Click here to switch to the map view.

The map label for this gene is pgl [H]

Identifier: 220904401

GI number: 220904401

Start: 1331360

End: 1332106

Strand: Reverse

Name: pgl [H]

Synonym: Ddes_1131

Alternate gene names: 220904401

Gene position: 1332106-1331360 (Counterclockwise)

Preceding gene: 220904402

Following gene: 220904398

Centisome position: 46.36

GC content: 60.24

Gene sequence:

>747_bases
ATGTCGGGCCTCAGCCGATCCATCCATCTTACGGTGCACATTCATAAAGACCCGGCCGCCATGGCCGAGCGCGCCGCACA
TATTCTTGCCGCCGCTTGCGAAGAGGCTGTTGCTGAAAGGGGTGTATTCCGCATTGCCCTGTCCGGCGGGCAGACTCCCA
TTCCTCTTTTCCGGCTGCTTGCCGGTGACGACTGGGCCGACCGGCTGCCCTGGGACAAGATAAGCATTTTCTGGGTGGAC
GAACGTTGCGTGGGGCCGGAACATGCCGACAGTAACTACGGCCTGGCCCGCAGGGAATTTCTCGGACATGTCCCGGCTAC
GCATTTTTACCGCATGCGCGGCGAAGAAGATCCTGTAGAAGCTGCCGTCAAGTATGAAGGACAGCTCCGTGCCGAATTCG
ACCTTGGACCGCAGGACCTCCCCCGGTTTGACTTTATGCTGCTTGGCATGGGCGAAGACGGGCATACCGGTTCCATTTTC
CCCCATTCCCCAGCCCTTGCGGAAAAGAAGCGGCTGGTTATTGACCAGTACGTTCCGGAACGCAAGGCCGACCGCCTTAC
CCTCACCCTGCCGGTGATCAACAATGCCCGCTGCTGCATGTTCCTTGTGACAGGGGCCGAAAAACATGATGTGCTCTCCC
GCGCCCTCAACCTGCTGGCTCCGCCCACACTGCCCGCCCAGATGGTGCGACCCGGCTTTGGCGAGCTTGTATGGGTCGTG
GATGAAGCTGCGGCCACAGGCGTATAG

Upstream 100 bases:

>100_bases
AGGCCGGAAATTCCCGGCTGCCAGGACGCGTTTTGCAGGCAAGTTCCCGCAAAACGGCCATGTAGGCCGTTTCCATCGTC
AACTTTGAAGGAGCCGCCAC

Downstream 100 bases:

>100_bases
CCTGAAAACATCATAAATCTTAGTGTGTTGTGCCAAAATGCGAAGAGGCTGCATCCTCTCTAGGAGCTGGCTTTCACCAG
GAAAGACAAGAGAACTCCCC

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MSGLSRSIHLTVHIHKDPAAMAERAAHILAAACEEAVAERGVFRIALSGGQTPIPLFRLLAGDDWADRLPWDKISIFWVD
ERCVGPEHADSNYGLARREFLGHVPATHFYRMRGEEDPVEAAVKYEGQLRAEFDLGPQDLPRFDFMLLGMGEDGHTGSIF
PHSPALAEKKRLVIDQYVPERKADRLTLTLPVINNARCCMFLVTGAEKHDVLSRALNLLAPPTLPAQMVRPGFGELVWVV
DEAAATGV

Sequences:

>Translated_248_residues
MSGLSRSIHLTVHIHKDPAAMAERAAHILAAACEEAVAERGVFRIALSGGQTPIPLFRLLAGDDWADRLPWDKISIFWVD
ERCVGPEHADSNYGLARREFLGHVPATHFYRMRGEEDPVEAAVKYEGQLRAEFDLGPQDLPRFDFMLLGMGEDGHTGSIF
PHSPALAEKKRLVIDQYVPERKADRLTLTLPVINNARCCMFLVTGAEKHDVLSRALNLLAPPTLPAQMVRPGFGELVWVV
DEAAATGV
>Mature_247_residues
SGLSRSIHLTVHIHKDPAAMAERAAHILAAACEEAVAERGVFRIALSGGQTPIPLFRLLAGDDWADRLPWDKISIFWVDE
RCVGPEHADSNYGLARREFLGHVPATHFYRMRGEEDPVEAAVKYEGQLRAEFDLGPQDLPRFDFMLLGMGEDGHTGSIFP
HSPALAEKKRLVIDQYVPERKADRLTLTLPVINNARCCMFLVTGAEKHDVLSRALNLLAPPTLPAQMVRPGFGELVWVVD
EAAATGV

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912586, Length=229, Percent_Identity=38.4279475982533, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI52145310, Length=240, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI115533058, Length=218, Percent_Identity=33.4862385321101, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI115533060, Length=218, Percent_Identity=33.4862385321101, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321957, Length=245, Percent_Identity=31.8367346938775, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324362, Length=218, Percent_Identity=34.4036697247706, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6319918, Length=220, Percent_Identity=34.5454545454545, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321687, Length=227, Percent_Identity=31.2775330396476, Blast_Score=82, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24641119, Length=240, Percent_Identity=35.8333333333333, Blast_Score=121, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 27397; Mature: 27266

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLSRSIHLTVHIHKDPAAMAERAAHILAAACEEAVAERGVFRIALSGGQTPIPLFRLL
CCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHH
AGDDWADRLPWDKISIFWVDERCVGPEHADSNYGLARREFLGHVPATHFYRMRGEEDPVE
CCCCHHHCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCHHHEEEECCCCCCHH
AAVKYEGQLRAEFDLGPQDLPRFDFMLLGMGEDGHTGSIFPHSPALAEKKRLVIDQYVPE
HHEEECCEEEEEECCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
RKADRLTLTLPVINNARCCMFLVTGAEKHDVLSRALNLLAPPTLPAQMVRPGFGELVWVV
CCCCEEEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCHHHHCCCCCCEEEEE
DEAAATGV
ECHHHCCC
>Mature Secondary Structure 
SGLSRSIHLTVHIHKDPAAMAERAAHILAAACEEAVAERGVFRIALSGGQTPIPLFRLL
CCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHH
AGDDWADRLPWDKISIFWVDERCVGPEHADSNYGLARREFLGHVPATHFYRMRGEEDPVE
CCCCHHHCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCHHHEEEECCCCCCHH
AAVKYEGQLRAEFDLGPQDLPRFDFMLLGMGEDGHTGSIFPHSPALAEKKRLVIDQYVPE
HHEEECCEEEEEECCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
RKADRLTLTLPVINNARCCMFLVTGAEKHDVLSRALNLLAPPTLPAQMVRPGFGELVWVV
CCCCEEEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCHHHHCCCCCCEEEEE
DEAAATGV
ECHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]