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The map label for this gene is adhc1 [H]

Identifier: 220916429

GI number: 220916429

Start: 1470462

End: 1471505

Strand: Reverse

Name: adhc1 [H]

Synonym: A2cp1_1323

Alternate gene names: 220916429

Gene position: 1471505-1470462 (Counterclockwise)

Preceding gene: 220916431

Following gene: 220916424

Centisome position: 29.26

GC content: 72.22

Gene sequence:

>1044_bases
ATGACCCAGGTCAAGGCCTGGGCTGCGCCGGCCGCCGGCGCGCCCCTCGTCCCCCACACCATCGAGCGCCGCGACGTCGG
CGAGCGCGACGTCCTCATCGACATCGCCTACTGCGGCGTCTGCCACTCGGACATCCACCAGGCGCGCGACGAGTGGGGCG
GCGCCGCCTTCCCCATGGTGCCCGGCCACGAGATCGTCGGCCGCGTCGCCCGCGTCGGCGCGAAGGTCACGCGCTTCCGG
CCCGGCGATCACGCCGGCGTCGGCTGCCTGGTGGACTCGTGCCGCACCTGCGATCCGTGCCGGCGCGATCTCGAGCAGTT
CTGCGAGCGCGGTCCGGCCTGGACCTACAACAGCACCGAGATGGACCGCCGCACGCCCACGCACGGCGGCTACTCGAAGC
AGGTGGTCGTGACCGAGGACTTCGCGCTGAAGGTGGCGCCCTCGCTCGACCTCGCCGCCGCCGCGCCGCTGCTCTGCGCC
GGCATCACCACCTACTCGCCGCTCCGCCACTGGAAGGTGGGCCCGGGCCAGCAGGTCGGCGTGGTGGGCCTGGGCGGCCT
CGGCCACATGGCGGTGAAGCTCGCCGCCGCCATGGGCGCGGAGGTCACGATGCTCAGCACCTCCCCGCGCAAGGAGGCCG
ACGCGCGCCGCCTGGGCGCGAGCGGCTTCGCGCTCACCAGCGACGACGCCACCTTCCGCCGCCTGCGCAACCGCTTCGAC
TTCATCCTCGACACCATCTCGGCGCCGCACGACTACGACCGGTACCTGGGCATGGTGAAGGTGGACGGGGCCATGGTGCT
GGTGGGCGTGCCGCCCGAGCGCATCCCGCTGCACGCGCACTCGCTCATCGGCGGCCGCCGCACCCTGGCCGGCTCGCTCA
TCGGCGGCATCGCCGAGACGCAGGAGATGCTGGACTTCTGCGCCGAGAAGCAGGTCGTCTCGGACGTGGAGGTCATCCCC
ATCGAGAAGATCAACGAGGCCTACGAGCGGATGATCCGCGGCGACGTGCGGTACCGGTTCGTCATCGACCTCGCGTCGCT
GTAG

Upstream 100 bases:

>100_bases
GCCCGCCGGGCCGGCCGCGGCGGCGCGCGGATTCCGCTGCGGCGGCGCCACCAGCCGCTAGATTCCTCCCCCCTCGACAT
CGTCAACAGGAGGCATCACC

Downstream 100 bases:

>100_bases
CCGCGCGGGCGCGCGCACCGGCGGCCAGCGGCGCCCCGGTGCGCCGGCGCCCGGCCATCACGCGCGGTGATCGTCACGCA
CCGTGATGTATGCGCGTGTG

Product: alcohol dehydrogenase GroES domain-containing protein

Products: NA

Alternate protein names: Ms-ADHC 1 [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTQVKAWAAPAAGAPLVPHTIERRDVGERDVLIDIAYCGVCHSDIHQARDEWGGAAFPMVPGHEIVGRVARVGAKVTRFR
PGDHAGVGCLVDSCRTCDPCRRDLEQFCERGPAWTYNSTEMDRRTPTHGGYSKQVVVTEDFALKVAPSLDLAAAAPLLCA
GITTYSPLRHWKVGPGQQVGVVGLGGLGHMAVKLAAAMGAEVTMLSTSPRKEADARRLGASGFALTSDDATFRRLRNRFD
FILDTISAPHDYDRYLGMVKVDGAMVLVGVPPERIPLHAHSLIGGRRTLAGSLIGGIAETQEMLDFCAEKQVVSDVEVIP
IEKINEAYERMIRGDVRYRFVIDLASL

Sequences:

>Translated_347_residues
MTQVKAWAAPAAGAPLVPHTIERRDVGERDVLIDIAYCGVCHSDIHQARDEWGGAAFPMVPGHEIVGRVARVGAKVTRFR
PGDHAGVGCLVDSCRTCDPCRRDLEQFCERGPAWTYNSTEMDRRTPTHGGYSKQVVVTEDFALKVAPSLDLAAAAPLLCA
GITTYSPLRHWKVGPGQQVGVVGLGGLGHMAVKLAAAMGAEVTMLSTSPRKEADARRLGASGFALTSDDATFRRLRNRFD
FILDTISAPHDYDRYLGMVKVDGAMVLVGVPPERIPLHAHSLIGGRRTLAGSLIGGIAETQEMLDFCAEKQVVSDVEVIP
IEKINEAYERMIRGDVRYRFVIDLASL
>Mature_346_residues
TQVKAWAAPAAGAPLVPHTIERRDVGERDVLIDIAYCGVCHSDIHQARDEWGGAAFPMVPGHEIVGRVARVGAKVTRFRP
GDHAGVGCLVDSCRTCDPCRRDLEQFCERGPAWTYNSTEMDRRTPTHGGYSKQVVVTEDFALKVAPSLDLAAAAPLLCAG
ITTYSPLRHWKVGPGQQVGVVGLGGLGHMAVKLAAAMGAEVTMLSTSPRKEADARRLGASGFALTSDDATFRRLRNRFDF
ILDTISAPHDYDRYLGMVKVDGAMVLVGVPPERIPLHAHSLIGGRRTLAGSLIGGIAETQEMLDFCAEKQVVSDVEVIPI
EKINEAYERMIRGDVRYRFVIDLASL

