCAGGGGATCGCGCGGCGGGTGCGGCCCCGGGTGGTGATCGTCTCGGGCGCGCAGGGGTGGGAGAAGCTCG
CGCCCATCGCCGGCGAGCTGTCCGCCGCCGGCCTGCGGGTGGTCCTCTCCGGCGAGCCGCTCGCCGCTCCGTCGCTCGTC
GCCGGCCTCTCGGCCGTCACCCTGGCCGACGCGACCGGGCCGGGCGCGCCCGGCCTGGACGGCGCGGAGCACGCCGCGCT
CGCCGCCGCGGTGGGCGAGGAGGACCCGTTCCTGCTGCTCTTCACGAGCGGCACCACCGGCCGGCCCAAGGGCGTCCGGC
TGCCGCAGCGCGCGATGGTGCACGCGGTCGAGGGCGGGACGCTGCCGGTCGGCACCACCGAGGACGACCTCGGCGTGCAC
TTCCTGCCCTTCGCCCACGTGGCCGGGCACGCCCAGTTCACGCTGGCGCTGGCCCAGGGGCACGCGCTCGCGATGACCGC
CCGGCGCGAGGACATCGAGCGCGCGCTGGAGCTCCACCCGACCTACCTGTTCTCGGTGCCGCTCGTGTACGAGCGGATCC
GCGCCGGCGTGCTGGCGCGGGTGGACGCGCTGCCGGGGCCGGCGCGCGCGCTCGCCCGGCGCGCGCTGGAGGCGGCGGCG
CGGGTGCGGGTGGACGGCTCGCGGCGTCTCTCCGACCGCGCCCTGGCGCGGCTCGCCGACCGGCTGGTGGGGCGCGCCGT
GCGGGCCAGGCTCGGCGGCCGCATCCGCGGCCTGTTCGCCGGCGGCGCCCCCGCGGCGCCGGCGCTGTTCCGGTTCTACG
AGGCGCTCGGCATCCCCATGGTCGAGCTCTACGGCATGAGCGAGACGGCCGGGCTCATCTCGTCCAACCTGTTCTCCGGC
CCGCGCCGCGCCGGCAGCGCCGGGTACCCGACGCCCGAGCACGACCTGCGCTTCGCCCCCGACGGAGAGCTGCAGGTGCG
CGGCCCGCTCCTGTTCACCGGCTACCTCGAGCCGGAGGACGCCGAGGATGCCTACACGGACGACGGCTTCTTCCGCACCG
GCGACGTCGGGTGCGAGGAGCCGGACGGCGCGCTCCGGATCGACGGCCGGAAGAAGAACCTCATGGTGCTCTCCACCGGC
AAGAAGGTGTCGCCCGAGCCGGTGGAGCAGGCCATCGCGGCCGCCGAGCCGTTCCAGGGCGCGGTGCTGCTCGGCGAGGG
ACGTCCGTTCGTGGCCGCGGCCGTGTTCGTGGCCAGGGAGGAGCTGGCCCGCTTCGCCGCGGCCGGCAAGGACGCGGCCG
AGGAGCTGCTCCCGCGCGCCCGCGCCGCGCTGGCCGCGTTCAGCGAGTTCGAGAAGCCCAAGCGCCTGCTGGTGATCCCG
GGCGCGCCGCACGAGCACCCCGCGCTCGTCACGCCGACGCTGAAGGTGAAGCGCGACGCGCTCGTCGAGTGGCTGGCGCC
CTCGCTGGCGCGGCTGTACGGCGCGGTGTAG

Upstream 100 bases:

>100_bases
GGTTGGGGGCGAGGCGGGGGGCCGCGCCCACCCACGGCTCCCGCCGTGACACGCTGGTGACACGCCCGGGGCACGCTCCC
ACCGGCCACCGGCCAGCCCC

Downstream 100 bases:

>100_bases
GCGCCGCCCGCCCTCGTCGCCGATCGTCACCCGAGGTGCGCCCGGGTCGCACCGCCCGTCGCGTGGACCCCGCCCGCGCG
ACTTGGGGCGGGCCGGGGCG

Product: Long-chain-fatty-acid--CoA ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 596; Mature: 595

Protein sequence:

>596_residues
MPTRLPLHRYAARTLPAMLEHTAARLPDKPFIRFFDPATPGAAPRAVTFAGFRAGVGRAAAFLRAHGVGPGTRILLLADN
APEWQMVALGAQLLRAEPAAIFASLSAEAAQGIARRVRPRVVIVSGAQGWEKLAPIAGELSAAGLRVVLSGEPLAAPSLV
AGLSAVTLADATGPGAPGLDGAEHAALAAAVGEEDPFLLLFTSGTTGRPKGVRLPQRAMVHAVEGGTLPVGTTEDDLGVH
FLPFAHVAGHAQFTLALAQGHALAMTARREDIERALELHPTYLFSVPLVYERIRAGVLARVDALPGPARALARRALEAAA
RVRVDGSRRLSDRALARLADRLVGRAVRARLGGRIRGLFAGGAPAAPALFRFYEALGIPMVELYGMSETAGLISSNLFSG
PRRAGSAGYPTPEHDLRFAPDGELQVRGPLLFTGYLEPEDAEDAYTDDGFFRTGDVGCEEPDGALRIDGRKKNLMVLSTG
KKVSPEPVEQAIAAAEPFQGAVLLGEGRPFVAAAVFVAREELARFAAAGKDAAEELLPRARAALAAFSEFEKPKRLLVIP
GAPHEHPALVTPTLKVKRDALVEWLAPSLARLYGAV

