Click here to switch to the map view.

The map label for this gene is mdh [H]

Identifier: 220905475

GI number: 220905475

Start: 2669108

End: 2670187

Strand: Reverse

Name: mdh [H]

Synonym: Ddes_2213

Alternate gene names: 220905475

Gene position: 2670187-2669108 (Counterclockwise)

Preceding gene: 220905476

Following gene: 220905474

Centisome position: 92.93

GC content: 55.65

Gene sequence:

>1080_bases
ATGTACCGTAATGCAAAAAATGTCGGTTATTATATGATTGGCCAGGGCAGCCTGAGCCAGCTCGGCGATCTTATGGCTCC
GCGCCGCAAGGCCGTGTCCGGCCCTGCTGTCTTCTTTCTGGATCACTTTTTCCAGGGCAAGGACCTGGCGGGAAAGCTGC
CTGTGGAAAGCGGCGACATGGTGCTCTATATCGACACCACCGGAGAGCCGACCACTGACAGCGTGGACGGCTATACCGCC
CAGGTGAAAACATTTTTGAACGGCGCGGAACCGTGCGCCCTGGTGGCCCTTGGCGGCGGCTGTGTGCTTGATACCTGCAA
GTGCGTGGGCAATCTGCTCACCAACCCCGGCAAGGCTGAAGACTATCAGGGCTGGGACCTTGTAAAAAATCCCGCGCCCT
ACAAGATCGCCGTACCCACCCTGTCGGGAACCGGGTCTGAAACCTCGCGCACCGGGATCATCTGCAATGAGGAAAAAAAC
ATCAAGCTGGGCATGAACAGCGACTTTACCATGTTCGACCAGGTGCTGATGGACCCCGACCTCACAGCCAGCGTGCCCCG
CAACCAGTACTTCTACACCGGCATCGACACCTACATGCACTGCTTTGAGAGCATCACCGGCTCTTACCGTAACGTGGTTG
TTGATTCTCTGGCTGAAAAGGCCATTGATCTCTGCAAGCAGATTTTTCTTTCGCAAGACATGATGAGCGAAGAAAACCGC
GAAAAGATGATGATCGCTTCCTACCTCGGCGGTATGGCTGCCGGCTTTGTGGGCGTGGTGCATCCCATTTCCGCCGGGCT
GAGCATGGTGCTGCATATGCGCCACGGCATCGCCAACTGTTATTCGCTGTCTGTGCAGGAAGATATATATCCCGAACAGT
ACAAGGAATTCATGCTCATGATGGAGCGGCAGGGCATTGACCTGCCCAAGGGTATCTGCCAGGGCCTTACCGATGCGCAG
TACGATGCGCTCTACGGGGCCAGCATTGTGCATGAAAAGCCGCTTTCCAACCGCCTTGGCCCGGATTTCAAAAAAATCCT
CACCAAGGAGAACGTCATCGGGCGTTTCAGAAGCATGTAG

Upstream 100 bases:

>100_bases
CCCGCCGGTCCGCGCCGCGCGCCGCTTTGCGGCATCGCTTGCCAGACCTGCGGCTATAGCGTATGGCCCGGAAATCCTAT
GCCATACTATGAGGGCAACT

Downstream 100 bases:

>100_bases
GCGCAGACAGCGCCGGATCGTCAAGATCATACAGTCTGTCGGCGGCGTGGGCGAGGCTCCGCCGCCGTCAGGCTCTTTCG
GAGCATCTGTCGCTAAGCGT

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MYRNAKNVGYYMIGQGSLSQLGDLMAPRRKAVSGPAVFFLDHFFQGKDLAGKLPVESGDMVLYIDTTGEPTTDSVDGYTA
QVKTFLNGAEPCALVALGGGCVLDTCKCVGNLLTNPGKAEDYQGWDLVKNPAPYKIAVPTLSGTGSETSRTGIICNEEKN
IKLGMNSDFTMFDQVLMDPDLTASVPRNQYFYTGIDTYMHCFESITGSYRNVVVDSLAEKAIDLCKQIFLSQDMMSEENR
EKMMIASYLGGMAAGFVGVVHPISAGLSMVLHMRHGIANCYSLSVQEDIYPEQYKEFMLMMERQGIDLPKGICQGLTDAQ
YDALYGASIVHEKPLSNRLGPDFKKILTKENVIGRFRSM

Sequences:

