BacMap

Definition	Anaeromyxobacter dehalogenans 2CP-1 chromosome, complete genome.
Accession	NC_011891
Length	5,029,329

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The map label for this gene is trxA [H]

Identifier: 220916562

GI number: 220916562

Start: 1630723

End: 1631052

Strand: Reverse

Name: trxA [H]

Synonym: A2cp1_1456

Alternate gene names: 220916562

Gene position: 1631052-1630723 (Counterclockwise)

Preceding gene: 220916569

Following gene: 220916557

Centisome position: 32.43

GC content: 66.06

Gene sequence:

>330_bases
ATGGCCTCGAACGACGTCGTAGTGCTGCAGGACTCCACCTTCGAGCAGGAGGTGCTGAAGAGCGAGACCCCCGTGCTCGT
GGACTTCTGGGCGGTGTGGTGCGGGCCCTGCAAGGCGATCGCGCCGGTCGTGGACGACCTGGCCGCCCGCTACAAGGGGA
AGCTGAAGGTCGCCAAGATGGACGTGGATCAGCACCAGAACGTGCCGCAGCAGTACGGCATCCGCTCGATCCCCACGCTG
CTCGTGTTCAAGGGCGGCCGCGTGGTCGACACCGTCATCGGCGCCGACAAGACGCGCCTCGAGGACAGCGTCAAGAAGGC
GATCGGCTAG

Upstream 100 bases:

>100_bases
GCGCACGGCGGAGCCGGAAATTAGCACGCCCGCCGCGCCGCTTGCCAGCCTCGGACCGCGCGGATATTACTCGCGCCAAC
TTCGGACATCGGGAGATTCC

Downstream 100 bases:

>100_bases
GCGGTCGTTCCCCGCTCGCGGCCGCCACGGCGGGCCGCGGGCGGGCGGGGGCGCGAGGTGCGGCAACGTGCCGCGTCGAC
CGCTCGACGCGCGCGCGGCA

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MASNDVVVLQDSTFEQEVLKSETPVLVDFWAVWCGPCKAIAPVVDDLAARYKGKLKVAKMDVDQHQNVPQQYGIRSIPTL
LVFKGGRVVDTVIGADKTRLEDSVKKAIG

Sequences:

>Translated_109_residues
MASNDVVVLQDSTFEQEVLKSETPVLVDFWAVWCGPCKAIAPVVDDLAARYKGKLKVAKMDVDQHQNVPQQYGIRSIPTL
LVFKGGRVVDTVIGADKTRLEDSVKKAIG
>Mature_108_residues
ASNDVVVLQDSTFEQEVLKSETPVLVDFWAVWCGPCKAIAPVVDDLAARYKGKLKVAKMDVDQHQNVPQQYGIRSIPTLL
VFKGGRVVDTVIGADKTRLEDSVKKAIG

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=44.3298969072165, Blast_Score=92, Evalue=8e-20,
Organism=Homo sapiens, GI5031973, Length=114, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=2e-14,
Organism=Homo sapiens, GI50592994, Length=84, Percent_Identity=36.9047619047619, Blast_Score=67, Evalue=2e-12,
Organism=Homo sapiens, GI20070125, Length=86, Percent_Identity=38.3720930232558, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI21361657, Length=85, Percent_Identity=37.6470588235294, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI24308127, Length=72, Percent_Identity=40.2777777777778, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082331, Length=93, Percent_Identity=52.6881720430108, Blast_Score=115, Evalue=8e-28,
Organism=Escherichia coli, GI1788936, Length=79, Percent_Identity=44.3037974683544, Blast_Score=91, Evalue=1e-20,
Organism=Escherichia coli, GI87081747, Length=95, Percent_Identity=35.7894736842105, Blast_Score=75, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17509965, Length=89, Percent_Identity=42.6966292134831, Blast_Score=81, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71998175, Length=102, Percent_Identity=40.1960784313725, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=35.4838709677419, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17510299, Length=82, Percent_Identity=45.1219512195122, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17556044, Length=110, Percent_Identity=32.7272727272727, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71980562, Length=102, Percent_Identity=36.2745098039216, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71980565, Length=99, Percent_Identity=34.3434343434343, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17554386, Length=110, Percent_Identity=36.3636363636364, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17549970, Length=99, Percent_Identity=36.3636363636364, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17507705, Length=82, Percent_Identity=31.7073170731707, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=79, Percent_Identity=40.5063291139241, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=79, Percent_Identity=40.5063291139241, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=79, Percent_Identity=40.5063291139241, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=108, Percent_Identity=32.4074074074074, Blast_Score=61, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6321648, Length=93, Percent_Identity=36.5591397849462, Blast_Score=77, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323072, Length=94, Percent_Identity=38.2978723404255, Blast_Score=75, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=104, Percent_Identity=28.8461538461538, Blast_Score=66, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24639826, Length=100, Percent_Identity=36, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28573567, Length=81, Percent_Identity=40.7407407407407, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17648013, Length=84, Percent_Identity=40.4761904761905, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24583090, Length=84, Percent_Identity=40.4761904761905, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24664269, Length=85, Percent_Identity=38.8235294117647, Blast_Score=78, Evalue=9e-16,
Organism=Drosophila melanogaster, GI17530795, Length=84, Percent_Identity=35.7142857142857, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921434, Length=83, Percent_Identity=38.5542168674699, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24658597, Length=103, Percent_Identity=34.9514563106796, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21358065, Length=89, Percent_Identity=35.9550561797753, Blast_Score=66, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639068, Length=90, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24664525, Length=104, Percent_Identity=38.4615384615385, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17647799, Length=104, Percent_Identity=38.4615384615385, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11957; Mature: 11826

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASNDVVVLQDSTFEQEVLKSETPVLVDFWAVWCGPCKAIAPVVDDLAARYKGKLKVAKM
CCCCCEEEEECCCHHHHHHCCCCCEEEHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEEE
DVDQHQNVPQQYGIRSIPTLLVFKGGRVVDTVIGADKTRLEDSVKKAIG
CCHHHCCCCHHCCCCCCCEEEEECCCCEEEHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
ASNDVVVLQDSTFEQEVLKSETPVLVDFWAVWCGPCKAIAPVVDDLAARYKGKLKVAKM
CCCCEEEEECCCHHHHHHCCCCCEEEHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEEE
DVDQHQNVPQQYGIRSIPTLLVFKGGRVVDTVIGADKTRLEDSVKKAIG
CCHHHCCCCHHCCCCCCCEEEEECCCCEEEHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]