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The map label for this gene is fadA [H]

Identifier: 218930771

GI number: 218930771

Start: 4231024

End: 4232187

Strand: Direct

Name: fadA [H]

Synonym: YPO3767

Alternate gene names: 218930771

Gene position: 4231024-4232187 (Clockwise)

Preceding gene: 218930770

Following gene: 218930774

Centisome position: 90.92

GC content: 49.4

Gene sequence:

>1164_bases
ATGGAAAATGTAGTCATTATTGATGCCGTGCGTACACCGATGGGCCGCTCCAAAGGGGGGGCTTTTCGTCATGTACGGGC
TGAAGACCTCTCTGCCCATTTAATGCGTGCCGTTATCAGCCGTAATCCTGGGTTGAATGCTGCTGAAATCGACGATATTT
ATTGGGGTTGTGTGCAACAAACGTTGGAGCAGGGTTTCAATATTGCCCGTAACGCGTCTTTATTAGCCGAAATTCCTCAC
AGCGTACCCGCTGTTACCGTTAATCGCCTGTGTGGCTCATCAATGCAAGCTCTGCATGATGGCGCACGAGCCATTATGGT
GGGTGATGCGAAGATCAGTTTGATTGGTGGAGTGGAACATATGGGCCACGTGCCAATGAACCACGGCGTGGATTTCCATC
CAGGAATGGGTCGCACTGTTGCCAAAGCGGCTGGAATGATGGGCTTGACCGCTGAGATGTTGGCTAAAATTCACAATATC
AGCCGCCAGTCACAAGATGAGTTTGCATTCCGTTCTCATCAACGTGCTTATGCTGCGACTCAGGCAGGGCATTTCGCAAA
AGAAATCGTTGCAACCAATGGGCATGATGCAGAAGGTGTATTAAAACGCTTTGATTTCGATGAAGTCATTCGTCCTGAAA
CAAATCTATCCGGTCTAGCAGCCTTGCGCCCTGCATTTGATCCGGTAAATGGCACAGTTACTGCAGGGACATCATCAGCC
TTGTCCGATGGGGCTTCTGCGATGCTGATTATGAGCGAATCCAGAGCGAAGTCATTAGGTTTAACCCCACGAGCACGTAT
CCGTTCGATGGCGGTCGTAGGTTGTGACCCCTCAATCATGGGCTATGGCCCGGTACCTGCTAGTCAATTGGCATTAAAAC
GTGCTGGCCTTGAATTGGCAGATATTGGTTTATTTGAGTTAAACGAGGCGTTTGCTGCTCAGTCACTGGCTTGTCTGAAA
GGTTTAGGTTTGTTAGAAAGCATGGACGATAAAGTAAACCTGAACGGTGGAGCCATTGCATTAGGTCACCCGTTAGGCTG
TTCAGGCGCACGGATCTCTACCACATTGTTAAACCTGATGGAGCGCCGTGACGTACAATTTGGGCTAGCAACCATGTGTA
TCGGCCTAGGGCAAGGTATTGCTACCGTATTTGAGCGCTTATAG

Upstream 100 bases:

>100_bases
CGGGGCTACGAGCTAAAGCTGAACATAACGAAAGTTATTATCCTGTGGCAGCAGCGCTGCTTGATGTTTCTACCAATCAA
CCAGCATGAGGTCTTAAAAT

Downstream 100 bases:

>100_bases
TAGCCAAATACATATAACCATCAAATACACATAACCATCAAACATAGACAACCACCCGACATCAAGAAATTAGGGGCCTG
AACGTAGGCCCTGATAACTG

Product: 3-ketoacyl-CoA thiolase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MENVVIIDAVRTPMGRSKGGAFRHVRAEDLSAHLMRAVISRNPGLNAAEIDDIYWGCVQQTLEQGFNIARNASLLAEIPH
SVPAVTVNRLCGSSMQALHDGARAIMVGDAKISLIGGVEHMGHVPMNHGVDFHPGMGRTVAKAAGMMGLTAEMLAKIHNI
SRQSQDEFAFRSHQRAYAATQAGHFAKEIVATNGHDAEGVLKRFDFDEVIRPETNLSGLAALRPAFDPVNGTVTAGTSSA
LSDGASAMLIMSESRAKSLGLTPRARIRSMAVVGCDPSIMGYGPVPASQLALKRAGLELADIGLFELNEAFAAQSLACLK
GLGLLESMDDKVNLNGGAIALGHPLGCSGARISTTLLNLMERRDVQFGLATMCIGLGQGIATVFERL

Sequences:

>Translated_387_residues
MENVVIIDAVRTPMGRSKGGAFRHVRAEDLSAHLMRAVISRNPGLNAAEIDDIYWGCVQQTLEQGFNIARNASLLAEIPH
SVPAVTVNRLCGSSMQALHDGARAIMVGDAKISLIGGVEHMGHVPMNHGVDFHPGMGRTVAKAAGMMGLTAEMLAKIHNI
SRQSQDEFAFRSHQRAYAATQAGHFAKEIVATNGHDAEGVLKRFDFDEVIRPETNLSGLAALRPAFDPVNGTVTAGTSSA
LSDGASAMLIMSESRAKSLGLTPRARIRSMAVVGCDPSIMGYGPVPASQLALKRAGLELADIGLFELNEAFAAQSLACLK
GLGLLESMDDKVNLNGGAIALGHPLGCSGARISTTLLNLMERRDVQFGLATMCIGLGQGIATVFERL
>Mature_387_residues
MENVVIIDAVRTPMGRSKGGAFRHVRAEDLSAHLMRAVISRNPGLNAAEIDDIYWGCVQQTLEQGFNIARNASLLAEIPH
SVPAVTVNRLCGSSMQALHDGARAIMVGDAKISLIGGVEHMGHVPMNHGVDFHPGMGRTVAKAAGMMGLTAEMLAKIHNI
SRQSQDEFAFRSHQRAYAATQAGHFAKEIVATNGHDAEGVLKRFDFDEVIRPETNLSGLAALRPAFDPVNGTVTAGTSSA
LSDGASAMLIMSESRAKSLGLTPRARIRSMAVVGCDPSIMGYGPVPASQLALKRAGLELADIGLFELNEAFAAQSLACLK
GLGLLESMDDKVNLNGGAIALGHPLGCSGARISTTLLNLMERRDVQFGLATMCIGLGQGIATVFERL

