BacMap

Definition	Yersinia pestis CO92 chromosome, complete genome.
Accession	NC_003143
Length	4,653,728

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The map label for this gene is yvgN [H]

Identifier: 218929871

GI number: 218929871

Start: 3137566

End: 3138459

Strand: Direct

Name: yvgN [H]

Synonym: YPO2805

Alternate gene names: 218929871

Gene position: 3137566-3138459 (Clockwise)

Preceding gene: 218929869

Following gene: 218929872

Centisome position: 67.42

GC content: 48.77

Gene sequence:

>894_bases
TTGCGCTATGCTTTTCCTACACAACAGTTGAAGGATAACGTCATGCAAACAGTAAAACTGAACAACGGTATTGCAATGCC
TCTGCTGGGCTTTGGTGTCTTCCAGATGACTAATACCGCGGAATGCGAGCGCGCAGTTATCGATGCGATTGAAACAGGCT
ATCGCCTCATAGACACCGCCGCTTCCTACCAGAATGAAACGCAGGTAGGGAATGCGCTTAAGCTGAGTGGTATTGCACGA
GATGAACTGTTTATCACGACTAAATTGTGGTTGCAGGATACCTATTATGAAGGTGCGAAAGCGCAGTTTGAACGCTCACT
GAATCGCCTACAACTGGATTATGTCGATCTGTACCTGATTCACCAACCCTATGGCGACGTTCATGGCGCATGGCGTGCAA
TGGAAGAATTACACCAGGCGGGCAAAATCCGTGCCATTGGCGTCAGTAACTTTCATCCGGACAGACTGGCTGATCTCATG
GCATTTAATAAGATCATTCCAGCCGTAAACCAAATTGAAGTTAATCCGTTCAACCAACAACTCCACGCTGTGCCATGGAT
GCAAAGCCGAGGTATTCAGCCAGAAGCATGGGCACCGTTTGCGGAAGGAAGAAACGGTCTCTTCCAGAATCCGGTATTAA
CCGCTATCGGCGAAAAATATGGCAAAAGCGTGGGACAGGTTGTATTACGCTGGATTTTCCAGCGCGGCATTGTCTCGCTG
GCAAAATCAGTGCGAAAAGGGCGAATGGAAGAGAATATTAACATTCTGGACTTCGAGCTCAGTGCTGAAGACATGCTGCA
GATAGCGGCTCTTGATACCGCAACGAGCGCCTTCTTCTCACATCGCGACCCGGCAATGGTGGAATGGCTGACTGGCCGTA
AACTTGATGTCTAA

Upstream 100 bases:

>100_bases
GGTTACCCAGAGTGGGTCGACCACGATGAACGGTTTTAAGCATTCATGAATATGACTAATAAACCCTAGTTAATTACCCC
TTCTAATCAAATAAATTACT

Downstream 100 bases:

>100_bases
GCCGCTATAGAAGAGGAGATTATTGATGCAAAAACGTTATCTCGGTAAATCCGGACTTGAAGTATCGGCACTGGGTCTGG
GCTGTATGGGGCTGAGCTAT

Product: putative aldo/keto reductase

Products: NA

Alternate protein names: GR; Methylglyoxal reductase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MRYAFPTQQLKDNVMQTVKLNNGIAMPLLGFGVFQMTNTAECERAVIDAIETGYRLIDTAASYQNETQVGNALKLSGIAR
DELFITTKLWLQDTYYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAMEELHQAGKIRAIGVSNFHPDRLADLM
AFNKIIPAVNQIEVNPFNQQLHAVPWMQSRGIQPEAWAPFAEGRNGLFQNPVLTAIGEKYGKSVGQVVLRWIFQRGIVSL
AKSVRKGRMEENINILDFELSAEDMLQIAALDTATSAFFSHRDPAMVEWLTGRKLDV

Sequences:

>Translated_297_residues
MRYAFPTQQLKDNVMQTVKLNNGIAMPLLGFGVFQMTNTAECERAVIDAIETGYRLIDTAASYQNETQVGNALKLSGIAR
DELFITTKLWLQDTYYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAMEELHQAGKIRAIGVSNFHPDRLADLM
AFNKIIPAVNQIEVNPFNQQLHAVPWMQSRGIQPEAWAPFAEGRNGLFQNPVLTAIGEKYGKSVGQVVLRWIFQRGIVSL
AKSVRKGRMEENINILDFELSAEDMLQIAALDTATSAFFSHRDPAMVEWLTGRKLDV
>Mature_297_residues
MRYAFPTQQLKDNVMQTVKLNNGIAMPLLGFGVFQMTNTAECERAVIDAIETGYRLIDTAASYQNETQVGNALKLSGIAR
DELFITTKLWLQDTYYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAMEELHQAGKIRAIGVSNFHPDRLADLM
AFNKIIPAVNQIEVNPFNQQLHAVPWMQSRGIQPEAWAPFAEGRNGLFQNPVLTAIGEKYGKSVGQVVLRWIFQRGIVSL
AKSVRKGRMEENINILDFELSAEDMLQIAALDTATSAFFSHRDPAMVEWLTGRKLDV

Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI24497577, Length=290, Percent_Identity=33.7931034482759, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI5174391, Length=290, Percent_Identity=33.7931034482759, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI310109922, Length=279, Percent_Identity=36.2007168458781, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI310109920, Length=300, Percent_Identity=34.3333333333333, Blast_Score=168, Evalue=4e-42,
Organism=Homo sapiens, GI45446745, Length=300, Percent_Identity=34.3333333333333, Blast_Score=168, Evalue=5e-42,
Organism=Homo sapiens, GI4503285, Length=300, Percent_Identity=34.3333333333333, Blast_Score=168, Evalue=5e-42,
Organism=Homo sapiens, GI5453543, Length=301, Percent_Identity=34.21926910299, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI24497583, Length=309, Percent_Identity=33.9805825242718, Blast_Score=167, Evalue=8e-42,
Organism=Homo sapiens, GI5174695, Length=294, Percent_Identity=32.6530612244898, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI24497585, Length=304, Percent_Identity=34.5394736842105, Blast_Score=158, Evalue=4e-39,
Organism=Homo sapiens, GI223468663, Length=292, Percent_Identity=33.2191780821918, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI4502049, Length=308, Percent_Identity=36.6883116883117, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI300116273, Length=277, Percent_Identity=31.4079422382672, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI93277124, Length=295, Percent_Identity=30.1694915254237, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI291291012, Length=283, Percent_Identity=31.8021201413428, Blast_Score=138, Evalue=5e-33,
Organism=Homo sapiens, GI300116271, Length=271, Percent_Identity=31.7343173431734, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI310109926, Length=118, Percent_Identity=44.9152542372881, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI207028673, Length=118, Percent_Identity=44.9152542372881, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI310109924, Length=151, Percent_Identity=31.1258278145695, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI87082198, Length=259, Percent_Identity=42.8571428571429, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI1786400, Length=255, Percent_Identity=34.9019607843137, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI1788081, Length=281, Percent_Identity=30.2491103202847, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI48994888, Length=200, Percent_Identity=31.5, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71998625, Length=262, Percent_Identity=37.4045801526718, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17564128, Length=307, Percent_Identity=33.2247557003257, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17537075, Length=295, Percent_Identity=33.5593220338983, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17537077, Length=295, Percent_Identity=32.8813559322034, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17561298, Length=273, Percent_Identity=32.2344322344322, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17550248, Length=285, Percent_Identity=33.6842105263158, Blast_Score=154, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17537079, Length=300, Percent_Identity=31.3333333333333, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17566692, Length=276, Percent_Identity=34.0579710144928, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17552492, Length=280, Percent_Identity=29.6428571428571, Blast_Score=132, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17561300, Length=274, Percent_Identity=31.021897810219, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17538386, Length=275, Percent_Identity=31.2727272727273, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17562292, Length=278, Percent_Identity=27.6978417266187, Blast_Score=128, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6324694, Length=284, Percent_Identity=38.3802816901408, Blast_Score=181, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6320576, Length=290, Percent_Identity=37.2413793103448, Blast_Score=179, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6322556, Length=267, Percent_Identity=33.7078651685393, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6321896, Length=325, Percent_Identity=31.3846153846154, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6320079, Length=282, Percent_Identity=31.2056737588652, Blast_Score=132, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6319625, Length=286, Percent_Identity=28.6713286713287, Blast_Score=109, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24657054, Length=278, Percent_Identity=39.2086330935252, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24663317, Length=288, Percent_Identity=35.4166666666667, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI45553081, Length=291, Percent_Identity=34.7079037800687, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24644950, Length=296, Percent_Identity=36.1486486486487, Blast_Score=168, Evalue=3e-42,
Organism=Drosophila melanogaster, GI21356425, Length=312, Percent_Identity=34.9358974358974, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI221378297, Length=316, Percent_Identity=33.8607594936709, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI20129731, Length=282, Percent_Identity=35.4609929078014, Blast_Score=158, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24662789, Length=290, Percent_Identity=34.8275862068965, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI281366140, Length=255, Percent_Identity=32.5490196078431, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24662781, Length=280, Percent_Identity=33.2142857142857, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24662785, Length=273, Percent_Identity=32.967032967033, Blast_Score=121, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: =1.1.1.283 [H]

Molecular weight: Translated: 33565; Mature: 33565

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYAFPTQQLKDNVMQTVKLNNGIAMPLLGFGVFQMTNTAECERAVIDAIETGYRLIDTA
CCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHH
ASYQNETQVGNALKLSGIARDELFITTKLWLQDTYYEGAKAQFERSLNRLQLDYVDLYLI
HHHCCHHHHCCEEEECCCCCCCEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHEEEEEEE
HQPYGDVHGAWRAMEELHQAGKIRAIGVSNFHPDRLADLMAFNKIIPAVNQIEVNPFNQQ
ECCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHEEECCCCCHH
LHAVPWMQSRGIQPEAWAPFAEGRNGLFQNPVLTAIGEKYGKSVGQVVLRWIFQRGIVSL
HHCCCCHHHCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKSVRKGRMEENINILDFELSAEDMLQIAALDTATSAFFSHRDPAMVEWLTGRKLDV
HHHHHHCHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MRYAFPTQQLKDNVMQTVKLNNGIAMPLLGFGVFQMTNTAECERAVIDAIETGYRLIDTA
CCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHH
ASYQNETQVGNALKLSGIARDELFITTKLWLQDTYYEGAKAQFERSLNRLQLDYVDLYLI
HHHCCHHHHCCEEEECCCCCCCEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHEEEEEEE
HQPYGDVHGAWRAMEELHQAGKIRAIGVSNFHPDRLADLMAFNKIIPAVNQIEVNPFNQQ
ECCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHEEECCCCCHH
LHAVPWMQSRGIQPEAWAPFAEGRNGLFQNPVLTAIGEKYGKSVGQVVLRWIFQRGIVSL
HHCCCCHHHCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKSVRKGRMEENINILDFELSAEDMLQIAALDTATSAFFSHRDPAMVEWLTGRKLDV
HHHHHHCHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]