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The map label for this gene is metR [H]

Identifier: 218930791

GI number: 218930791

Start: 4254451

End: 4255404

Strand: Direct

Name: metR [H]

Synonym: YPO3789

Alternate gene names: 218930791

Gene position: 4254451-4255404 (Clockwise)

Preceding gene: 218930789

Following gene: 218930799

Centisome position: 91.42

GC content: 53.04

Gene sequence:

>954_bases
ATGATCGAACTGAAACACTTACGCACCCTGCAAGCTTTGCGTAATACTGGCTCGCTGGCAGCGGCGGCAACGCAACTTCA
TCAGACCCAATCGGCCCTGTCCCATCAATTTAGTGATCTGGAACAGCGTCTGGGATTTCGCCTGTTTGTACGCAAAAGCC
AACCGCTGCGTTTCACGACGCAGGGGGAGATTTTGTTACAATTGGCAGAGCAAGTGCTGCCACAAATTAAACAGGCACTG
CAAACCTGCAATGAGCCACACCAAACGGCGTTACGCATCGCAATCGAGTGCCACAGCTGCATTCAGTGGCTGACACCCGC
GTTGGATAATTTCCATAAGCACTGGCCGCAAGTGACTATGGACTTCAAATCAGGCGTCACTTTTGACCCGCAACCCGCAT
TACAGCAAGGGGAACTGGATCTGGTGCTGACATCGGATATTTTGCCGCGCAGTGGCCTGCACTATTCACCGATGTTTGAT
TTTGAAGTGCGCCTGGTATTGGCTCCGGACCATCCGTTAGCCAATAAAGACCGCATTGAACCAGAAGATTTAGCGCCAGA
AGTATTGATGATTTATCCGGTGCAGCGACAGCGGCTGGATGTTTGGCGGCACTTCCTGCAACCCGCAGGCGTCAGCCCAT
CGTCGAAAAATGTGGATAACACATTGCTGCTGATCCAGATGGTATCAGCACGGATGGGTATCGCGGCATTGCCTCACTGG
GTGGTGGAGAGCTTTGAGCGCCAAGGATTGGTTGTCACTAAGACGCTGGGAGAAGGGTTGTGGAGCCGGTTATACGCTGC
CGTCCGTGATGGAGAACAGCGCCAACCAGTCACTGAAGCGTTTATTCGTTCTGCTCGTCAGCACGCTTGCGATCATTTGC
CGTTTGTAAAGGATGCGGTGCGATCCAACGCCGGTGTACCCACAGCGAAGCCATTATCACCGCAGCTCCAATGA

Upstream 100 bases:

>100_bases
TATTCCCCATTTAGCCATCCAGATGTTTACACATCTATAATCCGCAGGTACTGTATATTCCACAAGCGCATTTTTTTCAC
AGTCACTGTGAAGGACTCTC

Downstream 100 bases:

>100_bases
TAAAGCTGGGCCAATGCGGTTTTTCTTGCCAGATGGCCAGATTCACCAGTAGCCCAGCCGGAACATGTACATTATTCATG
ATGCCGAGTGTGCCGGCATC

Product: lysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MIELKHLRTLQALRNTGSLAAAATQLHQTQSALSHQFSDLEQRLGFRLFVRKSQPLRFTTQGEILLQLAEQVLPQIKQAL
QTCNEPHQTALRIAIECHSCIQWLTPALDNFHKHWPQVTMDFKSGVTFDPQPALQQGELDLVLTSDILPRSGLHYSPMFD
FEVRLVLAPDHPLANKDRIEPEDLAPEVLMIYPVQRQRLDVWRHFLQPAGVSPSSKNVDNTLLLIQMVSARMGIAALPHW
VVESFERQGLVVTKTLGEGLWSRLYAAVRDGEQRQPVTEAFIRSARQHACDHLPFVKDAVRSNAGVPTAKPLSPQLQ

Sequences:

>Translated_317_residues
MIELKHLRTLQALRNTGSLAAAATQLHQTQSALSHQFSDLEQRLGFRLFVRKSQPLRFTTQGEILLQLAEQVLPQIKQAL
QTCNEPHQTALRIAIECHSCIQWLTPALDNFHKHWPQVTMDFKSGVTFDPQPALQQGELDLVLTSDILPRSGLHYSPMFD
FEVRLVLAPDHPLANKDRIEPEDLAPEVLMIYPVQRQRLDVWRHFLQPAGVSPSSKNVDNTLLLIQMVSARMGIAALPHW
VVESFERQGLVVTKTLGEGLWSRLYAAVRDGEQRQPVTEAFIRSARQHACDHLPFVKDAVRSNAGVPTAKPLSPQLQ
>Mature_317_residues
MIELKHLRTLQALRNTGSLAAAATQLHQTQSALSHQFSDLEQRLGFRLFVRKSQPLRFTTQGEILLQLAEQVLPQIKQAL
QTCNEPHQTALRIAIECHSCIQWLTPALDNFHKHWPQVTMDFKSGVTFDPQPALQQGELDLVLTSDILPRSGLHYSPMFD
FEVRLVLAPDHPLANKDRIEPEDLAPEVLMIYPVQRQRLDVWRHFLQPAGVSPSSKNVDNTLLLIQMVSARMGIAALPHW
VVESFERQGLVVTKTLGEGLWSRLYAAVRDGEQRQPVTEAFIRSARQHACDHLPFVKDAVRSNAGVPTAKPLSPQLQ

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes. It is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=314, Percent_Identity=88.2165605095541, Blast_Score=570, Evalue=1e-164,
Organism=Escherichia coli, GI87082024, Length=279, Percent_Identity=29.7491039426523, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI157672245, Length=235, Percent_Identity=26.8085106382979, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788887, Length=288, Percent_Identity=26.7361111111111, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787879, Length=254, Percent_Identity=27.5590551181102, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87081904, Length=201, Percent_Identity=28.8557213930348, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787806, Length=300, Percent_Identity=23, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790399, Length=255, Percent_Identity=27.4509803921569, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786401, Length=160, Percent_Identity=28.125, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787530, Length=222, Percent_Identity=26.1261261261261, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786448, Length=234, Percent_Identity=25.6410256410256, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789204, Length=264, Percent_Identity=26.1363636363636, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788706, Length=178, Percent_Identity=26.9662921348315, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790208, Length=292, Percent_Identity=26.027397260274, Blast_Score=61, Evalue=8e-11,
Organism=Escherichia coli, GI1789173, Length=188, Percent_Identity=26.063829787234, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35779; Mature: 35779

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELKHLRTLQALRNTGSLAAAATQLHQTQSALSHQFSDLEQRLGFRLFVRKSQPLRFTT
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEECC
QGEILLQLAEQVLPQIKQALQTCNEPHQTALRIAIECHSCIQWLTPALDNFHKHWPQVTM
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
DFKSGVTFDPQPALQQGELDLVLTSDILPRSGLHYSPMFDFEVRLVLAPDHPLANKDRIE
HHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCC
PEDLAPEVLMIYPVQRQRLDVWRHFLQPAGVSPSSKNVDNTLLLIQMVSARMGIAALPHW
HHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VVESFERQGLVVTKTLGEGLWSRLYAAVRDGEQRQPVTEAFIRSARQHACDHLPFVKDAV
HHHHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
RSNAGVPTAKPLSPQLQ
HCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIELKHLRTLQALRNTGSLAAAATQLHQTQSALSHQFSDLEQRLGFRLFVRKSQPLRFTT
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEECC
QGEILLQLAEQVLPQIKQALQTCNEPHQTALRIAIECHSCIQWLTPALDNFHKHWPQVTM
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
DFKSGVTFDPQPALQQGELDLVLTSDILPRSGLHYSPMFDFEVRLVLAPDHPLANKDRIE
HHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCC
PEDLAPEVLMIYPVQRQRLDVWRHFLQPAGVSPSSKNVDNTLLLIQMVSARMGIAALPHW
HHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VVESFERQGLVVTKTLGEGLWSRLYAAVRDGEQRQPVTEAFIRSARQHACDHLPFVKDAV
HHHHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
RSNAGVPTAKPLSPQLQ
HCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]