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The map label for this gene is lcrD [H]

Identifier: 220915852

GI number: 220915852

Start: 829789

End: 831816

Strand: Reverse

Name: lcrD [H]

Synonym: A2cp1_0735

Alternate gene names: 220915852

Gene position: 831816-829789 (Counterclockwise)

Preceding gene: 220915853

Following gene: 220915843

Centisome position: 16.54

GC content: 78.85

Gene sequence:

>2028_bases
ATGATCCCCGTCCACGCCCTGCTCTCGCGCCTGCGCTCCTCCGGCGAGGCCCTGTTCGCGCTCGCCGTGCTGGGGCTGGT
GCTGCTGCTCGTCACCCCGCTCGCGCCCGCCGTGCTCGACCTGCTGCTCGCCACGAACCTGGCGGCGGCCGCCACGGTGC
TGGTGGTGACGCTGTTCGCCCGGGACGCGCTCCGGTTCGCGAGCTTCCCCACCCTGCTCCTGCTCACCACCCTGTTCCGC
CTCGCGCTCAACGTGAGCTCGACGCGGCTCGTGCTCTCGCGCGGCGAGGCCGGCCGGGTCATCGAGGCGTTCGGCCGGGT
GGTGGTCCAGGGAAACACGGTGGTCGGCGCGGTGGTGTTCGCGATCCTCACGCTGGTGCAGCTCCTGGTGGTGGCGAAGG
GCGCCGAGCGCGTCGCCGAGGTGGCGGCCCGCTTCACGCTCGACGCGCTCCCGGGCAAGCAGATGGCCATCGACGCCGAC
CTGCGCGCCGGGACGCTCGACGCGGGCGAGGCGCGGCGGCGGCGCCGGGCGCTGGAGCGGGAGAGCCAGCTCTACGGCGC
GATGGACGGCGCGCTCAAGTTCGTGAAGGGCGACGCGATCGCGGGCGTCGCGATCGTGATCGTCAACGTGGCGGGCGGCC
TCGTGGCCGGCATGCTGCGCGGCATGACGGCGGGCGACGCCGCGCGCCGGTACGCGCTGCTCGCCATCGGCGACGGGCTC
TCCTCGCAGATCCCGTCGCTGCTCGTCGCGGTCGCGGCCGGGATCGCGGTGACGCGGGTGGCGGGCGAGGAGGAGGGCGC
GACGCTCGGCGGCGAGATCGGGCGTCAGCTCCTCGCCGAGCCCGCGCCGCTCGCGGCGGTGGCGGCGCTGCTCGGCGCCC
TCGCGCTCGCGCCGGGGCTGCCGGCCGCGCCGTTCCTCGCGCTCGCCGGCGCCGGCGGCGCGGCGGCCTGGTGGATCGCG
CGGCGGGCGGCGCGCGCCCCGGCCCCGGCGACCGGAGCCTCGGTGGCGAGCGCGCCCGGTCCGTCCGGAGCGGACGCGGA
CGGCCCGGCGCCGCTCGCGCTGGAGCTCGCGGAAGATCTCCTCGCCGCGGCCGCCACGCCGGCCGGGCAGGAGGGGCTCG
CGGCGCTCCGCGAGACGGTGTGGCGCGCGCTCGGCGTCCGCACGCCGGCCATCGCGCTCCGGGCGGCCCCGCTGCCGGCG
GGCGGCCACCGCCTTCTCATCGACGAGATCCCGGCCGGCGGCGGCACCGCCCCCGCCGGTCAGGTGGTGGTCCTCGCCGC
GCCCGACGAGCTCGCGCTCGCGCGCATCGAGGCCGCGGTCGAGCGCGATCCCCTCTCCGGAAGGCCGGTGTCGGTGATCG
CGGAGGCGGACGCGCACCGCGCCCGCGCGCTGGGCGCGGTGCGCGGCCCGCTCGATCGCGCGCTCGCGGCCACCGCAGCG
GCGCTGCTCCGCCACGCGTCGCACCTCGTCGGCGTGCAGGAGGTGCAGGCGCTCCTCGATGGGCTCGAGCCCGGGGCGCC
CGCGCTGGTTCGCGAGGCGAGCCGGCAGCTCCCGCCCGCGCTGCTCGCGGAGGTGCTGCGGCGGCTGGTCGAGGAGGGCG
TCTCCATCCGGCCGCTGCGCACGATCCTGGAGGCGCTGCTCGAGGCGGGCGGCGCCGGGCGCGGGCCGGCCGCGCTGGCG
GAGTGCGCCCGGCGCGCGCTGCGTCGCCAGCTCGCGCACGCGCACGCGGGCGAGGGCCCGCTCGCCGCGCTGCTGCTGGA
TCCGGCCGCGGAGCAGGTGCTCCGCGAGGGGCTCGCAGGCGACGCGCTCGCCATCGACCCGCGGGTGGCCGCGGAGCTGA
TCGGACGCATCGGCGCCGAGGCGGAGCTTCAGGCAGCGCCGCCGGTGGTGCTGACCAGCGCCGACGTCCGACGGGCGCTC
CGCACCCTGCTCGCGCCCCGGCTCCCGGCCGTCGCGGTGCTCGCCTACGACGAGCTGCCTCCCGAGCTCACGGTCCGGCC
GCTCGGGCGCGTCGCGCTGGCGGCCTGA

Upstream 100 bases:

>100_bases
CCCTGCACCGCCTCGCCGAGGTCGGCGACGAGATCCCCGAGGCGCTCTACGAGGCCGCCGCCGCGGTCCTCGCACACCTG
TACGGCCTGGAGGCCCAGCC

Downstream 100 bases:

>100_bases
GGCCCGGAACGCAGCGCGGGGTCGCGGCCTCGCGGCCCGACCCCGCCACCACCGAGCAAAGCCGCGCGGTTACGCGCCGG
CGGCGACCGGGGGTGTGCCC

Product: type III secretion FHIPEP protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 675; Mature: 675

Protein sequence:

>675_residues
MIPVHALLSRLRSSGEALFALAVLGLVLLLVTPLAPAVLDLLLATNLAAAATVLVVTLFARDALRFASFPTLLLLTTLFR
LALNVSSTRLVLSRGEAGRVIEAFGRVVVQGNTVVGAVVFAILTLVQLLVVAKGAERVAEVAARFTLDALPGKQMAIDAD
LRAGTLDAGEARRRRRALERESQLYGAMDGALKFVKGDAIAGVAIVIVNVAGGLVAGMLRGMTAGDAARRYALLAIGDGL
SSQIPSLLVAVAAGIAVTRVAGEEEGATLGGEIGRQLLAEPAPLAAVAALLGALALAPGLPAAPFLALAGAGGAAAWWIA
RRAARAPAPATGASVASAPGPSGADADGPAPLALELAEDLLAAAATPAGQEGLAALRETVWRALGVRTPAIALRAAPLPA
GGHRLLIDEIPAGGGTAPAGQVVVLAAPDELALARIEAAVERDPLSGRPVSVIAEADAHRARALGAVRGPLDRALAATAA
ALLRHASHLVGVQEVQALLDGLEPGAPALVREASRQLPPALLAEVLRRLVEEGVSIRPLRTILEALLEAGGAGRGPAALA
ECARRALRRQLAHAHAGEGPLAALLLDPAAEQVLREGLAGDALAIDPRVAAELIGRIGAEAELQAAPPVVLTSADVRRAL
RTLLAPRLPAVAVLAYDELPPELTVRPLGRVALAA

Sequences:

>Translated_675_residues
MIPVHALLSRLRSSGEALFALAVLGLVLLLVTPLAPAVLDLLLATNLAAAATVLVVTLFARDALRFASFPTLLLLTTLFR
LALNVSSTRLVLSRGEAGRVIEAFGRVVVQGNTVVGAVVFAILTLVQLLVVAKGAERVAEVAARFTLDALPGKQMAIDAD
LRAGTLDAGEARRRRRALERESQLYGAMDGALKFVKGDAIAGVAIVIVNVAGGLVAGMLRGMTAGDAARRYALLAIGDGL
SSQIPSLLVAVAAGIAVTRVAGEEEGATLGGEIGRQLLAEPAPLAAVAALLGALALAPGLPAAPFLALAGAGGAAAWWIA
RRAARAPAPATGASVASAPGPSGADADGPAPLALELAEDLLAAAATPAGQEGLAALRETVWRALGVRTPAIALRAAPLPA
GGHRLLIDEIPAGGGTAPAGQVVVLAAPDELALARIEAAVERDPLSGRPVSVIAEADAHRARALGAVRGPLDRALAATAA
ALLRHASHLVGVQEVQALLDGLEPGAPALVREASRQLPPALLAEVLRRLVEEGVSIRPLRTILEALLEAGGAGRGPAALA
ECARRALRRQLAHAHAGEGPLAALLLDPAAEQVLREGLAGDALAIDPRVAAELIGRIGAEAELQAAPPVVLTSADVRRAL
RTLLAPRLPAVAVLAYDELPPELTVRPLGRVALAA
>Mature_675_residues
MIPVHALLSRLRSSGEALFALAVLGLVLLLVTPLAPAVLDLLLATNLAAAATVLVVTLFARDALRFASFPTLLLLTTLFR
LALNVSSTRLVLSRGEAGRVIEAFGRVVVQGNTVVGAVVFAILTLVQLLVVAKGAERVAEVAARFTLDALPGKQMAIDAD
LRAGTLDAGEARRRRRALERESQLYGAMDGALKFVKGDAIAGVAIVIVNVAGGLVAGMLRGMTAGDAARRYALLAIGDGL
SSQIPSLLVAVAAGIAVTRVAGEEEGATLGGEIGRQLLAEPAPLAAVAALLGALALAPGLPAAPFLALAGAGGAAAWWIA
RRAARAPAPATGASVASAPGPSGADADGPAPLALELAEDLLAAAATPAGQEGLAALRETVWRALGVRTPAIALRAAPLPA
GGHRLLIDEIPAGGGTAPAGQVVVLAAPDELALARIEAAVERDPLSGRPVSVIAEADAHRARALGAVRGPLDRALAATAA
ALLRHASHLVGVQEVQALLDGLEPGAPALVREASRQLPPALLAEVLRRLVEEGVSIRPLRTILEALLEAGGAGRGPAALA
ECARRALRRQLAHAHAGEGPLAALLLDPAAEQVLREGLAGDALAIDPRVAAELIGRIGAEAELQAAPPVVLTSADVRRAL
RTLLAPRLPAVAVLAYDELPPELTVRPLGRVALAA

Specific function: Could be involved in the secretion of the yop virulence proteins [H]

COG id: COG4789

COG function: function code U; Type III secretory pathway, component EscV

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family [H]

Homologues:

Organism=Escherichia coli, GI1788187, Length=683, Percent_Identity=36.4568081991215, Blast_Score=337, Evalue=2e-93,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001712
- InterPro:   IPR006302 [H]

Pfam domain/function: PF00771 FHIPEP [H]

EC number: NA

Molecular weight: Translated: 68414; Mature: 68414

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00994 FHIPEP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPVHALLSRLRSSGEALFALAVLGLVLLLVTPLAPAVLDLLLATNLAAAATVLVVTLFA
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDALRFASFPTLLLLTTLFRLALNVSSTRLVLSRGEAGRVIEAFGRVVVQGNTVVGAVVF
HHHHHHHCCHHHHHHHHHHHHHHCCCHHEEEEECCCCCHHHHHHCCEEEECCHHHHHHHH
AILTLVQLLVVAKGAERVAEVAARFTLDALPGKQMAIDADLRAGTLDAGEARRRRRALER
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHH
ESQLYGAMDGALKFVKGDAIAGVAIVIVNVAGGLVAGMLRGMTAGDAARRYALLAIGDGL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHEEEEEECCCH
SSQIPSLLVAVAAGIAVTRVAGEEEGATLGGEIGRQLLAEPAPLAAVAALLGALALAPGL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
PAAPFLALAGAGGAAAWWIARRAARAPAPATGASVASAPGPSGADADGPAPLALELAEDL
CCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
LAAAATPAGQEGLAALRETVWRALGVRTPAIALRAAPLPAGGHRLLIDEIPAGGGTAPAG
HHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHEEECCCCCCCCEEEEEECCCCCCCCCCC
QVVVLAAPDELALARIEAAVERDPLSGRPVSVIAEADAHRARALGAVRGPLDRALAATAA
CEEEEECCCHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCHHHHHHHHHHH
ALLRHASHLVGVQEVQALLDGLEPGAPALVREASRQLPPALLAEVLRRLVEEGVSIRPLR
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHH
TILEALLEAGGAGRGPAALAECARRALRRQLAHAHAGEGPLAALLLDPAAEQVLREGLAG
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHCCHHHHHHHHCCCCC
DALAIDPRVAAELIGRIGAEAELQAAPPVVLTSADVRRALRTLLAPRLPAVAVLAYDELP
CCEEECHHHHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHHHHCCCCCCEEEEEHHCCC
PELTVRPLGRVALAA
CCCCCCCCCHHHHCC
>Mature Secondary Structure
MIPVHALLSRLRSSGEALFALAVLGLVLLLVTPLAPAVLDLLLATNLAAAATVLVVTLFA
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDALRFASFPTLLLLTTLFRLALNVSSTRLVLSRGEAGRVIEAFGRVVVQGNTVVGAVVF
HHHHHHHCCHHHHHHHHHHHHHHCCCHHEEEEECCCCCHHHHHHCCEEEECCHHHHHHHH
AILTLVQLLVVAKGAERVAEVAARFTLDALPGKQMAIDADLRAGTLDAGEARRRRRALER
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHH
ESQLYGAMDGALKFVKGDAIAGVAIVIVNVAGGLVAGMLRGMTAGDAARRYALLAIGDGL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHEEEEEECCCH
SSQIPSLLVAVAAGIAVTRVAGEEEGATLGGEIGRQLLAEPAPLAAVAALLGALALAPGL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
PAAPFLALAGAGGAAAWWIARRAARAPAPATGASVASAPGPSGADADGPAPLALELAEDL
CCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
LAAAATPAGQEGLAALRETVWRALGVRTPAIALRAAPLPAGGHRLLIDEIPAGGGTAPAG
HHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHEEECCCCCCCCEEEEEECCCCCCCCCCC
QVVVLAAPDELALARIEAAVERDPLSGRPVSVIAEADAHRARALGAVRGPLDRALAATAA
CEEEEECCCHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCHHHHHHHHHHH
ALLRHASHLVGVQEVQALLDGLEPGAPALVREASRQLPPALLAEVLRRLVEEGVSIRPLR
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHH
TILEALLEAGGAGRGPAALAECARRALRRQLAHAHAGEGPLAALLLDPAAEQVLREGLAG
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHCCHHHHHHHHCCCCC
DALAIDPRVAAELIGRIGAEAELQAAPPVVLTSADVRRALRTLLAPRLPAVAVLAYDELP
CCEEECHHHHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHHHHCCCCCCEEEEEHHCCC
PELTVRPLGRVALAA
CCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11402007 [H]