Sequences:

>Translated_596_residues
MPTRLPLHRYAARTLPAMLEHTAARLPDKPFIRFFDPATPGAAPRAVTFAGFRAGVGRAAAFLRAHGVGPGTRILLLADN
APEWQMVALGAQLLRAEPAAIFASLSAEAAQGIARRVRPRVVIVSGAQGWEKLAPIAGELSAAGLRVVLSGEPLAAPSLV
AGLSAVTLADATGPGAPGLDGAEHAALAAAVGEEDPFLLLFTSGTTGRPKGVRLPQRAMVHAVEGGTLPVGTTEDDLGVH
FLPFAHVAGHAQFTLALAQGHALAMTARREDIERALELHPTYLFSVPLVYERIRAGVLARVDALPGPARALARRALEAAA
RVRVDGSRRLSDRALARLADRLVGRAVRARLGGRIRGLFAGGAPAAPALFRFYEALGIPMVELYGMSETAGLISSNLFSG
PRRAGSAGYPTPEHDLRFAPDGELQVRGPLLFTGYLEPEDAEDAYTDDGFFRTGDVGCEEPDGALRIDGRKKNLMVLSTG
KKVSPEPVEQAIAAAEPFQGAVLLGEGRPFVAAAVFVAREELARFAAAGKDAAEELLPRARAALAAFSEFEKPKRLLVIP
GAPHEHPALVTPTLKVKRDALVEWLAPSLARLYGAV
>Mature_595_residues
PTRLPLHRYAARTLPAMLEHTAARLPDKPFIRFFDPATPGAAPRAVTFAGFRAGVGRAAAFLRAHGVGPGTRILLLADNA
PEWQMVALGAQLLRAEPAAIFASLSAEAAQGIARRVRPRVVIVSGAQGWEKLAPIAGELSAAGLRVVLSGEPLAAPSLVA
GLSAVTLADATGPGAPGLDGAEHAALAAAVGEEDPFLLLFTSGTTGRPKGVRLPQRAMVHAVEGGTLPVGTTEDDLGVHF
LPFAHVAGHAQFTLALAQGHALAMTARREDIERALELHPTYLFSVPLVYERIRAGVLARVDALPGPARALARRALEAAAR
VRVDGSRRLSDRALARLADRLVGRAVRARLGGRIRGLFAGGAPAAPALFRFYEALGIPMVELYGMSETAGLISSNLFSGP
RRAGSAGYPTPEHDLRFAPDGELQVRGPLLFTGYLEPEDAEDAYTDDGFFRTGDVGCEEPDGALRIDGRKKNLMVLSTGK
KVSPEPVEQAIAAAEPFQGAVLLGEGRPFVAAAVFVAREELARFAAAGKDAAEELLPRARAALAAFSEFEKPKRLLVIPG
APHEHPALVTPTLKVKRDALVEWLAPSLARLYGAV

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI40807491, Length=591, Percent_Identity=26.7343485617597, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI42794756, Length=583, Percent_Identity=25.7289879931389, Blast_Score=149, Evalue=9e-36,
Organism=Homo sapiens, GI42794760, Length=583, Percent_Identity=25.7289879931389, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI42794758, Length=583, Percent_Identity=25.7289879931389, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI27477105, Length=492, Percent_Identity=27.8455284552846, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI57165412, Length=556, Percent_Identity=26.2589928057554, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI57165410, Length=556, Percent_Identity=25.8992805755396, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI42794754, Length=582, Percent_Identity=24.3986254295533, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI42794752, Length=582, Percent_Identity=24.3986254295533, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI83745141, Length=532, Percent_Identity=24.2481203007519, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI12669909, Length=591, Percent_Identity=23.5194585448393, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4758332, Length=451, Percent_Identity=26.1640798226164, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1788107, Length=569, Percent_Identity=23.5500878734622, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17556552, Length=570, Percent_Identity=24.9122807017544, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25147511, Length=612, Percent_Identity=24.8366013071895, Blast_Score=140, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17558820, Length=389, Percent_Identity=27.5064267352185, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17553312, Length=462, Percent_Identity=29.2207792207792, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17564090, Length=447, Percent_Identity=28.1879194630872, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17541856, Length=437, Percent_Identity=28.3752860411899, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17510401, Length=574, Percent_Identity=25.7839721254355, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32563687, Length=401, Percent_Identity=25.1870324189526, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193204819, Length=607, Percent_Identity=22.4052718286656, Blast_Score=97, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323903, Length=337, Percent_Identity=29.3768545994065, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6324893, Length=330, Percent_Identity=29.6969696969697, Blast_Score=120, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6320852, Length=610, Percent_Identity=23.7704918032787, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322182, Length=321, Percent_Identity=25.8566978193146, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19921316, Length=529, Percent_Identity=28.7334593572779, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24666501, Length=585, Percent_Identity=25.2991452991453, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24666497, Length=585, Percent_Identity=25.2991452991453, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI281366413, Length=585, Percent_Identity=25.2991452991453, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI17933690, Length=639, Percent_Identity=23.7871674491393, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI62471681, Length=448, Percent_Identity=25.8928571428571, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI62471687, Length=448, Percent_Identity=25.8928571428571, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24586634, Length=448, Percent_Identity=25.8928571428571, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI22026970, Length=448, Percent_Identity=25.8928571428571, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI62471689, Length=448, Percent_Identity=25.8928571428571, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI62471679, Length=448, Percent_Identity=25.8928571428571, Blast_Score=129, Evalue=7e-30,
Organism=Drosophila melanogaster, GI62471683, Length=448, Percent_Identity=25.8928571428571, Blast_Score=129, Evalue=7e-30,
Organism=Drosophila melanogaster, GI62471685, Length=448, Percent_Identity=25.8928571428571, Blast_Score=129, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24586636, Length=448, Percent_Identity=25.8928571428571, Blast_Score=129, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 62801; Mature: 62670

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTRLPLHRYAARTLPAMLEHTAARLPDKPFIRFFDPATPGAAPRAVTFAGFRAGVGRAA
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEEEHHHHHHHHHHH
AFLRAHGVGPGTRILLLADNAPEWQMVALGAQLLRAEPAAIFASLSAEAAQGIARRVRPR
HHHHHCCCCCCCEEEEEECCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCE
VVIVSGAQGWEKLAPIAGELSAAGLRVVLSGEPLAAPSLVAGLSAVTLADATGPGAPGLD
EEEEECCCCHHHHCCHHCCCCCCCEEEEECCCCCCCHHHHHCCHHEEEECCCCCCCCCCC
GAEHAALAAAVGEEDPFLLLFTSGTTGRPKGVRLPQRAMVHAVEGGTLPVGTTEDDLGVH
CHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHEEECCCEECCCCCCCCCCEE
FLPFAHVAGHAQFTLALAQGHALAMTARREDIERALELHPTYLFSVPLVYERIRAGVLAR
EECHHHHCCCCEEEEEEECCCEEEEHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHH
VDALPGPARALARRALEAAARVRVDGSRRLSDRALARLADRLVGRAVRARLGGRIRGLFA
HHCCCCHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
GGAPAAPALFRFYEALGIPMVELYGMSETAGLISSNLFSGPRRAGSAGYPTPEHDLRFAP
CCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECC
DGELQVRGPLLFTGYLEPEDAEDAYTDDGFFRTGDVGCEEPDGALRIDGRKKNLMVLSTG
CCCEEEECCEEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCCEEECCCCCCEEEEECC
KKVSPEPVEQAIAAAEPFQGAVLLGEGRPFVAAAVFVAREELARFAAAGKDAAEELLPRA
CCCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
RAALAAFSEFEKPKRLLVIPGAPHEHPALVTPTLKVKRDALVEWLAPSLARLYGAV
HHHHHHHHHHCCCCEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PTRLPLHRYAARTLPAMLEHTAARLPDKPFIRFFDPATPGAAPRAVTFAGFRAGVGRAA
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEEEHHHHHHHHHHH
AFLRAHGVGPGTRILLLADNAPEWQMVALGAQLLRAEPAAIFASLSAEAAQGIARRVRPR
HHHHHCCCCCCCEEEEEECCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCE
VVIVSGAQGWEKLAPIAGELSAAGLRVVLSGEPLAAPSLVAGLSAVTLADATGPGAPGLD
EEEEECCCCHHHHCCHHCCCCCCCEEEEECCCCCCCHHHHHCCHHEEEECCCCCCCCCCC
GAEHAALAAAVGEEDPFLLLFTSGTTGRPKGVRLPQRAMVHAVEGGTLPVGTTEDDLGVH
CHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHEEECCCEECCCCCCCCCCEE
FLPFAHVAGHAQFTLALAQGHALAMTARREDIERALELHPTYLFSVPLVYERIRAGVLAR
EECHHHHCCCCEEEEEEECCCEEEEHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHH
VDALPGPARALARRALEAAARVRVDGSRRLSDRALARLADRLVGRAVRARLGGRIRGLFA
HHCCCCHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
GGAPAAPALFRFYEALGIPMVELYGMSETAGLISSNLFSGPRRAGSAGYPTPEHDLRFAP
CCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECC
DGELQVRGPLLFTGYLEPEDAEDAYTDDGFFRTGDVGCEEPDGALRIDGRKKNLMVLSTG
CCCEEEECCEEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCCEEECCCCCCEEEEECC
KKVSPEPVEQAIAAAEPFQGAVLLGEGRPFVAAAVFVAREELARFAAAGKDAAEELLPRA
CCCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
RAALAAFSEFEKPKRLLVIPGAPHEHPALVTPTLKVKRDALVEWLAPSLARLYGAV
HHHHHHHHHHCCCCEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]