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The map label for this gene is hdrA2 [H]

Identifier: 220905389

GI number: 220905389

Start: 2563791

End: 2565026

Strand: Reverse

Name: hdrA2 [H]

Synonym: Ddes_2127

Alternate gene names: 220905389

Gene position: 2565026-2563791 (Counterclockwise)

Preceding gene: 220905391

Following gene: 220905388

Centisome position: 89.27

GC content: 58.82

Gene sequence:

>1236_bases
ATGTCCAATGCCATTCTCGTCGTGGGCGGCGGCTTTGCAGGCCTTACAGCCGCCATTGAAGCGGCGGAACTGGGTCACGA
CGTCTATATCGTCGAAAAGTCGCCCTGGCTTGGGGGCCGCGTGGCTCAGCTCAATAAATATTTTCCCAAACTCTGTCCCC
CCTCCTGCGGCTTGGAAATCCAGTTCCAGCGCATCAGGAAAAATCCGCGTGTGAAGTTCTTTACCCAGGCCGAAGTTGTG
GGCTTCAGCGGGGTCAAGGGTGACTATACCGTCAAGGTGCGCATCCAGCCGCGTCACACGGCGCCCCATAACGTGGATTT
CAGCCTGCTGGCTTCCAGCCTTGACGGCGAAAGCCCCAGTGAATTCGATTTTGGGCTGTCAAAGCGCAAGGGCTTGTACA
AGGCCATGCCTTTTGCCTTCCCCAGCCGCTACACTCTGGATAAGCAGACACTTTCCAAGGCCGACAAGGCCCGTGTGGCG
GGCAACCAGTTTCTGGATGTGACCGAGGCCCCCCGCGAAATCGAACTGGGCGTGGGTGCCGTGGTTATTGCCACCGGCTG
GAAGCCATATGATGTCACCCGGTTGAGCAACCTTGGTGCAGGCAACGTGAAAAACTGCATTTCCAACATGCAGATGGAGC
GTCTCGCCTCGCCCTGTGGTCCCACTGCCGGACGCATCACGCGCCCCACGGACGGCCGCAGGCCTCACCGCGTGGCTTTT
GTCCAGTGCGCCGGTTCGCGTGATCAGAATCATCTGAACTACTGTTCATACATCTGCTGTATGGCCACGCTCAAGCAGTG
CCAGTACATTGCCGAGCAGAATCCCGATACGCAGATTACAGTATATTATATTGATATGCGCGCTCCTGGCCGCTACGTGA
AAGTACTTGAAAAAGTCAAGGCCATGCCCAACGTGCATTTTGTCAAGGGCAAGGTCGCCGATGTGGTGCAGGCCGAGGGC
GACAAGGTGCGCCTGACGGCAGAAGACGCCGTAAGCGGCGAAAAGCTCACCCTTGATTATGACCTTGTGGTGCTGGCCAC
GGGCATGCAGCCCTCTTTGGCCGGCGAAGACGCGCCTCTGCCTCTGCCTCTTGACGAAGAAGGCTTTGTGGCGGGCGGCG
AGGAAGCCGGTATCTTTGCCGCCGGTTGCGCGCGCATGCCCCTCGATGTGATGCGCTCGGCTCAGTCCGGTACAGCCGCC
GCCCTGAAGGCGGTACAAACGGTGAAAGGGAGGTAG

Upstream 100 bases:

>100_bases
GCCCGTAAGGTTTGGCCGGATGCGGCCACTCCTTTTTTCCGCGGCGAGGGGCGTTGTCACTTCTTCAGCCGCTATGCAAC
AACGCAGGAGGATATCCAGG

Downstream 100 bases:

>100_bases
GCGGCATGTCCGGTAAGATTGGCGTCTATTTTGACCAGCAGAACATTGGCGGCGGCCTCGATGTAGAGGCGCTTGCCGCG
CAGACCTCGGCAAAGTGGGG

Product: heterodisulfide reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MSNAILVVGGGFAGLTAAIEAAELGHDVYIVEKSPWLGGRVAQLNKYFPKLCPPSCGLEIQFQRIRKNPRVKFFTQAEVV
GFSGVKGDYTVKVRIQPRHTAPHNVDFSLLASSLDGESPSEFDFGLSKRKGLYKAMPFAFPSRYTLDKQTLSKADKARVA
GNQFLDVTEAPREIELGVGAVVIATGWKPYDVTRLSNLGAGNVKNCISNMQMERLASPCGPTAGRITRPTDGRRPHRVAF
VQCAGSRDQNHLNYCSYICCMATLKQCQYIAEQNPDTQITVYYIDMRAPGRYVKVLEKVKAMPNVHFVKGKVADVVQAEG
DKVRLTAEDAVSGEKLTLDYDLVVLATGMQPSLAGEDAPLPLPLDEEGFVAGGEEAGIFAAGCARMPLDVMRSAQSGTAA
ALKAVQTVKGR

Sequences:

