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The map label for this gene is emrA [H]

Identifier: 218930292

GI number: 218930292

Start: 3638327

End: 3639499

Strand: Direct

Name: emrA [H]

Synonym: YPO3267

Alternate gene names: 218930292

Gene position: 3638327-3639499 (Clockwise)

Preceding gene: 218930291

Following gene: 218930293

Centisome position: 78.18

GC content: 49.7

Gene sequence:

>1173_bases
ATGAGTGAAAGTGCGGGAGCCCAAGCCCCACAACGACCGCAGAATAAAAAACAGCAACGTAAACGTGTACTGCTGTTGCT
GACGGCCATTTTTATTATGATCGGGGTGGCTTACCTTATTTATTGGTTCCTGGTGCTACGCCATCACCAAGAGACTGATA
ATGCCTATATTTCAGGCAACCAAGTCCAGATTATGTCTCAAGTTCCCGGCAGTGTGGTCAGTGTTCATTTCGAAAATACG
GACTTCGTCAAAAGTGGCGATGTGCTGGTGACACTCGACCCCACCGATGCAGAACAGGCATTTGAGCAAGCGAAAACTGC
CTTGGCAAATAGCGTGCGCCAAACCCACCAGCTCATTATTAACAGTAAACAGTATCAAGCGAATATTGCGCTGAAAAAAA
CGGAATTGAGCCAGGCACAAAATGACCTGAAGCGTCGGGTGGTCCTGGGGGCTGCCGCAGTCATCGGCCGTGAAGAATTG
CAACACGCACGTGATGCTGTTGAGGCGGCACAAGCGTCGTTGGATATGGCAGTGCAGCAATATAACGCCAATCAGGCGTT
GGTCCTCAATACGCCATTGGAGAAACAACCGGCGATTGAGCAGGCGGCCGCTAAAATGCGTGATGCCTGGCTCACCCTGC
AGCGCACCAAAGTAGTTAGCCCAATTAGCGGCTATGTCTCGCGTCGCAGTGTACAAGTGGGTGCTGAAATCAGTAGTGGT
ACGCCGTTAATGGCGGTGGTTCCGGCAGATCAACTGTGGATCGACGCTAACTTCAAAGAAACTCAGTTGGCGAACATGCG
AATTGGCCAACCGGCGACTATCGTGACCGATTTTTACGGTGATGATGTGGTTTATCAAGGGAAAGTGGTCGGTTTAGATA
TGGGAACCGGCAGTGCCTTCTCGCTACTACCCGCGCAAAATGCCACCGGTAACTGGATCAAAGTGGTCCAACGCCTGCCA
GTACGAATTGCATTGGATGAGAAACAACTGAAGGAGCATCCGTTACGTATTGGTCTGTCATCGCTGGTTAAAGTCGACAC
CGCCAATACCGATGGACACGTTTTGGCACAAAACGTGCGTAAAGAACCCGCGTTCATGACCAATGCATTGTCATTAGATT
TCGCGCCAGTTAATCAAATAATTAGCGATATTATTCATGCAAACGCCGATTAA

Upstream 100 bases:

>100_bases
GTTCCCCAAGCCCTGACGAAAATCAAGTGACTGGGGTGAACGAAGGCGGTCAACCCTCATACAACGTGCAAAATGACGGG
TATAGAGCGTGGAGAACACC

Downstream 100 bases:

>100_bases
TATCATGCCAATGCGGGTTACGTGCACCGGAGGCTATTGTGGCACAAAAACCGCTTGAAGGAGCACCACTCGCCTGGATG
ACGGTGGCGCTTTCATTAGC

Product: multidrug resistance protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MSESAGAQAPQRPQNKKQQRKRVLLLLTAIFIMIGVAYLIYWFLVLRHHQETDNAYISGNQVQIMSQVPGSVVSVHFENT
DFVKSGDVLVTLDPTDAEQAFEQAKTALANSVRQTHQLIINSKQYQANIALKKTELSQAQNDLKRRVVLGAAAVIGREEL
QHARDAVEAAQASLDMAVQQYNANQALVLNTPLEKQPAIEQAAAKMRDAWLTLQRTKVVSPISGYVSRRSVQVGAEISSG
TPLMAVVPADQLWIDANFKETQLANMRIGQPATIVTDFYGDDVVYQGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLP
VRIALDEKQLKEHPLRIGLSSLVKVDTANTDGHVLAQNVRKEPAFMTNALSLDFAPVNQIISDIIHANAD

Sequences:

>Translated_390_residues
MSESAGAQAPQRPQNKKQQRKRVLLLLTAIFIMIGVAYLIYWFLVLRHHQETDNAYISGNQVQIMSQVPGSVVSVHFENT
DFVKSGDVLVTLDPTDAEQAFEQAKTALANSVRQTHQLIINSKQYQANIALKKTELSQAQNDLKRRVVLGAAAVIGREEL
QHARDAVEAAQASLDMAVQQYNANQALVLNTPLEKQPAIEQAAAKMRDAWLTLQRTKVVSPISGYVSRRSVQVGAEISSG
TPLMAVVPADQLWIDANFKETQLANMRIGQPATIVTDFYGDDVVYQGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLP
VRIALDEKQLKEHPLRIGLSSLVKVDTANTDGHVLAQNVRKEPAFMTNALSLDFAPVNQIISDIIHANAD
>Mature_389_residues
SESAGAQAPQRPQNKKQQRKRVLLLLTAIFIMIGVAYLIYWFLVLRHHQETDNAYISGNQVQIMSQVPGSVVSVHFENTD
FVKSGDVLVTLDPTDAEQAFEQAKTALANSVRQTHQLIINSKQYQANIALKKTELSQAQNDLKRRVVLGAAAVIGREELQ
HARDAVEAAQASLDMAVQQYNANQALVLNTPLEKQPAIEQAAAKMRDAWLTLQRTKVVSPISGYVSRRSVQVGAEISSGT
PLMAVVPADQLWIDANFKETQLANMRIGQPATIVTDFYGDDVVYQGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPV
RIALDEKQLKEHPLRIGLSSLVKVDTANTDGHVLAQNVRKEPAFMTNALSLDFAPVNQIISDIIHANAD

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=389, Percent_Identity=69.6658097686375, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI1788711, Length=380, Percent_Identity=49.4736842105263, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI87081951, Length=306, Percent_Identity=29.0849673202614, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790519, Length=311, Percent_Identity=27.9742765273312, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789637, Length=310, Percent_Identity=25.8064516129032, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082036, Length=243, Percent_Identity=27.1604938271605, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42777; Mature: 42646

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESAGAQAPQRPQNKKQQRKRVLLLLTAIFIMIGVAYLIYWFLVLRHHQETDNAYISGN
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
QVQIMSQVPGSVVSVHFENTDFVKSGDVLVTLDPTDAEQAFEQAKTALANSVRQTHQLII
EEEEEECCCCCEEEEEECCCCEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
NSKQYQANIALKKTELSQAQNDLKRRVVLGAAAVIGREELQHARDAVEAAQASLDMAVQQ
CCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YNANQALVLNTPLEKQPAIEQAAAKMRDAWLTLQRTKVVSPISGYVSRRSVQVGAEISSG
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCEEEECCEECCC
TPLMAVVPADQLWIDANFKETQLANMRIGQPATIVTDFYGDDVVYQGKVVGLDMGTGSAF
CCEEEEECCCCEEEECCCCHHHHCCEECCCCCEEEEECCCCCEEEECEEEEEECCCCCCE
SLLPAQNATGNWIKVVQRLPVRIALDEKQLKEHPLRIGLSSLVKVDTANTDGHVLAQNVR
EEECCCCCCCHHHHHHHHCCCEEEECHHHHHHCCHHHCHHHHEEEECCCCCCHHHHHHHC
KEPAFMTNALSLDFAPVNQIISDIIHANAD
CCCCHHHHHHCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SESAGAQAPQRPQNKKQQRKRVLLLLTAIFIMIGVAYLIYWFLVLRHHQETDNAYISGN
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
QVQIMSQVPGSVVSVHFENTDFVKSGDVLVTLDPTDAEQAFEQAKTALANSVRQTHQLII
EEEEEECCCCCEEEEEECCCCEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
NSKQYQANIALKKTELSQAQNDLKRRVVLGAAAVIGREELQHARDAVEAAQASLDMAVQQ
CCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YNANQALVLNTPLEKQPAIEQAAAKMRDAWLTLQRTKVVSPISGYVSRRSVQVGAEISSG
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCEEEECCEECCC
TPLMAVVPADQLWIDANFKETQLANMRIGQPATIVTDFYGDDVVYQGKVVGLDMGTGSAF
CCEEEEECCCCEEEECCCCHHHHCCEECCCCCEEEEECCCCCEEEECEEEEEECCCCCCE
SLLPAQNATGNWIKVVQRLPVRIALDEKQLKEHPLRIGLSSLVKVDTANTDGHVLAQNVR
EEECCCCCCCHHHHHHHHCCCEEEECHHHHHHCCHHHCHHHHEEEECCCCCCHHHHHHHC
KEPAFMTNALSLDFAPVNQIISDIIHANAD
CCCCHHHHHHCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]