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The map label for this gene is gmhA

Identifier: 220904554

GI number: 220904554

Start: 1515304

End: 1515936

Strand: Direct

Name: gmhA

Synonym: Ddes_1285

Alternate gene names: 220904554

Gene position: 1515304-1515936 (Clockwise)

Preceding gene: 220904550

Following gene: 220904555

Centisome position: 52.73

GC content: 58.29

Gene sequence:

>633_bases
ATGAACGACAGCGCTCTTGACATCATAACCGCCCATGCGCGTGACGGCGCCCGGCTGAGGGAAACTTTTTTTGCGGAACA
AGCGACAATGTTGCGGGAAACAGCCCTGCGCATTGCAGCCTGTCTTGCTCGGGGCGGAAAAATCCTGCTCTGCGGCAATG
GCGGCAGCGCAGCAGATGCACAGCACCTTGCGGCGGAGTTTGTGAACCGCTTTCTTGTGGACAGGCCTGCCCTGCCGGCT
CTGGCCCTTACCACCGACACCTCGGCCCTTACCGCCATTGCCAATGATATGGACTTCAGCCAGGTATTTTCACGCCAGGT
GGAGGCACTGGGCCGCAAGGGAGACATTCTTGTAGGCATATCCACCTCCGGCAACAGCCCCAATGTGCTGGCCGCCCTTG
AGGCTGCCCGCCGGATAGGCATGCTTACGCTGGGCTTTACGGGCAGGGGCGGAGGCCGTATGGCCGCGCTCTGCCACATG
CTCGTGGACGTGGCAAATCCGAGCACTCCCCTTATACAGGAAATTCACATTACTGCCGGACATTTACTGTGCCAGCTGAC
TGATTATTACCTTTTTGAGAATGTGGCGGCACTTGCGCCCTATTTGCACGCAGACACCGTAAACGAGGATTGA

Upstream 100 bases:

>100_bases
CTCTTACCGCAAGCCCGCCGGCCTTACTTGTCAGGGCCGGCGCTTTGACATATGAACAGAAACTTCCTAGCCAAAATCAC
ATAACAAGGCCGCAACAGCC

Downstream 100 bases:

>100_bases
TCATGCCCATCTATGAGTACAGTTGCGAAAAATGCAGCCGGGATTTCGAAGAACTGGTTTTTGACGATACTTCTCCGGCC
TGCCCGCATTGCGGCTCTCA

Product: phosphoheptose isomerase

Products: NA

Alternate protein names: Sedoheptulose 7-phosphate isomerase

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MNDSALDIITAHARDGARLRETFFAEQATMLRETALRIAACLARGGKILLCGNGGSAADAQHLAAEFVNRFLVDRPALPA
LALTTDTSALTAIANDMDFSQVFSRQVEALGRKGDILVGISTSGNSPNVLAALEAARRIGMLTLGFTGRGGGRMAALCHM
LVDVANPSTPLIQEIHITAGHLLCQLTDYYLFENVAALAPYLHADTVNED

Sequences:

>Translated_210_residues
MNDSALDIITAHARDGARLRETFFAEQATMLRETALRIAACLARGGKILLCGNGGSAADAQHLAAEFVNRFLVDRPALPA
LALTTDTSALTAIANDMDFSQVFSRQVEALGRKGDILVGISTSGNSPNVLAALEAARRIGMLTLGFTGRGGGRMAALCHM
LVDVANPSTPLIQEIHITAGHLLCQLTDYYLFENVAALAPYLHADTVNED
>Mature_210_residues
MNDSALDIITAHARDGARLRETFFAEQATMLRETALRIAACLARGGKILLCGNGGSAADAQHLAAEFVNRFLVDRPALPA
LALTTDTSALTAIANDMDFSQVFSRQVEALGRKGDILVGISTSGNSPNVLAALEAARRIGMLTLGFTGRGGGRMAALCHM
LVDVANPSTPLIQEIHITAGHLLCQLTDYYLFENVAALAPYLHADTVNED

Specific function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1786416, Length=185, Percent_Identity=41.6216216216216, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI1789539, Length=161, Percent_Identity=47.2049689440994, Blast_Score=137, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHA_DESDA (B8J0B1)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002479866.1
- ProteinModelPortal:   B8J0B1
- GeneID:   7284977
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_1285
- HOGENOM:   HBG671955
- ProtClustDB:   PRK13937
- GO:   GO:0005737
- HAMAP:   MF_00067
- InterPro:   IPR020620
- InterPro:   IPR001347

Pfam domain/function: PF01380 SIS

EC number: =5.3.1.28

Molecular weight: Translated: 22279; Mature: 22279

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS51464 SIS

Important sites: BINDING 66-66 BINDING 126-126 BINDING 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDSALDIITAHARDGARLRETFFAEQATMLRETALRIAACLARGGKILLCGNGGSAADA
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHH
QHLAAEFVNRFLVDRPALPALALTTDTSALTAIANDMDFSQVFSRQVEALGRKGDILVGI
HHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEE
STSGNSPNVLAALEAARRIGMLTLGFTGRGGGRMAALCHMLVDVANPSTPLIQEIHITAG
ECCCCCCCHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
HLLCQLTDYYLFENVAALAPYLHADTVNED
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNDSALDIITAHARDGARLRETFFAEQATMLRETALRIAACLARGGKILLCGNGGSAADA
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHH
QHLAAEFVNRFLVDRPALPALALTTDTSALTAIANDMDFSQVFSRQVEALGRKGDILVGI
HHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEE
STSGNSPNVLAALEAARRIGMLTLGFTGRGGGRMAALCHMLVDVANPSTPLIQEIHITAG
ECCCCCCCHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
HLLCQLTDYYLFENVAALAPYLHADTVNED
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA