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The map label for this gene is lysC [H]

Identifier: 218930725

GI number: 218930725

Start: 4154404

End: 4155789

Strand: Direct

Name: lysC [H]

Synonym: YPO3719

Alternate gene names: 218930725

Gene position: 4154404-4155789 (Clockwise)

Preceding gene: 218930722

Following gene: 218930726

Centisome position: 89.27

GC content: 52.74

Gene sequence:

>1386_bases
ATGATTCAAGTCGCCCCCCAACAGACCCGCGATGCACCTTCTGCGACTGTCGTCGCCAAATTTGGCGGCACCAGCGTGGC
CAGTTTTGATGCCATGAGTCGTAGCGCCGATGTGGTTTTATCGAACCCGGACGTTCGTTTGGTGATCCTTTCTGCGTCTG
CCGGTATCACCAATCTGTTGGTTGCCCTTGCTGATGGCAGTGAGCCAGAAAAACGTGCAGACCATCTGGAGGATATTCGC
CATATTCAATACGATATTATTGCCAGACTCACTGATTCGACGGTGATCCGCGAAGAAATTGACCGCATGTTGGAAAACAT
TGCCATGCTGTCTGAGGCGGCCAGTCTGGCGACCTCCCCGGCCCTGACCGATGAGCTGGTCAGCCACGGTGAATTAATGT
CCACCCTGCTATTTGTCGAGCTGTTACGCCAACGTCAGGTTGCCGTGGAATGGTTTGATGTGCGAAAAGTCATGCGAACC
AATGACCGTTTTGGCCGCGCAGAGCCAGATACCTCGGCCTTGGCTGAACTGGCCCAAACACTGCTGGCACCGCGTATTGA
AGATGCCATTGTGGTCACACAAGGTTTTATCGGCAGCGAAGGCAAAGGCCGAACCACCACTCTGGGCCGTGGTGGCAGTG
ATTACACCGCCGCATTGTTAGGTGAAGCACTGAATGTCAGCCGTATCGATATCTGGACCGATGTGCCGGGGATATATACG
ACTGACCCGCGTGTCGTCCCGGCAGCAAAACGTATCGATAAAATCGCCTTTGAAGAAGCGGCCGAAATGGCAACCTTTGG
GGCGAAAATCCTGCATCCGGCCACTCTGCTACCGGCAGTACGCAGTGATATCCCGATGTTTGTCGGCTCCAGTAAAGATC
CTGCGGCTGGCGGCACCTTGGTCTGTAACGAAACCTACAACCCGCCGCTGTTCCGTGCTCTGGCACTACGCCGCAAGCAG
ACGCTGTTAACTTTGCACAGCTTAAATATGTTGCATGCGCGCGGTTTTCTGGCGGAAGTGTTTAATATTCTGGCGCGCCA
CAGTATCTCCGTGGATTTAATCACCACGTCTGAAGTGAGTGTCGCGTTAACATTGGATACCACCGGTTCAACGTCTACCG
GTGATAGCCTGCTGACCACCTCGTTATTGACGGAACTCTCTTCCCTGTGCCGGGTTGAAGTGGAAGAAGATCTGGCGTTG
GTGGCCATTATCGGCAACAACCTGTCTCAGGCTTGCGGCGTCGGTAAAGAGGTATTTGGTGTCTTGGATCCGTTCAATAT
TCGTATGATTTGTTACGGTGCCAGCAGCCATAATCTGTGTTTCCTGGTACCGGGTAATGACGCTGACAAAGTCGTACAAA
CGCTACATTACAATTTATTTGAATAA

Upstream 100 bases:

>100_bases
ATAGCCATTTCATTGACAGAAAGTGGATAACCCGTTATTTCCTTGTACAGAGAAAAATACAGATGCCCCCAAGATGGCAT
CACTGACACGAGGTTTTTAG

Downstream 100 bases:

>100_bases
AACAGATGTTATTTGAATAAAAGAGATGTTATTTGAATAAGACAGTTTATTTGAGTAAGACAACTTATTTGTGTAAGAGA
GCACATTAACACATTAATTT

Product: aspartate kinase III

Products: NA

Alternate protein names: Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MIQVAPQQTRDAPSATVVAKFGGTSVASFDAMSRSADVVLSNPDVRLVILSASAGITNLLVALADGSEPEKRADHLEDIR
HIQYDIIARLTDSTVIREEIDRMLENIAMLSEAASLATSPALTDELVSHGELMSTLLFVELLRQRQVAVEWFDVRKVMRT
NDRFGRAEPDTSALAELAQTLLAPRIEDAIVVTQGFIGSEGKGRTTTLGRGGSDYTAALLGEALNVSRIDIWTDVPGIYT
TDPRVVPAAKRIDKIAFEEAAEMATFGAKILHPATLLPAVRSDIPMFVGSSKDPAAGGTLVCNETYNPPLFRALALRRKQ
TLLTLHSLNMLHARGFLAEVFNILARHSISVDLITTSEVSVALTLDTTGSTSTGDSLLTTSLLTELSSLCRVEVEEDLAL
VAIIGNNLSQACGVGKEVFGVLDPFNIRMICYGASSHNLCFLVPGNDADKVVQTLHYNLFE

Sequences:

>Translated_461_residues
MIQVAPQQTRDAPSATVVAKFGGTSVASFDAMSRSADVVLSNPDVRLVILSASAGITNLLVALADGSEPEKRADHLEDIR
HIQYDIIARLTDSTVIREEIDRMLENIAMLSEAASLATSPALTDELVSHGELMSTLLFVELLRQRQVAVEWFDVRKVMRT
NDRFGRAEPDTSALAELAQTLLAPRIEDAIVVTQGFIGSEGKGRTTTLGRGGSDYTAALLGEALNVSRIDIWTDVPGIYT
TDPRVVPAAKRIDKIAFEEAAEMATFGAKILHPATLLPAVRSDIPMFVGSSKDPAAGGTLVCNETYNPPLFRALALRRKQ
TLLTLHSLNMLHARGFLAEVFNILARHSISVDLITTSEVSVALTLDTTGSTSTGDSLLTTSLLTELSSLCRVEVEEDLAL
VAIIGNNLSQACGVGKEVFGVLDPFNIRMICYGASSHNLCFLVPGNDADKVVQTLHYNLFE
>Mature_461_residues
MIQVAPQQTRDAPSATVVAKFGGTSVASFDAMSRSADVVLSNPDVRLVILSASAGITNLLVALADGSEPEKRADHLEDIR
HIQYDIIARLTDSTVIREEIDRMLENIAMLSEAASLATSPALTDELVSHGELMSTLLFVELLRQRQVAVEWFDVRKVMRT
NDRFGRAEPDTSALAELAQTLLAPRIEDAIVVTQGFIGSEGKGRTTTLGRGGSDYTAALLGEALNVSRIDIWTDVPGIYT
TDPRVVPAAKRIDKIAFEEAAEMATFGAKILHPATLLPAVRSDIPMFVGSSKDPAAGGTLVCNETYNPPLFRALALRRKQ
TLLTLHSLNMLHARGFLAEVFNILARHSISVDLITTSEVSVALTLDTTGSTSTGDSLLTTSLLTELSSLCRVEVEEDLAL
VAIIGNNLSQACGVGKEVFGVLDPFNIRMICYGASSHNLCFLVPGNDADKVVQTLHYNLFE

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=448, Percent_Identity=81.4732142857143, Blast_Score=694, Evalue=0.0,
Organism=Escherichia coli, GI1786183, Length=468, Percent_Identity=30.3418803418803, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI1790376, Length=286, Percent_Identity=32.1678321678322, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6320893, Length=507, Percent_Identity=28.5996055226824, Blast_Score=176, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 49691; Mature: 49691

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQVAPQQTRDAPSATVVAKFGGTSVASFDAMSRSADVVLSNPDVRLVILSASAGITNLL
CCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHCCCCCEEEECCCEEEEEEECCCCHHHHH
VALADGSEPEKRADHLEDIRHIQYDIIARLTDSTVIREEIDRMLENIAMLSEAASLATSP
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ALTDELVSHGELMSTLLFVELLRQRQVAVEWFDVRKVMRTNDRFGRAEPDTSALAELAQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LLAPRIEDAIVVTQGFIGSEGKGRTTTLGRGGSDYTAALLGEALNVSRIDIWTDVPGIYT
HHCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCEE
TDPRVVPAAKRIDKIAFEEAAEMATFGAKILHPATLLPAVRSDIPMFVGSSKDPAAGGTL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCEEECCCCCCCCCCEE
VCNETYNPPLFRALALRRKQTLLTLHSLNMLHARGFLAEVFNILARHSISVDLITTSEVS
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCEE
VALTLDTTGSTSTGDSLLTTSLLTELSSLCRVEVEEDLALVAIIGNNLSQACGVGKEVFG
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHCEEECCCEEEEEEECCCHHHHHCCCHHHHH
VLDPFNIRMICYGASSHNLCFLVPGNDADKVVQTLHYNLFE
CCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MIQVAPQQTRDAPSATVVAKFGGTSVASFDAMSRSADVVLSNPDVRLVILSASAGITNLL
CCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHCCCCCEEEECCCEEEEEEECCCCHHHHH
VALADGSEPEKRADHLEDIRHIQYDIIARLTDSTVIREEIDRMLENIAMLSEAASLATSP
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ALTDELVSHGELMSTLLFVELLRQRQVAVEWFDVRKVMRTNDRFGRAEPDTSALAELAQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LLAPRIEDAIVVTQGFIGSEGKGRTTTLGRGGSDYTAALLGEALNVSRIDIWTDVPGIYT
HHCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCEE
TDPRVVPAAKRIDKIAFEEAAEMATFGAKILHPATLLPAVRSDIPMFVGSSKDPAAGGTL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCEEECCCCCCCCCCEE
VCNETYNPPLFRALALRRKQTLLTLHSLNMLHARGFLAEVFNILARHSISVDLITTSEVS
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCEE
VALTLDTTGSTSTGDSLLTTSLLTELSSLCRVEVEEDLALVAIIGNNLSQACGVGKEVFG
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHCEEECCCEEEEEEECCCHHHHHCCCHHHHH
VLDPFNIRMICYGASSHNLCFLVPGNDADKVVQTLHYNLFE
CCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3003049; 8265357; 9278503; 6312411 [H]