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The map label for this gene is glpD [H]

Identifier: 218930933

GI number: 218930933

Start: 4421260

End: 4422681

Strand: Direct

Name: glpD [H]

Synonym: YPO3937

Alternate gene names: 218930933

Gene position: 4421260-4422681 (Clockwise)

Preceding gene: 218930929

Following gene: 218930939

Centisome position: 95.0

GC content: 52.46

Gene sequence:

>1422_bases
ATGGAAACCAAAGACTTGGCCTGTGCTACGTCTTCCGCCAGTTCCAAACTTATCCATGGTGGCTTACGCTATCTGGAACA
TTATGAATTCCGCTTGGTAAGTGAAGCCTTGGCCGAGCGTGAAGTGTTACTGAAACTGGCACCGCATATCGCATTCCCTA
TGCGCTTCCGCCTACCCCACCAGCCTCATCTACGCCCGGCATGGATGATCCGCACCGGCTTGTTCTTGTATGACCATTTG
GGCAAACGTACCAGCCTGCCTGCCAGTAAAGGGCTGCGTTTTGGGCCGGAATCTGTGTTAAAGCCCGAGTTGGTGCGCGG
TTTCGAATATTCTGACTGTTGGGTGGATGATGCCCGCCTGGTGGTGCTGAATGTGCAGGAAGTGGTTAAACACGGCGGTG
AAGTCCGAACCCGTACCAAAGTGACCCGCACATGGCGTGAACAAGGCCTATGGATGGTTGAAGCCCTTGATGTCAATACC
GGCAAAACCTTCACCTGGCGGGCTAAAGGCTTAGTGAATGCCACTGGCCCTTGGGTTAAACAGTTCTTCGACGATGGCCT
AAAGCTCAAATCACCTTATGGCATCCGCCTAATTAAAGGCAGCCACATTGTGGTGCCTCGGGTTCATAACCAACCGCAGG
CGTATATTCTGCAAAATGAAGATCACCGTATCGTTTTCGTTATCCCTTGGTTAGATGACTATTCCATCATCGGTACTACC
GACGTGGAATACCACGGCGATCCAAAAGAGGTGAAAATTGACGATCAGGAAATGACTTATCTGCTGAAAGTCTATAACGA
CCACTTTAAAAAACAGTTGGGTCGTGACGATATCGTCTGGACCTACTCTGGTGTGCGCCCGCTATGCGACGATGAATCAG
ATTCACCGCAAGCCGTTACCCGCGATTACACGCTAGATGTGGCCGATGAAGCGGGTCAGGCACCACTGCTGTCGGTCTTC
GGCGGTAAGCTCACCACGTACCGTAAATTGGCAGAACATGCGCTGGAAAAACTGTCAGCGTACTACCCGAATGTCGGCCC
AGCGTGGACTAAAACCGGTGCCTTGCCCGGTGGGGATATCGGCGGTAGTCGTGATAGCTATACCGTGCAATTACGCCACC
GCTATAACTGGTTGCCGGAAGGGTTAGCCCGCCGCTATACCCGTACCTATGGTAGCCACAGCGAGCTAATTTTAGCCAAC
GCGACCCGTCTTGAAAGCCTAGGTGAGCACTTTGGTCACGGCTTGTATGAGGCTGAATTGCGCTATTTGGTTGAGAACGA
GTGGGTCGTTGAGCTGGATGATGCTATCTGGCGTCGTACCAAATTAGGCATGGCCCTCAGCGATGAAGAGAAACAGCGGG
TAGCCCAGTGGCTGGCTGATGCGCACACTGAAAAACAACAGGCGCTGCCGCTGGTTTCTTAA

Upstream 100 bases:

>100_bases
TTTCTTCGGTTAAATCTTGGCTTATTTGTTGGTTTTTGATTACAATCGTGAGCGAAAACGAACATTAAAGCGCTGTTTCG
AACATTCAGAGGAAGGTAAC

Downstream 100 bases:

>100_bases
TAGCAAAGTTTAACATTGTTTAACTTTCGTCAATTTTTGCCTTTCTGGGCTGCATAGCGTTGTTCAAGCACCTCAAGAAA
TTTAAAAACCCTCTTCAATC

Product: glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
METKDLACATSSASSKLIHGGLRYLEHYEFRLVSEALAEREVLLKLAPHIAFPMRFRLPHQPHLRPAWMIRTGLFLYDHL
GKRTSLPASKGLRFGPESVLKPELVRGFEYSDCWVDDARLVVLNVQEVVKHGGEVRTRTKVTRTWREQGLWMVEALDVNT
GKTFTWRAKGLVNATGPWVKQFFDDGLKLKSPYGIRLIKGSHIVVPRVHNQPQAYILQNEDHRIVFVIPWLDDYSIIGTT
DVEYHGDPKEVKIDDQEMTYLLKVYNDHFKKQLGRDDIVWTYSGVRPLCDDESDSPQAVTRDYTLDVADEAGQAPLLSVF
GGKLTTYRKLAEHALEKLSAYYPNVGPAWTKTGALPGGDIGGSRDSYTVQLRHRYNWLPEGLARRYTRTYGSHSELILAN
ATRLESLGEHFGHGLYEAELRYLVENEWVVELDDAIWRRTKLGMALSDEEKQRVAQWLADAHTEKQQALPLVS

Sequences:

>Translated_473_residues
METKDLACATSSASSKLIHGGLRYLEHYEFRLVSEALAEREVLLKLAPHIAFPMRFRLPHQPHLRPAWMIRTGLFLYDHL
GKRTSLPASKGLRFGPESVLKPELVRGFEYSDCWVDDARLVVLNVQEVVKHGGEVRTRTKVTRTWREQGLWMVEALDVNT
GKTFTWRAKGLVNATGPWVKQFFDDGLKLKSPYGIRLIKGSHIVVPRVHNQPQAYILQNEDHRIVFVIPWLDDYSIIGTT
DVEYHGDPKEVKIDDQEMTYLLKVYNDHFKKQLGRDDIVWTYSGVRPLCDDESDSPQAVTRDYTLDVADEAGQAPLLSVF
GGKLTTYRKLAEHALEKLSAYYPNVGPAWTKTGALPGGDIGGSRDSYTVQLRHRYNWLPEGLARRYTRTYGSHSELILAN
ATRLESLGEHFGHGLYEAELRYLVENEWVVELDDAIWRRTKLGMALSDEEKQRVAQWLADAHTEKQQALPLVS
>Mature_473_residues
METKDLACATSSASSKLIHGGLRYLEHYEFRLVSEALAEREVLLKLAPHIAFPMRFRLPHQPHLRPAWMIRTGLFLYDHL
GKRTSLPASKGLRFGPESVLKPELVRGFEYSDCWVDDARLVVLNVQEVVKHGGEVRTRTKVTRTWREQGLWMVEALDVNT
GKTFTWRAKGLVNATGPWVKQFFDDGLKLKSPYGIRLIKGSHIVVPRVHNQPQAYILQNEDHRIVFVIPWLDDYSIIGTT
DVEYHGDPKEVKIDDQEMTYLLKVYNDHFKKQLGRDDIVWTYSGVRPLCDDESDSPQAVTRDYTLDVADEAGQAPLLSVF
GGKLTTYRKLAEHALEKLSAYYPNVGPAWTKTGALPGGDIGGSRDSYTVQLRHRYNWLPEGLARRYTRTYGSHSELILAN
ATRLESLGEHFGHGLYEAELRYLVENEWVVELDDAIWRRTKLGMALSDEEKQRVAQWLADAHTEKQQALPLVS

Specific function: Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses molecular oxygen or nitrate as electron acceptor [H]

COG id: COG0578

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI285002233, Length=488, Percent_Identity=28.8934426229508, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI285002231, Length=488, Percent_Identity=28.8934426229508, Blast_Score=142, Evalue=5e-34,
Organism=Escherichia coli, GI2367226, Length=473, Percent_Identity=75.0528541226216, Blast_Score=742, Evalue=0.0,
Organism=Escherichia coli, GI1788574, Length=463, Percent_Identity=26.9978401727862, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17509253, Length=485, Percent_Identity=27.8350515463918, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI115534726, Length=504, Percent_Identity=27.5793650793651, Blast_Score=129, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6322036, Length=486, Percent_Identity=26.9547325102881, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI161077125, Length=483, Percent_Identity=28.5714285714286, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24653942, Length=483, Percent_Identity=28.5714285714286, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24653944, Length=483, Percent_Identity=28.5714285714286, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI20130025, Length=483, Percent_Identity=28.5714285714286, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24586295, Length=493, Percent_Identity=24.7464503042596, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19921278, Length=484, Percent_Identity=23.3471074380165, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR000447 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.5.3 [H]

Molecular weight: Translated: 54008; Mature: 54008

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00978 FAD_G3PDH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METKDLACATSSASSKLIHGGLRYLEHYEFRLVSEALAEREVLLKLAPHIAFPMRFRLPH
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCC
QPHLRPAWMIRTGLFLYDHLGKRTSLPASKGLRFGPESVLKPELVRGFEYSDCWVDDARL
CCCCCHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCHHHCCHHHHCCCCCCCCEECCCEE
VVLNVQEVVKHGGEVRTRTKVTRTWREQGLWMVEALDVNTGKTFTWRAKGLVNATGPWVK
EEEEHHHHHHCCCCEEHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCCCCCHHHH
QFFDDGLKLKSPYGIRLIKGSHIVVPRVHNQPQAYILQNEDHRIVFVIPWLDDYSIIGTT
HHHCCCCEECCCCCEEEEECCEEEEECCCCCCCEEEEECCCCEEEEEEECCCCCEEEECC
DVEYHGDPKEVKIDDQEMTYLLKVYNDHFKKQLGRDDIVWTYSGVRPLCDDESDSPQAVT
CCEECCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCEEE
RDYTLDVADEAGQAPLLSVFGGKLTTYRKLAEHALEKLSAYYPNVGPAWTKTGALPGGDI
CCEEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GGSRDSYTVQLRHRYNWLPEGLARRYTRTYGSHSELILANATRLESLGEHFGHGLYEAEL
CCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHCCCHHHHHH
RYLVENEWVVELDDAIWRRTKLGMALSDEEKQRVAQWLADAHTEKQQALPLVS
HHHCCCCCEEEECHHHHHHHHCCCEECCHHHHHHHHHHHHHHCCHHHCCCCCC
>Mature Secondary Structure
METKDLACATSSASSKLIHGGLRYLEHYEFRLVSEALAEREVLLKLAPHIAFPMRFRLPH
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCC
QPHLRPAWMIRTGLFLYDHLGKRTSLPASKGLRFGPESVLKPELVRGFEYSDCWVDDARL
CCCCCHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCHHHCCHHHHCCCCCCCCEECCCEE
VVLNVQEVVKHGGEVRTRTKVTRTWREQGLWMVEALDVNTGKTFTWRAKGLVNATGPWVK
EEEEHHHHHHCCCCEEHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCCCCCHHHH
QFFDDGLKLKSPYGIRLIKGSHIVVPRVHNQPQAYILQNEDHRIVFVIPWLDDYSIIGTT
HHHCCCCEECCCCCEEEEECCEEEEECCCCCCCEEEEECCCCEEEEEEECCCCCEEEECC
DVEYHGDPKEVKIDDQEMTYLLKVYNDHFKKQLGRDDIVWTYSGVRPLCDDESDSPQAVT
CCEECCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCEEE
RDYTLDVADEAGQAPLLSVFGGKLTTYRKLAEHALEKLSAYYPNVGPAWTKTGALPGGDI
CCEEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GGSRDSYTVQLRHRYNWLPEGLARRYTRTYGSHSELILANATRLESLGEHFGHGLYEAEL
CCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHCCCHHHHHH
RYLVENEWVVELDDAIWRRTKLGMALSDEEKQRVAQWLADAHTEKQQALPLVS
HHHCCCCCEEEECHHHHHHHHCCCEECCHHHHHHHHHHHHHHCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1987111; 9278503; 3045087; 3045764 [H]