| Definition | Streptococcus pyogenes MGAS315 chromosome, complete genome. |
|---|---|
| Accession | NC_004070 |
| Length | 1,900,521 |
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The map label for this gene is hylA
Identifier: 21910201
GI number: 21910201
Start: 729429
End: 731852
Strand: Reverse
Name: hylA
Synonym: SpyM3_0665
Alternate gene names: NA
Gene position: 731852-729429 (Counterclockwise)
Preceding gene: 21910203
Following gene: 21910188
Centisome position: 38.51
GC content: 35.93
Gene sequence:
>2424_bases GTGAATACTTATTTTTGCACACACCATAAACAATTACTACTTTATTCAAACCTATTCCTTAGCTTTGCTATGATGGGCCA AGGAACTGCCATTTATGCCGATACACTGACTTCAAATTCAGAACCTAATAATACTTACTTTCAAACGCAAACGCTCACTA CTACAGATAGCGAAAAAAAGGTAGTACAGCCACAACAAAAAGACTACTATACTGAATTGTTAGACCAATGGAACAGTATT ATCGCAGGCAACGATGCTTATGATAAAACCAATCCTGACATGGTCACTTTTCATAATAAAGCTGAAAAGGATGCTCAAAA CATTATTAAAAGCTATCAAGGGCCTGACCACGAAAATAGAACTTACCTTTGGGAACATGCAAAGGATTATTCCGCTTCTA CTAATATCACGAAAACTTACCGCAATATTGAAAAAATAGCAAAACAGATCACTAATCCTGAATCATGCTATTATCAAGAT AGTAAAGCTATTGCTATTGTAAAAGACGGTATGGCCTTCATGTATGAACACGCTTATAATCTAAATCGTGAAAATCATCA AACAACTGGAAAAGAAAACAAAGAAAATTGGTGGGTTTATGAAATTGGAACTCCTCGTGCTATTAATAATACCTTATCCT TGATGTATCCTTATTTTACTCAAGAAGAAATCCTTAAATACACAGCTCCAATCGAAAAATTTGTGCCTGACCCTACTCGT TTTAGGGTTCGCGCTGCCAATTTTTCACCTTTTGAAGCCAGTAGCGGAAATTTAATTGATATGGGACGTGTTAAACTCAT TTCCGGTATTCTTCGTAAAGATGATCTCGAAATTAGTGATACAATCAAAGCAATTGAGAAAGTTTTCACGCTAGTTGACG AAGGAAATGGTTTTTACCAAGACGGTTCTTTAATTGATCACGTGGTTACTAACGCTCAAAGTCCACTTTATAAAAAAGGC ATTGCTTACACTGGAGCTTACGGTAATGTTCTTATAGATGGCTTATCGCAATTAATTCCTATTATTCAAAAAACAAAGTC TCCTATAGAAGCGGATAAAATGGCTACTATCTATCATTGGATTAACCATTCTTTTTTCCCTATCATCGTTCGTGGAGAAA TGATGGATATGACTCGAGGGCGTTCTATCAGTCGTTTTAATGCTCAATCTCATGTTGCTGGTATTGAAGCACTTCGTGCT ATTTTACGTATTGCTGACATGTCTGAAGAGCCTCACCGTTTGGCACTTAAAACACGTATAAAAACACTCGTCACACAAGG GAATGCTTTTTACAATGTCTATGATAATTTGAAAACCTATCACGATATCAAACTTATGAAAGAACTGCTAAGTGATACTT CTGTTCCAGTCCAAAAACTTGATAGTTACGTAGCTAGTTTCAATAGTATGGATAAATTGGCACTATATAATAATAAACAC GATTTTGCTTTTGGCCTATCAATGTTTTCGAATCGAACTCAAAATTATGAAGCTATGAATAATGAAAATCTTCATGGCTG GTTTACTTCTGATGGAATGTTTTACCTATACAATAACGATTTAGGACACTACAGTGAAAACTATTGGGCAACGGTAAATC CCTACCGCTTACCTGGAACCACAGAAACTGAGCAAAAACCACTAGAGGGAACTCCTGAGAATATTAAAACGAACTATCAA CAAGTTGGCATGACTAGTCTCTCTGATGACGCTTTTGTTGCAAGTAAAAAACTTAATAACACAAGTGCTCTAGCTGCTAT GACCTTCACTAATTGGAATAAAAGCCTCACTCTCAATAAAGGGTGGTTTATCTTAGGAAACAAAATAATCTTTGTTGGTA GCAATATCAAAAACCAGTCATCTCACAAGGCGTATACAACTATTGAGCAACGAAAAGAAAATCAAAAGCACCCTTACTGT TCTTATGTTAACAATCAACCCGTTGACTTGAATAATCAGCTAGTTGATTTTACAAACACTAAAAGTATTTTCCTTGAAAG TGATGATCCCGCTCAAAATATTGGTTACTACTTCTTCAAGCCAACAACACTTAGCATAAGTAAGGCACTTCAAACAGGGA AATGGCAAAACATAAAAGCTGATGACAAATCACCAGAAGCCATCAAAGAAGTTTCAAATACCTTTATCACTATCATGCAA AACCATACTCAAGATGGCGATCGTTATGCCTATATGATGCTTCCAAATATGACTCGTCAAGAATTTGAAACCTATATTAG CAAGCTTGATATCGACTTGTTAGAAAACAATGCTCTTAACTCTCATAAAATTCCCCACAAAAGACAACGACGCTTACCGC ATACTGGGTATCAGTCCTCCTCTTTAGAATTCTTAGGTGGAGCTTTAGTTGCTTCTTTTAACCATATCACAAAACCCTTT CGTAAGAAAGACTTAAGGATTTAG
Upstream 100 bases:
>100_bases TTTATGTAAGGGTTTATAAAAATACTTTAACGTGGTATATTTTTACTTAGTAAACCAATCTACTTTTATTATCTCATTTT TATATTGGAGGAATGTATCA
Downstream 100 bases:
>100_bases CTGTTATTGGAAAGTAAGGGTTAACAATGAAACGTTATTAAAGACAAAAAACTGGAAACTGCACTGAGCCCCAAAAGTTG GCTACTCTATTTGAAGTAAA
Product: extracellular hyaluronate lyase
Products: NA
Alternate protein names: Hyaluronidase; HYase [H]
Number of amino acids: Translated: 807; Mature: 807
Protein sequence:
>807_residues MNTYFCTHHKQLLLYSNLFLSFAMMGQGTAIYADTLTSNSEPNNTYFQTQTLTTTDSEKKVVQPQQKDYYTELLDQWNSI IAGNDAYDKTNPDMVTFHNKAEKDAQNIIKSYQGPDHENRTYLWEHAKDYSASTNITKTYRNIEKIAKQITNPESCYYQD SKAIAIVKDGMAFMYEHAYNLNRENHQTTGKENKENWWVYEIGTPRAINNTLSLMYPYFTQEEILKYTAPIEKFVPDPTR FRVRAANFSPFEASSGNLIDMGRVKLISGILRKDDLEISDTIKAIEKVFTLVDEGNGFYQDGSLIDHVVTNAQSPLYKKG IAYTGAYGNVLIDGLSQLIPIIQKTKSPIEADKMATIYHWINHSFFPIIVRGEMMDMTRGRSISRFNAQSHVAGIEALRA ILRIADMSEEPHRLALKTRIKTLVTQGNAFYNVYDNLKTYHDIKLMKELLSDTSVPVQKLDSYVASFNSMDKLALYNNKH DFAFGLSMFSNRTQNYEAMNNENLHGWFTSDGMFYLYNNDLGHYSENYWATVNPYRLPGTTETEQKPLEGTPENIKTNYQ QVGMTSLSDDAFVASKKLNNTSALAAMTFTNWNKSLTLNKGWFILGNKIIFVGSNIKNQSSHKAYTTIEQRKENQKHPYC SYVNNQPVDLNNQLVDFTNTKSIFLESDDPAQNIGYYFFKPTTLSISKALQTGKWQNIKADDKSPEAIKEVSNTFITIMQ NHTQDGDRYAYMMLPNMTRQEFETYISKLDIDLLENNALNSHKIPHKRQRRLPHTGYQSSSLEFLGGALVASFNHITKPF RKKDLRI
Sequences:
>Translated_807_residues MNTYFCTHHKQLLLYSNLFLSFAMMGQGTAIYADTLTSNSEPNNTYFQTQTLTTTDSEKKVVQPQQKDYYTELLDQWNSI IAGNDAYDKTNPDMVTFHNKAEKDAQNIIKSYQGPDHENRTYLWEHAKDYSASTNITKTYRNIEKIAKQITNPESCYYQD SKAIAIVKDGMAFMYEHAYNLNRENHQTTGKENKENWWVYEIGTPRAINNTLSLMYPYFTQEEILKYTAPIEKFVPDPTR FRVRAANFSPFEASSGNLIDMGRVKLISGILRKDDLEISDTIKAIEKVFTLVDEGNGFYQDGSLIDHVVTNAQSPLYKKG IAYTGAYGNVLIDGLSQLIPIIQKTKSPIEADKMATIYHWINHSFFPIIVRGEMMDMTRGRSISRFNAQSHVAGIEALRA ILRIADMSEEPHRLALKTRIKTLVTQGNAFYNVYDNLKTYHDIKLMKELLSDTSVPVQKLDSYVASFNSMDKLALYNNKH DFAFGLSMFSNRTQNYEAMNNENLHGWFTSDGMFYLYNNDLGHYSENYWATVNPYRLPGTTETEQKPLEGTPENIKTNYQ QVGMTSLSDDAFVASKKLNNTSALAAMTFTNWNKSLTLNKGWFILGNKIIFVGSNIKNQSSHKAYTTIEQRKENQKHPYC SYVNNQPVDLNNQLVDFTNTKSIFLESDDPAQNIGYYFFKPTTLSISKALQTGKWQNIKADDKSPEAIKEVSNTFITIMQ NHTQDGDRYAYMMLPNMTRQEFETYISKLDIDLLENNALNSHKIPHKRQRRLPHTGYQSSSLEFLGGALVASFNHITKPF RKKDLRI >Mature_807_residues MNTYFCTHHKQLLLYSNLFLSFAMMGQGTAIYADTLTSNSEPNNTYFQTQTLTTTDSEKKVVQPQQKDYYTELLDQWNSI IAGNDAYDKTNPDMVTFHNKAEKDAQNIIKSYQGPDHENRTYLWEHAKDYSASTNITKTYRNIEKIAKQITNPESCYYQD SKAIAIVKDGMAFMYEHAYNLNRENHQTTGKENKENWWVYEIGTPRAINNTLSLMYPYFTQEEILKYTAPIEKFVPDPTR FRVRAANFSPFEASSGNLIDMGRVKLISGILRKDDLEISDTIKAIEKVFTLVDEGNGFYQDGSLIDHVVTNAQSPLYKKG IAYTGAYGNVLIDGLSQLIPIIQKTKSPIEADKMATIYHWINHSFFPIIVRGEMMDMTRGRSISRFNAQSHVAGIEALRA ILRIADMSEEPHRLALKTRIKTLVTQGNAFYNVYDNLKTYHDIKLMKELLSDTSVPVQKLDSYVASFNSMDKLALYNNKH DFAFGLSMFSNRTQNYEAMNNENLHGWFTSDGMFYLYNNDLGHYSENYWATVNPYRLPGTTETEQKPLEGTPENIKTNYQ QVGMTSLSDDAFVASKKLNNTSALAAMTFTNWNKSLTLNKGWFILGNKIIFVGSNIKNQSSHKAYTTIEQRKENQKHPYC SYVNNQPVDLNNQLVDFTNTKSIFLESDDPAQNIGYYFFKPTTLSISKALQTGKWQNIKADDKSPEAIKEVSNTFITIMQ NHTQDGDRYAYMMLPNMTRQEFETYISKLDIDLLENNALNSHKIPHKRQRRLPHTGYQSSSLEFLGGALVASFNHITKPF RKKDLRI
Specific function: Unknown
COG id: NA
COG function: NA
Gene ontology:
Cell location: Secreted, cell wall; Peptidoglycan-anchor (Potential) [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the polysaccharide lyase 8 family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR008929 - InterPro: IPR008979 - InterPro: IPR011013 - InterPro: IPR014718 - InterPro: IPR014756 - InterPro: IPR019931 - InterPro: IPR011071 - InterPro: IPR012970 - InterPro: IPR004103 - InterPro: IPR003159 - InterPro: IPR012329 [H]
Pfam domain/function: PF02278 Lyase_8; PF02884 Lyase_8_C; PF08124 Lyase_8_N [H]
EC number: =4.2.2.1 [H]
Molecular weight: Translated: 92582; Mature: 92582
Theoretical pI: Translated: 7.62; Mature: 7.62
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 3.0 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 3.0 %Met (Mature Protein) 3.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNTYFCTHHKQLLLYSNLFLSFAMMGQGTAIYADTLTSNSEPNNTYFQTQTLTTTDSEKK CCCEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCCH VVQPQQKDYYTELLDQWNSIIAGNDAYDKTNPDMVTFHNKAEKDAQNIIKSYQGPDHENR HCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCC TYLWEHAKDYSASTNITKTYRNIEKIAKQITNPESCYYQDSKAIAIVKDGMAFMYEHAYN CEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHEEECCCEEEEEECCHHHHHHHHHC LNRENHQTTGKENKENWWVYEIGTPRAINNTLSLMYPYFTQEEILKYTAPIEKFVPDPTR CCCCCCCCCCCCCCCCEEEEECCCCCHHCCCHHEEECCCCHHHHHHHHCCHHHHCCCCCC FRVRAANFSPFEASSGNLIDMGRVKLISGILRKDDLEISDTIKAIEKVFTLVDEGNGFYQ EEEEECCCCCCCCCCCCEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEC DGSLIDHVVTNAQSPLYKKGIAYTGAYGNVLIDGLSQLIPIIQKTKSPIEADKMATIYHW CCCHHHHHHHCCCCCHHHCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH INHSFFPIIVRGEMMDMTRGRSISRFNAQSHVAGIEALRAILRIADMSEEPHRLALKTRI HCCCEEEEEEECCHHHHHCCCCCHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH KTLVTQGNAFYNVYDNLKTYHDIKLMKELLSDTSVPVQKLDSYVASFNSMDKLALYNNKH HHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCC DFAFGLSMFSNRTQNYEAMNNENLHGWFTSDGMFYLYNNDLGHYSENYWATVNPYRLPGT CHHHHHHHHHCCCCCCHHCCCCCCEEEEECCCEEEEEECCCCCCCCCCEEEECCEECCCC TETEQKPLEGTPENIKTNYQQVGMTSLSDDAFVASKKLNNTSALAAMTFTNWNKSLTLNK CCCCCCCCCCCCHHHHCCHHHHCCCCCCCCHHHHHHCCCCCCEEEEEEEECCCCEEEECC GWFILGNKIIFVGSNIKNQSSHKAYTTIEQRKENQKHPYCSYVNNQPVDLNNQLVDFTNT CEEEECCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCEEEECCC KSIFLESDDPAQNIGYYFFKPTTLSISKALQTGKWQNIKADDKSPEAIKEVSNTFITIMQ CEEEEECCCCHHHCCEEEECCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHEEEEEE NHTQDGDRYAYMMLPNMTRQEFETYISKLDIDLLENNALNSHKIPHKRQRRLPHTGYQSS CCCCCCCEEEEEECCCCCHHHHHHHHHHHCHHHHCCCCCCCCCCCCHHHHCCCCCCCCCC SLEFLGGALVASFNHITKPFRKKDLRI CHHHHHHHHHHHHHHHHCHHHHCCCCC >Mature Secondary Structure MNTYFCTHHKQLLLYSNLFLSFAMMGQGTAIYADTLTSNSEPNNTYFQTQTLTTTDSEKK CCCEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCCH VVQPQQKDYYTELLDQWNSIIAGNDAYDKTNPDMVTFHNKAEKDAQNIIKSYQGPDHENR HCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCC TYLWEHAKDYSASTNITKTYRNIEKIAKQITNPESCYYQDSKAIAIVKDGMAFMYEHAYN CEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHEEECCCEEEEEECCHHHHHHHHHC LNRENHQTTGKENKENWWVYEIGTPRAINNTLSLMYPYFTQEEILKYTAPIEKFVPDPTR CCCCCCCCCCCCCCCCEEEEECCCCCHHCCCHHEEECCCCHHHHHHHHCCHHHHCCCCCC FRVRAANFSPFEASSGNLIDMGRVKLISGILRKDDLEISDTIKAIEKVFTLVDEGNGFYQ EEEEECCCCCCCCCCCCEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEC DGSLIDHVVTNAQSPLYKKGIAYTGAYGNVLIDGLSQLIPIIQKTKSPIEADKMATIYHW CCCHHHHHHHCCCCCHHHCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH INHSFFPIIVRGEMMDMTRGRSISRFNAQSHVAGIEALRAILRIADMSEEPHRLALKTRI HCCCEEEEEEECCHHHHHCCCCCHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH KTLVTQGNAFYNVYDNLKTYHDIKLMKELLSDTSVPVQKLDSYVASFNSMDKLALYNNKH HHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCC DFAFGLSMFSNRTQNYEAMNNENLHGWFTSDGMFYLYNNDLGHYSENYWATVNPYRLPGT CHHHHHHHHHCCCCCCHHCCCCCCEEEEECCCEEEEEECCCCCCCCCCEEEECCEECCCC TETEQKPLEGTPENIKTNYQQVGMTSLSDDAFVASKKLNNTSALAAMTFTNWNKSLTLNK CCCCCCCCCCCCHHHHCCHHHHCCCCCCCCHHHHHHCCCCCCEEEEEEEECCCCEEEECC GWFILGNKIIFVGSNIKNQSSHKAYTTIEQRKENQKHPYCSYVNNQPVDLNNQLVDFTNT CEEEECCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCEEEECCC KSIFLESDDPAQNIGYYFFKPTTLSISKALQTGKWQNIKADDKSPEAIKEVSNTFITIMQ CEEEEECCCCHHHCCEEEECCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHEEEEEE NHTQDGDRYAYMMLPNMTRQEFETYISKLDIDLLENNALNSHKIPHKRQRRLPHTGYQSS CCCCCCCEEEEEECCCCCHHHHHHHHHHHCHHHHCCCCCCCCCCCCHHHHCCCCCCCCCC SLEFLGGALVASFNHITKPFRKKDLRI CHHHHHHHHHHHHHHHHCHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11463916; 8112843; 9573623 [H]