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=398, Percent_Identity=40.7035175879397, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=42.0918367346939, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI148539872, Length=400, Percent_Identity=40.25, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI4557237, Length=409, Percent_Identity=35.4523227383863, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI4504327, Length=433, Percent_Identity=33.4872979214781, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI194353979, Length=240, Percent_Identity=34.1666666666667, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI48994986, Length=387, Percent_Identity=80.3617571059432, Blast_Score=660, Evalue=0.0,
Organism=Escherichia coli, GI1787663, Length=406, Percent_Identity=45.320197044335, Blast_Score=317, Evalue=6e-88,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=45.320197044335, Blast_Score=274, Evalue=8e-75,
Organism=Escherichia coli, GI87082165, Length=401, Percent_Identity=42.14463840399, Blast_Score=271, Evalue=5e-74,
Organism=Escherichia coli, GI1788683, Length=416, Percent_Identity=33.8942307692308, Blast_Score=187, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI133906874, Length=399, Percent_Identity=40.6015037593985, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17551802, Length=430, Percent_Identity=33.4883720930233, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17535921, Length=403, Percent_Identity=33.9950372208437, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI25147385, Length=397, Percent_Identity=31.4861460957179, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17535917, Length=401, Percent_Identity=27.1820448877805, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322031, Length=395, Percent_Identity=39.2405063291139, Blast_Score=226, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6325229, Length=410, Percent_Identity=33.6585365853659, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24655093, Length=401, Percent_Identity=41.8952618453865, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI17648125, Length=398, Percent_Identity=39.9497487437186, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI17137578, Length=432, Percent_Identity=34.9537037037037, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24640423, Length=395, Percent_Identity=33.1645569620253, Blast_Score=176, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40918; Mature: 40918

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENVVIIDAVRTPMGRSKGGAFRHVRAEDLSAHLMRAVISRNPGLNAAEIDDIYWGCVQQ
CCCEEEEEECCCCCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TLEQGFNIARNASLLAEIPHSVPAVTVNRLCGSSMQALHDGARAIMVGDAKISLIGGVEH
HHHHCCCHHHCCHHHHHCCCCCCHHHHHHHHCHHHHHHHCCCCEEEECCCEEEEEECHHH
MGHVPMNHGVDFHPGMGRTVAKAAGMMGLTAEMLAKIHNISRQSQDEFAFRSHQRAYAAT
HCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
QAGHFAKEIVATNGHDAEGVLKRFDFDEVIRPETNLSGLAALRPAFDPVNGTVTAGTSSA
HHHHHHHHHHHCCCCCHHHHHHHCCHHHHCCCCCCCCHHHHHCCCCCCCCCEEECCCCHH
LSDGASAMLIMSESRAKSLGLTPRARIRSMAVVGCDPSIMGYGPVPASQLALKRAGLELA
HHCCCCEEEEEECCHHHHCCCCCHHHHHEEEEECCCCCCCCCCCCCHHHHHHHHCCCCHH
DIGLFELNEAFAAQSLACLKGLGLLESMDDKVNLNGGAIALGHPLGCSGARISTTLLNLM
HCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEECCCCCCCCCHHHHHHHHHH
ERRDVQFGLATMCIGLGQGIATVFERL
HHHCHHHHHHHHHHHHCCHHHHHHHCC
>Mature Secondary Structure
MENVVIIDAVRTPMGRSKGGAFRHVRAEDLSAHLMRAVISRNPGLNAAEIDDIYWGCVQQ
CCCEEEEEECCCCCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TLEQGFNIARNASLLAEIPHSVPAVTVNRLCGSSMQALHDGARAIMVGDAKISLIGGVEH
HHHHCCCHHHCCHHHHHCCCCCCHHHHHHHHCHHHHHHHCCCCEEEECCCEEEEEECHHH
MGHVPMNHGVDFHPGMGRTVAKAAGMMGLTAEMLAKIHNISRQSQDEFAFRSHQRAYAAT
HCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
QAGHFAKEIVATNGHDAEGVLKRFDFDEVIRPETNLSGLAALRPAFDPVNGTVTAGTSSA
HHHHHHHHHHHCCCCCHHHHHHHCCHHHHCCCCCCCCHHHHHCCCCCCCCCEEECCCCHH
LSDGASAMLIMSESRAKSLGLTPRARIRSMAVVGCDPSIMGYGPVPASQLALKRAGLELA
HHCCCCEEEEEECCHHHHCCCCCHHHHHEEEEECCCCCCCCCCCCCHHHHHHHHCCCCHH
DIGLFELNEAFAAQSLACLKGLGLLESMDDKVNLNGGAIALGHPLGCSGARISTTLLNLM
HCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEECCCCCCCCCHHHHHHHHHH
ERRDVQFGLATMCIGLGQGIATVFERL
HHHCHHHHHHHHHHHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA