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The map label for this gene is trpE [H]

Identifier: 220904858

GI number: 220904858

Start: 1913162

End: 1914616

Strand: Reverse

Name: trpE [H]

Synonym: Ddes_1592

Alternate gene names: 220904858

Gene position: 1914616-1913162 (Counterclockwise)

Preceding gene: 220904859

Following gene: 220904857

Centisome position: 66.63

GC content: 60.82

Gene sequence:

>1455_bases
ATGAAAGAGAACGGTGACAGGTTGCATTTGCTCACGTTGCGACAGTCCGCCCGGTGGCTGCCGGCGGACATGGATACCCC
CATCAGCCTGTTTATGGGCATGGTGGGCGCCGGTAACGGCATTTTGCTGGAAAGCGCCGAGGTGGACGGCCGCTGGGGGC
GCTACAGTATTCTTGCCTGCGATCCGGCTCTTTTCATCGCCTGCCGCGAAGGCAGGCTGGCCCTGGGTGTGAAAGACCAG
AGGCTTGCCGCGCTTATGGTTTTTGAAGGCCGCCCTTTTGTGGAGGGCCTGCGTGCGCTCATGGCAGCCCTGGAGGTGCA
GCCGCCTGAAAATGCCGCAAATCTGCCGCCCATTACCCGCGCCCTGTACGGGTATCTGGGGTTTGGCATGGCGGGGCTGT
TCAATCCGGTGCTGGCATCCACCATGCCGGAAAACGAAGCAGACTGCCTGCTCATCCTGCCTGCCACCGTGCTGGTTTTC
GATCACCTGTACAACCGGCTGTGCCAGGTGAGTCTTGGCGACCACCGGCCCCTGAACAGCGGCCGCCAGCCCTTGGAGGT
GAACGCGGCCAGGGCTTCCGGTCCGGCTATTGATCCCGGTATGGTGCGGTCCGAACCTGATGAAGAGGGGTACAAGAGCT
TTGTGCGCCGCATCAAGGAAATGCTGCGTCAGGGCGAGGCCATACAAGTCGTGCCCTCGGTGCGTTTTTCCACGCCGTTT
ATGGGCAATCCTTTTGAACTGTACCGGCGTATGCGGCGCTTTAACGCGTCTCCCTACATGTTTTACATGCGCTTTCCGGA
GCTGACGCTCTTCGGCTCTTCGCCTGAAGTGATGGTGCGCTGCACCGCGGGCTGCCTGCAGCTCTCGCCCATCGCGGGTA
CACGCAAGCGCGGGGCCGATGATCTGGAGGACGCACGTCTGGCGGCCGAACTGCGGGACGACCCCAAGGAACGCGCCGAG
CATGTCATGCTGGTAGATCTTGGCCGCAACGATCTTGGCCGCGTGGCACGGCCCGGCACGGTAACGCTTGAACGCTATAT
GGAAGTGGAGCGTTACTCCCACGTCATGCATCTTACAAGCCGGGTTACAGCCCGTCTGGATGTGGGGCTGGACGCCCTGG
ATGTGCTGGCCGCCACTTTTCCGGCGGGCACGGTATCGGGCGCGCCCAAAATACGGGCCATGCAGATCATCCGCGAGCTT
GAGGGGCGCAGCCGCGGTCCCTACGCGGGATGCATCGGCTGGCTCGGACTGGACAGGGACAGTGTGAACCTGGATATGGG
CATTACCATTCGCAGCATGTGGCTGCGTGACAACAGGCTCTTCTGGCAGGCGGGCGGAGGAATCGTTCATGATTCGGACC
CGGATATGGAATGGAAAGAAGTTTGCAATAAGTCAGCCATTATGCGCCTTGCCCTGCGAACGGAGGACGAAGAGTATGTT
TCTTCTTATAGATAA

Upstream 100 bases:

>100_bases
GGGCTAAATAGTTCCGGTACGTAGGTATAGCTGTATGCAGGCGCCGTCTCCCTTGGGAGGCGGCGCTTTTTTTTTGTTCT
ACAACTCGAGGATACGGCAG

Downstream 100 bases:

>100_bases
TTACGATTCTTTTACATATAATCTGGTACAGGCCTTTCACGCCCTGGGGCACAAGCCTGTAGTTATGACCAACGACGACC
CCGCAGTGCTTGGCATGGCT

Product: Anthranilate synthase

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MKENGDRLHLLTLRQSARWLPADMDTPISLFMGMVGAGNGILLESAEVDGRWGRYSILACDPALFIACREGRLALGVKDQ
RLAALMVFEGRPFVEGLRALMAALEVQPPENAANLPPITRALYGYLGFGMAGLFNPVLASTMPENEADCLLILPATVLVF
DHLYNRLCQVSLGDHRPLNSGRQPLEVNAARASGPAIDPGMVRSEPDEEGYKSFVRRIKEMLRQGEAIQVVPSVRFSTPF
MGNPFELYRRMRRFNASPYMFYMRFPELTLFGSSPEVMVRCTAGCLQLSPIAGTRKRGADDLEDARLAAELRDDPKERAE
HVMLVDLGRNDLGRVARPGTVTLERYMEVERYSHVMHLTSRVTARLDVGLDALDVLAATFPAGTVSGAPKIRAMQIIREL
EGRSRGPYAGCIGWLGLDRDSVNLDMGITIRSMWLRDNRLFWQAGGGIVHDSDPDMEWKEVCNKSAIMRLALRTEDEEYV
SSYR

Sequences:

