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The map label for this gene is hemK [H]

Identifier: 220915514

GI number: 220915514

Start: 444618

End: 445478

Strand: Reverse

Name: hemK [H]

Synonym: A2cp1_0395

Alternate gene names: 220915514

Gene position: 445478-444618 (Counterclockwise)

Preceding gene: 220915515

Following gene: 220915513

Centisome position: 8.86

GC content: 78.51

Gene sequence:

>861_bases
GTGAGCGACGGCGGGGCCTGGACGACGCTCCGCCTCCTCGCCTGGACCCAGGAGTTCTTCGGCCGCAAGGGCGTGGACGC
GCCGCGGCTCACCGCGGAGCTGCTGCTCGCGCACGCGCTGCGCTGCGAGCGGATGCGGCTCTACCTCGACTTCGACAAGC
CGCTCGGCGAGCCGGAGCTGGCCGCGTTCCGCGACCTGGTGCGGCGCCGGGCCGAGGGCGAGCCCACCGCCTACCTCACC
GGCCGGCGCGACTTCTACGGCCGGCCGTTCCTCGTGGACGCGCGCGTGCTCGTCCCGCGGCCGGAGACCGAGCTGGTGCT
GGAGGCGGCGCGCGACGCGCTGCCGGAGGGCGGGGCCGCGCTCGACCTGTGCACCGGGTCCGGCGCGCTGGGCGTGTCGC
TCGCGCTGGAGCGGCCCGGCGCGCGGGTGGTCGCGACCGACCTCTCCGCCGACGCGCTCGCGGTCGCCGCCGAGAACGCG
CGCGCGCTCGGCGCGGCGGTGGACCTGCGCCAGGGCGACCTGTGGGCGCCGCTCCGGGCGGGCGAGCGCTTCGACGTGAT
CGTGTCCAATCCGCCCTACGTGCCGCGTGGCGAGCTGGACACGCTGCCCCGCGAGGTCCGGCGCGAGCCGCGGCTGGCGC
TGGACGGCGGCCCGGACGGCCTCTCCCTGCTCCGGCGCATCGTGGAGGGTGCCCCGGCCCGCCTCGCCCCCGGCGGCACG
CTGGTGCTGGAGATGCACGAGGGCCACCTGGAGCTCCTGCCGCGCCTGTGCCGCGACGCGGGGTTCGCGCAAGCGGAGGC
CCGACGGGACCTGGCCGGCCTGCCCCGGCTCACGGTGGCGCGCCTGCCGGGCGCCGCGTAG

Upstream 100 bases:

>100_bases
GCGACGTGCAGGACGTCATCGACGCCTGCCGGACGTTCTACGCGGCCCAGGCGCTGCGCGAGGCGTCGCGCGGCGAGGCC
GGGGCGGCGGAGCGGCGGGC

Downstream 100 bases:

>100_bases
AATCCGCGCCGCCGCTCGCATCCCGCTTGCACGCTGCACCGTCCGGGCGATCCCCTGCCCTGACGCGAAGGAGCCATCGT
TTGGACAAGATCGTGATCGA

Product: modification methylase, HemK family

Products: NA

Alternate protein names: M.XfaHemK2P [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MSDGGAWTTLRLLAWTQEFFGRKGVDAPRLTAELLLAHALRCERMRLYLDFDKPLGEPELAAFRDLVRRRAEGEPTAYLT
GRRDFYGRPFLVDARVLVPRPETELVLEAARDALPEGGAALDLCTGSGALGVSLALERPGARVVATDLSADALAVAAENA
RALGAAVDLRQGDLWAPLRAGERFDVIVSNPPYVPRGELDTLPREVRREPRLALDGGPDGLSLLRRIVEGAPARLAPGGT
LVLEMHEGHLELLPRLCRDAGFAQAEARRDLAGLPRLTVARLPGAA

Sequences:

>Translated_286_residues
MSDGGAWTTLRLLAWTQEFFGRKGVDAPRLTAELLLAHALRCERMRLYLDFDKPLGEPELAAFRDLVRRRAEGEPTAYLT
GRRDFYGRPFLVDARVLVPRPETELVLEAARDALPEGGAALDLCTGSGALGVSLALERPGARVVATDLSADALAVAAENA
RALGAAVDLRQGDLWAPLRAGERFDVIVSNPPYVPRGELDTLPREVRREPRLALDGGPDGLSLLRRIVEGAPARLAPGGT
LVLEMHEGHLELLPRLCRDAGFAQAEARRDLAGLPRLTVARLPGAA
>Mature_285_residues
SDGGAWTTLRLLAWTQEFFGRKGVDAPRLTAELLLAHALRCERMRLYLDFDKPLGEPELAAFRDLVRRRAEGEPTAYLTG
RRDFYGRPFLVDARVLVPRPETELVLEAARDALPEGGAALDLCTGSGALGVSLALERPGARVVATDLSADALAVAAENAR
ALGAAVDLRQGDLWAPLRAGERFDVIVSNPPYVPRGELDTLPREVRREPRLALDGGPDGLSLLRRIVEGAPARLAPGGTL
VLEMHEGHLELLPRLCRDAGFAQAEARRDLAGLPRLTVARLPGAA

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=300, Percent_Identity=30.3333333333333, Blast_Score=111, Evalue=7e-25,
Organism=Escherichia coli, GI1787463, Length=270, Percent_Identity=34.4444444444444, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI87082085, Length=224, Percent_Identity=38.3928571428571, Blast_Score=123, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24582226, Length=239, Percent_Identity=31.3807531380753, Blast_Score=98, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 30912; Mature: 30781

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDGGAWTTLRLLAWTQEFFGRKGVDAPRLTAELLLAHALRCERMRLYLDFDKPLGEPEL
CCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCEEEEEEEECCCCCCHHH
AAFRDLVRRRAEGEPTAYLTGRRDFYGRPFLVDARVLVPRPETELVLEAARDALPEGGAA
HHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCCE
LDLCTGSGALGVSLALERPGARVVATDLSADALAVAAENARALGAAVDLRQGDLWAPLRA
EEEECCCCCCEEEEEEECCCCEEEEECCCCCHHEEEHHCCHHHHHEEECCCCCCCCCCCC
GERFDVIVSNPPYVPRGELDTLPREVRREPRLALDGGPDGLSLLRRIVEGAPARLAPGGT
CCEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCCEECCCCE
LVLEMHEGHLELLPRLCRDAGFAQAEARRDLAGLPRLTVARLPGAA
EEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECCCCCCC
>Mature Secondary Structure 
SDGGAWTTLRLLAWTQEFFGRKGVDAPRLTAELLLAHALRCERMRLYLDFDKPLGEPEL
CCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCEEEEEEEECCCCCCHHH
AAFRDLVRRRAEGEPTAYLTGRRDFYGRPFLVDARVLVPRPETELVLEAARDALPEGGAA
HHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCCE
LDLCTGSGALGVSLALERPGARVVATDLSADALAVAAENARALGAAVDLRQGDLWAPLRA
EEEECCCCCCEEEEEEECCCCEEEEECCCCCHHEEEHHCCHHHHHEEECCCCCCCCCCCC
GERFDVIVSNPPYVPRGELDTLPREVRREPRLALDGGPDGLSLLRRIVEGAPARLAPGGT
CCEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCCEECCCCE
LVLEMHEGHLELLPRLCRDAGFAQAEARRDLAGLPRLTVARLPGAA
EEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]