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The map label for this gene is prs [H]

Identifier: 21910318

GI number: 21910318

Start: 835565

End: 836545

Strand: Reverse

Name: prs [H]

Synonym: SpyM3_0782

Alternate gene names: 21910318

Gene position: 836545-835565 (Counterclockwise)

Preceding gene: 21910319

Following gene: 21910317

Centisome position: 44.02

GC content: 38.23

Gene sequence:

>981_bases
ATGACTGAACGATATGCTGACAAGCAAATCAAACTGTTCTCACTCACATCAAATCTTCCAATTGCTGAAAAAATTGCTAA
AGCTGCTGGAATCCCTCTTGGAAAAATGTCTTCACGTCAATTTTCCGATGGAGAAATTATGATCAATATTGAAGAAACAG
TGCGTGGAGATGATATCTATATTATTCAATCCACTAGTTTTCCTGTCAATGATAATCTTTGGGAATTACTCATCATGATT
GATGCTTGTCAACGTGCAAGTGCTAATACCGTCAATATTGTATTGCCATACTTTGGTTACTCTCGTCAAGACCGTGTCGC
TAAGCCCCGCGAACCGATTACTGCTAAACTAGTAGCTAATATGCTGACTAAAGCTGGTATTGATCGTGTAGTGACGCTTG
ACTTACATGCTGTTCAGGTACAAGGTTTTTTTGATATTCCAGTGGATAACCTCTTTACAGTCCCTCTTTTTGCAGAACGT
TACAGTAAATTAGGCTTATCAGGTTCTGATGTTGTTGTCGTTAGCCCTAAAAATTCTGGAATTAAACGTGCTAGAAGCTT
GGCTGAATATCTTGATTCCCCGATTGCTATTATCGACTATGCACAAGATGATTCTGAACGTGAACAAGGTTATATTATTG
GTGATGTTTCTGGTAAAAAAGCCATTTTAATTGATGATATTTTAAATACTGGGAAAACCTTTGCAGAAGCTGCTAAAATT
CTTGAACGCTCAGGCGCTACTGATACTTACGCGGTCGCTAGCCATGGCTTATTTGCTGGTGGAGCTGCTGAGGTATTAGA
AACAGCTCCAATCAAAGAAATTATCGTTACAGATTCTGTTAAAACTAAAAATCGTGTGCCAGAAAACGTTACTTATCTTA
GCGCCAGTGATTTAATCGCAGAAGCTATTATTCGTATCCATGAAAGAAGACCCTTAAGTCCACTTTTTTCTTATCAACCT
AAAGGCAAAAATAACGCATGA

Upstream 100 bases:

>100_bases
TCTGTTAAAATAGGGATGTCAATTAAACACTTTTGGGTAATGTGACTCATTAATAAAACAGTTTACCCAATTTTATTGAA
GTTAAGGAGCTAAATCTATC

Downstream 100 bases:

>100_bases
CTTACTTTGATAACGCCGCCACCACACCACTTAGTCCTAATGTGATTAGGGCGATGACAGCAGCTATGCAAGATAACTTT
GGTAACCCCTCTAGTATTCA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK 2; Phosphoribosyl pyrophosphate synthase 2; P-Rib-PP synthase 2; PRPP synthase 2 [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MTERYADKQIKLFSLTSNLPIAEKIAKAAGIPLGKMSSRQFSDGEIMINIEETVRGDDIYIIQSTSFPVNDNLWELLIMI
DACQRASANTVNIVLPYFGYSRQDRVAKPREPITAKLVANMLTKAGIDRVVTLDLHAVQVQGFFDIPVDNLFTVPLFAER
YSKLGLSGSDVVVVSPKNSGIKRARSLAEYLDSPIAIIDYAQDDSEREQGYIIGDVSGKKAILIDDILNTGKTFAEAAKI
LERSGATDTYAVASHGLFAGGAAEVLETAPIKEIIVTDSVKTKNRVPENVTYLSASDLIAEAIIRIHERRPLSPLFSYQP
KGKNNA

Sequences:

>Translated_326_residues
MTERYADKQIKLFSLTSNLPIAEKIAKAAGIPLGKMSSRQFSDGEIMINIEETVRGDDIYIIQSTSFPVNDNLWELLIMI
DACQRASANTVNIVLPYFGYSRQDRVAKPREPITAKLVANMLTKAGIDRVVTLDLHAVQVQGFFDIPVDNLFTVPLFAER
YSKLGLSGSDVVVVSPKNSGIKRARSLAEYLDSPIAIIDYAQDDSEREQGYIIGDVSGKKAILIDDILNTGKTFAEAAKI
LERSGATDTYAVASHGLFAGGAAEVLETAPIKEIIVTDSVKTKNRVPENVTYLSASDLIAEAIIRIHERRPLSPLFSYQP
KGKNNA
>Mature_325_residues
TERYADKQIKLFSLTSNLPIAEKIAKAAGIPLGKMSSRQFSDGEIMINIEETVRGDDIYIIQSTSFPVNDNLWELLIMID
ACQRASANTVNIVLPYFGYSRQDRVAKPREPITAKLVANMLTKAGIDRVVTLDLHAVQVQGFFDIPVDNLFTVPLFAERY
SKLGLSGSDVVVVSPKNSGIKRARSLAEYLDSPIAIIDYAQDDSEREQGYIIGDVSGKKAILIDDILNTGKTFAEAAKIL
ERSGATDTYAVASHGLFAGGAAEVLETAPIKEIIVTDSVKTKNRVPENVTYLSASDLIAEAIIRIHERRPLSPLFSYQPK
GKNNA

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=315, Percent_Identity=41.5873015873016, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI28557709, Length=320, Percent_Identity=41.25, Blast_Score=248, Evalue=5e-66,
Organism=Homo sapiens, GI4506129, Length=315, Percent_Identity=40.9523809523809, Blast_Score=248, Evalue=7e-66,
Organism=Homo sapiens, GI84875539, Length=318, Percent_Identity=40.5660377358491, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI4506133, Length=343, Percent_Identity=34.402332361516, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI194018537, Length=330, Percent_Identity=33.9393939393939, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI310128524, Length=140, Percent_Identity=35.7142857142857, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI310115209, Length=140, Percent_Identity=35.7142857142857, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI310118259, Length=140, Percent_Identity=35.7142857142857, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI310119946, Length=140, Percent_Identity=35.7142857142857, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1787458, Length=314, Percent_Identity=44.5859872611465, Blast_Score=264, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI25149168, Length=315, Percent_Identity=40.9523809523809, Blast_Score=233, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI17554702, Length=315, Percent_Identity=40.9523809523809, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI71989924, Length=314, Percent_Identity=41.0828025477707, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17554704, Length=312, Percent_Identity=40.7051282051282, Blast_Score=230, Evalue=9e-61,
Organism=Caenorhabditis elegans, GI17570245, Length=348, Percent_Identity=32.183908045977, Blast_Score=181, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6319403, Length=321, Percent_Identity=40.4984423676012, Blast_Score=229, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6320946, Length=314, Percent_Identity=40.7643312101911, Blast_Score=226, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6321776, Length=315, Percent_Identity=39.3650793650794, Blast_Score=214, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6322667, Length=191, Percent_Identity=38.7434554973822, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6324511, Length=107, Percent_Identity=42.9906542056075, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355239, Length=315, Percent_Identity=42.2222222222222, Blast_Score=244, Evalue=5e-65,
Organism=Drosophila melanogaster, GI45551540, Length=338, Percent_Identity=39.3491124260355, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI281362873, Length=343, Percent_Identity=33.5276967930029, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24651454, Length=343, Percent_Identity=33.5276967930029, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24651458, Length=343, Percent_Identity=33.5276967930029, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI24651456, Length=343, Percent_Identity=33.5276967930029, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI24651462, Length=190, Percent_Identity=38.4210526315789, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24651464, Length=190, Percent_Identity=38.4210526315789, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45552010, Length=190, Percent_Identity=38.4210526315789, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 35723; Mature: 35592

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERYADKQIKLFSLTSNLPIAEKIAKAAGIPLGKMSSRQFSDGEIMINIEETVRGDDIY
CCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHCCCCEEE
IIQSTSFPVNDNLWELLIMIDACQRASANTVNIVLPYFGYSRQDRVAKPREPITAKLVAN
EEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
MLTKAGIDRVVTLDLHAVQVQGFFDIPVDNLFTVPLFAERYSKLGLSGSDVVVVSPKNSG
HHHHCCCCEEEEEEEEEEEECCEEECCCCCEEECHHHHHHHHHCCCCCCCEEEECCCCCH
IKRARSLAEYLDSPIAIIDYAQDDSEREQGYIIGDVSGKKAILIDDILNTGKTFAEAAKI
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCCEEEEEHHHHHCCHHHHHHHHH
LERSGATDTYAVASHGLFAGGAAEVLETAPIKEIIVTDSVKTKNRVPENVTYLSASDLIA
HHHCCCCCEEHHHCCCCCCCCHHHHHHHCCCHHEEEECCCHHHCCCCCCEEEECHHHHHH
EAIIRIHERRPLSPLFSYQPKGKNNA
HHHHHHHCCCCCCHHHCCCCCCCCCC
>Mature Secondary Structure 
TERYADKQIKLFSLTSNLPIAEKIAKAAGIPLGKMSSRQFSDGEIMINIEETVRGDDIY
CCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHCCCCEEE
IIQSTSFPVNDNLWELLIMIDACQRASANTVNIVLPYFGYSRQDRVAKPREPITAKLVAN
EEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
MLTKAGIDRVVTLDLHAVQVQGFFDIPVDNLFTVPLFAERYSKLGLSGSDVVVVSPKNSG
HHHHCCCCEEEEEEEEEEEECCEEECCCCCEEECHHHHHHHHHCCCCCCCEEEECCCCCH
IKRARSLAEYLDSPIAIIDYAQDDSEREQGYIIGDVSGKKAILIDDILNTGKTFAEAAKI
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCCEEEEEHHHHHCCHHHHHHHHH
LERSGATDTYAVASHGLFAGGAAEVLETAPIKEIIVTDSVKTKNRVPENVTYLSASDLIA
HHHCCCCCEEHHHCCCCCCCCHHHHHHHCCCHHEEEECCCHHHCCCCCCEEEECHHHHHH
EAIIRIHERRPLSPLFSYQPKGKNNA
HHHHHHHCCCCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]