>Translated_411_residues
MSNAILVVGGGFAGLTAAIEAAELGHDVYIVEKSPWLGGRVAQLNKYFPKLCPPSCGLEIQFQRIRKNPRVKFFTQAEVV
GFSGVKGDYTVKVRIQPRHTAPHNVDFSLLASSLDGESPSEFDFGLSKRKGLYKAMPFAFPSRYTLDKQTLSKADKARVA
GNQFLDVTEAPREIELGVGAVVIATGWKPYDVTRLSNLGAGNVKNCISNMQMERLASPCGPTAGRITRPTDGRRPHRVAF
VQCAGSRDQNHLNYCSYICCMATLKQCQYIAEQNPDTQITVYYIDMRAPGRYVKVLEKVKAMPNVHFVKGKVADVVQAEG
DKVRLTAEDAVSGEKLTLDYDLVVLATGMQPSLAGEDAPLPLPLDEEGFVAGGEEAGIFAAGCARMPLDVMRSAQSGTAA
ALKAVQTVKGR
>Mature_410_residues
SNAILVVGGGFAGLTAAIEAAELGHDVYIVEKSPWLGGRVAQLNKYFPKLCPPSCGLEIQFQRIRKNPRVKFFTQAEVVG
FSGVKGDYTVKVRIQPRHTAPHNVDFSLLASSLDGESPSEFDFGLSKRKGLYKAMPFAFPSRYTLDKQTLSKADKARVAG
NQFLDVTEAPREIELGVGAVVIATGWKPYDVTRLSNLGAGNVKNCISNMQMERLASPCGPTAGRITRPTDGRRPHRVAFV
QCAGSRDQNHLNYCSYICCMATLKQCQYIAEQNPDTQITVYYIDMRAPGRYVKVLEKVKAMPNVHFVKGKVADVVQAEGD
KVRLTAEDAVSGEKLTLDYDLVVLATGMQPSLAGEDAPLPLPLDEEGFVAGGEEAGIFAAGCARMPLDVMRSAQSGTAAA
LKAVQTVKGR

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit [H]

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR003953
- InterPro:   IPR012285 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF00037 Fer4 [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 44523; Mature: 44391

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAILVVGGGFAGLTAAIEAAELGHDVYIVEKSPWLGGRVAQLNKYFPKLCPPSCGLEI
CCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEE
QFQRIRKNPRVKFFTQAEVVGFSGVKGDYTVKVRIQPRHTAPHNVDFSLLASSLDGESPS
EEHHHCCCCCEEEEEEEEEEECCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHCCCCCCC
EFDFGLSKRKGLYKAMPFAFPSRYTLDKQTLSKADKARVAGNQFLDVTEAPREIELGVGA
CCCCCCHHHCCHHHHCCCCCCCCCEECHHHHHHHHHHHHCCCCEEECCCCCCEEECCCCE
VVIATGWKPYDVTRLSNLGAGNVKNCISNMQMERLASPCGPTAGRITRPTDGRRPHRVAF
EEEEECCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCEEEE
VQCAGSRDQNHLNYCSYICCMATLKQCQYIAEQNPDTQITVYYIDMRAPGRYVKVLEKVK
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHH
AMPNVHFVKGKVADVVQAEGDKVRLTAEDAVSGEKLTLDYDLVVLATGMQPSLAGEDAPL
HCCCEEEECCCHHHHHHCCCCEEEEEEHHCCCCCEEEEEEEEEEEEECCCCCCCCCCCCC
PLPLDEEGFVAGGEEAGIFAAGCARMPLDVMRSAQSGTAAALKAVQTVKGR
CCCCCCCCCEECCCCCCEEEECHHCCCHHHHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNAILVVGGGFAGLTAAIEAAELGHDVYIVEKSPWLGGRVAQLNKYFPKLCPPSCGLEI
CCEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEE
QFQRIRKNPRVKFFTQAEVVGFSGVKGDYTVKVRIQPRHTAPHNVDFSLLASSLDGESPS
EEHHHCCCCCEEEEEEEEEEECCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHCCCCCCC
EFDFGLSKRKGLYKAMPFAFPSRYTLDKQTLSKADKARVAGNQFLDVTEAPREIELGVGA
CCCCCCHHHCCHHHHCCCCCCCCCEECHHHHHHHHHHHHCCCCEEECCCCCCEEECCCCE
VVIATGWKPYDVTRLSNLGAGNVKNCISNMQMERLASPCGPTAGRITRPTDGRRPHRVAF
EEEEECCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCEEEE
VQCAGSRDQNHLNYCSYICCMATLKQCQYIAEQNPDTQITVYYIDMRAPGRYVKVLEKVK
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHH
AMPNVHFVKGKVADVVQAEGDKVRLTAEDAVSGEKLTLDYDLVVLATGMQPSLAGEDAPL
HCCCEEEECCCHHHHHHCCCCEEEEEEHHCCCCCEEEEEEEEEEEEECCCCCCCCCCCCC
PLPLDEEGFVAGGEEAGIFAAGCARMPLDVMRSAQSGTAAALKAVQTVKGR
CCCCCCCCCEECCCCCCEEEECHHCCCHHHHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9063468; 11930014 [H]