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The map label for this gene is atoS [H]

Identifier: 220915246

GI number: 220915246

Start: 140471

End: 141967

Strand: Reverse

Name: atoS [H]

Synonym: A2cp1_0125

Alternate gene names: 220915246

Gene position: 141967-140471 (Counterclockwise)

Preceding gene: 220915247

Following gene: 220915245

Centisome position: 2.82

GC content: 76.42

Gene sequence:

>1497_bases
ATGACGCTGCGGCTGAAGCTGTTCGTGCTCATCGCCGGCGTCATCATCTTCGCCATGTCCGGCGTGACCGCGGTGGCGCT
CTGGCGCGAGCTGGTGCGCGGGCAGGAGCTCCTGCTCCGCGAGGGCGTGGCGCTCGCCTCGACCACCGCCACCGGCGCCT
CGCACTGGGTGCGCGAGGGCGGGGTCGATCCGGGCGGCCCGGAGGCGCTGCCGGCGCTCCTCGAGCGGCTGGTCTCCTCG
GCCCCGCTCGACCGCGCCTGGATCGTGGACTCCGCCGGCAAGGTGCTCGCGTGCGTGTCGCGGACCGGCGAGCCCTGCCC
CGAAGGCGTGCCGCCGAGCGAGTTCCAGGCGGCGGACTGGCCGCTCCAGACGCTCTCGCGCCTGGTGCGGCCGGAGGGGA
TCGTCGCCTCCGCGCCCATCGTGCGCGCCGGCGCGGTGGTGGGCGCGGTGCGGGTGGACTTCACGCACGAGGAGGTGGTG
GGCGCCGCCCGCGACCTCGCCTGGGGCGCCGCCGCGGTGGCGGCGTTCTGGATCGCGCTCGGACACCTGCTCGCGGCCAT
CTTCATCCGCCAGGTGACCCAGCCGCTCGTCTCGCTCGCCAGCGCGGCCGAGTCGCTCGCCGAGGAGCGCGGCGTCCGGC
TGGAGGAGCCCGAGGACCGGGAGCTCGTGGACCTCGTCCGCGCCTTCAACCACATGTCCGCCCGGCTCGACGAGCGGCGC
GCCGAGAACCAGCGGCTCATCGCCGAGCTGGAGGAGCGCGTGGCGCAGAAGACCCGCGAGGTGCTGCGCGCCGACCGGCT
GGCCACGCTGGGCGGCATCGCGGCCGGGTTCGCGCACGAGCTCGGCAACTCGCTCAACGTCATCCGCGGCTACGCCGCGG
TCACCTCGCGCGAGCTGCCCGACGACTCGCCGCACCGCTCCGACGTGGAGGCGATCCGGCGGGAGGTGACGCGGGCCGCG
GGGCTCATCGAGCGGTTCCTGGTGTTCGCGCGGGCGCGCACGGTCCACCCGCTGGTGCAGCCGGTCGAGCCCATCCTGCG
CGAGGCGGTGGAGGTGCTCGGTCCGGCCGCAGCGCACGCGAAGGTCGAGCGCGCGGTCGAGGTCGAGCCCGGCCTGCCCG
AGGTGCTCGCCGACGCGGAGCTGCTCCGGCAGGCGTTCCTCAACCTGGGCGTGAACGCGGTGCAGGCCATGCAGGACCGC
GGCGGCGGGAAGCTCACCGTCCGGGCGCTGCGCGAGCCGGGCGGCCTGGTGGTCGAGTTCCACGACACCGGCCCCGGCAT
CGACGCCGAGGCGGCCGCGCACGTGTTCGAGCCGTTCTTCACCACCAAGGCGAGCGGGACGGGCCTCGGCCTCGCCATCG
TGCGCCAGGCCGCCGAGGCGCACGGCGGCACGGTGGAGGTGGCCGGCGCGCCCGGCGCCGGTGCCACGTTCCGGGTCCAC
CTGCCGGCCGCCGAGGCCGGCGCCGCCGCGGACGCCGCGGCGGGAGGCGCGGGGTAG

