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The map label for this gene is aat [H]

Identifier: 218929644

GI number: 218929644

Start: 2872809

End: 2874023

Strand: Direct

Name: aat [H]

Synonym: YPO2558

Alternate gene names: 218929644

Gene position: 2872809-2874023 (Clockwise)

Preceding gene: 218929627

Following gene: 218929645

Centisome position: 61.73

GC content: 49.14

Gene sequence:

>1215_bases
ATGTCCCCCATTGAGAAATCCAGCAAACTGGACAACGTCTGTTATGACATTCGTGGACCGGTGCTAAAAGAAGCTAAGCG
TCTTGAAGAGGAAGGTAACAAGGTTCTGAAACTGAACATCGGCAACCCTGCCCCGTTTGGTTTCGATGCACCCGACGAGA
TTCTGGTGGATGTAATCCGTAATTTACCGACCGCACAAGGCTATTGCGACTCCAAAGGCTTGTTTTCGGCACGTAAAGCC
ATTATGCAACACTATCAAGCCCGCAATATCCGTGATCTGACGGTCGAGGATATCTACATTGGAAACGGTGTTTCCGAGTT
GATCGTTCAATCCATGCAAGCATTACTGAATTTGGGTGATGAAATGCTAGTACCCGCACCGGATTACCCGCTGTGGACAG
CTGCCGTGTCGCTCTCAAGTGGTAAAGCGATTCATTATATGTGTGATGAAGAGTCAGGCTGGTTCCCTGATTTGGATGAT
ATTCGCAGCAAAATCACTCCGCGTACCCGTGGGATTGTGATTATCAACCCGAATAACCCAACCGGTGCGGTATACAGCAA
AGAGCTGCTGTTAGAAATTGTTGAAATTGCTCGCCAGAATGACCTAATTATTTTCGCTGATGAGATCTACGATAAAATTT
TGTATGACGATGCTCAGCACCATTCGATCGCCGCATTAGCCCCTGATTTGCTGACCGTTACGTTCAATGGGCTGTCTAAA
ACATACCGTGTTGCGGGTTTCCGCCAGGGCTGGATGGTGTTGAACGGGCCGAAAAAGCACGCTAAAGGGTATATTGAAGG
CTTGGAAATGCTGGCATCGATGCGTTTGTGCGCCAACGTACCAATGCAGCATGCGATTCAAACCGCCTTGGGCGGCTATC
AGAGCATTAGTGAGTTTATCCAACCTGGTGGCCGTTTGTACGAGCAGCGTGATCGGGCCTGGGAGCTTATCAACCAAATC
CCCGGTGTTTCCTGTGTGAAACCTCAGGGCGCGTTGTATATGTTCCCACGTATTGATCAGAAACGTTTTAACCTGAAAGA
CGACCAGAAGTTGGTATTGGATCTGTTGTTGCAAGAGAAAGTGCTATTGGTGCAAGGTAGCGCCTTTAACTGGCCGTACC
CGGACCATGTGCGGATCGTCACGCTGCCACGGGTGGATGAGCTAGAGATGGCGGTGAGGAAGCTGGGGCGGTTCTTAGAG
ACGTATCATCAGTAA

Upstream 100 bases:

>100_bases
ATGTATAGAACTTCAAAAATCAGTGGCGTCGGAGTACATTGAGCACCTTGCAGTGTTCCACGCTGAGGACACGCTTTTAC
CAGCAAAAGGCTCATTTTTT

Downstream 100 bases:

>100_bases
TTGTATGATTGGGGGATGAGGGCTGTTGATGAATCACTAAATCATCATCAACTGGAGCCTGATCCCCCGAACAAGTCAAT
TAATGTCAACCGAAACCCAA

Product: aminotransferase AlaT

Products: oxaloacetate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MSPIEKSSKLDNVCYDIRGPVLKEAKRLEEEGNKVLKLNIGNPAPFGFDAPDEILVDVIRNLPTAQGYCDSKGLFSARKA
IMQHYQARNIRDLTVEDIYIGNGVSELIVQSMQALLNLGDEMLVPAPDYPLWTAAVSLSSGKAIHYMCDEESGWFPDLDD
IRSKITPRTRGIVIINPNNPTGAVYSKELLLEIVEIARQNDLIIFADEIYDKILYDDAQHHSIAALAPDLLTVTFNGLSK
TYRVAGFRQGWMVLNGPKKHAKGYIEGLEMLASMRLCANVPMQHAIQTALGGYQSISEFIQPGGRLYEQRDRAWELINQI
PGVSCVKPQGALYMFPRIDQKRFNLKDDQKLVLDLLLQEKVLLVQGSAFNWPYPDHVRIVTLPRVDELEMAVRKLGRFLE
TYHQ

Sequences:

>Translated_404_residues
MSPIEKSSKLDNVCYDIRGPVLKEAKRLEEEGNKVLKLNIGNPAPFGFDAPDEILVDVIRNLPTAQGYCDSKGLFSARKA
IMQHYQARNIRDLTVEDIYIGNGVSELIVQSMQALLNLGDEMLVPAPDYPLWTAAVSLSSGKAIHYMCDEESGWFPDLDD
IRSKITPRTRGIVIINPNNPTGAVYSKELLLEIVEIARQNDLIIFADEIYDKILYDDAQHHSIAALAPDLLTVTFNGLSK
TYRVAGFRQGWMVLNGPKKHAKGYIEGLEMLASMRLCANVPMQHAIQTALGGYQSISEFIQPGGRLYEQRDRAWELINQI
PGVSCVKPQGALYMFPRIDQKRFNLKDDQKLVLDLLLQEKVLLVQGSAFNWPYPDHVRIVTLPRVDELEMAVRKLGRFLE
TYHQ
>Mature_403_residues
SPIEKSSKLDNVCYDIRGPVLKEAKRLEEEGNKVLKLNIGNPAPFGFDAPDEILVDVIRNLPTAQGYCDSKGLFSARKAI
MQHYQARNIRDLTVEDIYIGNGVSELIVQSMQALLNLGDEMLVPAPDYPLWTAAVSLSSGKAIHYMCDEESGWFPDLDDI
RSKITPRTRGIVIINPNNPTGAVYSKELLLEIVEIARQNDLIIFADEIYDKILYDDAQHHSIAALAPDLLTVTFNGLSKT
YRVAGFRQGWMVLNGPKKHAKGYIEGLEMLASMRLCANVPMQHAIQTALGGYQSISEFIQPGGRLYEQRDRAWELINQIP
GVSCVKPQGALYMFPRIDQKRFNLKDDQKLVLDLLLQEKVLLVQGSAFNWPYPDHVRIVTLPRVDELEMAVRKLGRFLET
YHQ

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4507369, Length=378, Percent_Identity=27.7777777777778, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI19263340, Length=473, Percent_Identity=26.215644820296, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI215599424, Length=347, Percent_Identity=27.6657060518732, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI4885351, Length=438, Percent_Identity=24.8858447488584, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI95147551, Length=268, Percent_Identity=24.6268656716418, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI169881279, Length=268, Percent_Identity=24.6268656716418, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI56713256, Length=299, Percent_Identity=24.4147157190635, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI56713254, Length=299, Percent_Identity=24.4147157190635, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI169881281, Length=254, Percent_Identity=25.9842519685039, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1788627, Length=404, Percent_Identity=89.6039603960396, Blast_Score=768, Evalue=0.0,
Organism=Escherichia coli, GI1788722, Length=380, Percent_Identity=26.5789473684211, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1786816, Length=238, Percent_Identity=24.7899159663866, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17567663, Length=370, Percent_Identity=28.3783783783784, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71981209, Length=464, Percent_Identity=25, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17567369, Length=242, Percent_Identity=28.099173553719, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71994476, Length=211, Percent_Identity=27.4881516587678, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71994472, Length=211, Percent_Identity=27.4881516587678, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71981215, Length=293, Percent_Identity=24.9146757679181, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6320317, Length=361, Percent_Identity=28.808864265928, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6323118, Length=357, Percent_Identity=28.5714285714286, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6322401, Length=357, Percent_Identity=22.4089635854342, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI18859735, Length=380, Percent_Identity=26.5789473684211, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24641770, Length=483, Percent_Identity=27.1221532091097, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24641760, Length=483, Percent_Identity=27.1221532091097, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24641768, Length=483, Percent_Identity=27.1221532091097, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24641766, Length=483, Percent_Identity=27.1221532091097, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24641764, Length=483, Percent_Identity=27.1221532091097, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI45551451, Length=483, Percent_Identity=27.1221532091097, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI28573069, Length=323, Percent_Identity=23.8390092879257, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24646114, Length=323, Percent_Identity=23.8390092879257, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI28573067, Length=323, Percent_Identity=23.8390092879257, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI28573065, Length=323, Percent_Identity=23.8390092879257, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.1

Molecular weight: Translated: 45542; Mature: 45411

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPIEKSSKLDNVCYDIRGPVLKEAKRLEEEGNKVLKLNIGNPAPFGFDAPDEILVDVIR
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHH
NLPTAQGYCDSKGLFSARKAIMQHYQARNIRDLTVEDIYIGNGVSELIVQSMQALLNLGD
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCC
EMLVPAPDYPLWTAAVSLSSGKAIHYMCDEESGWFPDLDDIRSKITPRTRGIVIINPNNP
CEEECCCCCCHHHHEEECCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCEEEEECCCCC
TGAVYSKELLLEIVEIARQNDLIIFADEIYDKILYDDAQHHSIAALAPDLLTVTFNGLSK
CCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCCHHHHCCCEEEEEECCCHH
TYRVAGFRQGWMVLNGPKKHAKGYIEGLEMLASMRLCANVPMQHAIQTALGGYQSISEFI
HHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHH
QPGGRLYEQRDRAWELINQIPGVSCVKPQGALYMFPRIDQKRFNLKDDQKLVLDLLLQEK
CCCHHHHHHHHHHHHHHHHCCCCEEECCCCCEEECCCCCCHHCCCCCHHHHHHHHHHHCC
VLLVQGSAFNWPYPDHVRIVTLPRVDELEMAVRKLGRFLETYHQ
EEEEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SPIEKSSKLDNVCYDIRGPVLKEAKRLEEEGNKVLKLNIGNPAPFGFDAPDEILVDVIR
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHH
NLPTAQGYCDSKGLFSARKAIMQHYQARNIRDLTVEDIYIGNGVSELIVQSMQALLNLGD
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCC
EMLVPAPDYPLWTAAVSLSSGKAIHYMCDEESGWFPDLDDIRSKITPRTRGIVIINPNNP
CEEECCCCCCHHHHEEECCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCEEEEECCCCC
TGAVYSKELLLEIVEIARQNDLIIFADEIYDKILYDDAQHHSIAALAPDLLTVTFNGLSK
CCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCCHHHHCCCEEEEEECCCHH
TYRVAGFRQGWMVLNGPKKHAKGYIEGLEMLASMRLCANVPMQHAIQTALGGYQSISEFI
HHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHH
QPGGRLYEQRDRAWELINQIPGVSCVKPQGALYMFPRIDQKRFNLKDDQKLVLDLLLQEK
CCCHHHHHHHHHHHHHHHHCCCCEEECCCCCEEECCCCCCHHCCCCCHHHHHHHHHHHCC
VLLVQGSAFNWPYPDHVRIVTLPRVDELEMAVRKLGRFLETYHQ
EEEEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate; 2-oxoglutarate

Specific reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]