>Translated_359_residues
MYRNAKNVGYYMIGQGSLSQLGDLMAPRRKAVSGPAVFFLDHFFQGKDLAGKLPVESGDMVLYIDTTGEPTTDSVDGYTA
QVKTFLNGAEPCALVALGGGCVLDTCKCVGNLLTNPGKAEDYQGWDLVKNPAPYKIAVPTLSGTGSETSRTGIICNEEKN
IKLGMNSDFTMFDQVLMDPDLTASVPRNQYFYTGIDTYMHCFESITGSYRNVVVDSLAEKAIDLCKQIFLSQDMMSEENR
EKMMIASYLGGMAAGFVGVVHPISAGLSMVLHMRHGIANCYSLSVQEDIYPEQYKEFMLMMERQGIDLPKGICQGLTDAQ
YDALYGASIVHEKPLSNRLGPDFKKILTKENVIGRFRSM
>Mature_359_residues
MYRNAKNVGYYMIGQGSLSQLGDLMAPRRKAVSGPAVFFLDHFFQGKDLAGKLPVESGDMVLYIDTTGEPTTDSVDGYTA
QVKTFLNGAEPCALVALGGGCVLDTCKCVGNLLTNPGKAEDYQGWDLVKNPAPYKIAVPTLSGTGSETSRTGIICNEEKN
IKLGMNSDFTMFDQVLMDPDLTASVPRNQYFYTGIDTYMHCFESITGSYRNVVVDSLAEKAIDLCKQIFLSQDMMSEENR
EKMMIASYLGGMAAGFVGVVHPISAGLSMVLHMRHGIANCYSLSVQEDIYPEQYKEFMLMMERQGIDLPKGICQGLTDAQ
YDALYGASIVHEKPLSNRLGPDFKKILTKENVIGRFRSM

Specific function: May Act On The Acetaldehyde Produced From The Degradation Of Ethanolamine. [C]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Integral Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI87082107, Length=280, Percent_Identity=31.4285714285714, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI48994951, Length=227, Percent_Identity=28.1938325991189, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789163, Length=218, Percent_Identity=26.605504587156, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1787493, Length=210, Percent_Identity=24.7619047619048, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17537053, Length=264, Percent_Identity=28.7878787878788, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321181, Length=291, Percent_Identity=29.2096219931272, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24657991, Length=262, Percent_Identity=29.7709923664122, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 39457; Mature: 39457

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRNAKNVGYYMIGQGSLSQLGDLMAPRRKAVSGPAVFFLDHFFQGKDLAGKLPVESGDM
CCCCCCCCCEEEECCCCHHHHHHHHCCHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCE
VLYIDTTGEPTTDSVDGYTAQVKTFLNGAEPCALVALGGGCVLDTCKCVGNLLTNPGKAE
EEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCC
DYQGWDLVKNPAPYKIAVPTLSGTGSETSRTGIICNEEKNIKLGMNSDFTMFDQVLMDPD
CCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEECCCCCEEECCCCCHHHHHHHHCCCC
LTASVPRNQYFYTGIDTYMHCFESITGSYRNVVVDSLAEKAIDLCKQIFLSQDMMSEENR
CCCCCCCCCEEEECHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
EKMMIASYLGGMAAGFVGVVHPISAGLSMVLHMRHGIANCYSLSVQEDIYPEQYKEFMLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHCCCHHHHHHHHHH
MERQGIDLPKGICQGLTDAQYDALYGASIVHEKPLSNRLGPDFKKILTKENVIGRFRSM
HHHCCCCCCHHHHCCCCCCHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYRNAKNVGYYMIGQGSLSQLGDLMAPRRKAVSGPAVFFLDHFFQGKDLAGKLPVESGDM
CCCCCCCCCEEEECCCCHHHHHHHHCCHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCE
VLYIDTTGEPTTDSVDGYTAQVKTFLNGAEPCALVALGGGCVLDTCKCVGNLLTNPGKAE
EEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCC
DYQGWDLVKNPAPYKIAVPTLSGTGSETSRTGIICNEEKNIKLGMNSDFTMFDQVLMDPD
CCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEECCCCCEEECCCCCHHHHHHHHCCCC
LTASVPRNQYFYTGIDTYMHCFESITGSYRNVVVDSLAEKAIDLCKQIFLSQDMMSEENR
CCCCCCCCCEEEECHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
EKMMIASYLGGMAAGFVGVVHPISAGLSMVLHMRHGIANCYSLSVQEDIYPEQYKEFMLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHCCCHHHHHHHHHH
MERQGIDLPKGICQGLTDAQYDALYGASIVHEKPLSNRLGPDFKKILTKENVIGRFRSM
HHHCCCCCCHHHHCCCCCCHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]