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The map label for this gene is hpmB [H]

Identifier: 218930726

GI number: 218930726

Start: 4156357

End: 4158042

Strand: Direct

Name: hpmB [H]

Synonym: YPO3720

Alternate gene names: 218930726

Gene position: 4156357-4158042 (Clockwise)

Preceding gene: 218930725

Following gene: 218930727

Centisome position: 89.31

GC content: 46.92

Gene sequence:

>1686_bases
ATGATTAGAAAACGTACTGCGTTATGGCTTGTACTCAGTACTGGCGCTCAAGCCGAGACGCCTTTGGCCATAGAGACCCC
ATCTTCCATTAATGAATCTCGCCAGTCACTACAAAATAATGCCAAAGAAATTAATCAGCTAGTAGAAGAAAAACGCCACC
AACAGATCACACAACACAACACCGGACAAAGTGAATTATCTCGTCCGGCCCCCCCTGCACCGGTGTTACCCGAAGATACG
CAGTGCCTACCCATTAATGGCGTTTATATTCAGGGGATCACCTTATTAACAGAGGATGATTTAAGTGAATTAAGTGCGAT
CCCTGAACAATGTATTCATCCTGATAATATTAACCTTCTGACCCGTGAACTCACTCATATCTATATGGATAAAGGGTATA
TCACGGCGCGGATTCAATTTATTCCACCAGATGCTGACGGAAAATTAGGTCTGGATATTACCGAAGGGTTTGTCGAAGCG
ATTGATAGCACGGACACCGGGTTAGATGGCGAGACGGTATTCCCGAATATGATCGGCAAGCCGCTCAATATTACTCGCCT
TGATCAAGGACTGGACCAGGCAAACCGTTTGCCCTCAAATAAAGTCACCGTCGATATTCTGCCCGGAACACTACCCGGTG
GTTCTATTCTTAAACTGCATAATACACCGTCAACGCCCTGGCATTTGACCACCTCGATGGACAATTACGGTAATAAAAAT
ACCGGTAAATGGCTAAGTCGCAACGCCTTATCTTTCGATAATCCGTTGGGCTTATCGGATTCCGTCAGTATCAATATCAG
CAATACCGTTGATCGCCCCCAACATAATTATAGCCGTGCTTACTCAATGTTTTATTCGGTCCCTTACGGTGCCTTGACCT
TTAGTGGCTTTGGTAGTTATGCCGAATACCGTTATCCAATGAAATTGCAGTTTAATACAGCCAAGTTACATGGAGAAACA
CAGCAACACGGTTTACGGGCAGATTATGTTTTCTATCGCGATCAAAGCCAGATTAATGGGCTAAGTGCGCAATTAACCTA
TAAACGGGCCAGTAATTATCTGAATGAAGAAAAAATTGCTATCAGCAGCCCGACGCTAACAATCTTTGAATTAGGCCTTA
ATCACCTGCACGTCCTGCCCATGGGCTTATTCAATATCAATGTCAGCCTTGAGCAGGGCTTGCCTTGGCTGGGCGCGGAG
CGCTCAAATGGCCCATTAGCGAACTATCAAGATAGCCAATTCACTAAAGCTAAGACCTCAATTACCTCCAATCACTACTT
TGCACTGTTTGATGATACCTATCTGTTCAGCAATCAATTTTATGGCCAGTACACCCGTGACCGGTTACCCGGCGTGGAAT
GGCTCAGCATCACTGACAGCAGTGCCATCCGTGGCTTTAGCCGCAATACCTTATCCGCCGACCAAGGCTGGTATTTACAA
AACACCCTCTCCCGTCGTTTCACCTTGGGTGACGCCACGCTAACCCCTCGCGTAGGGCTTGATACGGGCCGTCTCCAGCA
AAAACCACAGGGGTGGGTCAGCGCTATGGGGCTAAGCGCTGGCGTCAGCCTTAATTACCAGAATGCCACCTTGGATATAG
AAGCCAGCCGTGGCCGGTTACTCTCCGGCCCATCGAAGATTAACGATCCAACACAAATTCTGGCGCGTTTTTCTTACCGC
TTTTAA

Upstream 100 bases:

>100_bases
AGGGACGGTAATTGTGCTGCCCGTCAATTTGACTCAGGGACAGAAAGAGCTGCGCCTGCAAATAAATTTGTTCGGTCAGT
CTATTTCTCAATCAGATATT

Downstream 100 bases:

>100_bases
TGCAATTTTCCCTTGAGAACACCTTGTTACTCATACCAGGAAATATCACCCCAAAATGGAGATGTAAAAATGAAGAAACA
CACCTTTAAGCTCTCACCGG

Product: hemolysin activator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MIRKRTALWLVLSTGAQAETPLAIETPSSINESRQSLQNNAKEINQLVEEKRHQQITQHNTGQSELSRPAPPAPVLPEDT
QCLPINGVYIQGITLLTEDDLSELSAIPEQCIHPDNINLLTRELTHIYMDKGYITARIQFIPPDADGKLGLDITEGFVEA
IDSTDTGLDGETVFPNMIGKPLNITRLDQGLDQANRLPSNKVTVDILPGTLPGGSILKLHNTPSTPWHLTTSMDNYGNKN
TGKWLSRNALSFDNPLGLSDSVSINISNTVDRPQHNYSRAYSMFYSVPYGALTFSGFGSYAEYRYPMKLQFNTAKLHGET
QQHGLRADYVFYRDQSQINGLSAQLTYKRASNYLNEEKIAISSPTLTIFELGLNHLHVLPMGLFNINVSLEQGLPWLGAE
RSNGPLANYQDSQFTKAKTSITSNHYFALFDDTYLFSNQFYGQYTRDRLPGVEWLSITDSSAIRGFSRNTLSADQGWYLQ
NTLSRRFTLGDATLTPRVGLDTGRLQQKPQGWVSAMGLSAGVSLNYQNATLDIEASRGRLLSGPSKINDPTQILARFSYR
F

Sequences:

>Translated_561_residues
MIRKRTALWLVLSTGAQAETPLAIETPSSINESRQSLQNNAKEINQLVEEKRHQQITQHNTGQSELSRPAPPAPVLPEDT
QCLPINGVYIQGITLLTEDDLSELSAIPEQCIHPDNINLLTRELTHIYMDKGYITARIQFIPPDADGKLGLDITEGFVEA
IDSTDTGLDGETVFPNMIGKPLNITRLDQGLDQANRLPSNKVTVDILPGTLPGGSILKLHNTPSTPWHLTTSMDNYGNKN
TGKWLSRNALSFDNPLGLSDSVSINISNTVDRPQHNYSRAYSMFYSVPYGALTFSGFGSYAEYRYPMKLQFNTAKLHGET
QQHGLRADYVFYRDQSQINGLSAQLTYKRASNYLNEEKIAISSPTLTIFELGLNHLHVLPMGLFNINVSLEQGLPWLGAE
RSNGPLANYQDSQFTKAKTSITSNHYFALFDDTYLFSNQFYGQYTRDRLPGVEWLSITDSSAIRGFSRNTLSADQGWYLQ
NTLSRRFTLGDATLTPRVGLDTGRLQQKPQGWVSAMGLSAGVSLNYQNATLDIEASRGRLLSGPSKINDPTQILARFSYR
F
>Mature_561_residues
MIRKRTALWLVLSTGAQAETPLAIETPSSINESRQSLQNNAKEINQLVEEKRHQQITQHNTGQSELSRPAPPAPVLPEDT
QCLPINGVYIQGITLLTEDDLSELSAIPEQCIHPDNINLLTRELTHIYMDKGYITARIQFIPPDADGKLGLDITEGFVEA
IDSTDTGLDGETVFPNMIGKPLNITRLDQGLDQANRLPSNKVTVDILPGTLPGGSILKLHNTPSTPWHLTTSMDNYGNKN
TGKWLSRNALSFDNPLGLSDSVSINISNTVDRPQHNYSRAYSMFYSVPYGALTFSGFGSYAEYRYPMKLQFNTAKLHGET
QQHGLRADYVFYRDQSQINGLSAQLTYKRASNYLNEEKIAISSPTLTIFELGLNHLHVLPMGLFNINVSLEQGLPWLGAE
RSNGPLANYQDSQFTKAKTSITSNHYFALFDDTYLFSNQFYGQYTRDRLPGVEWLSITDSSAIRGFSRNTLSADQGWYLQ
NTLSRRFTLGDATLTPRVGLDTGRLQQKPQGWVSAMGLSAGVSLNYQNATLDIEASRGRLLSGPSKINDPTQILARFSYR
F

Specific function: Member of a two partner secretion pathway (TPS) in which it mediates the secretion of hemolysin [H]

COG id: COG2831

COG function: function code U; Hemolysin activation/secretion protein

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tpsB (TC 1.B.20) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005565
- InterPro:   IPR013686 [H]

Pfam domain/function: PF08479 POTRA_2; PF03865 ShlB [H]

EC number: NA

Molecular weight: Translated: 62468; Mature: 62468

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRKRTALWLVLSTGAQAETPLAIETPSSINESRQSLQNNAKEINQLVEEKRHQQITQHN
CCCCEEEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TGQSELSRPAPPAPVLPEDTQCLPINGVYIQGITLLTEDDLSELSAIPEQCIHPDNINLL
CCHHHHCCCCCCCCCCCCCCCEEEECCEEEEEEEEEECCCHHHHHHHHHHHCCCCCCHHH
TRELTHIYMDKGYITARIQFIPPDADGKLGLDITEGFVEAIDSTDTGLDGETVFPNMIGK
HHHHHHHEECCCEEEEEEEEECCCCCCEECCCHHHHHHHHHCCCCCCCCCCEECHHHCCC
PLNITRLDQGLDQANRLPSNKVTVDILPGTLPGGSILKLHNTPSTPWHLTTSMDNYGNKN
CCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEECCCCCCCEEEEECCCCCCCCC
TGKWLSRNALSFDNPLGLSDSVSINISNTVDRPQHNYSRAYSMFYSVPYGALTFSGFGSY
CCCHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCH
AEYRYPMKLQFNTAKLHGETQQHGLRADYVFYRDQSQINGLSAQLTYKRASNYLNEEKIA
HHEECCEEEEEEEHEECCCHHHCCCCEEEEEEECCHHCCCCEEEEEHHHHHCCCCCCEEE
ISSPTLTIFELGLNHLHVLPMGLFNINVSLEQGLPWLGAERSNGPLANYQDSQFTKAKTS
ECCCCEEEEECCCCEEEEEEEEEEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHE
ITSNHYFALFDDTYLFSNQFYGQYTRDRLPGVEWLSITDSSAIRGFSRNTLSADQGWYLQ
ECCCCEEEEEECEEEECCCCCCCHHHHCCCCCEEEEECCCHHHCCCCCCCCCCCCCEEHH
NTLSRRFTLGDATLTPRVGLDTGRLQQKPQGWVSAMGLSAGVSLNYQNATLDIEASRGRL
HHHHHEEEECCCEECCCCCCCCCHHCCCCCHHHHHHCCCCCEEEEECCEEEEEECCCCCE
LSGPSKINDPTQILARFSYRF
ECCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MIRKRTALWLVLSTGAQAETPLAIETPSSINESRQSLQNNAKEINQLVEEKRHQQITQHN
CCCCEEEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TGQSELSRPAPPAPVLPEDTQCLPINGVYIQGITLLTEDDLSELSAIPEQCIHPDNINLL
CCHHHHCCCCCCCCCCCCCCCEEEECCEEEEEEEEEECCCHHHHHHHHHHHCCCCCCHHH
TRELTHIYMDKGYITARIQFIPPDADGKLGLDITEGFVEAIDSTDTGLDGETVFPNMIGK
HHHHHHHEECCCEEEEEEEEECCCCCCEECCCHHHHHHHHHCCCCCCCCCCEECHHHCCC
PLNITRLDQGLDQANRLPSNKVTVDILPGTLPGGSILKLHNTPSTPWHLTTSMDNYGNKN
CCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEECCCCCCCEEEEECCCCCCCCC
TGKWLSRNALSFDNPLGLSDSVSINISNTVDRPQHNYSRAYSMFYSVPYGALTFSGFGSY
CCCHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCH
AEYRYPMKLQFNTAKLHGETQQHGLRADYVFYRDQSQINGLSAQLTYKRASNYLNEEKIA
HHEECCEEEEEEEHEECCCHHHCCCCEEEEEEECCHHCCCCEEEEEHHHHHCCCCCCEEE
ISSPTLTIFELGLNHLHVLPMGLFNINVSLEQGLPWLGAERSNGPLANYQDSQFTKAKTS
ECCCCEEEEECCCCEEEEEEEEEEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHE
ITSNHYFALFDDTYLFSNQFYGQYTRDRLPGVEWLSITDSSAIRGFSRNTLSADQGWYLQ
ECCCCEEEEEECEEEECCCCCCCHHHHCCCCCEEEEECCCHHHCCCCCCCCCCCCCEEHH
NTLSRRFTLGDATLTPRVGLDTGRLQQKPQGWVSAMGLSAGVSLNYQNATLDIEASRGRL
HHHHHEEEECCCEECCCCCCCCCHHCCCCCHHHHHHCCCCCEEEEECCEEEEEECCCCCE
LSGPSKINDPTQILARFSYRF
ECCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3290200 [H]