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The map label for this gene is ntrY [H]

Identifier: 220916306

GI number: 220916306

Start: 1343928

End: 1345505

Strand: Reverse

Name: ntrY [H]

Synonym: A2cp1_1199

Alternate gene names: 220916306

Gene position: 1345505-1343928 (Counterclockwise)

Preceding gene: 220916307

Following gene: 220916305

Centisome position: 26.75

GC content: 76.55

Gene sequence:

>1578_bases
ATGAGCGCCCCCGGCCGCGCCCCCGCGCCCGCGGGCACCGCCGCGCCGGGCCGCCTCCGCCGGCTGCTCGGCCACCTGCG
CATGTCGCGCTTCGAGGCGCGCATCACGCTCGCGCTGGTGATCGCGGCCAGCCTCCCGCCGCTCGGGGCCATCCTGCTCG
CCGGGCGGCTCGCCGAGGAGAACCTGACGCTCGGGCTCGACCCGCGGGTGGTGGACCGCCTGGAGTCGATCCCGTCGCTC
TACGGCGACCTGTTCCAGGCGCGCAAGGCGCTCTACGCCGAGCAGGCGCGCGCGCTCGCCCGCGGGCTCCCGCGCGATCC
CGCCGCCGGCTCCGCCTACCTGGCGAGCGCCCTGGAGCGGACCCCGCGGCTGCGGCGGGTGATCTGGACCGGCCCCGACG
GCCAGGTGGTGAGCGAGGCCGAGACGCAGGCGCCGAACCCAGAGGGCGAGTGGCGCGAGGCGCCGGCGCGGGTGGGCCTG
CCCGGCGGCGGCCAGCTCGAGTGCGTGTTCGCGATCGAGGCCCGCTACTTCGCCGAGGTGGCGGAGTCCCGCGAGCTGGC
GGAGCTGGTGCAGAACGTGGAGCGGCTCCAGGCGGAGATCCGGCGCAGCTACGTGCGCGCGTTCGGGCTGCTGCTGGTGG
CCTGGGCGGTGGTGGCCGCCGGGGTGGGCTTCTGGCTGGCGCGGCGGACCACCCGGCGCGTGTCCGACCTGGTGCGCGCG
GTCCGGCGGCTCGCGGCCGGCGACCTCGCGGTGCAGGTGGACCCGGGCCGCCACGTCGACGAGGTGGCCGGGCTGGCGCG
CGCGTTCAACGCGATGGTGCGCGAGGTGCGCGAGAGCCGCGACCGCATCGTGTACCTGGAGAAGATCTCCGGGTGGCAGG
AGGTGGCGCGCCGGCTGGCCCACGAGATCAAGAACCCGCTCACGCCCATGCAGCTCGCCTTCCAGCAGCTCGAGGCGCGC
TGGAAGGCGACGCCCGGCGGCGACCCGGCGTTCGGGAGGCTGCTCGCGGACGCCGGCGAGATCGTGCGCGAGGAGATCGG
CACGCTGCAGCGCCTGGTGGAGGAGTTCTCCGGCTTCGCCAAGCTGCCGCAGGTGCGGCCCGAGCCGTCCGACCTGGGCG
AGTTCGTGGAGGAGTTCGTGCGCACCAGCCCGCAGATCGCCGAGGCGGCGGACGTGGACGTGGTCCGCGCCAGCCCCAGC
TGCCCGGTGGGGCTCGACCGCGCGCTCATGCGCCGCGTGCTCGCGAACCTGTGCGCGAACGCGGTCGAGGCGGCGCGGCC
CGGGCGCGCCCGCATCCACCTCGGGGTGGCCCGTACCCGCGACCGGGCGGTGCTGACGGTCGCGGACGAGGGGCCGGGGA
TCGAGCGCGACCTGCGCGAGCGGATCTTCGACCCCTACTTCACCACCAAGGGCACCGGGACCGGCCTCGGCCTCGCCATC
GTGAAGAAGATCGTCCTGCAGCACGGCGGGGAGATCCAGGCCGGGGAGCGGCCCGGGGGCGGCGCGTCCTTCACCGTCGC
GCTGCCGCTCGCCGCGCCGGGCGATTCGCCGGGCGCGGCCAGGGCGCTGCGCGGTTAG

Upstream 100 bases:

>100_bases
TCGGGGCGGTGGCGAGCTTCCTGCTCCGCGACCCGGACCCCGGCACCGACGTGCGCCTGCTCCGCTCGGCCCCGTTCAGC
CTCGCCCAGGTGAGCGTCCG

Downstream 100 bases:

>100_bases
AATCCGCGCCATGCCCTACGACCTGACCGACCGCCTCGCCCTCGTCACCGGCGCGACCTCCGGCATCGGCGCCGCCTGCG
TGGACGCGCTCGTCGGCGCC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MSAPGRAPAPAGTAAPGRLRRLLGHLRMSRFEARITLALVIAASLPPLGAILLAGRLAEENLTLGLDPRVVDRLESIPSL
YGDLFQARKALYAEQARALARGLPRDPAAGSAYLASALERTPRLRRVIWTGPDGQVVSEAETQAPNPEGEWREAPARVGL
PGGGQLECVFAIEARYFAEVAESRELAELVQNVERLQAEIRRSYVRAFGLLLVAWAVVAAGVGFWLARRTTRRVSDLVRA
VRRLAAGDLAVQVDPGRHVDEVAGLARAFNAMVREVRESRDRIVYLEKISGWQEVARRLAHEIKNPLTPMQLAFQQLEAR
WKATPGGDPAFGRLLADAGEIVREEIGTLQRLVEEFSGFAKLPQVRPEPSDLGEFVEEFVRTSPQIAEAADVDVVRASPS
CPVGLDRALMRRVLANLCANAVEAARPGRARIHLGVARTRDRAVLTVADEGPGIERDLRERIFDPYFTTKGTGTGLGLAI
VKKIVLQHGGEIQAGERPGGGASFTVALPLAAPGDSPGAARALRG

Sequences:

>Translated_525_residues
MSAPGRAPAPAGTAAPGRLRRLLGHLRMSRFEARITLALVIAASLPPLGAILLAGRLAEENLTLGLDPRVVDRLESIPSL
YGDLFQARKALYAEQARALARGLPRDPAAGSAYLASALERTPRLRRVIWTGPDGQVVSEAETQAPNPEGEWREAPARVGL
PGGGQLECVFAIEARYFAEVAESRELAELVQNVERLQAEIRRSYVRAFGLLLVAWAVVAAGVGFWLARRTTRRVSDLVRA
VRRLAAGDLAVQVDPGRHVDEVAGLARAFNAMVREVRESRDRIVYLEKISGWQEVARRLAHEIKNPLTPMQLAFQQLEAR
WKATPGGDPAFGRLLADAGEIVREEIGTLQRLVEEFSGFAKLPQVRPEPSDLGEFVEEFVRTSPQIAEAADVDVVRASPS
CPVGLDRALMRRVLANLCANAVEAARPGRARIHLGVARTRDRAVLTVADEGPGIERDLRERIFDPYFTTKGTGTGLGLAI
VKKIVLQHGGEIQAGERPGGGASFTVALPLAAPGDSPGAARALRG
>Mature_524_residues
SAPGRAPAPAGTAAPGRLRRLLGHLRMSRFEARITLALVIAASLPPLGAILLAGRLAEENLTLGLDPRVVDRLESIPSLY
GDLFQARKALYAEQARALARGLPRDPAAGSAYLASALERTPRLRRVIWTGPDGQVVSEAETQAPNPEGEWREAPARVGLP
GGGQLECVFAIEARYFAEVAESRELAELVQNVERLQAEIRRSYVRAFGLLLVAWAVVAAGVGFWLARRTTRRVSDLVRAV
RRLAAGDLAVQVDPGRHVDEVAGLARAFNAMVREVRESRDRIVYLEKISGWQEVARRLAHEIKNPLTPMQLAFQQLEARW
KATPGGDPAFGRLLADAGEIVREEIGTLQRLVEEFSGFAKLPQVRPEPSDLGEFVEEFVRTSPQIAEAADVDVVRASPSC
PVGLDRALMRRVLANLCANAVEAARPGRARIHLGVARTRDRAVLTVADEGPGIERDLRERIFDPYFTTKGTGTGLGLAIV
KKIVLQHGGEIQAGERPGGGASFTVALPLAAPGDSPGAARALRG

Specific function: Member of the two-component regulatory system ntrY/ntrX involved in nitrogen level control. Probably activates ntrX by phosphorylation [H]

COG id: COG5000

COG function: function code T; Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=242, Percent_Identity=30.5785123966942, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1790436, Length=240, Percent_Identity=30.4166666666667, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788393, Length=299, Percent_Identity=28.0936454849498, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789808, Length=297, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1787894, Length=321, Percent_Identity=26.791277258567, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790300, Length=254, Percent_Identity=31.496062992126, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790346, Length=103, Percent_Identity=38.8349514563107, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786912, Length=222, Percent_Identity=30.6306306306306, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1786783, Length=287, Percent_Identity=26.1324041811847, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788713, Length=286, Percent_Identity=24.1258741258741, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI145693157, Length=121, Percent_Identity=38.0165289256198, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI87082128, Length=255, Percent_Identity=27.4509803921569, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR017232 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56714; Mature: 56583

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPGRAPAPAGTAAPGRLRRLLGHLRMSRFEARITLALVIAASLPPLGAILLAGRLAEE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
NLTLGLDPRVVDRLESIPSLYGDLFQARKALYAEQARALARGLPRDPAAGSAYLASALER
CCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
TPRLRRVIWTGPDGQVVSEAETQAPNPEGEWREAPARVGLPGGGQLECVFAIEARYFAEV
CHHHHEEEEECCCCCEECCHHHCCCCCCCCHHCCCCCCCCCCCCCEEEEEEHHHHHHHHH
AESRELAELVQNVERLQAEIRRSYVRAFGLLLVAWAVVAAGVGFWLARRTTRRVSDLVRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRRLAAGDLAVQVDPGRHVDEVAGLARAFNAMVREVRESRDRIVYLEKISGWQEVARRLA
HHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHCCHHHHHHHHH
HEIKNPLTPMQLAFQQLEARWKATPGGDPAFGRLLADAGEIVREEIGTLQRLVEEFSGFA
HHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLPQVRPEPSDLGEFVEEFVRTSPQIAEAADVDVVRASPSCPVGLDRALMRRVLANLCAN
HCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHH
AVEAARPGRARIHLGVARTRDRAVLTVADEGPGIERDLRERIFDPYFTTKGTGTGLGLAI
HHHHCCCCCCEEEEEEEECCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHH
VKKIVLQHGGEIQAGERPGGGASFTVALPLAAPGDSPGAARALRG
HHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHCCCC
>Mature Secondary Structure 
SAPGRAPAPAGTAAPGRLRRLLGHLRMSRFEARITLALVIAASLPPLGAILLAGRLAEE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
NLTLGLDPRVVDRLESIPSLYGDLFQARKALYAEQARALARGLPRDPAAGSAYLASALER
CCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
TPRLRRVIWTGPDGQVVSEAETQAPNPEGEWREAPARVGLPGGGQLECVFAIEARYFAEV
CHHHHEEEEECCCCCEECCHHHCCCCCCCCHHCCCCCCCCCCCCCEEEEEEHHHHHHHHH
AESRELAELVQNVERLQAEIRRSYVRAFGLLLVAWAVVAAGVGFWLARRTTRRVSDLVRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRRLAAGDLAVQVDPGRHVDEVAGLARAFNAMVREVRESRDRIVYLEKISGWQEVARRLA
HHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHCCHHHHHHHHH
HEIKNPLTPMQLAFQQLEARWKATPGGDPAFGRLLADAGEIVREEIGTLQRLVEEFSGFA
HHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLPQVRPEPSDLGEFVEEFVRTSPQIAEAADVDVVRASPSCPVGLDRALMRRVLANLCAN
HCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHH
AVEAARPGRARIHLGVARTRDRAVLTVADEGPGIERDLRERIFDPYFTTKGTGTGLGLAI
HHHHCCCCCCEEEEEEEECCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHH
VKKIVLQHGGEIQAGERPGGGASFTVALPLAAPGDSPGAARALRG
HHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1661370 [H]