>Translated_484_residues
MKENGDRLHLLTLRQSARWLPADMDTPISLFMGMVGAGNGILLESAEVDGRWGRYSILACDPALFIACREGRLALGVKDQ
RLAALMVFEGRPFVEGLRALMAALEVQPPENAANLPPITRALYGYLGFGMAGLFNPVLASTMPENEADCLLILPATVLVF
DHLYNRLCQVSLGDHRPLNSGRQPLEVNAARASGPAIDPGMVRSEPDEEGYKSFVRRIKEMLRQGEAIQVVPSVRFSTPF
MGNPFELYRRMRRFNASPYMFYMRFPELTLFGSSPEVMVRCTAGCLQLSPIAGTRKRGADDLEDARLAAELRDDPKERAE
HVMLVDLGRNDLGRVARPGTVTLERYMEVERYSHVMHLTSRVTARLDVGLDALDVLAATFPAGTVSGAPKIRAMQIIREL
EGRSRGPYAGCIGWLGLDRDSVNLDMGITIRSMWLRDNRLFWQAGGGIVHDSDPDMEWKEVCNKSAIMRLALRTEDEEYV
SSYR
>Mature_484_residues
MKENGDRLHLLTLRQSARWLPADMDTPISLFMGMVGAGNGILLESAEVDGRWGRYSILACDPALFIACREGRLALGVKDQ
RLAALMVFEGRPFVEGLRALMAALEVQPPENAANLPPITRALYGYLGFGMAGLFNPVLASTMPENEADCLLILPATVLVF
DHLYNRLCQVSLGDHRPLNSGRQPLEVNAARASGPAIDPGMVRSEPDEEGYKSFVRRIKEMLRQGEAIQVVPSVRFSTPF
MGNPFELYRRMRRFNASPYMFYMRFPELTLFGSSPEVMVRCTAGCLQLSPIAGTRKRGADDLEDARLAAELRDDPKERAE
HVMLVDLGRNDLGRVARPGTVTLERYMEVERYSHVMHLTSRVTARLDVGLDALDVLAATFPAGTVSGAPKIRAMQIIREL
EGRSRGPYAGCIGWLGLDRDSVNLDMGITIRSMWLRDNRLFWQAGGGIVHDSDPDMEWKEVCNKSAIMRLALRTEDEEYV
SSYR

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=532, Percent_Identity=33.6466165413534, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI1788114, Length=435, Percent_Identity=31.264367816092, Blast_Score=195, Evalue=6e-51,
Organism=Escherichia coli, GI87082077, Length=276, Percent_Identity=30.4347826086957, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1786809, Length=266, Percent_Identity=25.5639097744361, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320935, Length=478, Percent_Identity=33.2635983263598, Blast_Score=239, Evalue=8e-64,
Organism=Saccharomyces cerevisiae, GI6324361, Length=399, Percent_Identity=25.8145363408521, Blast_Score=106, Evalue=8e-24,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 53956; Mature: 53956

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKENGDRLHLLTLRQSARWLPADMDTPISLFMGMVGAGNGILLESAEVDGRWGRYSILAC
CCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEEE
DPALFIACREGRLALGVKDQRLAALMVFEGRPFVEGLRALMAALEVQPPENAANLPPITR
CCEEEEEECCCCEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHH
ALYGYLGFGMAGLFNPVLASTMPENEADCLLILPATVLVFDHLYNRLCQVSLGDHRPLNS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCC
GRQPLEVNAARASGPAIDPGMVRSEPDEEGYKSFVRRIKEMLRQGEAIQVVPSVRFSTPF
CCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEECCCC
MGNPFELYRRMRRFNASPYMFYMRFPELTLFGSSPEVMVRCTAGCLQLSPIAGTRKRGAD
CCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCEEEEEECCCEEECCCCCCCCCCCC
DLEDARLAAELRDDPKERAEHVMLVDLGRNDLGRVARPGTVTLERYMEVERYSHVMHLTS
CHHHHHHHHHHHCCHHHHCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RVTARLDVGLDALDVLAATFPAGTVSGAPKIRAMQIIRELEGRSRGPYAGCIGWLGLDRD
HHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHEEECCCCC
SVNLDMGITIRSMWLRDNRLFWQAGGGIVHDSDPDMEWKEVCNKSAIMRLALRTEDEEYV
CCEEEECEEEEEEEEECCEEEEEECCCEEECCCCCCHHHHHCCHHHHHHHHHCCCCHHHH
SSYR
HCCC
>Mature Secondary Structure
MKENGDRLHLLTLRQSARWLPADMDTPISLFMGMVGAGNGILLESAEVDGRWGRYSILAC
CCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEEE
DPALFIACREGRLALGVKDQRLAALMVFEGRPFVEGLRALMAALEVQPPENAANLPPITR
CCEEEEEECCCCEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHH
ALYGYLGFGMAGLFNPVLASTMPENEADCLLILPATVLVFDHLYNRLCQVSLGDHRPLNS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCC
GRQPLEVNAARASGPAIDPGMVRSEPDEEGYKSFVRRIKEMLRQGEAIQVVPSVRFSTPF
CCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEECCCC
MGNPFELYRRMRRFNASPYMFYMRFPELTLFGSSPEVMVRCTAGCLQLSPIAGTRKRGAD
CCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCEEEEEECCCEEECCCCCCCCCCCC
DLEDARLAAELRDDPKERAEHVMLVDLGRNDLGRVARPGTVTLERYMEVERYSHVMHLTS
CHHHHHHHHHHHCCHHHHCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RVTARLDVGLDALDVLAATFPAGTVSGAPKIRAMQIIRELEGRSRGPYAGCIGWLGLDRD
HHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHEEECCCCC
SVNLDMGITIRSMWLRDNRLFWQAGGGIVHDSDPDMEWKEVCNKSAIMRLALRTEDEEYV
CCEEEECEEEEEEEEECCEEEEEECCCEEECCCCCCHHHHHCCHHHHHHHHHCCCCHHHH
SSYR
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]