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The map label for this gene is atoC [H]

Identifier: 220915245

GI number: 220915245

Start: 139089

End: 140468

Strand: Reverse

Name: atoC [H]

Synonym: A2cp1_0124

Alternate gene names: 220915245

Gene position: 140468-139089 (Counterclockwise)

Preceding gene: 220915246

Following gene: 220915244

Centisome position: 2.79

GC content: 72.32

Gene sequence:

>1380_bases
ATGGCGAGCGCGAAGAAGCCCAACCTGATGGTCATCGACGACCTGGACAGCGCGCGCCAGATGATGAAGCGCACGCTGGC
CCGCTCCTACGACGTCTACGACTTCCCCTCGGTGGCGGAGGCGGTGCCGGCGGTGGAGCGCGCCGACTTCGACTGCATCG
TCACCGACCTGCGCATGCCGGGCATCGACGGCATCGAAGGGCTGCGCCGCTTCCAGGCGAAGGTGCCGGAGATCCCGGTG
ATCCTCGTCACCGCGTTCGCCACCGTGGAGACCGCGGTCGAGGCGATGAAGGCGGGCGCGTTCGACTACCTGAAGAAGCC
GTTCGAGCCGGAGGAGCTGGAGCTGGTGGTGGCGCGCGCGGTGGAGCACGCGCGGGTGAAGAAGGAGAACGCCCGGCTCC
GCTCCGCGCTCGCCGGCCAGTTCAGCGTGCACGGGATCGTGGGCAAGTCGCAGTCCATGAAGGACCTGGTCTCGATGCTG
GAGCGCATCGCGCCGTCCGACGTGCCCATCCTCATCGAGGGCGAGTCCGGCACCGGCAAGGACCTGCTCGCCCGCGCCGC
CCACGCGCTCTCCTCGCGCGCGCAGGGGCCGTACGTCGCGCTCAACATGAGCGCGATCCCGGAGAACCTGGCCGAGTCGG
AGCTGTTCGGCCACGAGAAGGGCGCGTTCACCGGCGCCGACCAGCCGCGGGCCGGGTTCTTCGCCGCGGCGGAGGGCGGC
ACGCTGTTCCTCGACGAGATCGGCCTGTTGCCCCCGGCGCTCCAGCCGAAGCTCCTGCGCGTCCTGCAGGATGGCGAGTT
CATCCCGGTCGGCAGCCGCAAGGCGCGCAAGGCGAACGTGCGGGTGGTGGCGGCCACCAACGAGGATCTGCTGCGGCGCG
TGAAGGAGGGGAAGTTCCGCGAGGACCTCTGGTTCCGGCTCCGGGTGGTCCCGCTGCGCCTGCCCCCGCTCCGCGAGCGG
CGCGAGGACATCCCGCTGCTCGTCGAGCACCTGGTGCAGAAGCACGCGCTCCGGCTCTCGCGCCCGCCGCTCCAGCCCGA
CGCCGAGGCCATGCGGGCGCTCCTCGACCACCCATGGCCGGGCAACATCCGCGAGCTGGAGCACGCCATCGAGCGGGGGC
TGCTGCTCGCGCGCGGCGAGGCCATCGCGCTCGCCGACCTGCCGCCGGAGCTCACGCCTTCCGGCGACGCGGCCGGCGGC
GCCGACGAGGGACGCTACCGGCGCGCCCGCGACGCCTGGGAGAAGCGCTTCCTCGAGGACGTGCTGCGCGAGGCGGGCGG
GCAGGTGGCGCGGGCCGCCGAGCTGTCCGGGCTGCACCGATCCACGTTCTACGAGAAGCTCGCGCGGCACGGGCTCGCCG
ACAAGGACGCGAAGCCCTGA

Upstream 100 bases:

>100_bases
TGGCCGGCGCGCCCGGCGCCGGTGCCACGTTCCGGGTCCACCTGCCGGCCGCCGAGGCCGGCGCCGCCGCGGACGCCGCG
GCGGGAGGCGCGGGGTAGCC

Downstream 100 bases:

>100_bases
CGCGGGACCGCCGCCCCGGCGCGCCCCGCGTCCGCGCGGCGCGGCCCGCGGACGCCGCCGCGATCGCGCGGGCGATGCGC
GCCGCGGTGCGCGGGGTCCC

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MASAKKPNLMVIDDLDSARQMMKRTLARSYDVYDFPSVAEAVPAVERADFDCIVTDLRMPGIDGIEGLRRFQAKVPEIPV
ILVTAFATVETAVEAMKAGAFDYLKKPFEPEELELVVARAVEHARVKKENARLRSALAGQFSVHGIVGKSQSMKDLVSML
ERIAPSDVPILIEGESGTGKDLLARAAHALSSRAQGPYVALNMSAIPENLAESELFGHEKGAFTGADQPRAGFFAAAEGG
TLFLDEIGLLPPALQPKLLRVLQDGEFIPVGSRKARKANVRVVAATNEDLLRRVKEGKFREDLWFRLRVVPLRLPPLRER
REDIPLLVEHLVQKHALRLSRPPLQPDAEAMRALLDHPWPGNIRELEHAIERGLLLARGEAIALADLPPELTPSGDAAGG
ADEGRYRRARDAWEKRFLEDVLREAGGQVARAAELSGLHRSTFYEKLARHGLADKDAKP

Sequences:

>Translated_459_residues
MASAKKPNLMVIDDLDSARQMMKRTLARSYDVYDFPSVAEAVPAVERADFDCIVTDLRMPGIDGIEGLRRFQAKVPEIPV
ILVTAFATVETAVEAMKAGAFDYLKKPFEPEELELVVARAVEHARVKKENARLRSALAGQFSVHGIVGKSQSMKDLVSML
ERIAPSDVPILIEGESGTGKDLLARAAHALSSRAQGPYVALNMSAIPENLAESELFGHEKGAFTGADQPRAGFFAAAEGG
TLFLDEIGLLPPALQPKLLRVLQDGEFIPVGSRKARKANVRVVAATNEDLLRRVKEGKFREDLWFRLRVVPLRLPPLRER
REDIPLLVEHLVQKHALRLSRPPLQPDAEAMRALLDHPWPGNIRELEHAIERGLLLARGEAIALADLPPELTPSGDAAGG
ADEGRYRRARDAWEKRFLEDVLREAGGQVARAAELSGLHRSTFYEKLARHGLADKDAKP
>Mature_458_residues
ASAKKPNLMVIDDLDSARQMMKRTLARSYDVYDFPSVAEAVPAVERADFDCIVTDLRMPGIDGIEGLRRFQAKVPEIPVI
LVTAFATVETAVEAMKAGAFDYLKKPFEPEELELVVARAVEHARVKKENARLRSALAGQFSVHGIVGKSQSMKDLVSMLE
RIAPSDVPILIEGESGTGKDLLARAAHALSSRAQGPYVALNMSAIPENLAESELFGHEKGAFTGADQPRAGFFAAAEGGT
LFLDEIGLLPPALQPKLLRVLQDGEFIPVGSRKARKANVRVVAATNEDLLRRVKEGKFREDLWFRLRVVPLRLPPLRERR
EDIPLLVEHLVQKHALRLSRPPLQPDAEAMRALLDHPWPGNIRELEHAIERGLLLARGEAIALADLPPELTPSGDAAGGA
DEGRYRRARDAWEKRFLEDVLREAGGQVARAAELSGLHRSTFYEKLARHGLADKDAKP

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=455, Percent_Identity=42.8571428571429, Blast_Score=355, Evalue=5e-99,
Organism=Escherichia coli, GI1790437, Length=444, Percent_Identity=42.7927927927928, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI1790299, Length=476, Percent_Identity=40.7563025210084, Blast_Score=327, Evalue=9e-91,
Organism=Escherichia coli, GI1788905, Length=451, Percent_Identity=39.4678492239468, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI87082117, Length=341, Percent_Identity=45.1612903225806, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1789087, Length=343, Percent_Identity=44.8979591836735, Blast_Score=255, Evalue=4e-69,
Organism=Escherichia coli, GI1789233, Length=333, Percent_Identity=40.8408408408408, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI87082152, Length=236, Percent_Identity=53.3898305084746, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI87081872, Length=320, Percent_Identity=41.25, Blast_Score=211, Evalue=7e-56,
Organism=Escherichia coli, GI1787583, Length=317, Percent_Identity=40.0630914826498, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1786524, Length=327, Percent_Identity=38.2262996941896, Blast_Score=187, Evalue=9e-49,
Organism=Escherichia coli, GI1789828, Length=266, Percent_Identity=36.4661654135338, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI87081858, Length=298, Percent_Identity=31.8791946308725, Blast_Score=138, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50537; Mature: 50406

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASAKKPNLMVIDDLDSARQMMKRTLARSYDVYDFPSVAEAVPAVERADFDCIVTDLRMP
CCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHCHHHHCCCCEEEEECCCC
GIDGIEGLRRFQAKVPEIPVILVTAFATVETAVEAMKAGAFDYLKKPFEPEELELVVARA
CCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHH
VEHARVKKENARLRSALAGQFSVHGIVGKSQSMKDLVSMLERIAPSDVPILIEGESGTGK
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCH
DLLARAAHALSSRAQGPYVALNMSAIPENLAESELFGHEKGAFTGADQPRAGFFAAAEGG
HHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCC
TLFLDEIGLLPPALQPKLLRVLQDGEFIPVGSRKARKANVRVVAATNEDLLRRVKEGKFR
EEEEHHHCCCCCCCCHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCHHHHHHHHCCCHH
EDLWFRLRVVPLRLPPLRERREDIPLLVEHLVQKHALRLSRPPLQPDAEAMRALLDHPWP
HHHEEEEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCC
GNIRELEHAIERGLLLARGEAIALADLPPELTPSGDAAGGADEGRYRRARDAWEKRFLED
CCHHHHHHHHHHCEEEECCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
VLREAGGQVARAAELSGLHRSTFYEKLARHGLADKDAKP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
ASAKKPNLMVIDDLDSARQMMKRTLARSYDVYDFPSVAEAVPAVERADFDCIVTDLRMP
CCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHCHHHHCCCCEEEEECCCC
GIDGIEGLRRFQAKVPEIPVILVTAFATVETAVEAMKAGAFDYLKKPFEPEELELVVARA
CCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHH
VEHARVKKENARLRSALAGQFSVHGIVGKSQSMKDLVSMLERIAPSDVPILIEGESGTGK
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCH
DLLARAAHALSSRAQGPYVALNMSAIPENLAESELFGHEKGAFTGADQPRAGFFAAAEGG
HHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCC
TLFLDEIGLLPPALQPKLLRVLQDGEFIPVGSRKARKANVRVVAATNEDLLRRVKEGKFR
EEEEHHHCCCCCCCCHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCHHHHHHHHCCCHH
EDLWFRLRVVPLRLPPLRERREDIPLLVEHLVQKHALRLSRPPLQPDAEAMRALLDHPWP
HHHEEEEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCC
GNIRELEHAIERGLLLARGEAIALADLPPELTPSGDAAGGADEGRYRRARDAWEKRFLED
CCHHHHHHHHHHCEEEECCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
VLREAGGQVARAAELSGLHRSTFYEKLARHGLADKDAKP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]