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The map label for this gene is atoC [H]

Identifier: 220916290

GI number: 220916290

Start: 1324011

End: 1325456

Strand: Reverse

Name: atoC [H]

Synonym: A2cp1_1183

Alternate gene names: 220916290

Gene position: 1325456-1324011 (Counterclockwise)

Preceding gene: 220916291

Following gene: 220916288

Centisome position: 26.35

GC content: 72.34

Gene sequence:

>1446_bases
ATGGACCCGACCAAGGCGAGCATCCTGGTGGTGGACGACGAGCGGAACATCCGGCGCACGCTGCGGATGGTGCTCGAGGC
CGAGGGCTACGCGGTGCTGGAGGCCGAGAGCGCCGAGCAGGGGCTGGAGGTGCTCCAGTCCGAGCCGGTGGACCTCGGCG
TCTTCGACATCCGCCTCCCCGGCATGGACGGCCTGACCCTGCTCTCGCGCGCCCGCGAGCTGTGGCGCGACCTGCCGGTC
ATCATGATCTCCGGCCACGCCGACACGAGCGACGTGGTGGACGCGGTGAAGCGCGGGGCGACCGACTTCTTCTCCAAGCC
GGTGGACCGCGACCGCGTCCTCGTCTCGGTGCGCAACGCGCTCTCGCGCCGCGACCTCGAGGGCAAGGTCCAGGCGCTCT
CCGCGCGCGAGCGCCGCTTCTCCGACGACATGCTGGGCGAGAGCCCCGCCATGCGGAAGCTGCGGGAGGACATCGGGAAG
GTGGCGCCCACCAGCGGCCGCGTGCTGGTCCTGGGCGAGTCCGGCACCGGCAAGGAGCTGGTCGCGGCCGAGGTGCACCG
TCAGTCGAGGCGCGCCGACGGGCCGTTCGTGAAGGTGAACTGCGCGGCCATCCCCTCCGAGCTCATCGAGTCGGAGCTGT
TCGGCCACGAGAAGGGCAGCTTCTCCGGCGCCGCGGCGCGCCGGCGCGGCCAGTTCGAGGTGGCGCACGGCGGCACGCTG
TTCCTCGACGAGATCGGCGACATGGGGCTGTCGGCCCAGGCCAAGGTGCTCCGCGCGCTCCAGACCGGCGAGGTGGTCCG
GGTCGGCAGCGAGAAGGCGTTCACGGTGGACGTCCGGATCATCGCCGCGACGAACAAGGACCTGGAGGAGGAGGTGCGGA
ACGGCACGTTCCGCGAGGACCTGTTCTTCCGCCTCAACGTCGTGCCGCTCACGGTGCCGCCGCTCCGCGACCGGCTCGAC
GACGTGCCGGTGCTCGCCGAGCGCTTCTTCCAGCTCGCCACCCGCGAGAACGGCCTGCGCCCGAAGCCGGTGGACCCCGC
CGTCTACGACCGGCTGAGGCAGCACCGCTGGCCCGGCAACGTCCGCGAGCTCCGCAACGTGTGCGAGCGGATGGTGATCA
TGAGCGGCGAGCGCATCACCGCCGCCGACGTCCCGGAGACGGTCGGCCCGCGCGCCGCGCCGCCCCCGCCCCCCGGCTCC
GCCGACCTGTCCCGCTACGGCGAGGTGCCGCTGAAGGAGCTCCGCGACCTGGTCGAGCGCGACTACATCCTTTCGCGGCT
CGAGGAGCACGACTGGAACATCACCCAGGCCGCGCAGGCGCTCGGCGTCGAGCGCACCAACCTCCACAAGAAGATCAAGC
AGCACGGGCTCTCTCGCGCCGGCCGCGCGCCGCCGAGGGAGGAGGTCGAGCCCGACGAGGGCGGCGAGGGAAACGCGGAG
GGCTGA

Upstream 100 bases:

>100_bases
GCTCGCTCGTGATCCTGGCCCGGCCCGCCGAGGTGTGACGGCGCCTCCGCCGCGCGCGGCGCGGGCGTCCCGGGCCGAGG
TCGCCTATGATCGCGCCCGC

Downstream 100 bases:

>100_bases
CGAGGGCTACGGGAGCCGATCCGCCGGCTTCCCCGCCCGCTTCTCGGCGAGGCAGCGCTGCAGCGCCGCGTCTCCGGTCC
AGCCGCAGGCCCCGTCCGCC

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MDPTKASILVVDDERNIRRTLRMVLEAEGYAVLEAESAEQGLEVLQSEPVDLGVFDIRLPGMDGLTLLSRARELWRDLPV
IMISGHADTSDVVDAVKRGATDFFSKPVDRDRVLVSVRNALSRRDLEGKVQALSARERRFSDDMLGESPAMRKLREDIGK
VAPTSGRVLVLGESGTGKELVAAEVHRQSRRADGPFVKVNCAAIPSELIESELFGHEKGSFSGAAARRRGQFEVAHGGTL
FLDEIGDMGLSAQAKVLRALQTGEVVRVGSEKAFTVDVRIIAATNKDLEEEVRNGTFREDLFFRLNVVPLTVPPLRDRLD
DVPVLAERFFQLATRENGLRPKPVDPAVYDRLRQHRWPGNVRELRNVCERMVIMSGERITAADVPETVGPRAAPPPPPGS
ADLSRYGEVPLKELRDLVERDYILSRLEEHDWNITQAAQALGVERTNLHKKIKQHGLSRAGRAPPREEVEPDEGGEGNAE
G

Sequences:

>Translated_481_residues
MDPTKASILVVDDERNIRRTLRMVLEAEGYAVLEAESAEQGLEVLQSEPVDLGVFDIRLPGMDGLTLLSRARELWRDLPV
IMISGHADTSDVVDAVKRGATDFFSKPVDRDRVLVSVRNALSRRDLEGKVQALSARERRFSDDMLGESPAMRKLREDIGK
VAPTSGRVLVLGESGTGKELVAAEVHRQSRRADGPFVKVNCAAIPSELIESELFGHEKGSFSGAAARRRGQFEVAHGGTL
FLDEIGDMGLSAQAKVLRALQTGEVVRVGSEKAFTVDVRIIAATNKDLEEEVRNGTFREDLFFRLNVVPLTVPPLRDRLD
DVPVLAERFFQLATRENGLRPKPVDPAVYDRLRQHRWPGNVRELRNVCERMVIMSGERITAADVPETVGPRAAPPPPPGS
ADLSRYGEVPLKELRDLVERDYILSRLEEHDWNITQAAQALGVERTNLHKKIKQHGLSRAGRAPPREEVEPDEGGEGNAE
G
>Mature_481_residues
MDPTKASILVVDDERNIRRTLRMVLEAEGYAVLEAESAEQGLEVLQSEPVDLGVFDIRLPGMDGLTLLSRARELWRDLPV
IMISGHADTSDVVDAVKRGATDFFSKPVDRDRVLVSVRNALSRRDLEGKVQALSARERRFSDDMLGESPAMRKLREDIGK
VAPTSGRVLVLGESGTGKELVAAEVHRQSRRADGPFVKVNCAAIPSELIESELFGHEKGSFSGAAARRRGQFEVAHGGTL
FLDEIGDMGLSAQAKVLRALQTGEVVRVGSEKAFTVDVRIIAATNKDLEEEVRNGTFREDLFFRLNVVPLTVPPLRDRLD
DVPVLAERFFQLATRENGLRPKPVDPAVYDRLRQHRWPGNVRELRNVCERMVIMSGERITAADVPETVGPRAAPPPPPGS
ADLSRYGEVPLKELRDLVERDYILSRLEEHDWNITQAAQALGVERTNLHKKIKQHGLSRAGRAPPREEVEPDEGGEGNAE
G

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=458, Percent_Identity=43.2314410480349, Blast_Score=353, Evalue=2e-98,
Organism=Escherichia coli, GI1790299, Length=465, Percent_Identity=41.505376344086, Blast_Score=335, Evalue=4e-93,
Organism=Escherichia coli, GI1790437, Length=457, Percent_Identity=42.0131291028446, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI1788905, Length=459, Percent_Identity=37.2549019607843, Blast_Score=299, Evalue=3e-82,
Organism=Escherichia coli, GI1789233, Length=326, Percent_Identity=42.9447852760736, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI87082117, Length=366, Percent_Identity=41.5300546448087, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI87082152, Length=324, Percent_Identity=43.2098765432099, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI1789087, Length=365, Percent_Identity=38.9041095890411, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI87081872, Length=330, Percent_Identity=38.7878787878788, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1786524, Length=345, Percent_Identity=39.1304347826087, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1787583, Length=335, Percent_Identity=37.0149253731343, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI87081858, Length=320, Percent_Identity=31.25, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI1789828, Length=283, Percent_Identity=34.2756183745583, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1786911, Length=183, Percent_Identity=30.6010928961749, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790863, Length=116, Percent_Identity=34.4827586206897, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789809, Length=117, Percent_Identity=34.1880341880342, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787229, Length=124, Percent_Identity=33.0645161290323, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786599, Length=164, Percent_Identity=30.4878048780488, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786747, Length=124, Percent_Identity=30.6451612903226, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788394, Length=175, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787375, Length=177, Percent_Identity=28.8135593220339, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53237; Mature: 53237

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4 ; PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPTKASILVVDDERNIRRTLRMVLEAEGYAVLEAESAEQGLEVLQSEPVDLGVFDIRLP
CCCCCEEEEEEECCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCEEEEEEEEC
GMDGLTLLSRARELWRDLPVIMISGHADTSDVVDAVKRGATDFFSKPVDRDRVLVSVRNA
CCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHH
LSRRDLEGKVQALSARERRFSDDMLGESPAMRKLREDIGKVAPTSGRVLVLGESGTGKEL
HHHCCCHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHH
VAAEVHRQSRRADGPFVKVNCAAIPSELIESELFGHEKGSFSGAAARRRGQFEVAHGGTL
HHHHHHHHHHCCCCCEEEEEHHHCCHHHHHHHHHCCCCCCCCCHHHHCCCCEEEECCCEE
FLDEIGDMGLSAQAKVLRALQTGEVVRVGSEKAFTVDVRIIAATNKDLEEEVRNGTFRED
EEEHHCCCCCCHHHHHHHHHHCCCEEEECCCCEEEEEEEEEEECCCCHHHHHHCCCCHHC
LFFRLNVVPLTVPPLRDRLDDVPVLAERFFQLATRENGLRPKPVDPAVYDRLRQHRWPGN
CEEEEEEEEEECCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCC
VRELRNVCERMVIMSGERITAADVPETVGPRAAPPPPPGSADLSRYGEVPLKELRDLVER
HHHHHHHHHHHHHHCCCEEEECCCCHHCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHH
DYILSRLEEHDWNITQAAQALGVERTNLHKKIKQHGLSRAGRAPPREEVEPDEGGEGNAE
HHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
G
C
>Mature Secondary Structure
MDPTKASILVVDDERNIRRTLRMVLEAEGYAVLEAESAEQGLEVLQSEPVDLGVFDIRLP
CCCCCEEEEEEECCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCEEEEEEEEC
GMDGLTLLSRARELWRDLPVIMISGHADTSDVVDAVKRGATDFFSKPVDRDRVLVSVRNA
CCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHH
LSRRDLEGKVQALSARERRFSDDMLGESPAMRKLREDIGKVAPTSGRVLVLGESGTGKEL
HHHCCCHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHH
VAAEVHRQSRRADGPFVKVNCAAIPSELIESELFGHEKGSFSGAAARRRGQFEVAHGGTL
HHHHHHHHHHCCCCCEEEEEHHHCCHHHHHHHHHCCCCCCCCCHHHHCCCCEEEECCCEE
FLDEIGDMGLSAQAKVLRALQTGEVVRVGSEKAFTVDVRIIAATNKDLEEEVRNGTFRED
EEEHHCCCCCCHHHHHHHHHHCCCEEEECCCCEEEEEEEEEEECCCCHHHHHHCCCCHHC
LFFRLNVVPLTVPPLRDRLDDVPVLAERFFQLATRENGLRPKPVDPAVYDRLRQHRWPGN
CEEEEEEEEEECCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCC
VRELRNVCERMVIMSGERITAADVPETVGPRAAPPPPPGSADLSRYGEVPLKELRDLVER
HHHHHHHHHHHHHHCCCEEEECCCCHHCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHH
DYILSRLEEHDWNITQAAQALGVERTNLHKKIKQHGLSRAGRAPPREEVEPDEGGEGNAE
HHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]