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The map label for this gene is fabB [H]

Identifier: 218929829

GI number: 218929829

Start: 3089861

End: 3091084

Strand: Direct

Name: fabB [H]

Synonym: YPO2757

Alternate gene names: 218929829

Gene position: 3089861-3091084 (Clockwise)

Preceding gene: 218929827

Following gene: 218929831

Centisome position: 66.4

GC content: 49.51

Gene sequence:

>1224_bases
ATGAAGCGTGCAGTAATTACTGGCTTGGGTATTGTTTCCAGCATTGGTAATAACCAGCAGGAAGTTTTGGCATCTTTGCA
GGAAGGCCGCTCTGGCATTACTTTCGCTCAAGAATTTAAAGACGCAGGTATGCGCAGCCATGTATGGGGTGATGTAAAAC
TCCAGTCTGAGCCTAAAGATCTCATCGACCGCAAAGTGCTGCGTTTTATGAGCGATGCCTCCATTTATGCTTATCTTGCG
ATGCAAGAAGCGATTGCTGACTCTGGGTTGTCTGATTCTCAGGTTTCTAATTTCCGCAGCGGATTGGTGGTGGGTTCAGG
TGGGGGGTCGCCACGTAACCAGGTTGCTGGTTCTGATGCGATGCGCACTCCACGCGGCCTGAAAGGTGTTGGCCCTTATA
TGGTGACTAAAGCCATGGCATCCGGTGTCTCCGCGTGTCTGGCAACACCGTTTAAAATCAAAGGGGTTAACTACTCTATC
AGTTCCGCTTGTGCGACTTCTGCTCATTGTATTGGCCATGCTTTGGAGCTGATCCAATTGGGCAAACAGGACATCGTCTT
TGCCGGTGGTGGTGAAGAACTGTGCTGGGAAATGGCCTGTGAATTTGACGCGATGGGCGCATTATCGACCAAATATAATG
ATACCCCGGCTAAAGCTTCCCGTACTTACGATCAAGACCGTGATGGTTTTGTGATCGCAGGTGGTGGCGGTATGGTCGTG
GTTGAAGAGCTGGAACATGCTCTGGCCCGTGGCGCACATATTTACGCTGAGATCGTGGGCTATGGTGCCACTTCAGATGG
TGCTGACATGGTTGCACCGTCAGGCGAAGGCGCAGTTCGTTGCATGCAAATGGCAATGGCAGGTGTTGATACGCCAATCG
ACTACATGAACGTACACGGTACCTCTACCCCGGTTGGTGATGTAAAAGAGCTAGGTGCAATTCGTGAAGTGTTTGGTAAT
AACACGCCAGCGATTTCCTCAACCAAAGCAATGACTGGCCATTCCCTTGGGGCGGCGGGTGTACATGAGGCTATCTTCAG
CTTGCTGATGGTTGAACATGGCTTTATCGCACCAAGCATTAACATTGATAATCTGGATGAACAAGCGCAGGGGATGAATA
TCATCACTGAGACAACGCAACGTGAACTGACCACGGTGATGTCTAACAGTTTTGGTTTCGGTGGCACTAATGCAACATTA
GTGATGCGTAAATATCAGAAGTAA

Upstream 100 bases:

>100_bases
TTTCTGGCTATATTACGCTGATCGGACTTGTTCGGCGTACAACTGTACGCTAAAGTGCGTTGCAAAATCCCGAATGTAAA
ATTAGTGGAAGAGGTATTTA

Downstream 100 bases:

>100_bases
GCTTAAACGCAAAACTGTTTTGCTGATTCAGATTTACTCCCCAAAGCCTACGAGAGATCGTAGGCTTGAGGTTATTGACA
AAGTGCCCGCGACGGAGAGA

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MKRAVITGLGIVSSIGNNQQEVLASLQEGRSGITFAQEFKDAGMRSHVWGDVKLQSEPKDLIDRKVLRFMSDASIYAYLA
MQEAIADSGLSDSQVSNFRSGLVVGSGGGSPRNQVAGSDAMRTPRGLKGVGPYMVTKAMASGVSACLATPFKIKGVNYSI
SSACATSAHCIGHALELIQLGKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPAKASRTYDQDRDGFVIAGGGGMVV
VEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMQMAMAGVDTPIDYMNVHGTSTPVGDVKELGAIREVFGN
NTPAISSTKAMTGHSLGAAGVHEAIFSLLMVEHGFIAPSINIDNLDEQAQGMNIITETTQRELTTVMSNSFGFGGTNATL
VMRKYQK

Sequences:

>Translated_407_residues
MKRAVITGLGIVSSIGNNQQEVLASLQEGRSGITFAQEFKDAGMRSHVWGDVKLQSEPKDLIDRKVLRFMSDASIYAYLA
MQEAIADSGLSDSQVSNFRSGLVVGSGGGSPRNQVAGSDAMRTPRGLKGVGPYMVTKAMASGVSACLATPFKIKGVNYSI
SSACATSAHCIGHALELIQLGKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPAKASRTYDQDRDGFVIAGGGGMVV
VEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMQMAMAGVDTPIDYMNVHGTSTPVGDVKELGAIREVFGN
NTPAISSTKAMTGHSLGAAGVHEAIFSLLMVEHGFIAPSINIDNLDEQAQGMNIITETTQRELTTVMSNSFGFGGTNATL
VMRKYQK
>Mature_407_residues
MKRAVITGLGIVSSIGNNQQEVLASLQEGRSGITFAQEFKDAGMRSHVWGDVKLQSEPKDLIDRKVLRFMSDASIYAYLA
MQEAIADSGLSDSQVSNFRSGLVVGSGGGSPRNQVAGSDAMRTPRGLKGVGPYMVTKAMASGVSACLATPFKIKGVNYSI
SSACATSAHCIGHALELIQLGKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPAKASRTYDQDRDGFVIAGGGGMVV
VEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMQMAMAGVDTPIDYMNVHGTSTPVGDVKELGAIREVFGN
NTPAISSTKAMTGHSLGAAGVHEAIFSLLMVEHGFIAPSINIDNLDEQAQGMNIITETTQRELTTVMSNSFGFGGTNATL
VMRKYQK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=35.5608591885441, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI223972627, Length=167, Percent_Identity=41.3173652694611, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI41872631, Length=337, Percent_Identity=26.7062314540059, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1788663, Length=407, Percent_Identity=85.2579852579853, Blast_Score=710, Evalue=0.0,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=38.3495145631068, Blast_Score=235, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI71983541, Length=418, Percent_Identity=34.4497607655502, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71983535, Length=259, Percent_Identity=39.3822393822394, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI212642053, Length=367, Percent_Identity=26.4305177111717, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=367, Percent_Identity=26.7029972752044, Blast_Score=98, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6320904, Length=445, Percent_Identity=30.561797752809, Blast_Score=177, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=37.29216152019, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI19920632, Length=341, Percent_Identity=27.2727272727273, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221330659, Length=341, Percent_Identity=27.2727272727273, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24581345, Length=342, Percent_Identity=23.0994152046784, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42834; Mature: 42834

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRAVITGLGIVSSIGNNQQEVLASLQEGRSGITFAQEFKDAGMRSHVWGDVKLQSEPKD
CCCCEEEHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEECCCCHH
LIDRKVLRFMSDASIYAYLAMQEAIADSGLSDSQVSNFRSGLVVGSGGGSPRNQVAGSDA
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEECCCCCCCHHCCCCHH
MRTPRGLKGVGPYMVTKAMASGVSACLATPFKIKGVNYSISSACATSAHCIGHALELIQL
HCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCEEHHHHHHHHHHHHHHHHHHHHC
GKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPAKASRTYDQDRDGFVIAGGGGMVV
CCCCEEEECCCHHHHHHHHHCHHHCCCCCCCCCCCCCHHHCCCCCCCCCEEEECCCCEEE
VEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMQMAMAGVDTPIDYMNVHG
HHHHHHHHHCCHHEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHEECCC
TSTPVGDVKELGAIREVFGNNTPAISSTKAMTGHSLGAAGVHEAIFSLLMVEHGFIAPSI
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
NIDNLDEQAQGMNIITETTQRELTTVMSNSFGFGGTNATLVMRKYQK
CCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MKRAVITGLGIVSSIGNNQQEVLASLQEGRSGITFAQEFKDAGMRSHVWGDVKLQSEPKD
CCCCEEEHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEECCCCHH
LIDRKVLRFMSDASIYAYLAMQEAIADSGLSDSQVSNFRSGLVVGSGGGSPRNQVAGSDA
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEECCCCCCCHHCCCCHH
MRTPRGLKGVGPYMVTKAMASGVSACLATPFKIKGVNYSISSACATSAHCIGHALELIQL
HCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCEEHHHHHHHHHHHHHHHHHHHHC
GKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPAKASRTYDQDRDGFVIAGGGGMVV
CCCCEEEECCCHHHHHHHHHCHHHCCCCCCCCCCCCCHHHCCCCCCCCCEEEECCCCEEE
VEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMQMAMAGVDTPIDYMNVHG
HHHHHHHHHCCHHEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHEECCC
TSTPVGDVKELGAIREVFGNNTPAISSTKAMTGHSLGAAGVHEAIFSLLMVEHGFIAPSI
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
NIDNLDEQAQGMNIITETTQRELTTVMSNSFGFGGTNATLVMRKYQK
CCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]