Specific function: Prefers aldehydes over alcohols [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501929, Length=354, Percent_Identity=27.4011299435028, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI34577061, Length=354, Percent_Identity=27.683615819209, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI71565152, Length=367, Percent_Identity=26.158038147139, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4501933, Length=364, Percent_Identity=27.1978021978022, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI262073058, Length=350, Percent_Identity=24.5714285714286, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI71743840, Length=350, Percent_Identity=24.5714285714286, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1786518, Length=348, Percent_Identity=54.5977011494253, Blast_Score=349, Evalue=1e-97,
Organism=Escherichia coli, GI87082401, Length=344, Percent_Identity=33.1395348837209, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI87081918, Length=326, Percent_Identity=31.5950920245399, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI226510992, Length=317, Percent_Identity=26.813880126183, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786552, Length=377, Percent_Identity=27.5862068965517, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788073, Length=261, Percent_Identity=24.5210727969349, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790045, Length=283, Percent_Identity=26.8551236749117, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=341, Percent_Identity=31.9648093841642, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71988145, Length=342, Percent_Identity=28.3625730994152, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17562582, Length=330, Percent_Identity=28.4848484848485, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI25146526, Length=369, Percent_Identity=26.0162601626016, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=371, Percent_Identity=26.1455525606469, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=336, Percent_Identity=26.4880952380952, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562878, Length=218, Percent_Identity=29.8165137614679, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=267, Percent_Identity=25.8426966292135, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=321, Percent_Identity=37.3831775700935, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6319949, Length=350, Percent_Identity=35.1428571428571, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6323729, Length=338, Percent_Identity=30.1775147928994, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324486, Length=326, Percent_Identity=29.7546012269939, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323961, Length=327, Percent_Identity=30.5810397553517, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319621, Length=331, Percent_Identity=27.7945619335347, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6319258, Length=309, Percent_Identity=24.2718446601942, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320033, Length=367, Percent_Identity=26.7029972752044, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17737895, Length=363, Percent_Identity=26.7217630853994, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17137530, Length=211, Percent_Identity=27.4881516587678, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17737897, Length=211, Percent_Identity=27.4881516587678, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 37644; Mature: 37512

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVKAWAAPAAGAPLVPHTIERRDVGERDVLIDIAYCGVCHSDIHQARDEWGGAAFPMV
CCCCCCCCCCCCCCCCCCCCCHHCCCCCCCEEEEEHHHHCHHHHHHHHHHHHCCEECCCC
PGHEIVGRVARVGAKVTRFRPGDHAGVGCLVDSCRTCDPCRRDLEQFCERGPAWTYNSTE
CCHHHHHHHHHHCCHHEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCC
MDRRTPTHGGYSKQVVVTEDFALKVAPSLDLAAAAPLLCAGITTYSPLRHWKVGPGQQVG
CCCCCCCCCCCCCEEEEECCCEEEECCCCCHHHHHHHHHHCCHHCCCHHHCCCCCCCEEE
VVGLGGLGHMAVKLAAAMGAEVTMLSTSPRKEADARRLGASGFALTSDDATFRRLRNRFD
EEEECCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCCEEECCCHHHHHHHHHHH
FILDTISAPHDYDRYLGMVKVDGAMVLVGVPPERIPLHAHSLIGGRRTLAGSLIGGIAET
HHHHHHCCCCCHHHHCCEEEECCEEEEEECCCCCCCCHHHHHHCCHHHHHHHHHHHHHHH
QEMLDFCAEKQVVSDVEVIPIEKINEAYERMIRGDVRYRFVIDLASL
HHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHCCCEEEEEEEECCC
>Mature Secondary Structure 
TQVKAWAAPAAGAPLVPHTIERRDVGERDVLIDIAYCGVCHSDIHQARDEWGGAAFPMV
CCCCCCCCCCCCCCCCCCCCHHCCCCCCCEEEEEHHHHCHHHHHHHHHHHHCCEECCCC
PGHEIVGRVARVGAKVTRFRPGDHAGVGCLVDSCRTCDPCRRDLEQFCERGPAWTYNSTE
CCHHHHHHHHHHCCHHEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCC
MDRRTPTHGGYSKQVVVTEDFALKVAPSLDLAAAAPLLCAGITTYSPLRHWKVGPGQQVG
CCCCCCCCCCCCCEEEEECCCEEEECCCCCHHHHHHHHHHCCHHCCCHHHCCCCCCCEEE
VVGLGGLGHMAVKLAAAMGAEVTMLSTSPRKEADARRLGASGFALTSDDATFRRLRNRFD
EEEECCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCCEEECCCHHHHHHHHHHH
FILDTISAPHDYDRYLGMVKVDGAMVLVGVPPERIPLHAHSLIGGRRTLAGSLIGGIAET
HHHHHHCCCCCHHHHCCEEEECCEEEEEECCCCCCCCHHHHHHCCHHHHHHHHHHHHHHH
QEMLDFCAEKQVVSDVEVIPIEKINEAYERMIRGDVRYRFVIDLASL
HHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11257547 [H]