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The map label for this gene is cidA [H]

Identifier: 220915221

GI number: 220915221

Start: 110294

End: 110710

Strand: Reverse

Name: cidA [H]

Synonym: A2cp1_0100

Alternate gene names: 220915221

Gene position: 110710-110294 (Counterclockwise)

Preceding gene: 220915223

Following gene: 220915220

Centisome position: 2.2

GC content: 79.62

Gene sequence:

>417_bases
ATGCCTCGCGCCGTCCCCGCAGCCTCCCCCGCCGCCCCGCCGCCCCGCACCGCCGCGCTGCTGGCGCTCCCGCTCCAGCT
CCTCGCGCTGGGCGCGTTCTGGGGCGCGGGCGCGCTCGCCGCCCGCGCGCTGCGCCTCCCGCTCCCCGGCGGCGTGGTGG
GGATGCTGCTGCTCCTCGCCGCGCTCCGGCTCGGCGTGGTGCGGGCGGAGTGGCTGGAGCGGGGGGCCGCGTGGCTGTTC
CGCCACATGCTGCTCTTCTTCATCCCGGCCGCGGTCGGCGCCATCCAGTACCCGGAGCTGCTCGGCGGCGAGGGGGCCCG
CGCGCTCGCGGTGGTGGCGGTGAGCACGGTGCTCGTGATGGCGGTGACCGGGGCCACGGTGGAGTGGCTGGCGCGCCGCC
GCGAGGAGGCGCCGTGA

Upstream 100 bases:

>100_bases
CAGCCCGCGCAGATCCATCCGCGCCTCCATGCCTGTCCGGAATGCATCCTAGTCCAAAGATTCACTTCCATCATGGCAGG
GCGCCGCCTAGGTTCCGCCG

Downstream 100 bases:

>100_bases
TCGCCGCCGCCTGGATCGCCGTCACCGCCGCGCTGTACGCGGCCGCCCGCGCGCTGCACCGTCGCTTCCCGCGGCCGTGG
CTCACGCCGCTGCTGGTCGT

Product: LrgA family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 138; Mature: 137

Protein sequence:

>138_residues
MPRAVPAASPAAPPPRTAALLALPLQLLALGAFWGAGALAARALRLPLPGGVVGMLLLLAALRLGVVRAEWLERGAAWLF
RHMLLFFIPAAVGAIQYPELLGGEGARALAVVAVSTVLVMAVTGATVEWLARRREEAP

Sequences:

>Translated_138_residues
MPRAVPAASPAAPPPRTAALLALPLQLLALGAFWGAGALAARALRLPLPGGVVGMLLLLAALRLGVVRAEWLERGAAWLF
RHMLLFFIPAAVGAIQYPELLGGEGARALAVVAVSTVLVMAVTGATVEWLARRREEAP
>Mature_137_residues
PRAVPAASPAAPPPRTAALLALPLQLLALGAFWGAGALAARALRLPLPGGVVGMLLLLAALRLGVVRAEWLERGAAWLFR
HMLLFFIPAAVGAIQYPELLGGEGARALAVVAVSTVLVMAVTGATVEWLARRREEAP

Specific function: Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. W

COG id: COG1380

COG function: function code R; Putative effector of murein hydrolase LrgA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CidA/LrgA family. CidA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788463, Length=100, Percent_Identity=34, Blast_Score=60, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005538 [H]

Pfam domain/function: PF03788 LrgA [H]

EC number: NA

Molecular weight: Translated: 14357; Mature: 14226

Theoretical pI: Translated: 12.03; Mature: 12.03

Prosite motif: PS00285 POTATO_INHIBITOR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRAVPAASPAAPPPRTAALLALPLQLLALGAFWGAGALAARALRLPLPGGVVGMLLLLA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
ALRLGVVRAEWLERGAAWLFRHMLLFFIPAAVGAIQYPELLGGEGARALAVVAVSTVLVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHH
AVTGATVEWLARRREEAP
HHHCHHHHHHHHHHCCCC
>Mature Secondary Structure 
PRAVPAASPAAPPPRTAALLALPLQLLALGAFWGAGALAARALRLPLPGGVVGMLLLLA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
ALRLGVVRAEWLERGAAWLFRHMLLFFIPAAVGAIQYPELLGGEGARALAVVAVSTVLVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHH
AVTGATVEWLARRREEAP
HHHCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA