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The map label for this gene is acoB [H]

Identifier: 21910198

GI number: 21910198

Start: 724257

End: 725258

Strand: Direct

Name: acoB [H]

Synonym: SpyM3_0662

Alternate gene names: 21910198

Gene position: 724257-725258 (Clockwise)

Preceding gene: 21910197

Following gene: 21910199

Centisome position: 38.11

GC content: 42.42

Gene sequence:

>1002_bases
ATGATGTCAGAAACAAAATTAATGGCTTTGCGTGAAGCAGTCAACCTTGCTATGACTGAGGAAATGCGCAAGGACGAAAA
CATTTTCCTTATGGGAGAAGACGTAGGGGTTTACGGAGGAGACTTCGGGACTTCTGTTGGAATGATTGAAGAATTTGGTC
CTAAACGTGTTAAAGATACCCCAATTTCAGAAGCTGCTATCTCTGGTGCGGCTATTGGTGCAGCTATTACAGGACTACGT
CCAATTGTCGACGTTACCTTCATGGATTTCCTTACCATCATGATGGACGCTATCGTGAATAATGGTGCTAAAAATAATTA
CATGTTCGGTGGAGGCCTTATTACCCCTGTAACCTTCCGTGTGGCATCAGGTTCTGGTATTGGTTCCGCTGCGCAACACT
CACAATCTCTTGAAGCATGGTTGACTCACATTCCAGGAATCAAAGCTGTTGCTCCTGGTAATGCCAACGATGCTAAAGGC
TTATTAAAATCAGCTATCCGTGATAATAACATTGTTCTTTTCATGGAACCAAAAGCGCTTTATGGTAAAAAAGAAGAAGT
TAACCAAGATCCTGACTTCTATATCCCACTTGGCAAAGGTGACATCAAACGTGAAGGAACTGATTTGACAATTGTGTCAT
ACGGTCGTATGTTGGAGCGTGTTCTTCAAGCGGCTGAAGAAGTTGCAGCGGATGGTATTAACGTTGAAGTTGTTGACCCA
CGTACCCTCATCCCACTTGATAAAGAGTTGATTATTGAATCTGTTAAGAAAACAGGTAAATTGATGCTTGTCAACGATGC
CTACAAGACCGGTGGATTCATTGGGGAAATTGCAACCATGATTACCGAAAGTGAAGCCTTTGATTACCTTGATCATCCAA
TCGTTCGTCTTGCAAGTGAAGATGTTCCAGTACCTTATGCACGTGTACTTGAACAAGCGATCTTACCAGACGTTGAGAAA
ATCAAAGCTGCTATTGTGAAAATGGCAAACAAAGGCAACTAG

Upstream 100 bases:

>100_bases
GATCCAGAACTTTCAGTAGCCTTCGAAGACGTTTGGGTTGACTAAGATCACCTTGTCAGTAAGAAGCAATCGTATTTGAA
TAATAAATGGAGAAATAAAA

Downstream 100 bases:

>100_bases
AAGATAAGGCAAGTGGTCTGATAAAGGCTATGTTTATCAGTAACGTCTCAGCTAAAAACTATTTTGAAAGTTTTTAGAAG
AACTGAGTTGTCTTATCCCG

Product: putative acetoin dehydrogenase (TPP-dependent) beta chain

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MMSETKLMALREAVNLAMTEEMRKDENIFLMGEDVGVYGGDFGTSVGMIEEFGPKRVKDTPISEAAISGAAIGAAITGLR
PIVDVTFMDFLTIMMDAIVNNGAKNNYMFGGGLITPVTFRVASGSGIGSAAQHSQSLEAWLTHIPGIKAVAPGNANDAKG
LLKSAIRDNNIVLFMEPKALYGKKEEVNQDPDFYIPLGKGDIKREGTDLTIVSYGRMLERVLQAAEEVAADGINVEVVDP
RTLIPLDKELIIESVKKTGKLMLVNDAYKTGGFIGEIATMITESEAFDYLDHPIVRLASEDVPVPYARVLEQAILPDVEK
IKAAIVKMANKGN

Sequences:

>Translated_333_residues
MMSETKLMALREAVNLAMTEEMRKDENIFLMGEDVGVYGGDFGTSVGMIEEFGPKRVKDTPISEAAISGAAIGAAITGLR
PIVDVTFMDFLTIMMDAIVNNGAKNNYMFGGGLITPVTFRVASGSGIGSAAQHSQSLEAWLTHIPGIKAVAPGNANDAKG
LLKSAIRDNNIVLFMEPKALYGKKEEVNQDPDFYIPLGKGDIKREGTDLTIVSYGRMLERVLQAAEEVAADGINVEVVDP
RTLIPLDKELIIESVKKTGKLMLVNDAYKTGGFIGEIATMITESEAFDYLDHPIVRLASEDVPVPYARVLEQAILPDVEK
IKAAIVKMANKGN
>Mature_333_residues
MMSETKLMALREAVNLAMTEEMRKDENIFLMGEDVGVYGGDFGTSVGMIEEFGPKRVKDTPISEAAISGAAIGAAITGLR
PIVDVTFMDFLTIMMDAIVNNGAKNNYMFGGGLITPVTFRVASGSGIGSAAQHSQSLEAWLTHIPGIKAVAPGNANDAKG
LLKSAIRDNNIVLFMEPKALYGKKEEVNQDPDFYIPLGKGDIKREGTDLTIVSYGRMLERVLQAAEEVAADGINVEVVDP
RTLIPLDKELIIESVKKTGKLMLVNDAYKTGGFIGEIATMITESEAFDYLDHPIVRLASEDVPVPYARVLEQAILPDVEK
IKAAIVKMANKGN

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156564403, Length=326, Percent_Identity=43.8650306748466, Blast_Score=283, Evalue=1e-76,
Organism=Homo sapiens, GI291084858, Length=326, Percent_Identity=42.3312883435583, Blast_Score=262, Evalue=3e-70,
Organism=Homo sapiens, GI4557353, Length=333, Percent_Identity=38.4384384384384, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI34101272, Length=333, Percent_Identity=38.4384384384384, Blast_Score=214, Evalue=1e-55,
Organism=Escherichia coli, GI1786622, Length=234, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538422, Length=327, Percent_Identity=45.2599388379205, Blast_Score=288, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17506935, Length=330, Percent_Identity=39.3939393939394, Blast_Score=192, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6319698, Length=328, Percent_Identity=44.5121951219512, Blast_Score=288, Evalue=1e-78,
Organism=Drosophila melanogaster, GI21358145, Length=326, Percent_Identity=41.4110429447853, Blast_Score=271, Evalue=4e-73,
Organism=Drosophila melanogaster, GI24650940, Length=326, Percent_Identity=41.4110429447853, Blast_Score=271, Evalue=4e-73,
Organism=Drosophila melanogaster, GI160714828, Length=334, Percent_Identity=37.7245508982036, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI160714832, Length=334, Percent_Identity=37.7245508982036, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24650943, Length=85, Percent_Identity=41.1764705882353, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24650945, Length=85, Percent_Identity=41.1764705882353, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45551847, Length=236, Percent_Identity=27.5423728813559, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45550715, Length=236, Percent_Identity=27.5423728813559, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24645119, Length=236, Percent_Identity=27.5423728813559, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR000089
- InterPro:   IPR011053
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35940; Mature: 35940

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSETKLMALREAVNLAMTEEMRKDENIFLMGEDVGVYGGDFGTSVGMIEEFGPKRVKDT
CCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCC
PISEAAISGAAIGAAITGLRPIVDVTFMDFLTIMMDAIVNNGAKNNYMFGGGLITPVTFR
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCEECCEEEE
VASGSGIGSAAQHSQSLEAWLTHIPGIKAVAPGNANDAKGLLKSAIRDNNIVLFMEPKAL
EECCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCCCEEEEECCHHH
YGKKEEVNQDPDFYIPLGKGDIKREGTDLTIVSYGRMLERVLQAAEEVAADGINVEVVDP
CCCHHHCCCCCCEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEECC
RTLIPLDKELIIESVKKTGKLMLVNDAYKTGGFIGEIATMITESEAFDYLDHPIVRLASE
CEECCCCHHHHHHHHHHCCCEEEEECCHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHCCC
DVPVPYARVLEQAILPDVEKIKAAIVKMANKGN
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMSETKLMALREAVNLAMTEEMRKDENIFLMGEDVGVYGGDFGTSVGMIEEFGPKRVKDT
CCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCC
PISEAAISGAAIGAAITGLRPIVDVTFMDFLTIMMDAIVNNGAKNNYMFGGGLITPVTFR
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCEECCEEEE
VASGSGIGSAAQHSQSLEAWLTHIPGIKAVAPGNANDAKGLLKSAIRDNNIVLFMEPKAL
EECCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCCCEEEEECCHHH
YGKKEEVNQDPDFYIPLGKGDIKREGTDLTIVSYGRMLERVLQAAEEVAADGINVEVVDP
CCCHHHCCCCCCEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEECC
RTLIPLDKELIIESVKKTGKLMLVNDAYKTGGFIGEIATMITESEAFDYLDHPIVRLASE
CEECCCCHHHHHHHHHHCCCEEEEECCHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHCCC
DVPVPYARVLEQAILPDVEKIKAAIVKMANKGN
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]