Upstream 100 bases:

>100_bases
CGTCCGGCAAGGCCCACGCCGAGGGCACCGCCTGCACCACCTGCCACGCGTTCGTGGGCGCCCCGCTGCCGACCTTCCCG
ACCGACGAGGGGGGCGCGCG

Downstream 100 bases:

>100_bases
CCATGGCGAGCGCGAAGAAGCCCAACCTGATGGTCATCGACGACCTGGACAGCGCGCGCCAGATGATGAAGCGCACGCTG
GCCCGCTCCTACGACGTCTA

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MTLRLKLFVLIAGVIIFAMSGVTAVALWRELVRGQELLLREGVALASTTATGASHWVREGGVDPGGPEALPALLERLVSS
APLDRAWIVDSAGKVLACVSRTGEPCPEGVPPSEFQAADWPLQTLSRLVRPEGIVASAPIVRAGAVVGAVRVDFTHEEVV
GAARDLAWGAAAVAAFWIALGHLLAAIFIRQVTQPLVSLASAAESLAEERGVRLEEPEDRELVDLVRAFNHMSARLDERR
AENQRLIAELEERVAQKTREVLRADRLATLGGIAAGFAHELGNSLNVIRGYAAVTSRELPDDSPHRSDVEAIRREVTRAA
GLIERFLVFARARTVHPLVQPVEPILREAVEVLGPAAAHAKVERAVEVEPGLPEVLADAELLRQAFLNLGVNAVQAMQDR
GGGKLTVRALREPGGLVVEFHDTGPGIDAEAAAHVFEPFFTTKASGTGLGLAIVRQAAEAHGGTVEVAGAPGAGATFRVH
LPAAEAGAAADAAAGGAG

Sequences:

>Translated_498_residues
MTLRLKLFVLIAGVIIFAMSGVTAVALWRELVRGQELLLREGVALASTTATGASHWVREGGVDPGGPEALPALLERLVSS
APLDRAWIVDSAGKVLACVSRTGEPCPEGVPPSEFQAADWPLQTLSRLVRPEGIVASAPIVRAGAVVGAVRVDFTHEEVV
GAARDLAWGAAAVAAFWIALGHLLAAIFIRQVTQPLVSLASAAESLAEERGVRLEEPEDRELVDLVRAFNHMSARLDERR
AENQRLIAELEERVAQKTREVLRADRLATLGGIAAGFAHELGNSLNVIRGYAAVTSRELPDDSPHRSDVEAIRREVTRAA
GLIERFLVFARARTVHPLVQPVEPILREAVEVLGPAAAHAKVERAVEVEPGLPEVLADAELLRQAFLNLGVNAVQAMQDR
GGGKLTVRALREPGGLVVEFHDTGPGIDAEAAAHVFEPFFTTKASGTGLGLAIVRQAAEAHGGTVEVAGAPGAGATFRVH
LPAAEAGAAADAAAGGAG
>Mature_497_residues
TLRLKLFVLIAGVIIFAMSGVTAVALWRELVRGQELLLREGVALASTTATGASHWVREGGVDPGGPEALPALLERLVSSA
PLDRAWIVDSAGKVLACVSRTGEPCPEGVPPSEFQAADWPLQTLSRLVRPEGIVASAPIVRAGAVVGAVRVDFTHEEVVG
AARDLAWGAAAVAAFWIALGHLLAAIFIRQVTQPLVSLASAAESLAEERGVRLEEPEDRELVDLVRAFNHMSARLDERRA
ENQRLIAELEERVAQKTREVLRADRLATLGGIAAGFAHELGNSLNVIRGYAAVTSRELPDDSPHRSDVEAIRREVTRAAG
LIERFLVFARARTVHPLVQPVEPILREAVEVLGPAAAHAKVERAVEVEPGLPEVLADAELLRQAFLNLGVNAVQAMQDRG
GGKLTVRALREPGGLVVEFHDTGPGIDAEAAAHVFEPFFTTKASGTGLGLAIVRQAAEAHGGTVEVAGAPGAGATFRVHL
PAAEAGAAADAAAGGAG

