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The map label for this gene is clpA [C]

Identifier: 220915955

GI number: 220915955

Start: 943509

End: 945791

Strand: Reverse

Name: clpA [C]

Synonym: A2cp1_0841

Alternate gene names: 220915955

Gene position: 945791-943509 (Counterclockwise)

Preceding gene: 220915956

Following gene: 220915953

Centisome position: 18.81

GC content: 70.87

Gene sequence:

>2283_bases
ATGGTGACGGTGTCCAAGGAGCTGCAGCAGACCCTCCAGGCCGCGGTGGGCGAGGCCCGCCGCCGGCGCCACGAGTACGT
GACGCTGGAGCACCTGCTCCACGCCATGACCAAGGACAAGGTCGCGTCCGAGGTGCTGCTCGCCTGCGGCGCCGACCTGA
AGCTGCTCGAGCGCGAGCTGGAGGAGTACCTCGACCGGACGCTCGAGTCGGTGGCCGCCGGCCAGGATCCCGAGCAGACC
GCCGCGTTCCAGCGGGTGCTGCAGCGCGCCGCCTGGCACGTGCAGGGGTCGGGCCGCACCGAGCTGAACGCCGGCGACGT
GCTCGTCGCCATCACGCGCGAGCGCGGCTCGCACGCGGTCTACCTGCTCGAGAAGCAGGGCGTCCGCCGCCTCGACATCC
TCCAGTACATCTCCCACGGCGTGAGCAAGGACGGCGAGGACTCGCCGGGCGGCGCCGAGGGCGAGGGCGACGGCGACGAG
GGCGCCCCGCGCCCGGTGAAGGATCCGTTCCGCACGTTCACGGTGAACCTGGTCGAGCGCGCCGCGCAGGGTCAGATCGA
CCCGCTCATCGGCCGCGACGCCGAGATCGAGCGGACCATCCAGGTGCTCTGCCGCCGCCGCAAGAACAACCCGGTGTTCG
TGGGCGAGCCGGGCGTGGGCAAGACCGCCATCGTCGAGGGCCTGGCGCTCCGCATCCACGAGAAGCAGGTCCCGGCGGTC
CTGGAGAAGGCGGCGATCTACTCGCTCGACATGGGCGCGCTGCTCGCCGGCACCAAGTTCCGCGGCGAGTTCGAGCAGCG
GCTGAAGGGCGTCATCGCCGGGGTGAAGAAGACCCCCAACGCCATCCTGTTCATCGACGAGATCCACACCATCGTCGGCG
CCGGCGCCACCACCGGCTCCTCGATGGACGCGTCGAACCTCCTCAAGCCGGCGCTCGCCTCGGGCGAGCTGCGCTGCATC
GGCTCGACCACGTTCCACGACTACAAGCAGACGTTCGAGCGCGACCACGCGCTCGCCCGCCGCTTCCAGAAGATCGAGGT
CCACGAGCCCTCGGTCGAGGACACGGTCAAGATCCTGCGCGGCCTGAAGAAGGTCTACGAGGAGCACCACGGCGTGGAGT
ACACGCCGCGCGCGCTCCGGGCCGCCGCCGAGCTGTCGGCGAAGCACATCAACGACCGGCAGCTGCCGGACAAAGCCATC
GACGTGCTCGACGAGGCCGGCGCGCGCGACCGGATGCGCCCGGAGGCCCGGCGGCACCGCCGCATCACCGGCCGCGACGT
GGAGCGGGTGGTCGCGAAGATCGCCAAGATCCCCGAGCGCACCGTCTCGGCGGACGACCAGGCGCAGCTCCGCAGCCTCG
TGCCCGAGCTGCGGAAGGTCATCTACGGGCAGGACCAGGCCATCGACGCCATCGCCAGCGCCATCAAGCTCTCGCGCTCG
GGCCTGGCGTCGCCCGAGAAGCCCATCGGCAGCTTCCTGTTCTCCGGGCCCACCGGAGTGGGCAAGACCGAGCTGGCGAA
GCAGCTCGCCCGCATCCTCGGGGTCGAGTTCCTGCGCTTCGACATGACCGAGTACCAGGAGAAGCACACGGTCTCCCGGC
TCATCGGCGCGCCCCCGGGCTACGTGGGCTTCGACCAGGGCGGCCTGCTCACCGACGCGATCCGCAAGACGCCGTACGCG
GTGCTGCTGCTCGACGAGATCGAGAAGGCCCACCCGGACATCTACAACCTGCTGCTCCAGGTGATGGATCACGCCACGCT
CACCGACAACAACGGGCGCAAGGCCGACTTCCGCCACGTGGTGCTGGTGATGACCACTAACGCCGGCGCGCACGAGCTGG
CCGCCCGCCGCGTCGGCTTCGGGACCGACCAGTCGGATCCGGGCAACGCGCGCAACGCCATCGAGCGCACCTTCACGCCC
GAGTTCCGCAACCGGCTCGACGCGTGGGTGGCGTTCGACTCGCTCGCCCCCGAGGTGATCCTGCGGGTGGTGGACAAGAT
GGTGAAGGAGCTGGAGGGGCAGCTCGCGGAGAAGAAGGTCCGCATCGAGCTGACCGCCGAGGGCCGGGCCTGGCTCGCCG
AGCACGGCTTCGACCGCAAGATGGGCGCCCGCCCCATGGCGCGGCTCATCCAGAACGAGCTGAAGAAGCCGCTCGCCGAG
CGGATCCTGTTCGGCGACCTCGCCGCCGGCGGCACGGTCCGCGTGGACGTGGACGCGGAGGGCGCGAAGCTGGTGCTGAC
GGTCGCCGCCCCGGCGCCGAAGCCGGTGCCCGAGCCGGCGTAG

Upstream 100 bases:

>100_bases
TCTATCCCTACGAGATCGCCGAGACGAAGGCGCGGAAGACGATGGACCTGGCGCGCGAGGCGGAATACCCGCTGCTCGTG
ACGATCGAGCCGGAGTAGCG

Downstream 100 bases:

>100_bases
CGCAGCTCGCGATCCGTGGATCGCACGCGAGCGAAGCGAGCCGCCGGGGCGCCGCCGCGCGCGCGGCGAAGCCGCCCGCG
GCTGCGCAGGGGACCCGGCG

Product: ATP-dependent Clp protease, ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 760; Mature: 760

Protein sequence:

>760_residues
MVTVSKELQQTLQAAVGEARRRRHEYVTLEHLLHAMTKDKVASEVLLACGADLKLLERELEEYLDRTLESVAAGQDPEQT
AAFQRVLQRAAWHVQGSGRTELNAGDVLVAITRERGSHAVYLLEKQGVRRLDILQYISHGVSKDGEDSPGGAEGEGDGDE
GAPRPVKDPFRTFTVNLVERAAQGQIDPLIGRDAEIERTIQVLCRRRKNNPVFVGEPGVGKTAIVEGLALRIHEKQVPAV
LEKAAIYSLDMGALLAGTKFRGEFEQRLKGVIAGVKKTPNAILFIDEIHTIVGAGATTGSSMDASNLLKPALASGELRCI
GSTTFHDYKQTFERDHALARRFQKIEVHEPSVEDTVKILRGLKKVYEEHHGVEYTPRALRAAAELSAKHINDRQLPDKAI
DVLDEAGARDRMRPEARRHRRITGRDVERVVAKIAKIPERTVSADDQAQLRSLVPELRKVIYGQDQAIDAIASAIKLSRS
GLASPEKPIGSFLFSGPTGVGKTELAKQLARILGVEFLRFDMTEYQEKHTVSRLIGAPPGYVGFDQGGLLTDAIRKTPYA
VLLLDEIEKAHPDIYNLLLQVMDHATLTDNNGRKADFRHVVLVMTTNAGAHELAARRVGFGTDQSDPGNARNAIERTFTP
EFRNRLDAWVAFDSLAPEVILRVVDKMVKELEGQLAEKKVRIELTAEGRAWLAEHGFDRKMGARPMARLIQNELKKPLAE
RILFGDLAAGGTVRVDVDAEGAKLVLTVAAPAPKPVPEPA

Sequences:

>Translated_760_residues
MVTVSKELQQTLQAAVGEARRRRHEYVTLEHLLHAMTKDKVASEVLLACGADLKLLERELEEYLDRTLESVAAGQDPEQT
AAFQRVLQRAAWHVQGSGRTELNAGDVLVAITRERGSHAVYLLEKQGVRRLDILQYISHGVSKDGEDSPGGAEGEGDGDE
GAPRPVKDPFRTFTVNLVERAAQGQIDPLIGRDAEIERTIQVLCRRRKNNPVFVGEPGVGKTAIVEGLALRIHEKQVPAV
LEKAAIYSLDMGALLAGTKFRGEFEQRLKGVIAGVKKTPNAILFIDEIHTIVGAGATTGSSMDASNLLKPALASGELRCI
GSTTFHDYKQTFERDHALARRFQKIEVHEPSVEDTVKILRGLKKVYEEHHGVEYTPRALRAAAELSAKHINDRQLPDKAI
DVLDEAGARDRMRPEARRHRRITGRDVERVVAKIAKIPERTVSADDQAQLRSLVPELRKVIYGQDQAIDAIASAIKLSRS
GLASPEKPIGSFLFSGPTGVGKTELAKQLARILGVEFLRFDMTEYQEKHTVSRLIGAPPGYVGFDQGGLLTDAIRKTPYA
VLLLDEIEKAHPDIYNLLLQVMDHATLTDNNGRKADFRHVVLVMTTNAGAHELAARRVGFGTDQSDPGNARNAIERTFTP
EFRNRLDAWVAFDSLAPEVILRVVDKMVKELEGQLAEKKVRIELTAEGRAWLAEHGFDRKMGARPMARLIQNELKKPLAE
RILFGDLAAGGTVRVDVDAEGAKLVLTVAAPAPKPVPEPA
>Mature_760_residues
MVTVSKELQQTLQAAVGEARRRRHEYVTLEHLLHAMTKDKVASEVLLACGADLKLLERELEEYLDRTLESVAAGQDPEQT
AAFQRVLQRAAWHVQGSGRTELNAGDVLVAITRERGSHAVYLLEKQGVRRLDILQYISHGVSKDGEDSPGGAEGEGDGDE
GAPRPVKDPFRTFTVNLVERAAQGQIDPLIGRDAEIERTIQVLCRRRKNNPVFVGEPGVGKTAIVEGLALRIHEKQVPAV
LEKAAIYSLDMGALLAGTKFRGEFEQRLKGVIAGVKKTPNAILFIDEIHTIVGAGATTGSSMDASNLLKPALASGELRCI
GSTTFHDYKQTFERDHALARRFQKIEVHEPSVEDTVKILRGLKKVYEEHHGVEYTPRALRAAAELSAKHINDRQLPDKAI
DVLDEAGARDRMRPEARRHRRITGRDVERVVAKIAKIPERTVSADDQAQLRSLVPELRKVIYGQDQAIDAIASAIKLSRS
GLASPEKPIGSFLFSGPTGVGKTELAKQLARILGVEFLRFDMTEYQEKHTVSRLIGAPPGYVGFDQGGLLTDAIRKTPYA
VLLLDEIEKAHPDIYNLLLQVMDHATLTDNNGRKADFRHVVLVMTTNAGAHELAARRVGFGTDQSDPGNARNAIERTFTP
EFRNRLDAWVAFDSLAPEVILRVVDKMVKELEGQLAEKKVRIELTAEGRAWLAEHGFDRKMGARPMARLIQNELKKPLAE
RILFGDLAAGGTVRVDVDAEGAKLVLTVAAPAPKPVPEPA

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=332, Percent_Identity=30.7228915662651, Blast_Score=157, Evalue=3e-38,
Organism=Escherichia coli, GI1787109, Length=746, Percent_Identity=56.0321715817694, Blast_Score=848, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=417, Percent_Identity=45.083932853717, Blast_Score=314, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6320464, Length=335, Percent_Identity=45.3731343283582, Blast_Score=293, Evalue=6e-80,
Organism=Saccharomyces cerevisiae, GI6323002, Length=237, Percent_Identity=50.210970464135, Blast_Score=244, Evalue=4e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83624; Mature: 83624

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTVSKELQQTLQAAVGEARRRRHEYVTLEHLLHAMTKDKVASEVLLACGADLKLLEREL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EEYLDRTLESVAAGQDPEQTAAFQRVLQRAAWHVQGSGRTELNAGDVLVAITRERGSHAV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEEEEEEECCCCEEE
YLLEKQGVRRLDILQYISHGVSKDGEDSPGGAEGEGDGDEGAPRPVKDPFRTFTVNLVER
EEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AAQGQIDPLIGRDAEIERTIQVLCRRRKNNPVFVGEPGVGKTAIVEGLALRIHEKQVPAV
HHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHH
LEKAAIYSLDMGALLAGTKFRGEFEQRLKGVIAGVKKTPNAILFIDEIHTIVGAGATTGS
HHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCC
SMDASNLLKPALASGELRCIGSTTFHDYKQTFERDHALARRFQKIEVHEPSVEDTVKILR
CCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
GLKKVYEEHHGVEYTPRALRAAAELSAKHINDRQLPDKAIDVLDEAGARDRMRPEARRHR
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHC
RITGRDVERVVAKIAKIPERTVSADDQAQLRSLVPELRKVIYGQDQAIDAIASAIKLSRS
CCCCCHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GLASPEKPIGSFLFSGPTGVGKTELAKQLARILGVEFLRFDMTEYQEKHTVSRLIGAPPG
CCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YVGFDQGGLLTDAIRKTPYAVLLLDEIEKAHPDIYNLLLQVMDHATLTDNNGRKADFRHV
CCCCCCCCCHHHHHHHCCEEEEEHHHHHHHCCHHHHHHHHHHHCCEECCCCCCCCCCEEE
VLVMTTNAGAHELAARRVGFGTDQSDPGNARNAIERTFTPEFRNRLDAWVAFDSLAPEVI
EEEEECCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LRVVDKMVKELEGQLAEKKVRIELTAEGRAWLAEHGFDRKMGARPMARLIQNELKKPLAE
HHHHHHHHHHHHHHHHCCEEEEEEEECCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
RILFGDLAAGGTVRVDVDAEGAKLVLTVAAPAPKPVPEPA
HHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MVTVSKELQQTLQAAVGEARRRRHEYVTLEHLLHAMTKDKVASEVLLACGADLKLLEREL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EEYLDRTLESVAAGQDPEQTAAFQRVLQRAAWHVQGSGRTELNAGDVLVAITRERGSHAV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEEEEEEECCCCEEE
YLLEKQGVRRLDILQYISHGVSKDGEDSPGGAEGEGDGDEGAPRPVKDPFRTFTVNLVER
EEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AAQGQIDPLIGRDAEIERTIQVLCRRRKNNPVFVGEPGVGKTAIVEGLALRIHEKQVPAV
HHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHH
LEKAAIYSLDMGALLAGTKFRGEFEQRLKGVIAGVKKTPNAILFIDEIHTIVGAGATTGS
HHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCC
SMDASNLLKPALASGELRCIGSTTFHDYKQTFERDHALARRFQKIEVHEPSVEDTVKILR
CCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
GLKKVYEEHHGVEYTPRALRAAAELSAKHINDRQLPDKAIDVLDEAGARDRMRPEARRHR
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHC
RITGRDVERVVAKIAKIPERTVSADDQAQLRSLVPELRKVIYGQDQAIDAIASAIKLSRS
CCCCCHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GLASPEKPIGSFLFSGPTGVGKTELAKQLARILGVEFLRFDMTEYQEKHTVSRLIGAPPG
CCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YVGFDQGGLLTDAIRKTPYAVLLLDEIEKAHPDIYNLLLQVMDHATLTDNNGRKADFRHV
CCCCCCCCCHHHHHHHCCEEEEEHHHHHHHCCHHHHHHHHHHHCCEECCCCCCCCCCEEE
VLVMTTNAGAHELAARRVGFGTDQSDPGNARNAIERTFTPEFRNRLDAWVAFDSLAPEVI
EEEEECCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LRVVDKMVKELEGQLAEKKVRIELTAEGRAWLAEHGFDRKMGARPMARLIQNELKKPLAE
HHHHHHHHHHHHHHHHCCEEEEEEEECCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
RILFGDLAAGGTVRVDVDAEGAKLVLTVAAPAPKPVPEPA
HHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]