Specific function: Member of the two-component regulatory system AtoS/AtoC; may activate AtoC by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=229, Percent_Identity=36.6812227074236, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1789808, Length=308, Percent_Identity=29.2207792207792, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786600, Length=303, Percent_Identity=26.7326732673267, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790300, Length=254, Percent_Identity=29.1338582677165, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1786912, Length=257, Percent_Identity=26.8482490272374, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI87081816, Length=330, Percent_Identity=26.969696969697, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI48994928, Length=137, Percent_Identity=33.5766423357664, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI145693157, Length=220, Percent_Identity=28.6363636363636, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788393, Length=402, Percent_Identity=23.6318407960199, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1789149, Length=341, Percent_Identity=24.633431085044, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790567, Length=95, Percent_Identity=37.8947368421053, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790346, Length=219, Percent_Identity=27.3972602739726, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52359; Mature: 52228

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRLKLFVLIAGVIIFAMSGVTAVALWRELVRGQELLLREGVALASTTATGASHWVREG
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCHHHHHHHHC
GVDPGGPEALPALLERLVSSAPLDRAWIVDSAGKVLACVSRTGEPCPEGVPPSEFQAADW
CCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCC
PLQTLSRLVRPEGIVASAPIVRAGAVVGAVRVDFTHEEVVGAARDLAWGAAAVAAFWIAL
CHHHHHHHHCCCCCEECCCHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
GHLLAAIFIRQVTQPLVSLASAAESLAEERGVRLEEPEDRELVDLVRAFNHMSARLDERR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AENQRLIAELEERVAQKTREVLRADRLATLGGIAAGFAHELGNSLNVIRGYAAVTSRELP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
DDSPHRSDVEAIRREVTRAAGLIERFLVFARARTVHPLVQPVEPILREAVEVLGPAAAHA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
KVERAVEVEPGLPEVLADAELLRQAFLNLGVNAVQAMQDRGGGKLTVRALREPGGLVVEF
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCCCEEEEE
HDTGPGIDAEAAAHVFEPFFTTKASGTGLGLAIVRQAAEAHGGTVEVAGAPGAGATFRVH
ECCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEE
LPAAEAGAAADAAAGGAG
CCCHHCCCCHHCCCCCCC
>Mature Secondary Structure 
TLRLKLFVLIAGVIIFAMSGVTAVALWRELVRGQELLLREGVALASTTATGASHWVREG
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCHHHHHHHHC
GVDPGGPEALPALLERLVSSAPLDRAWIVDSAGKVLACVSRTGEPCPEGVPPSEFQAADW
CCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCC
PLQTLSRLVRPEGIVASAPIVRAGAVVGAVRVDFTHEEVVGAARDLAWGAAAVAAFWIAL
CHHHHHHHHCCCCCEECCCHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
GHLLAAIFIRQVTQPLVSLASAAESLAEERGVRLEEPEDRELVDLVRAFNHMSARLDERR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AENQRLIAELEERVAQKTREVLRADRLATLGGIAAGFAHELGNSLNVIRGYAAVTSRELP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
DDSPHRSDVEAIRREVTRAAGLIERFLVFARARTVHPLVQPVEPILREAVEVLGPAAAHA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
KVERAVEVEPGLPEVLADAELLRQAFLNLGVNAVQAMQDRGGGKLTVRALREPGGLVVEF
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCCCEEEEE
HDTGPGIDAEAAAHVFEPFFTTKASGTGLGLAIVRQAAEAHGGTVEVAGAPGAGATFRVH
ECCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEE
LPAAEAGAAADAAAGGAG
CCCHHCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8346225; 9097040; 9278503 [H]